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Cited by 122Blood Pressure and Hypertension StudiesCardiovascular Function and Risk FactorsCardiovascular Health and Disease Prevention

Relationship Between Central Sympathetic Drive and Magnetic Resonance Imaging–Determined Left Ventricular Mass in Essential Hypertension

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Burns, Joanna, Sivananthan, Mohan U., Ball, Stephen G., Mackintosh, Alan F., Mary, David A.S.G., Greenwood, John P.·2007·Circulation
DOI 10.1161/circulationaha.106.668863PMC PMC3925820
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Abstract

Background— Sympathetic activation has been implicated in the development of left ventricular hypertrophy (LVH). However, the relationship between sympathetic activation and LV mass (LVM) has not been clearly defined across a range of arterial pressure measurements. The present study was planned to determine that relationship, using cardiac magnetic resonance imaging to accurately quantify LVM, in hypertensive patients with and without LVH and in normal subjects. Methods and Results— Twenty-four patients with uncomplicated and untreated essential hypertension (LVH[−]) were compared with 25 patients with essential hypertension and left ventricular hypertrophy (LVH[+]) and 24 normal control subjects. Resting muscle sympathetic nerve activity was quantified as multiunit bursts and single units. Cardiac magnetic resonance imaging–determined LVM was indexed to body surface area (LVM index); in the LVH[−] group, LVM index was 67±2.1 g/m 2 , a value between those of the LVH[+] (91±3.4 g/m 2 ) and normal control (57±2.2 g/m 2 ) groups, respectively. The sympathetic activity in the LVH[−] group (53±1.3 bursts per 100 cardiac beats and 63±1.6 impulses per 100 cardiac beats) was between (at least P <0.001) those of the LVH[+] (66±1.7 bursts per 100 cardiac beats and 77±2.2 impulses per 100 cardiac beats) and normal control (39±3.0 bursts per 100 cardiac beats and 45±3.4 impulses per 100 cardiac beats) groups. Significant positive correlation existed between sympathetic activity and LVM index in the LVH[−] and LVH[+] groups (at least r =0.76, P <0.0001) but not in the normal control group. However, no consistent relationship existed between arterial blood pressure and sympathetic activity or LVM index. Conclusions— These findings further support the hypothesis that central sympathetic activation is associated with the development of LVH in human hypertension.

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  • Microneurographic studies almost universally show that sympathetic nerve traffic is potentiated in established hypertension in middle age and in elderly as well as young patients.

    “As far as the second issue is concerned, microneurographic studies almost universally shown that sympathetic nerve traffic is potentiated in established hypertension in middle age and in elderly as well as young patients38–46.”

    From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [44]

  • Adrenergic neural factors may contribute to the development and progression of target organ damage, as documented by pronounced increases in sympathetic nerve traffic and cardiac norepinephrine spillover rate in patients with hypertension complicated by left ventricular hypertrophy or left ventricular diastolic dysfunction.

    “Adrenergic neural factors may also contribute to the development and progression of target organ damage, as documented by the pronounced increase in sympathetic nerve traffic and cardiac norepinephrine spillover rate in patients in which hypertension is complicated by left ventricular hypertrophy or left ventricular diastolic dysfunction40,42,44,45.”

    From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [44]

  • The sympathetic neural outflow is commonly activated also to the heart and skeletal muscle vasculature, but renal sympathetic activation is central to hypertension pathogenesis.

    “The sympathetic neural outflow is commonly activated also to the heart, shown with selective cardiac norepinephrine spillover measurements28, and to the skeletal muscle vasculature, demonstrated with microneurographic nerve traffic recording32,33,38–46, but it is the renal sympathetic activation which is central to hypertension pathogenesis96–97.”

    From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [44]

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Authors
Burns, J., Sivananthan, M. U., Ball, S. G., Mackintosh, A. F., Mary, D. A. S. G., & Greenwood, J. P.
Affiliations
Leeds Teaching Hospitals NHS Trust (GB)
ORCID
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2007-04-17
Volume
115
Issue
15
Pages
1999-2005
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/circulationaha.106.668863
PMC
PMC3925820
OpenAlex
W1999017667
Cited by
122
References
50
Citations by year
2026: 2 · 2025: 6 · 2024: 1 · 2023: 3 · 2022: 6 · 2021: 2 · 2020: 6 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 8 · 2015: 7 · 2014: 12 · 2013: 10 · 2012: 12
FWCI
6.58
Type
journal article
Language
en
Open access
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
British Heart Foundation (PG/03/001/14631)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Keywords
essential hypertension, left ventricular hypertrophy, muscle sympathetic nerve activity, left ventricular mass, cardiac magnetic resonance imaging, arterial blood pressure, hypertensive heart disease
MeSH terms
Cardiac Volume, Electrophysiology, Female, Heart Ventricles, Humans, Hypertension, Magnetic Resonance Imaging, Male, Middle Aged, Organ Size, Predictive Value of Tests, Reference Values, Sympathetic Nervous System, Hypertrophy, Left Ventricular

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