Cited by 143Cardiovascular Function and Risk FactorsBlood Pressure and Hypertension StudiesCardiovascular Health and Disease Prevention

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Influence of contemporary versus 30-year blood pressure levels on left ventricular mass and geometry: The Framingham Heart Study

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Lauer, Michael S., Anderson, Keaven M., Levy, Daniel·1991·Journal of the American College of Cardiology

DOI 10.1016/0735-1097(91)90549-o

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Abstract

To determine whether long-term blood pressure levels correlate with left ventricular mass, echocardiographic measurements were performed in 152 men and 299 women who were participants in the Framingham Heart Study. All subjects were free of obesity and cardiovascular and pulmonary disease, were not taking antihypertensive medications and had echocardiographic studies that were adequate for estimating left ventricular mass. Thirty-year average systolic blood pressure was correlated with left ventricular mass (corrected for height) (r = 0.27, p less than 0.001 in men; r = 0.31, p less than 0.001 in women). Multivariate linear regression analyses taking into account age and body mass index showed 30-year average systolic blood pressure to be a significant independent predictor of left ventricular mass (p less than 0.01 in men and women). Systolic blood pressure at echocardiography was not independently associated with left ventricular mass when 30-year systolic blood pressure was entered into the multivariate model. The prevalence of left ventricular hypertrophy was associated with 30-year average systolic blood pressure (odds ratio for every 20-mm Hg increase in blood pressure: 3.20, p less than 0.05 in men; 3.27, p less than 0.001 in women). The increase in left ventricular mass associated with 30-year average systolic blood pressure reflected changes in left ventricular wall thickness but not in left ventricular internal dimension. Thirty-year average diastolic blood pressure was also correlated with left ventricular mass but to a lesser degree than was systolic blood pressure (r = 0.18, p less than 0.05 in men; r = 0.18, p less than 0.01 in women).(ABSTRACT TRUNCATED AT 250 WORDS)

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Authors: Lauer, M. S., Anderson, K. M., & Levy, D.
Affiliations: Beth Israel Deaconess Medical Center (US)
Harvard University (US)
Corresponding author: Levy, Daniel
ORCID: Lauer, Michael S.
Anderson, Keaven M.
Levy, Daniel
Venue: Journal of the American College of Cardiology
Publisher: Elsevier BV
Published: 1991-11
Volume: 18
Issue: 5
Pages: 1287-1294
ISSN: 0735-1097 (ISSN-L)
DOI: 10.1016/0735-1097(91)90549-o
OpenAlex: W2004994041
Cited by: 143
References: 30
Citations by year: 2025: 3 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 1 · 2020: 8 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 2 · 2015: 3 · 2014: 4 · 2013: 3 · 2012: 3
FWCI: 5.11
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 7928 d)
Locations: Journal of the American College of Cardiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (n01hc038038-022, 5t32hl007374-41)
National Heart, Lung, and Blood Institute (N01-HC-38038, HL07374)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Keywords: left ventricular mass, left ventricular hypertrophy, systolic blood pressure, diastolic blood pressure, left ventricular wall thickness, left ventricular geometry, Framingham Heart Study
MeSH terms: Adult, Aging, Blood Pressure, Body Height, Echocardiography, Female, Follow-Up Studies, Cardiomegaly, Heart Ventricles, Humans, Male, Middle Aged, Prospective Studies, Reference Values, Regression Analysis, Body Mass Index, Prevalence

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Influence of contemporary versus 30-year blood pressure levels on left ventricular mass and geometry: The Framingham Heart Study

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