Diurnal pattern of QTc interval: How long is prolonged?
Open accessAbstract
Objectives This study sought to evaluate the range and variability of the QT and corrected QT (QTc) intervals over 24 h and to assess their pattern and relation to heart rate variability.Background Recent Holter monitoring data have revealed a high degree of daily variability in the QTc interval. The pattern of this variability and its relation to heart rate variability remain poorly characterized.Methods We developed and validated a new method for continuous measurement of QT intervals from three-channel, 24-h Holter recordings. Average RR, QT, QTc and heart rate variability were measured from 5-min segments of data from 21 healthy subjects.Results Measurement of 6,048 segments showed mean (+/- SD) RR, QT and QTc intervals of 830 +/- 100, 407 +/- 23 and 445 +/- 16 ms, respectively (mean QTc interval for men 434 +/- 12 ms, 457 +/- 10 ms for women, p < 0.0001). The average maximal QTc interval was 495 +/- 21 ms and the average QTc range 95 +/- 20 ms. The maximal QTc interval was > or = 500 ms in 6 subjects and > or = 490 ms in 13. The 95% upper confidence limit for the mean 24-h QTc interval was 452 ms (men 439 ms, women 461 ms). The RR, QT and QTc intervals and the high frequency component of heart rate variability were greater during sleep. Both the QTc interval and the variability between hourly minimal and maximal QTc intervals reached their circadian peak shortly after awakening, before declining to daytime levels.Conclusions The maximal QTc interval over 24 h in normal subjects is longer than heretofore thought. Both QT and QTc intervals are longer during sleep. The QTc interval and QTc variability reach a peak shortly after awakening, which may reflect increased autonomic instability during early waking hours, and the time of the peak value corresponds in time to the period of reported increased vulnerability to ventricular tachycardia and sudden cardiac death. These findings have implications regarding the definition of QT prolongation and its use in predicting arrhythmias and sudden death.
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Cites
STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT
Martin Bland, J., & Altman, D. (1986) · The Lancet · doi:10.1016/s0140-6736(86)90837-8 · Cited by 47,965 · see citing works
Beckett, A. H., Rowland, M., & TURNER, P. (1965) · The Lancet · doi:10.1016/s0140-6736(65)91037-8 · Cited by 16,917 · see citing works
Cardiovascular neural regulation explored in the frequency domain.
Malliani, A., Pagani, M., Lombardi, F., & Cerutti, S. (1991) · Circulation · doi:10.1161/01.cir.84.2.482 · Cited by 3,569 · see citing works
Cardiovascular Survey Methods.
Rose, G., & Blackburn, H. (1968) · Annals of Internal Medicine · doi:10.7326/0003-4819-69-6-1335_2 · Cited by 3,065 · see citing works
Circadian variation and triggers of onset of acute cardiovascular disease.
Muller, J. E., Tofler, G. H., & Stone, P. H. (1989) · Circulation · doi:10.1161/01.cir.79.4.733 · Cited by 1,426 · see citing works
Schwartz, P. J., Periti, M., & Malliani, A. (1975) · American Heart Journal · doi:10.1016/0002-8703(75)90089-7 · Cited by 913 · see citing works
QT interval prolongation as predictor of sudden death in patients with myocardial infarction.
Schwartz, P. J., & Wolf, S. (1978) · Circulation · doi:10.1161/01.cir.57.6.1074 · Cited by 757 · see citing works
An improved method for adjusting the QT interval for heart rate (the Framingham Heart Study)
Sagie, A., Larson, M. G., Goldberg, R. J., Bengtson, J. R., & Levy, D. A. (1992) · The American Journal of Cardiology · doi:10.1016/0002-9149(92)90562-d · Cited by 715 · see citing works
Sex differences in the evolution of the electrocardiographic QT interval with age.
Rautaharju, P. M., Sh, Z., Wong, S., Hp, C., Berenson, G. S., Prineas, R., & Davignon, A. (1992) · PubMed · Cited by 635 · see citing works
QT interval prolongation predicts cardiovascular mortality in an apparently healthy population.
Schouten, E. G., Dekker, J. M., Meppelink, P., Kok, F. J., Vandenbroucke, J. P., & Pool, J. (1991) · Circulation · doi:10.1161/01.cir.84.4.1516 · Cited by 632 · see citing works
The Measurement of the Q-T Interval of the Electrocardiogram
Lepeschkin, E., & Surawicz, B. (1952) · Circulation · doi:10.1161/01.cir.6.3.378 · Cited by 628 · see citing works
Algra, A., Tijssen, J. G. P., Roelandt, J. R. T. C., Pool, J., & Lubsen, J. C. (1991) · Circulation · doi:10.1161/01.cir.83.6.1888 · Cited by 591 · see citing works
Selzer, A., & WRAY, H. W. (1964) · Circulation · doi:10.1161/01.cir.30.1.17 · Cited by 564 · see citing works
Measurement of the QT interval and the risk associated with QTc interval prolongation: A review
Moss, A. J. (1993) · The American Journal of Cardiology · doi:10.1016/0002-9149(93)90036-c · Cited by 476 · see citing works
Rate-corrected QT interval: Techniques and limitations
Funck‐Brentano, C., & Jaillon, P. (1993) · The American Journal of Cardiology · doi:10.1016/0002-9149(93)90035-b · Cited by 401 · see citing works
Electrocardiographic quantitation of ventricular repolarization.
Merri, M., Benhorin, J., Alberti, M., Locati, E. H., & Moss, A. J. (1989) · Circulation · doi:10.1161/01.cir.80.5.1301 · Cited by 401 · see citing works
Spectral analysis of heart rate variability in the assessment of autonomic diabetic neuropathy
Pagani, M., Malfatto, G., Pierini, S., Casati, R., Masu, A. M., Poli, M., Guzzetti, S., Lombardi, F., Cerutti, S., & Malliani, A. (1988) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(88)90078-1 · Cited by 378 · see citing works
Ahnve, S. (1985) · American Heart Journal · doi:10.1016/0002-8703(85)90564-2 · Cited by 320 · see citing works
Myers, G. A., Martin, G. J., Magid, N. M., Barnett, P. S., Schaad, J. W., Weiss, J. S., Lesch, M., & Singer, D. H. (1986) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.1986.325694 · Cited by 318 · see citing works
Self-citationInfluence of heart rate and inhibition of autonomic tone on the QT interval.
Ahnve, S., & Vallin, H. (1982) · Circulation · doi:10.1161/01.cir.65.3.435 · Cited by 295 · see citing works
Principles of Clinical Electrocardiography
(1957) · JAMA · doi:10.1001/jama.1957.02970400078033 · Cited by 274 · see citing works
Litovsky, S. H., & Antzelevitch, C. (1990) · Circulation Research · doi:10.1161/01.res.67.3.615 · Cited by 267 · see citing works
Diurnal variation of the QT interval--influence of the autonomic nervous system.
Bexton, R. S., Vallin, H., & Camm, A. J. (1986) · Heart · doi:10.1136/hrt.55.3.253 · Cited by 241 · see citing works
Goldberg, R. J., Bengtson, J. R., Chen, Z., Anderson, K. M., Locati, E. H., & Levy, D. A. (1991) · The American Journal of Cardiology · doi:10.1016/0002-9149(91)90099-7 · Cited by 235 · see citing works
Ray, A. A. (1982) · SAS Institute eBooks · Cited by 229 · see citing works
New algorithm for QT interval analysis in 24-hour Holter ECG: performance and applications
Laguna, P., Thakor, N. V., Caminal, P., Jané, R., Yoon, H.-R., de Luna, A. B., Vicens Martí, C., & Soldevila, J. G. (1990) · Medical & Biological Engineering & Computing · doi:10.1007/bf02441680 · Cited by 228 · see citing works
Prolongation of the Q-T interval in man during sleep
Browne, K. F., Prystowsky, E. N., Heger, J. J., Chilson, D. A., & Zipes, D. P. (1983) · The American Journal of Cardiology · doi:10.1016/0002-9149(83)90068-1 · Cited by 215 · see citing works
Adrenergic effects on the QT interval of the electrocardiogram
Abildskov, J. A. (1976) · American Heart Journal · doi:10.1016/s0002-8703(76)80256-6 · Cited by 209 · see citing works
Biological rhythms and medicine
Smolensky, M. H., & D’Alonzo, G. E. (1984) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(84)90060-0 · Cited by 206 · see citing works
How to measure the QT interval—What is normal?
Garson, A. (1993) · The American Journal of Cardiology · doi:10.1016/0002-9149(93)90034-a · Cited by 204 · see citing works
Morganroth, J., Brozovich, F. V., McDonald, J. T., & Jacobs, R. A. (1991) · The American Journal of Cardiology · doi:10.1016/0002-9149(91)90541-r · Cited by 183 · see citing works
Comprehensive Electrocardiology : Theory and Practice in Health and Disease
Macfarlane, P. W., & Lawrie, T. D. V. (1989) · Medical Entomology and Zoology · Cited by 177 · see citing works
Puddu, P. E., Jouve, R., Mariotti, S., Giampaoli, S., Lanti, M., Reale, A., & Menotti, A. (1988) · Journal of Electrocardiology · doi:10.1016/0022-0736(88)90096-9 · Cited by 137 · see citing works
Role of sympathovagal interaction in diurnal variation of QT interval
Murakawa, Y., Inoue, H., Nozaki, A., & Sugimoto, T. (1992) · The American Journal of Cardiology · doi:10.1016/0002-9149(92)90230-v · Cited by 107 · see citing works
Physiologic relation between cardiac cycle and QT duration in healthy volunteers
Lecocq, B., Lecocq, V., & Jaillon, P. (1989) · The American Journal of Cardiology · doi:10.1016/0002-9149(89)90425-6 · Cited by 90 · see citing works
THE NORMAL DURATION OF THE ELECTROCARDIOGRAPHIC VENTRICULAR COMPLEX
Adams, W. (1936) · Journal of Clinical Investigation · doi:10.1172/jci100784 · Cited by 88 · see citing works
Kovács, S. (1985) · American Heart Journal · doi:10.1016/0002-8703(85)90472-7 · Cited by 83 · see citing works
Ong, J. J. C., Sarma, J. S. M., Venkataraman, K., Levin, S. R., & Singh, B. N. (1993) · American Heart Journal · doi:10.1016/0002-8703(93)90166-7 · Cited by 83 · see citing works
Contribution of heart rate to QT interval shortening during exercise
Fananapazir, L., Bennett, D. H., & Faragher, E. B. (1983) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a061458 · Cited by 77 · see citing works
Sarma, J. S. M., Venkataraman, K., NICOD, P. H., Polikar, R., Smith, J., Schoenbaum, M. P., & Singh, B. N. (1990) · The American Journal of Cardiology · doi:10.1016/0002-9149(90)90933-r · Cited by 61 · see citing works
Comprehensive Electrocardiography: Theory and Practice in Health and Disease
Chung, E. K. Y. (1989) · JAMA · doi:10.1001/jama.1989.03430040143052 · Cited by 54 · see citing works
Correlates of QT prolongation in older adults (the Cardiovascular Health Study)
Rautaharju, P. M., Manolio, T. A., Psaty, B. M., Borhani, N. O., & Furberg, C. D. (1994) · The American Journal of Cardiology · doi:10.1016/0002-9149(94)90156-2 · Cited by 42 · see citing works
Principles of Clinical Electrocardiography.
(1973) · Annals of Internal Medicine · doi:10.7326/0003-4819-79-2-329_10 · Cited by 38 · see citing works
Functional Characteristics of QT Prediction Formulas. The Concepts of QTmax and QT Rate Sensitivity
Rautaharju, P. M., Zhou, S., Wong, S., Prineas, R. J., & Berenson, G. S. (1993) · Computers and Biomedical Research · doi:10.1006/cbmr.1993.1012 · Cited by 28 · see citing works
Regulation of QT interval during postural transitory changes in heart rate in normal subjects
Yamada, A., Hayano, J., Horie, K., Ieda, K., Mukai, S., Yamada, M., & Fujinami, T. (1993) · The American Journal of Cardiology · doi:10.1016/0002-9149(93)90922-y · Cited by 27 · see citing works
Vicens Martí, C., Soldevila, J. G., Homs, E., Viñoles, X., & de Luna, A. B. (1992) · American Heart Journal · doi:10.1016/0002-8703(92)90953-s · Cited by 23 · see citing works
Vagus-Induced Changes in Ventricular Electrophysiology of the Dog Heart With and Without β-Blockade
Amlie, J., & Refsum, H. (1981) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-198111000-00006 · Cited by 20 · see citing works
Flagged first, then by citations
2 of the 49 references couldn’t be matched to a known paper.
Research works printed but not linked: 4
- Lepeschkin E. Modern Electrocardiography. Vol. 1. Baltimore: Williams & Wilkins, 1951:180-8.
- II. Bazett HC. An analysis of time-relations of the electrocardiogram. Heart 1920;7:353-70.
- Hegglin R, Holtzmann M. Die Klinische Bedeutung des Verlangerter- Distanz (Systolendauer) in Electrokardiogram. Z Klin Med 1937;132:1-32.
- Molnar J, Zhang F, Weiss JS, Rosenthal J. Why not Bazett's? Evaluation of 5 QT correction formulas using a new software assisted method of contin- uous QT measurement from 24-hour Holter recordings [abstract]. PACE 1995;18:852.
Cited by
Sorted by citations
AHA/ACCF/HRS Recommendations for the Standardization and Interpretation of the Electrocardiogram
Surawicz, B., Childers, R., Deal, B. J., & Gettes, L. S. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.12.013 · Cited by 2,053 · see citing works
AHA/ACCF/HRS Recommendations for the Standardization and Interpretation of the Electrocardiogram
Rautaharju, P. M., Surawicz, B., & Gettes, L. S. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.12.014 · Cited by 1,019 · see citing works
Sex differences in healthy human heart rate variability: A meta-analysis
Koenig, J., & Thayer, J. F. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.03.007 · Cited by 860 · see citing works
Prolonged QTc Interval and Risk of Sudden Cardiac Death in a Population of Older Adults
Straus, S. M. J. M., Kors, J. A., De Bruin, M. L., van der Hooft, C. S., Hofman, A., Heeringa, J., Deckers, J. W., Kingma, J. H., Sturkenboom, M. C. J. M., Stricker, B. H. C., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.08.067 · Cited by 833 · see citing works
What Clinicians Should Know About the QT Interval
Al‐Khatib, S. M., LaPointe, N. M. A., Kramer, J. M., & Califf, R. M. (2003) · JAMA · doi:10.1001/jama.289.16.2120 · Cited by 671 · see citing works
AHA/ACCF/HRS Recommendations for the Standardization and Interpretation of the Electrocardiogram
Rautaharju, P. M., Surawicz, B., & Gettes, L. S. (2009) · Circulation · doi:10.1161/circulationaha.108.191096 · Cited by 412 · see citing works
Gupta, A. K., Lawrence, A. T., Krishnan, K., Kavinsky, C. J., & Trohman, R. G. (2007) · American Heart Journal · doi:10.1016/j.ahj.2007.01.040 · Cited by 355 · see citing works
Sleep and Cardiovascular Disease
Wolk, R. A., Gami, A. S., García‐Touchard, A., & Somers, V. K. (2005) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2005.07.002 · Cited by 327 · see citing works
Circadian rhythms and cardiovascular health
Portaluppi, F., Tiseo, R., Smolensky, M. H., Hermida, R. C., Ayala, D. E., & Fabbian, F. (2011) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2011.04.003 · Cited by 310 · see citing works
Steinberg, J. S., Varma, N., Cygankiewicz, I., Aziz, P., Balsam, P., Baranchuk, A., Cantillon, D. J., Dilaveris, P., Dubner, S. J., El-Sherif, N., et al. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.03.038 · Cited by 303 · see citing works
Evaluation of Drug-Induced QT Interval Prolongation
Malík, M., & Camm, A. J. (2001) · Drug Safety · doi:10.2165/00002018-200124050-00001 · Cited by 272 · see citing works
Bednar, M. M., Harrigan, E. P., Anziano, R., Camm, A. J., & Ruskin, J. N. (2001) · Progress in Cardiovascular Diseases · doi:10.1053/pcad.2001.21469 · Cited by 275 · see citing works
Electrocardiographic QT Interval and Mortality
Zhang, Y., Post, W. S., Blasco‐Colmenares, E., Dalal, D., Tomaselli, G. F., & Güallar, E. (2011) · Epidemiology · doi:10.1097/ede.0b013e318225768b · Cited by 264 · see citing works
Ziprasidone in the Management of Schizophrenia
Taylor, D. M. (2003) · CNS Drugs · doi:10.2165/00023210-200317060-00004 · Cited by 230 · see citing works
Antimicrobial-Associated QT Interval Prolongation: Pointes of Interest
Goldstein, E. J. C., Owens, R. C., & Nolin, T. D. (2006) · Clinical Infectious Diseases · doi:10.1086/508873 · Cited by 230 · see citing works
Mechanisms, Risk Factors, and Management of Acquired Long QT Syndrome: A Comprehensive Review
Kallergis, E. M., Goudis, C. A., SIMANTIRAKIS, E. N., KOCHIADAKIS, G. E., & Vardas, P. E. (2012) · The Scientific World JOURNAL · doi:10.1100/2012/212178 · Cited by 199 · see citing works
Long QT syndrome: Diagnosis and management
Khan, I. A. (2002) · American Heart Journal · doi:10.1067/mhj.2002.120295 · Cited by 199 · see citing works
Swan, H., Viitasalo, M. T., Piippo, K., Laitinen, P. H., KONTULA, K. K., & Toivonen, L. K. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00255-7 · Cited by 194 · see citing works
Ng, F., Mammen, O. K., Wilting, I., Sachs, G. S., Ferrier, I. N., Cassidy, F., Beaulieu, S., Yatham, L. N., & Berk, M. (2009) · Bipolar Disorders · doi:10.1111/j.1399-5618.2009.00737.x · Cited by 192 · see citing works
The Molecular Ggenetics of the Long QT Syndrome: Genes Causing Fainting and Sudden Death
Vincent, G. M. (1998) · Annual Review of Medicine · doi:10.1146/annurev.med.49.1.263 · Cited by 187 · see citing works
Antipsychotic drugs and QT prolongation
Stöllberger, C., Huber, J. O., & Finsterer, J. (2005) · International Clinical Psychopharmacology · doi:10.1097/01.yic.0000166405.49473.70 · Cited by 168 · see citing works
Clinical and therapeutic aspects of congenital and acquired long QT syndrome
Khan, I. A. (2002) · The American Journal of Medicine · doi:10.1016/s0002-9343(01)01011-7 · Cited by 155 · see citing works
Drug induced QT prolongation: the measurement and assessment of the QT interval in clinical practice
Isbister, G. K., & Page, C. B. (2012) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12040 · Cited by 153 · see citing works
Benoit, S. R., Mendelsohn, A. B., Nourjah, P. A., Staffa, J. A., & Graham, D. J. (2005) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/01.hjr.0000173110.21851.a9 · Cited by 149 · see citing works
The cardiomyocyte molecular clock, regulation of <i>Scn5a</i> , and arrhythmia susceptibility
Schroder, E. A., Lefta, M., Zhang, X., Bartos, D. C., Feng, H.-Z., Zhao, Y., Patwardhan, A., Jin, J.-P., Esser, K. A., & Delisle, B. P. (2013) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00383.2012 · Cited by 147 · see citing works
Effects of Gender on Cardiac Arrhythmias
LARSEN, J. A., & Kadish, A. H. (1998) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.1998.tb00950.x · Cited by 145 · see citing works
Acquired QT interval prolongation and HERG: implications for drug discovery and development
Finlayson, K., Witchel, H. J., McCulloch, J., & Sharkey, J. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.07.019 · Cited by 147 · see citing works
Pickham, D. M., Helfenbein, E. D., Shinn, J. A., Chan, G. K., Funk, M., Weinacker, A. B., Liu, J., & Drew, B. J. (2011) · Critical Care Medicine · doi:10.1097/ccm.0b013e318232db4a · Cited by 145 · see citing works
Heart rate variability: a tool to explore the sleeping brain?
Chouchou, F., & Desseilles, M. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00402 · Cited by 145 · see citing works
POLYMORPHIC VENTRICULAR TACHYCARDIA, LONG Q-T SYNDROME, AND TORSADES DE POINTES
PASSMAN, R. S., & Kadish, A. H. (2001) · Medical Clinics of North America · doi:10.1016/s0025-7125(05)70318-7 · Cited by 141 · see citing works
Cavero, I., Mestre, M., Guillon, J.-M., & Crumb, W. (2000) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.1.5.947 · Cited by 139 · see citing works
Assessing QT Interval Prolongation and its Associated Risks with Antipsychotics
Nielsen, J., Graff, C., Kanters, J. K., Toft, E. S., Taylor, D. M., & Meyer, J. M. (2011) · CNS Drugs · doi:10.2165/11587800-000000000-00000 · Cited by 133 · see citing works
Impact of age on QT interval and QT dispersion in healthy subjects: a regression analysis
Mangoni, A. A. (2003) · Age and Ageing · doi:10.1093/ageing/32.3.326 · Cited by 133 · see citing works
Camilleri, M., Beyens, G., Kerstens, R., Robinson, P., & Vandeplassche, L. M. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01398.x · Cited by 132 · see citing works
QT Prolongation with Antimicrobial Agents
Owens, R. C. (2004) · Drugs · doi:10.2165/00003495-200464100-00005 · Cited by 132 · see citing works
Circadian rhythms in cardiac arrhythmias and opportunities for their chronotherapy
Portaluppi, F., & Hermida, R. C. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.10.011 · Cited by 130 · see citing works
Piotrovsky, V. (2005) · The AAPS Journal · doi:10.1208/aapsj070363 · Cited by 124 · see citing works
Steinberg, J. S., Varma, N., Cygankiewicz, I., Aziz, P. F., Balsam, P., Baranchuk, A. M., Cantillon, D. J., Dilaveris, P., Dubner, S., El‐Sherif, N., et al. (2017) · Annals of Noninvasive Electrocardiology · doi:10.1111/anec.12447 · Cited by 118 · see citing works
Gender differences in arrhythmias
Wolbrette, D. L., Naccarelli, G. V., Curtis, A. B., Lehmann, M. H., & Kadish, A. H. (2002) · Clinical Cardiology · doi:10.1002/clc.4950250203 · Cited by 116 · see citing works
Antipsychotic agents and QT changes.
Welch, R. W., & Chue, P. S. (2000) · PubMed Central · Cited by 115 · see citing works
Aydın, M., Altin, R., Özeren, A., Kart, L., BİLGE, M., & Ünalacak, M. (2004) · Europe PMC (PubMed Central) · Cited by 109 · see citing works
Incidence and relevance of QTc-interval prolongation caused by tyrosine kinase inhibitors
Kloth, J. S. L., Pagani, A., Verboom, M. C., Malovini, A. L., Napolitano, C., Kruit, W. H. J., Sleijfer, S., Steeghs, N., Zambelli, A., & Mathijssen, R. H. J. (2015) · British Journal of Cancer · doi:10.1038/bjc.2015.82 · Cited by 107 · see citing works
Salvi, V., Karnad, D. R., Panicker, G. K., & Kothari, S. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00427.x · Cited by 103 · see citing works
Ball, P. D., Stahlmann, R., Kubin, R., Choudhri, S., & Owens, R. C. (2004) · Clinical Therapeutics · doi:10.1016/s0149-2918(04)90170-1 · Cited by 102 · see citing works
Circadian modulation of QT rate dependence in healthy volunteers
Extramiana, F., Maison‐Blanche, P., Badilini, F., Pinoteau, J., Deseo, T., & Coumel, P. (1999) · Journal of Electrocardiology · doi:10.1016/s0022-0736(99)90019-5 · Cited by 100 · see citing works
Circadian Variation of Cardiac K + Channel Gene Expression
Yamashita, T., Sekiguchi, A., Iwasaki, Y., Sagara, K., Iinuma, H., Hatano, S., Fu, L.-T., & Watanabe, H. (2003) · Circulation · doi:10.1161/01.cir.0000058752.79734.f0 · Cited by 99 · see citing works
Risk Assessment for Antimicrobial Agent‐Induced QTc Interval Prolongation and Torsades de Pointes
Owens, R. C. (2001) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.21.3.301.34206 · Cited by 93 · see citing works
Roche, F., Court‐Fortune, Pichot, V., Duverney, Costes, Emonot, Vergnon, Geyssant, Lacour, & Barthélemy, J. (1999) · Clinical Physiology · doi:10.1046/j.1365-2281.1999.00163.x · Cited by 93 · see citing works
Sex differences in repolarization homogeneity and its circadian pattern
Smetana, P., Batchvarov, V. N., Hnatkova, K., Camm, A. J., & Malík, M. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00962.2001 · Cited by 93 · see citing works
Roboz, G. J., Ritchie, E. K., Carlin, R. F., Samuel, M., Gale, L., Provenzano, J. L., Curcio, T. J., Feldman, E. J., & Kligfield, P. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2013.51.2913 · Cited by 91 · see citing works
Assessing proarrhythmic potential of drugs when optimal studies are infeasible
Rock, E. P., Finkle, J. K., Fingert, H. J., Booth, B. P., Garnett, C. E., Grant, S. N., Justice, R. L., Kovacs, R. J., Kowey, P. R., Rodríguez, I., et al. (2009) · American Heart Journal · doi:10.1016/j.ahj.2009.02.020 · Cited by 85 · see citing works
Englund, A., Behrens, S., Wegscheider, K., & Rowland, E. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00369-1 · Cited by 84 · see citing works
Novel Insights in the Congenital Long QT Syndrome
Wehrens, X. H. T., Vos, M. A., Doevendans, P. A., & Wellens, H. J. J. (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-137-12-200212170-00012 · Cited by 83 · see citing works
van der Linde, H. J., Deuren, B. V., Somers, Y., Loenders, B., Towart, R., & Gallacher, D. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00934.x · Cited by 81 · see citing works
Molnár, J., Weiss, J., Zhang, F., & Rosenthal, J. E. (1996) · The American Journal of Cardiology · doi:10.1016/s0002-9149(96)00468-7 · Cited by 82 · see citing works
Self-citationQT Assessment in Early Drug Development: The Long and the Short of It
Lester, R. M., Paglialunga, S., & Johnson, I. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20061324 · Cited by 80 · see citing works
QT interval and mortality from coronary artery disease
Davey, P. P. (2000) · Progress in Cardiovascular Diseases · doi:10.1053/pcad.2000.0420359 · Cited by 75 · see citing works
Rate Correction of the QT Interval
Hodges, M. (1997) · Cardiac Electrophysiology Review · doi:10.1023/a:1009933509868 · Cited by 71 · see citing works
Patterson, S. D. (2005) · Drug Information Journal · doi:10.1177/009286150503900304 · Cited by 65 · see citing works
Molnár, J., Rosenthal, J. E., Weiss, J. S., & Somberg, J. C. (1997) · The American Journal of Cardiology · doi:10.1016/s0002-9149(97)00080-5 · Cited by 65 · see citing works
Self-citationCipriani, A., Zorzi, A., Ceccato, D., Capone, F., Parolin, M., Donato, F., Fioretto, P., Pesavento, R., Previato, L., Maffei, P., et al. (2020) · International Journal of Cardiology · doi:10.1016/j.ijcard.2020.05.036 · Cited by 64 · see citing works
Circadian Rhythm of the Corrected QT Interval: Impact of Different Heart Rate Correction Models
Smetana, P., Batchvarov, V. N., Hnatkova, K., Camm, A. J., & Malík, M. (2003) · Pacing and Clinical Electrophysiology · doi:10.1046/j.1460-9592.2003.00054.x · Cited by 64 · see citing works
Beaumont, C., Young, G. C., Cavalier, T., & Young, M. A. (2014) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12468 · Cited by 58 · see citing works
Circadian variation of arrhythmia onset patterns in patients with persistent atrial fibrillation
Mitchell, A. R. J., Spurrell, P. A. R., & Sulke, N. (2003) · American Heart Journal · doi:10.1016/s0002-8703(03)00405-8 · Cited by 58 · see citing works
Evaluation of Autonomic Influences on QT Dispersion Using the Head‐Up Tilt Test in Healthy Subjects
Nakagawa, M., TAKAHASHI, N., Iwao, T., Yonemochi, H., OOIE, T., Hara, M., Saikawa, T., & ITO, M. (1999) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.1999.tb00595.x · Cited by 58 · see citing works
Normal Ventricular Repolarization and QT Interval
Locati, E. H., Bagliani, G., & Padeletti, L. (2017) · Cardiac Electrophysiology Clinics · doi:10.1016/j.ccep.2017.05.007 · Cited by 54 · see citing works
Pater, C. (2005) · Current Controlled Trials in Cardiovascular Medicine · doi:10.1186/1468-6708-6-1 · Cited by 53 · see citing works
Wolbrette, D. L., & Patel, H. M. (1999) · Current Opinion in Cardiology · doi:10.1097/00001573-199901000-00007 · Cited by 53 · see citing works
QT Prolongation and Malignant Arrhythmia: How Serious a Problem?
Antoniou, C. K., Dilaveris, P., Manolakou, P., Galanakos, S., Magkas, N., Gatzoulis, K. A., & Tousoulis, D. M. (2017) · European Cardiology Review · doi:10.15420/ecr.2017:16:1 · Cited by 52 · see citing works
Automatic detection of the electrocardiogram T-wave end
Daskalov, I. K., & Christov, I. I. (1999) · Medical & Biological Engineering & Computing · doi:10.1007/bf02513311 · Cited by 52 · see citing works
Ruiz-Garcı́a, A., Baverel, P., Bottino, D. C., Dolton, M., Feng, Y., González-García, I., Kim, J., Robey, S., Singh, I., Turner, D. C., et al. (2023) · Journal of Pharmacokinetics and Pharmacodynamics · doi:10.1007/s10928-023-09850-2 · Cited by 54 · see citing works
Brell, J. M. (2010) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2010.05.005 · Cited by 50 · see citing works
Circadian Profile of QT Interval and QT Interval Variability in 172 Healthy Volunteers
Bonnemeier, H., WIEGAND, U. K. H., BRAASCH, W., Brandes, A., Richardt, G., & Potratz, J. (2003) · Pacing and Clinical Electrophysiology · doi:10.1046/j.1460-9592.2003.00053.x · Cited by 50 · see citing works
The Influence of Gender on Arrhythmias
Peters, R. W., & Gold, M. R. (2004) · Cardiology in Review · doi:10.1097/01.crd.0000096416.94304.bd · Cited by 50 · see citing works
Yi, G., Guo, X., Reardon, M. J., Gallagher, M. M., Hnatkova, K., Camm, A. J., & Malík, M. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00071-x · Cited by 50 · see citing works
Kleiman, R., Darpö, B., Brown, R., Rudo, T. J., Chamoun, S., Albert, D. J., Bos, J. M., & Ackerman, M. J. (2021) · Annals of Noninvasive Electrocardiology · doi:10.1111/anec.12872 · Cited by 48 · see citing works
Sex differences in cardiac autonomic regulation and in repolarisation electrocardiography
Smetana, P., & Malík, M. (2013) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-013-1228-x · Cited by 48 · see citing works
Changes in Repolarization Dynamicity and the Assessment of the Arrhythmic Risk
Maison‐Blanche, P., & Coumel, P. (1997) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.1997.tb06111.x · Cited by 47 · see citing works
Kim, S.-H., Nam, G., Baek, S.-J., Choi, H. O., Kim, K. H., Choi, K.-J., Joung, B., Pak, H., Lee, M.-H., Kim, S. S., et al. (2012) · Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2011.02287.x · Cited by 46 · see citing works
The congenital long QT syndrome Type 3: An update
Pérez‐Riera, A. R., Barbosa‐Barros, R., Raimundo, R. D., Barbosa, M. P. D. C. D. R., Sorpreso, I. C. E., & de Abreu, L. C. (2017) · Indian Pacing and Electrophysiology Journal · doi:10.1016/j.ipej.2017.10.011 · Cited by 46 · see citing works
Circadian Rhythm in the Cardiovascular System: Considerations in Non-Invasive Electrophysiology
Guo, Y., & Stein, P. K. (2002) · Cardiac Electrophysiology Review · doi:10.1023/a:1016337210738 · Cited by 45 · see citing works
Spatial Distribution of QT Intervals: An Alternative Approach to QT Dispersion
Leeuwen, P. V., Hailer, B., & Wehr, M. H. (1996) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.1996.tb03248.x · Cited by 45 · see citing works
Risk assessment of drug-induced QT prolongation
Isbister, G. K. (2015) · Australian Prescriber · doi:10.18773/austprescr.2015.003 · Cited by 44 · see citing works
Accurately measured and properly heart-rate corrected QTc intervals show little daytime variability
Malík, M., Hnatkova, K., Schmidt, A., & Smetana, P. (2008) · Heart Rhythm · doi:10.1016/j.hrthm.2008.07.023 · Cited by 43 · see citing works
Acute Sleep Deprivation is Associated with Increased QT Dispersion in Healthy Young Adults
Özer, O., Ozbala, B., Sarı, İ., Davutoğlu, V., Maden, E., Baltacı, Y., Yavuz, S., & Aksoy, M. F. (2008) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2008.01125.x · Cited by 40 · see citing works
Sex-Selective QT Prolongation During Rapid Eye Movement Sleep
Lanfranchi, P. A., Shamsuzzaman, A., Ackerman, M. J., Kára, T., Jurák, P., Wolk, R. A., & Somers, V. K. (2002) · Circulation · doi:10.1161/01.cir.0000030183.10934.95 · Cited by 40 · see citing works
Translational pharmacokinetic-pharmacodynamic modeling of QTc effects in dog and human.
Parkinson, J., Visser, S., Jarvis, P., Pollard, C., Valentin, J., Yates, J., & Ewart, L. (2013) · Journal of pharmacological and toxicological methods · doi:10.1016/j.vascn.2013.03.007 · Cited by 42 · see citing works
EFFECT OF AUTONOMIC NERVOUS FUNCTION ON QT INTERVAL IN DOGS
Harada, T., Abe, J., Shiotani, M., Hamada, Y., & Horii, I. (2005) · The Journal of Toxicological Sciences · doi:10.2131/jts.30.229 · Cited by 40 · see citing works
Effects of shift work on QTc interval and blood pressure in relation to heart rate variability
Murata, K., Yano, E., Hashimoto, H., Karita, K., & Dakeishi, M. (2005) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-004-0592-4 · Cited by 39 · see citing works
Ratner, P. H., Lim, J. C., & Georges, G. C. (2000) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2000.105525 · Cited by 39 · see citing works
Isralls, S., Baisley, K. J., Ngam, E., Grant, A. D., & Millard, J. (2021) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofab413 · Cited by 38 · see citing works
Measurement of high resolution ECG QT interval during controlled euglycaemia and hypoglycaemia
Ireland, R. H., Robinson, R. T. C. E., Heller, S. R., Marques, J. L. B., & Harris, N. D. (2000) · Physiological Measurement · doi:10.1088/0967-3334/21/2/309 · Cited by 38 · see citing works
QT prolongation and dispersion in myocardial ischemia and infarction
TOMASSONI, G. F., Pisanò, E., Gardner, L. H., Krucoff, M. W., & Natale, A. (1998) · Journal of Electrocardiology · doi:10.1016/s0022-0736(98)80073-3 · Cited by 37 · see citing works
Assessment of QTc Prolongation for Non‐Cardiac‐Related Drugs from a Drug Development Perspective
Bonate, P. L., & Russell, T. (1999) · The Journal of Clinical Pharmacology · doi:10.1177/00912709922007912 · Cited by 37 · see citing works
Moon, K. A., Zhang, Y., Güallar, E., Francesconi, K. A., Goessler, W., Umans, J. G., Best, L. G., Howard, B. V., Devereux, R. B., Okin, P. M., et al. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2018.04.129 · Cited by 35 · see citing works
Electrocardiographic QTc interval: short-term weight loss effects
Pietrobelli, A., Rothacker, D. Q., Gallagher, D., & Heymsfield, S. (1997) · International Journal of Obesity · doi:10.1038/sj.ijo.0800374 · Cited by 35 · see citing works
HIV Infection Is Associated With Variability in Ventricular Repolarization
Heravi, A. S., Etzkorn, L., Urbanek, J. K., Crainiceanu, C. M., Punjabi, N. M., Ashikaga, H., Brown, T. T., Budoff, M. J., DʼSouza, G., Magnani, J. W., et al. (2019) · Circulation · doi:10.1161/circulationaha.119.043042 · Cited by 33 · see citing works
Cardiac Effects of Ebastine and Other Antihistamines in Humans
Moss, A. J., & Morganroth, J. (1999) · Drug Safety · doi:10.2165/00002018-199921001-00009 · Cited by 33 · see citing works
Electrical behavior of T-Wave polarity alternans in patients with congenital long QT syndrome
Cruz, F. E. S., Ig, M., Fagundes, M., Barbosa, R., Alves, P. W. C., Sá, R., Boghossian, S. H. C., & Ribeiro, J. C. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)00694-x · Cited by 33 · see citing works
Changes in heart rate variability and QT variability during the first trimester of pregnancy
Carpenter, R. E., D׳Silva, L., Emery, S. J., Uzun, O., Rassi, D., & Lewis, M. J. (2015) · Physiological Measurement · doi:10.1088/0967-3334/36/3/531 · Cited by 32 · see citing works
- Authors
- Molnar, J., Zhang, F., Weiss, J., Ehlert, F. A., & Rosenthal, J. E.
- Affiliations
- Northwestern University (US)
- Corresponding author
- Rosenthal, James E.
- ORCID
- Ehlert, Frederick A.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 1996-01
- Volume
- 27
- Issue
- 1
- Pages
- 76-83
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W160020775
- Cited by
- 312
- References
- 49
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 4 · 2023: 6 · 2022: 3 · 2021: 8 · 2020: 6 · 2019: 4 · 2018: 8 · 2017: 12 · 2016: 5 · 2015: 8 · 2014: 17 · 2013: 18 · 2012: 11
- FWCI
- 12.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › ECG Monitoring and Analysis
- Keywords
- QTc interval, diurnal variation, circadian rhythm, heart rate variability, QT prolongation, sleep, awakening, autonomic instability, sudden cardiac death, ventricular tachycardia, Holter monitoring, QT interval measurement
- MeSH terms
- Adult, Aged, Circadian Rhythm, Diagnosis, Computer-Assisted, Female, Heart Conduction System, Heart Rate, Humans, Male, Middle Aged, Reference Values, Reproducibility of Results, Observer Variation, Electrocardiography, Ambulatory, Linear Models, Least-Squares Analysis, Sex Distribution
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