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Binding of tricyclic antidepressant drugs to trophozoites of giardia lamblia
Abstract
1. Parameters affecting the binding of the tricyclic drugs imipramine and 3-chloroimipramine to Giardia lamblia trophozoites were studied. 2. Two to three times more chlorimipramine than imipramine was bound, consistent with a similar difference in suppressing parasite growth (Weinbach et al., 1985). 3. Kinetic analysis and the ease with which bound drugs can be washed out of the parasites indicate that noncovalent forces are involved in the drug-parasite interaction. 4. Evidence is presented that such drugs probably bind to parasite protein at common binding sites. 5. The data relate to our earlier observation that chlorimipramine is about ten times more effective than metronidazole (Crouch et al., 1986) in suppressing G. lamblia growth in vitro. Tricyclic drugs, therefore, merit serious consideration as novel therapeutic agents against giardiasis.
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TCAs prevent growth of gut pathogens E. coli, Yersinia enterocolitica and Giardia lamblia.
“Another class of antidepressants, tricyclic antidepressants (TCAs), have been shown to prevent the growth of gut pathogens such as E. coli, Yersinia enterocolitica (Csiszar and Molnar, 1992;Molnar, 1988) and the parasite Giardia lamblia (Weinbach et al., 1992).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Weinbach et al., 1992
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Cites
LIGAND: A versatile computerized approach for characterization of ligand-binding systems
Munson, P. J., & Rodbard, D. (1980) · Analytical Biochemistry · doi:10.1016/0003-2697(80)90515-1 · Cited by 8,373
Phylogenetic Meaning of the Kingdom Concept: an Unusual Ribosomal RNA from Giardia lamblia
Sogin, M. L., Gunderson, J. H., Elwood, H. J., Alonso, R. A., & Peattie, D. A. (1989) · Science · doi:10.1126/science.2911720 · Cited by 707
Properties of 3H-diazepam binding to benzodiazepine receptors in rat cerebral cortex
Möhler, H., & Okada, T. (1977) · Life Sciences · doi:10.1016/0024-3205(77)90191-6 · Cited by 325
Demonstration of specific high affinity binding sites for [3H] imipramine in human brain
Rehavi, M., Paul, S. M., Skolnick, P., & Goodwin, F. K. (1980) · Life Sciences · doi:10.1016/0024-3205(80)90213-1 · Cited by 256
Demonstration of specific “high affinity” binding sites for [3H] imipramine on human platelets
Paul, S. M., Rehavi, M., Skolnick, P., & Goodwin, F. K. (1980) · Life Sciences · doi:10.1016/0024-3205(80)90116-2 · Cited by 198
ON THE ACTIVE STRUCTURE OF LOCAL ANESTHETICS
Ritchie, J. M., & Greengard, P. (1961) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)26097-9 · Cited by 180
Antigenic variation of a cysteine-rich protein in Giardia lamblia.
Adam, R. D., Aggarwal, A., Lal, A. A., de la Cruz, V. F., McCutchan, T. F., & Nash, T. E. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.167.1.109 · Cited by 138
Uncouplers of oxidation phosphorylation
Heytler, P. G. (1980) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(80)90027-3 · Cited by 98
Edlind, T. D. (1989) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.33.4.484 · Cited by 61
Characteristics and regulation of high affinity [3H]imipramine binding to rat hippocampal membranes
Kinnier, W. J., Chuang, D. M., Gwynn, G. J., & Costa, E. (1981) · Neuropharmacology · doi:10.1016/0028-3908(81)90170-2 · Cited by 54
Respiratory Metabolism of Giardia lamblia
Weinbach, E. C., Claggett, C. E., Keister, D. B., Diamond, L. S., & Kon, H. (1980) · Journal of Parasitology · doi:10.2307/3280835 · Cited by 53
Self-citationEffects of tricyclic antidepressant drugs on energy-linked reactions in mitochondria
Weinbach, E. C., Costa, J. L., Nelson, B. D., Claggett, C. E., Hundal, T., Bradley, D., & Morris, S. J. (1986) · Biochemical Pharmacology · doi:10.1016/0006-2952(86)90108-5 · Cited by 48
Self-citationMolecular aspects of the imipramine ‘receptor’
Davis, A. (1984) · Cellular and Molecular Life Sciences · doi:10.1007/bf01951960 · Cited by 40
Crouch, A. A., Seow, W. K., & Thong, Y. H. (1986) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(86)90249-x · Cited by 37
Analogs of 5-methylthioribose, a novel class of antiprotozoal agents
Riscoe, M. K., Ferro, A. J., & Fitchen, J. H. (1988) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.32.12.1904 · Cited by 35
Human platelet imipramine recognition sites: Biochemical and pharmacological characterization
Wennogle, L. P., Beer, B., & Meyerson, L. R. (1981) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(81)90065-4 · Cited by 35
Biochemistry of enteric parasitic protozoa
Weinbach, E. C. (1981) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(81)90092-x · Cited by 28
Self-citationMass Cultivation of Giardia lamblia in a Serum-Free Medium
Wieder, S. C., Keister, D. B., & Reiner, D. S. (1983) · Journal of Parasitology · doi:10.2307/3280897 · Cited by 22
The activity of tricyclic antidepressant drugs against Trypanosoma cruzi
Doyle, P. S., & Weinbach, E. C. (1989) · Experimental Parasitology · doi:10.1016/0014-4894(89)90102-1 · Cited by 21
Self-citationTakeuchi, T., Kobayashi, S., Tanabe, M., & Fujiwara, T. (1985) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.27.1.65 · Cited by 21
Rehavi, M., Tracer, H. L., Rice, K. C., Skolnick, P., & Paul, S. M. (1983) · Life Sciences · doi:10.1016/0024-3205(83)90210-2 · Cited by 21
Antidepressant drugs suppress growth of the human pathogenic protozoan Giardia lamblia.
Weinbach, E. C., Jl, C., & Wieder, S. C. (1985) · PubMed · Cited by 16
Self-citationLow-affinity binding of [3H]imipramine to primary astrocyte cultures
Waniewski, R. A., Katz, D. M., & Kimelberg, H. K. (1987) · Biochemical Pharmacology · doi:10.1016/0006-2952(87)90714-3 · Cited by 4
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- SAS User's Guide: Statistics (1985) (5th edn), pp. 575–606. SAS Institute, Cary, NC.
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The neuroendocrinology of the microbiota-gut-brain axis: a behavioural perspective
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“coli, Yersinia enterocolitica (Csiszar and Molnar, 1992; Molnar, 1988) and the parasite Giardia lamblia (Weinbach et al., 1992).”
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Skonieczna‐Żydecka, K., Marlicz, W. M., Misera, A., Koulaouzidis, A., & Łoniewski, I. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7120521 · Cited by 151
Antimicrobial Properties on Non-Antibiotic Drugs in the Era of Increased Bacterial Resistance
Lagadinou, M., Onisor, M. O., Rigas, A., Musetescu, D.-V., Gkentzi, D., Assimakopoulos, S. F., Panos, G. Z., & Marangos, M. N. (2020) · Antibiotics · doi:10.3390/antibiotics9030107 · Cited by 126
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Kulda, J., & Nohýnková, E. (1995) · Elsevier eBooks · doi:10.1016/b978-0-12-426020-7.50008-6 · Cited by 77
The immunostimulating and antimicrobial properties of lithium and antidepressants
Lieb, J. (2004) · Journal of Infection · doi:10.1016/j.jinf.2004.03.006 · Cited by 59
Liśkiewicz, P., Pełka-Wysiecka, J., Kaczmarczyk, M., Łoniewski, I., Wroński, M., Bąba-Kubiś, A., Skonieczna‐Żydecka, K., Marlicz, W. M., Misiak, B., & Samochowiec, J. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8020164 · Cited by 44
Misera, A., Łoniewski, I., Palma, J., Kulaszyńska, M., Czarnecka, W., Kaczmarczyk, M., Liśkiewicz, P., Samochowiec, J., & Skonieczna‐Żydecka, K. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1125022 · Cited by 28
Lithium and antidepressants: Stimulating immune function and preventing and reversing infection
Lieb, J. (2007) · Medical Hypotheses · doi:10.1016/j.mehy.2006.12.005 · Cited by 16
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Metadata
- Authors
- Weinbach, E. C., Levenbook, L., & Alling, D. W.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Weinbach, Eugene C.
- Venue
- Comparative Biochemistry and Physiology Part C: Comparative Pharmacology
- Publisher
- Elsevier BV
- Published
- 1992-07
- Volume
- 102
- Issue
- 3
- Pages
- 391-396
- ISSN
- 0306-4492 (ISSN-L)
- OpenAlex
- W1979102386
- Cited by
- 18
- References
- 24
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 1
- FWCI
- 0.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Comparative Biochemistry and Physiology Part C Comparative Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology
- Topics
- Life Sciences › Immunology and Microbiology › Parasitology › Parasitic Infections and Diagnostics
- Health Sciences › Medicine › Epidemiology › Trypanosoma species research and implications
- Life Sciences › Immunology and Microbiology › Parasitology › Helminth infection and control
- Keywords
- tricyclic antidepressants, Giardia lamblia, trophozoites, drug binding, imipramine, clomipramine, metronidazole, giardiasis, binding kinetics, non-covalent binding, binding sites, antiparasitic drugs
- MeSH terms
- Animals, Binding Sites, Binding, Competitive, Clomipramine, Hydrogen-Ion Concentration, Imipramine, Indicators and Reagents, Kinetics, Subcellular Fractions, Temperature, Protozoan Proteins, Giardia lamblia
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