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Cited by 14Alcohol Consumption and Health EffectsSubstance Abuse Treatment and OutcomesAlcoholism and Thiamine Deficiency

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Changes in blood acetaldehyde levels after ethanol administration in alcoholics

Takase, Shujiro, Yasuhara, Minoru, Takada, Akira, Ueshima, Yasuhiro·1990·Alcohol
DOI 10.1016/0741-8329(90)90058-k
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Abstract

Serial changes in blood ethanol (Et-OH) and acetaldehyde (Ac-CHO) levels following a single oral administration of 0.8 g/kg of Et-OH were determined in order to clarify the metabolism of Ac-CHO in alcoholic liver disease (ALD). The Et-OH metabolic rate (EMR) in alcoholics either with or without liver disease was significantly higher than the rate in nonalcoholics. Peak values of blood Ac-CHO levels and the Ac-CHO/EMR ratios in ALD were significantly higher than those in subjects with nonALD or alcoholics and nonalcoholics without liver disease. In the type I aldehyde dehydrogenase isozyme deficient cases (unusual type), blood Ac-CHO levels and Ac-CHO/EMR ratios were very high and the levels remain at a plateau until 90 minutes after Et-OH administration and then decreased relatively quickly. Changes in blood Ac-CHO levels and Ac-CHO/EMR ratios in ALD were similar to those in cases of the unusual type. These results indicate that Ac-CHO metabolism in ALD is decreased relative to its production and that this decrease might be due to increased production of Ac-CHO in the nonalcohol dehydrogenase pathway located in the microsomes, in which degradation of Ac-CHO was slow.

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Crossref · 10.1016/0741-8329(90)90058-k

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Research works printed but not linked: 24

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Cited by

Metadata

Authors
Takase, S., Yasuhara, M., Takada, A., & Ueshima, Y.
Affiliations
Kanazawa Medical University (JP)
Corresponding author
Takada, Akira
ORCID
Ueshima, Yasuhiro
Venue
Alcohol
Publisher
Elsevier BV
Published
1990-01
Volume
7
Issue
1
Pages
37-41
ISSN
0741-8329 (ISSN-L)
DOI
10.1016/0741-8329(90)90058-k
OpenAlex
W2050713315
Cited by
14
References
1
Citations by year
2022: 1 · 2021: 1
FWCI
1.89
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Alcohol (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Health Sciences › Medicine › Clinical Neurology › Alcoholism and Thiamine Deficiency
Keywords
blood acetaldehyde, alcohol metabolism, alcoholic liver disease, alcoholism, aldehyde dehydrogenase deficiency
MeSH terms
Acetaldehyde, Adult, Ethanol, Alcoholism, Aldehyde Dehydrogenase, Humans, Isoenzymes, Kinetics, Liver, Liver Diseases, Alcoholic, Middle Aged

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