The DOI matches its Crossref record.
Elevated blood acetaldehyde in alcoholics with accelerated ethanol elimination
Abstract
Alcoholics and controls given ethanol (1.2 g/kg body weight) were analyzed for blood and breath acetaldehyde using the more sensitive and reliable semicarbazide method. The acetaldehyde levels in controls were almost undetectable (less than 2 microM), but were found to be elevated (10--10 microM) in 6 of 8 alcoholics. Breath acetaldehyde and blood acetaldehyde co-fluctuated during the experiments. Fructose infusion transiently increased blood acetaldehyde, but only in 4 of the alcoholics. The apparent discrepancy between our finding and the simultaneously reported low acetaldehyde level in alcoholics (Eriksson and Peachy, this volume) may be explained by the different status of the alcoholics tested. Our alcoholics were tested on the day after hospital admission and eliminated ethanol 5% faster than controls. It is suggested that elevated blood acetaldehyde occurs regularly after interrupted drinking in heavy alcohol abusers with fast ethanol elimination, possibly combined with reduced liver aldehyde dehydrogenase activity, but that the phenomenon may rapidly disappear upon abstinence and hospital treatment, which reduces disturbances in hepatic functions and the ethanol elimination rate.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In human ALD, blood acetaldehyde level is significantly upregulated and its increase parallels the elevation of ethanol concentration [140,141,142,143].”
From Pathophysiological Aspects of Alcohol Metabolism in the Liver (2021) · cites this paper as [142]
Citations
Cites
No references could be resolved yet.
Research works printed but not linked: 17
- Eriksson, 1977, The determination of acetaldehyde in biological samples by headspace chromatography, Analyt. Biochem., 80, 116, 10.1016/0003-2697(77)90631-5 · DOI
- Eriksson, 1980, Problems and pitfalls in acetaldehyde determinations, Alcoholism clin. ex. Res., 4, 22, 10.1111/j.1530-0277.1980.tb04786.x · DOI
- Eriksson, 1980, Lack of difference in blood acetaldehyde of alcoholics and controls after ethanol ingestion, Pharmac. Biochem. Behav., 13, 101, 10.1016/S0091-3057(80)80016-5 · DOI
- Jenkins, 1980, Selectively reduced hepatic acetaldehyde dehydrogenase in alcoholics, Lancet 1, 8169, 628, 10.1016/S0140-6736(80)91121-6 · DOI
- Korsten, 1975, High blood acetaldehyde levels after ethanol administration. Difference between alcoholic and non-alcoholic subjects, New Engl. J. Med., 292, 386, 10.1056/NEJM197502202920802 · DOI · Paper page
- Lindros, 1978, Acetaldehyde—its metabolism and role in the actions of alcohol, Vol. 4, 111
- Mezey, 1971, Rates of ethanol clearance and activities of the ethanol-oxidizing enzymes in chronic alcoholic patients, Gastroenterology, 61, 707, 10.1016/S0016-5085(19)33432-8 · DOI
- Mizoy, 1979, Relationship between facial flushing and blood acetaldehyde levels after alcohol intake, Pharmac. Biochem. Behav., 10, 303, 10.1016/0091-3057(79)90105-9 · DOI
- Pikkarainen, 1980, Breath acetaldehyde. Evidence for acetaldehyde production by oropharynx microflora and by lung microsomes, Vol. 132
- Pikkarainen, 1979, A method for determination of “free” acetaldehyde in plasma, Alcoholism: clin. exp. Res., 3, 259, 10.1111/j.1530-0277.1979.tb05311.x · DOI
- Salaspuro, 1978, Non-uniformity of blood ethanol elimination: Its exaggeration after chronic consumption, Annls. Clin. Res., 10, 294
- Stowell, 1977, Acetaldehyde formation during deprotenization of human blood samples containing ethanol, Biochem. Med., 18, 392, 10.1016/0006-2944(77)90075-8 · DOI
- Stowell, 1979, An improved method for the determination of acetaldehyde in human blood with minimal ethanol interference, Clinica chim. Acta, 98, 201, 10.1016/0009-8981(79)90146-3 · DOI
- Stowell, 1980, Breath and blood acetaldehyde concentrations and their correlation during normal and calcium carbimide-modified ethanol oxidation in man, Biochem. Pharmac., 29, 783, 10.1016/0006-2952(80)90557-2 · DOI
- Truitt, 1970, Ethanol-induced release of acetaldehyde from blood and its effect on the determination of acetaldehyde Q Jl Stud, Alcohol, 31, 1
- Truitt, 1971, Blood acetaldehyde levels after alcohol consumption by alcoholic and nonalcoholic subjects, Vol. 3, 212
- von Wartburg, 1979, Determination of acetaldehyde human blood, Experientia, 35, 1682, 10.1007/BF01953271 · DOI
Cited by
Sorted by citations
Pathophysiological Aspects of Alcohol Metabolism in the Liver
Hyun, J., Han, J., Lee, C., Yoon, M., & Jung, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115717 · Cited by 324
Metadata
- Authors
- Lindros, K. O., Stowell, A., Pikkarainen, P., & Salaspuro, M.
- Affiliations
- University of Helsinki (FI)
- Corresponding author
- Lindros, Kai O.
- ORCID
- Salaspuro, Mikko
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 1980-01
- Volume
- 13
- Pages
- 119-124
- ISSN
- 0091-3057 (ISSN-L)
- OpenAlex
- W2038506905
- Cited by
- 120
- References
- 0
- Citations by year
- 2026: 2 · 2025: 4 · 2023: 1 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 1 · 2016: 2 · 2015: 2 · 2012: 2
- FWCI
- 8.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Clinical Neurology › Alcoholism and Thiamine Deficiency
- Keywords
- blood acetaldehyde, alcoholism, ethanol elimination rate, fructose infusion, aldehyde dehydrogenase, liver function, alcohol abstinence
- MeSH terms
- Acetaldehyde, Adult, Ethanol, Alcoholism, Breath Tests, Humans, Metabolic Clearance Rate, Middle Aged
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Elevated blood acetaldehyde in alcoholics with accelerated ethanol elimination. https://app.cochat.ai/papers/10.1016/s0091-3057(80)80019-0
- The paper
- Lindros, K. O., Stowell, A., Pikkarainen, P., & Salaspuro, M. (1980). Elevated blood acetaldehyde in alcoholics with accelerated ethanol elimination. Pharmacology Biochemistry and Behavior. https://doi.org/10.1016/s0091-3057(80)80019-0
