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Prevalence of symptoms among patients with advanced cancer: An international collaborative study
Open accessAbstract
The aims of this study were (a) to estimate the prevalence of pain and eight other common symptoms in a large population of patients with advanced cancer from different palliative care centers, and (b) to assess the differences in prevalence of the symptoms by primary site. In 1990-1991, the prevalence of eight major symptoms and performance status were assessed prospectively among 1840 cancer patients in seven hospices in Europe, the United States, and Australia. The data were collected at each institution using structured data collection sheets from the World Health Organization's (WHO) Cancer and Palliative Care Unit. The prevalence of moderate to severe pain was 51%, ranging from 43% in stomach cancer to 80% in gynecological cancers. Nausea was most prevalent in gynecological (42%) and stomach (36%) cancers, and dyspnea (46%) in lung cancer. There were statistically significant differences in the prevalence of most symptoms depending on the primary site of cancer and the hospice. Population-based follow-up studies are needed to document the incidence and prevalence of symptoms throughout the course of the disease.
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“Adults with advanced cancer report a range of palliative care challenges, including anxiety and depression in the face of imminent loss and how to make the most of their remaining time, spiritual/ existential needs related to making sense of their illness, fear of dying/death, and physical symptoms [4–11].”
From A randomized controlled trial of a multi-modal palliative care intervention to promote advance care planning and psychological well-being among adults with advanced cancer: study protocol. (2022) · cites this paper as [6]
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Sorted by citations
Prevalence of pain in patients with cancer: a systematic review of the past 40 years
van den Beuken-van Everdingen, M. H. J., de Rijke, J. M., Kessels, A. G., Schouten, H. C., van Kleef, M., & Patijn, J. (2007) · Annals of Oncology · doi:10.1093/annonc/mdm056 · Cited by 1,923
Solano, J. P., Gomes, B., & Higginson, I. J. (2006) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2005.06.007 · Cited by 1,191
Symptom Prevalence in Patients with Incurable Cancer: A Systematic Review
Teunissen, S. C. C. M., Wesker, W., Kruitwagen, C., de Haes, H. C. J. M., Voest, E. E., & de Graeff, A. (2007) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2006.10.015 · Cited by 990
The Prevalence of Symptoms in End-Stage Renal Disease: A Systematic Review
Murtagh, F. E., Addington-Hall, J. M., & Higginson, I. J. (2007) · Advances in Chronic Kidney Disease · doi:10.1053/j.ackd.2006.10.001 · Cited by 985
Smith, T. J., Staats, P. S., Deer, T. R., Stearns, L. J., Rauck, R. L., Boortz-Marx, R. L., Buchser, E., Català, E., Bryce, D. A., Coyne, P. J., et al. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.02.118 · Cited by 737
Metadata
- Authors
- Vainio, A., & Auvinen, A.
- Affiliations
- World Health Organization (CH)
- Finnish Cancer Registry (FI)
- ORCID
- Auvinen, Anssi
- Venue
- Journal of Pain and Symptom Management
- Publisher
- Elsevier BV
- Published
- 1996-07
- Volume
- 12
- Issue
- 1
- Pages
- 3-10
- ISSN
- 0885-3924 (ISSN-L)
- OpenAlex
- W2075464999
- Cited by
- 455
- References
- 36
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 8 · 2023: 8 · 2022: 9 · 2021: 11 · 2020: 10 · 2019: 13 · 2018: 16 · 2017: 10 · 2016: 13 · 2015: 10 · 2014: 10 · 2013: 18 · 2012: 21
- FWCI
- 12.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Pain and Symptom Management (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative Care and End-of-Life Issues
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative and Oncologic Care
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Keywords
- advanced cancer, symptom prevalence, cancer pain, nausea, dyspnea, performance status, primary tumor site, gynecologic cancer, gastric cancer, lung cancer, hospice care, palliative care
- MeSH terms
- Humans, Neoplasms, Pain, Palliative Care
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