Mid- to Late-Life Time-Averaged Cumulative Blood Pressure and Late-Life Cardiac Structure, Function, and Heart Failure
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Limited data exist regarding systolic blood pressure (SBP) through mid- to late-life and late-life cardiac function and heart failure (HF) risk. Among 4578 HF-free participants in the ARIC study (Atherosclerosis Risk in Communities) attending the fifth visit (2011–2013; age 75±5 years), time-averaged cumulative SBP was calculated as the sum of averaged SBPs from adjacent consecutive visits (visits 1–5) indexed to total observation time (24±1 years). Calculations were performed using measured SBPs and also incorporating antihypertensive medication specific effect constants (underlying SBP). Outcomes included comprehensive echocardiography at visit 5 and post-visit 5 incident HF, HF with preserved ejection fraction, and reduced ejection fraction. Higher cumulative SBP was associated with greater left ventricular mass and worse diastolic measures (all P <0.001), associations that were stronger with underlying compared with cumulative SBP (all P <0.05). At 5.6±1.2 years follow-up post-visit 5, higher cumulative measured and underlying SBP were associated with incident HF (hazard ratio per 10 mm Hg for measured: 1.12 [1.01–1.24]; underlying: 1.19 [95% CI, 1.10–1.30]) and HF with preserved ejection fraction (measured: 1.15 [1.00–1.33]; underlying: 1.28 [1.14–1.45]), but not HF with reduced ejection fraction (measured: 1.11 [0.94–1.32]; underlying: 1.11 [0.96–1.24]). Associations with HF and HF with preserved ejection fraction were more robust with cumulative underlying compared with measured SBP (all P <0.05). Time-averaged cumulative SBP in mid to late life is associated with worse cardiac function and risk of incident HF, especially HF with preserved ejection fraction, in late life. These associations were stronger considering underlying as opposed to measured SBP, highlighting the importance of prevention and effective treatment of hypertension to prevent late-life cardiac dysfunction and HF.
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The CARDIA study and ARIC cohort indicate that people with high cumulative systolic BP over many years have worse cardiac function and higher risk of incident heart failure later in life than those with lower cumulative systolic BP.
“Mounting evidence, including data from the CARDIA study27 and the ARIC cohort28, indicates that individuals with high cumulative systolic BP levels over many years have worse cardiac function and increased risk of incident heart failure in later life compared with individuals with lower cumulative systolic BP levels.”
From Blood pressure and its variability: classic and novel measurement techniques (2022) · cites this paper as [28]
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Lang, R. M., Bierig, M., Devereux, R. B., Flachskampf, F. A., Foster, E., Pellikka, P. A., Picard, M. H., Roman, M. J., Seward, J., Shanewise, J. S., et al. (2005) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2005.10.005 · Cited by 11,318 · see citing works
Self-citationWhelton, P. K., Carey, R. M., Aronow, W. S., Casey, D. E., Collins, K. J., Dennison Himmelfarb, C., DePalma, S. M., Gidding, S., Jamerson, K. A., Jones, D. W., et al. (2018) · Hypertension · doi:10.1161/hyp.0000000000000065 · Cited by 7,391 · see citing works
A Randomized Trial of Intensive versus Standard Blood-Pressure Control
The SPRINT Research Group (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1511939 · Cited by 6,325 · see citing works
The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group (2002) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.288.23.2981 · Cited by 5,664 · see citing works
A Novel Paradigm for Heart Failure With Preserved Ejection Fraction
Paulus, W. J., & Tschöpe, C. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.02.092 · Cited by 3,564 · see citing works
(1989) · PubMed · Cited by 3,139 · see citing works
Treatment of hypertension in patients 80 years of age or older
Beckett, N. S., Peters, R., Fletcher, A. E., Staessen, J. A., Liu, L., Dumitrascu, D., Stoyanovsky, V., Antikainen, R. L., Nikitin, Y., Anderson, C., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0801369 · Cited by 3,092 · see citing works
Wall stress and patterns of hypertrophy in the human left ventricle.
Grossman, W., Jones, D., & McLaurin, L. P. (1975) · Journal of Clinical Investigation · doi:10.1172/jci108079 · Cited by 2,403 · see citing works
Williamson, J. D., Supiano, M. A., Applegate, W. B., Berlowitz, D. R., Campbell, R. C., Chertow, G. M., Fine, L. J., Haley, W. E., Hawfield, A. T., Ix, J. H., et al. (2016) · JAMA · doi:10.1001/jama.2016.7050 · Cited by 1,261 · see citing works
Phenotype-Specific Treatment of Heart Failure With Preserved Ejection Fraction: A Multiorgan Roadmap
Shah, S. J., Kitzman, D. W., Borlaug, B. A., van Heerebeek, L., Zile, M. R., Kass, D. A., & Paulus, W. J. (2016) · Circulation · doi:10.1161/circulationaha.116.021884 · Cited by 1,003 · see citing works
Nitrosative stress drives heart failure with preserved ejection fraction
Schiattarella, G. G., Altamirano, F. J., Tong, D., French, K. M., Villalobos, E., Kim, S. Y., Luo, X., Jiang, N., May, H. I., Wang, Z. V., et al. (2019) · Nature · doi:10.1038/s41586-019-1100-z · Cited by 956 · see citing works
Potential US Population Impact of the 2017 ACC/AHA High Blood Pressure Guideline
Muntner, P., Carey, R. M., Gidding, S. S., Jones, D. W., Taler, S. J., Wright, J. T., & Whelton, P. K. (2017) · Circulation · doi:10.1161/circulationaha.117.032582 · Cited by 942 · see citing works
Impaired Systolic Function by Strain Imaging in Heart Failure With Preserved Ejection Fraction
Kraigher‐Krainer, E., Shah, A. M., Gupta, D. K., Santos, Â. B. S., Claggett, B. L., Pieske, B. M., Zile, M. R., Voors, A. A., Lefkowitz, M., Packer, M., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.09.052 · Cited by 751 · see citing works
Self-citationWhite, A., Folsom, A. R., Chambless, L. E., Sharret, A. R., Yang, K., Conwill, D. E., HIGGINS, M. W., Williams, O. D., Tyroler, H. A., & The ARIC Investigators (1996) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(95)00041-0 · Cited by 688 · see citing works
Kostis, J. B. (1997) · JAMA · doi:10.1001/jama.278.3.212 · Cited by 620 · see citing works
Solomon, S. D., Janardhanan, R., Verma, A. K., Bourgoun, M., Daley, W. L., Purkayastha, D., Lacourcière, Y., Hippler, S. E., Fields, H., Naqvi, T. Z., et al. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60980-5 · Cited by 327 · see citing works
Self-citationSengupta, P. P., Krishnamoorthy, V. K., Korinek, J. K., Narula, J., Vannan, M. A., Lester, S. J., Tajik, J. A., Seward, J. B., Khandheria, B. K., & Bëlohlávek, M. (2007) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2006.10.013 · Cited by 323 · see citing works
Initial Monotherapy and Combination Therapy and Hypertension Control the First Year
Egan, B. M., Bandyopadhyay, D., Shaftman, S. R., Wagner, C. S., Zhao, Y., & Yu-Isenberg, K. S. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.194167 · Cited by 246 · see citing works
Mizuguchi, Y., Oishi, Y., Miyoshi, H., Íuchi, A., Nagase, N., & Oki, T. (2008) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2008.07.016 · Cited by 245 · see citing works
Relationship between longitudinal and radial contractility in subclinical diabetic heart disease
Fang, Z. Y., Leano, R., & Marwick, T. H. (2004) · Clinical Science · doi:10.1042/cs20030153 · Cited by 240 · see citing works
Ference, B. A., Bhatt, D. L., Catapano, A. L., Packard, C. J., Graham, I. M., Kaptoge, S. K., Ference, T. B., Guo, Q., Laufs, U., Ruff, C. T., et al. (2019) · JAMA · doi:10.1001/jama.2019.14120 · Cited by 222 · see citing works
Davis, B. R., Kostis, J. B., Simpson, L. M., Black, H. R., Cushman, W. C., Einhorn, P. T., Farber, M. A., Ford, C. E., Levy, D. A., Massie, B. M., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.762229 · Cited by 204 · see citing works
Tientcheu, D., Ayers, C. R., Das, S. R., McGuire, D. K., de Lemos, J. A., Khera, A., Kaplan, N. M., Victor, R. G., & Vongpatanasin, W. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.09.007 · Cited by 201 · see citing works
Shah, A. M., Cheng, S. C., Skali, H., Wu, J. C., Mangion, J. R., Kitzman, D. W., Matsushita, K., Konety, S., Butler, K. R., Fox, E. R., et al. (2013) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.113.000736 · Cited by 163 · see citing works
Self-citationCumulative Blood Pressure in Early Adulthood and Cardiac Dysfunction in Middle Age
Kishi, S., Teixido-Tura, G., Ning, H., Venkatesh, B. A., Wu, C., Almeida, A., Choi, E.-Y., Gjesdal, O., Jacobs, D. R., Schreiner, P. J., et al. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.04.042 · Cited by 143 · see citing works
Lauer, M. S., Anderson, K. M., & Levy, D. (1991) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(91)90549-o · Cited by 143 · see citing works
A Summary of the Effects of Antihypertensive Medications on Measured Blood Pressure
WU, J., Kraja, A. T., Oberman, A., Lewis, C. E., Ellison, R. C., Arnett, D. K., HEISS, G. M., Lalouel, J.-M., Turner, S. T., & Hunt, S. C. (2005) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2005.01.011 · Cited by 139 · see citing works
Solomon, S. D., Verma, A. K., Desai, A. S., Hassanein, A. H., Izzo, J. L., Oparil, S., Lacourcière, Y., Lee, J., Seifu, Y., Hilkert, R. J., et al. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.138529 · Cited by 127 · see citing works
Self-citationPrognostic Value of Masked Uncontrolled Hypertension
Pierdomenico, S. D., Pierdomenico, A. M., Coccina, F., Clement, D. L., Buyzere, M. D., Bacquer, D. D., Ben‐Dov, I. Z., Vongpatanasin, W., Banegas, J. R., Ruilope, L. M., et al. (2018) · Hypertension · doi:10.1161/hypertensionaha.118.11499 · Cited by 118 · see citing works
Antecedent Blood Pressure, Body Mass Index, and the Risk of Incident Heart Failure in Later Life
Lee, D. S., Massaro, J. M., Wang, T. J., Kannel, W. B., Benjamin, E. J., Kenchaiah, S., Levy, D. A., D’Agostino, R. B., & Vasan, R. S. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.095380 · Cited by 106 · see citing works
Carasso, S., Cohen, O., Mutlak, D., Adler, Z., Lessick, J., Reisner, S. A., Rakowski, H., Bolotin, G., & Agmon, Y. (2009) · American Heart Journal · doi:10.1016/j.ahj.2009.07.008 · Cited by 83 · see citing works
Briasoulis, Α., Agarwal, V., Tousoulis, D., & Stefanadis, C. (2013) · Heart · doi:10.1136/heartjnl-2013-304111 · Cited by 78 · see citing works
Redmond, N., Booth, J. N., Tanner, R. M., Diaz, K. M., Abdalla, M., Sims, M., Muntner, P., & Shimbo, D. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.115.002284 · Cited by 64 · see citing works
Methods to estimate underlying blood pressure: The Atherosclerosis Risk in Communities (ARIC) Study
Balakrishnan, P., BEATY, T. L., Young, J. H., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0179234 · Cited by 42 · see citing works
Benefits of Early Hypertension Control on Cardiovascular Outcomes in Patients With Diabetes
O’Connor, P. J., Vazquez‐Benitez, G., Schmittdiel, J. A., Parker, E. D., Trower, N. K., DESAI, J. R., Margolis, K. L., & Magid, D. J. (2012) · Diabetes Care · doi:10.2337/dc12-0284 · Cited by 31 · see citing works
Low-dose eplerenone decreases left ventricular mass in treatment-resistant hypertension
Schneider, A., Schwab, J., Karg, M. V., Kalizki, T., Reinold, A., Schneider, M. P., Schmieder, R. E., & Schmidt, B. M. W. (2017) · Journal of Hypertension · doi:10.1097/hjh.0000000000001264 · Cited by 24 · see citing works
Antecedent blood pressure as a predictor of cardiovascular disease
Bonifonte, A., Ayer, T., Veledar, E., Clark, A., & Wilson, P. W. F. (2015) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2015.06.013 · Cited by 24 · see citing works
Flagged first, then by citations
Research works printed but not linked: 10
- [1]Kannel WB. Blood pressure as cardiovascular risk factor: prevention and treatment. JAMA. 1996; 275(20): 1571– 1576. 8622248
- [6]Gray L, Lee IM, Sesso HD, Batty GD. Blood pressure in early adulthood, hypertension in middle age, and future CVD mortality: HAHS (Harvard Alumni Health Study). J Am Coll Cardiol. 2011; 58(23): 2396– 403. 22115646 PMC3253414
- [7]Vasan RS, Massaro JM, Wilson PW, Framingham Heart Study. Antecedent blood pressure and risk of cardiovascular disease: the Framingham Heart Study. Circulation. 2002; 105(1): 48– 53. 11772875
- [8]Allen N, Berry JD, Ning H, Van Horn L, Dyer A, Lloyd-Jones DM. Impact of blood pressure and blood pressure change during middle age on the remaining lifetime risk for cardiovascular disease: the cardiovascular lifetime risk pooling project. Circulation. 2012; 125(1): 37– 44. 22184621 PMC3310202
- [12]Ghosh AK, Hardy RJ, Francis DP, Medical Research Council National Survey of Health and Development (NHSD) Scientific and Data Collection Team. Midlife blood pressure change and left ventricular mass and remodelling in older age in the 1946 British Birth Cohort Study. Eur Heart J. 2014; 35(46): 3287– 95. 25246483 PMC4258225
- [20]Rosamond WD, Chang PP, Baggett C, Johnson A, Bertoni AG, Shahar E, Deswal A, Heiss G, Chambless LE. Classification of heart failure in the atherosclerosis risk in communities (ARIC) study: a comparison of diagnostic criteria. Circ Heart Fail. 2012 3 1; 5(2): 152– 9. 22271752 PMC3326579
- [25]Beckett NS, Peters R, Fletcher AE, HYVET Study Group. Treatment of hypertension in patients 80 years of age or older. N Engl J Med. 2008; 358(18): 1887– 98. 18378519
- [28]Mancia G, Carugo S, Grassi G, Pressioni Arteriose Monitorate E Loro Associazioni (PAMELA) Study. Prevalence of left ventricular hypertrophy in hypertensive patients without and with blood pressure control: data from the PAMELA population. Pressioni Arteriose Monitorate E Loro Associazioni. Hypertension. 2002; 39(3): 744– 9. 11897756
- [36]Devereux RB, Dahlof B, Gerdts E, Regression of hypertensive left ventricular hypertrophy by losartan compared with atenolol: the Losartan Intervention for Endpoint Reduction in Hypertension (LIFE) trial. Circulation. 2004; 110(11): 1456– 62. 15326072
- [45]Parati G, Bilo G, Ochoa JE. Benefits of tight blood pressure control in diabetic patients with hypertension: importance of early and sustained implementation of effective treatment strategies. Diabetes Care. 2011 5; 34 Suppl 2: S297– 303. 21525472 PMC3632196
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Blood pressure and its variability: classic and novel measurement techniques
Schutte, A. E., Kollias, A., & Stergiou, G. S. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00690-0 · Cited by 335 · see citing works
- Authors
- Teramoto, K., Nadruz Junior, W., Matsushita, K., Claggett, B., John, J. E., Skali, H., Solomon, S., Cheng, S., & Shah, A. M.
- Affiliations
- Brigham and Women's Hospital (US)
- Cardiology Division, State University of Campinas, São Paulo, Brazil (W.N.J.)
- Johns Hopkins University (US)
- Cedars-Sinai Medical Center (US)
- ORCID
- Venue
- Hypertension
- Published
- 2020-09
- Volume
- 76
- Issue
- 3
- Pages
- 808-818
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- PMC
- PMC8262121
- OpenAlex
- W3034630844
- Cited by
- 36
- References
- 37
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 7 · 2023: 4 · 2022: 8 · 2021: 5
- FWCI
- 2.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (U54AG065141)
- National Heart, Lung, and Blood Institute (HHSN268201700004I, R01HL143227, HHSN268201700001I, HHSN268201700005C, HHSN268201700003I, K24HL152008, HHSN268201700005I, HHSN268201700001C, R01HL143224, R01HL142983, HHSN268201700002I, R01HL150342, HHSN268201700003C, HHSN268201700002C, HHSN268201700004C, R01HL135008, T32HL094301, R01HL131532)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- systolic blood pressure, heart failure, heart failure with preserved ejection fraction, heart failure with reduced ejection fraction, left ventricular mass, diastolic function, cardiac structure, antihypertensive drugs, older adults
- MeSH terms
- Heart Disease Risk Factors, Aged, Blood Pressure, Echocardiography, Female, Heart Failure, Heart Ventricles, Humans, Hypertension, Japan, Male, Organ Size, Prognosis, Public Health, Stroke Volume, Ventricular Function, Left, Early Medical Intervention
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