Symptom Prevalence in Patients with Incurable Cancer: A Systematic Review

Teunissen, Saskia C.C.M.; Wesker, Wendy; Kruitwagen, Cas; de Haes, Hanneke C.J.M.; Voest, Emile E.; de Graeff, Alexander

doi:10.1016/j.jpainsymman.2006.10.015

Cited by 990Palliative Care and End-of-Life IssuesPalliative and Oncologic CareCancer survivorship and care

Symptom Prevalence in Patients with Incurable Cancer: A Systematic Review

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Teunissen, Saskia C.C.M., Wesker, Wendy, Kruitwagen, Cas, de Haes, Hanneke C.J.M., Voest, Emile E., de Graeff, Alexander·2007·Journal of Pain and Symptom Management

DOI 10.1016/j.jpainsymman.2006.10.015

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Abstract

The suffering of patients with incurable cancer is determined to a large degree by the presence and intensity of the symptoms of their disease. Knowledge of symptom prevalence is important for clinical practice. The main aim of this study was to obtain a reliable estimation of symptom prevalence in patients with incurable cancer by performing a systematic review of studies assessing this topic. We included 44 studies (including 25,074 patients) on overall symptom prevalence (Group 1) and six studies (including 2,219 patients) on symptom prevalence during the last one to two weeks of life (Group 2). In these studies, symptom prevalence was assessed by a questionnaire, a standardized interview, or the medical record. We identified 37 symptoms assessed in at least five studies. Almost all symptoms occurred in more than 10% of the patients. Five symptoms (fatigue, pain, lack of energy, weakness, and appetite loss) occurred in more than 50% of the patients of Group 1. Weight loss occurred significantly more often in Group 2 compared to Group 1, and pain, nausea, and urinary symptoms occurred significantly less often. Generally, symptom prevalence was highest if assessed by a questionnaire. The results of this study should be used to guide doctors and nurses in symptom management. Proper attention to symptom burden and suffering should be the basis for individually tailored treatment aimed at improving or maintaining quality of life of patients in their last period of life.

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“Up to half of adults with metastatic cancer report elevated anxiety or depression [9, 16, 17]”
From A randomized controlled trial of a multi-modal palliative care intervention to promote advance care planning and psychological well-being among adults with advanced cancer: study protocol. (2022) · cites this paper as [16]

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“Up to half of adults with metastatic cancer report elevated anxiety or depression [9, 16, 17], which can be associated with poor quality of life, more severe physical symptoms [18, 19], and earlier cancer-related mortality [20–22].”
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Authors: Teunissen, S. C. C. M., Wesker, W., Kruitwagen, C., de Haes, H. C. J. M., Voest, E. E., & de Graeff, A.
Affiliations: Utrecht University (NL)
ORCID: Teunissen, Saskia C.C.M.
Kruitwagen, Cas
Voest, Emile E.
Venue: Journal of Pain and Symptom Management
Publisher: Elsevier BV
Published: 2007-07
Volume: 34
Issue: 1
Pages: 94-104
ISSN: 0885-3924 (ISSN-L)
DOI: 10.1016/j.jpainsymman.2006.10.015
OpenAlex: W2161943291
Cited by: 990
References: 61
Citations by year: 2026: 36 · 2025: 44 · 2024: 40 · 2023: 66 · 2022: 74 · 2021: 56 · 2020: 58 · 2019: 62 · 2018: 50 · 2017: 70 · 2016: 62 · 2015: 60 · 2014: 72 · 2013: 52 · 2012: 58
FWCI: 3.98
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4579 d)
Locations: Journal of Pain and Symptom Management (publishedVersion)
PubMed (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Pure Amsterdam UMC (submittedVersion)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative Care and End-of-Life Issues
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative and Oncologic Care
Health Sciences › Medicine › Oncology › Cancer survivorship and care
Keywords: symptom prevalence, incurable cancer, terminal cancer, symptom burden, last days of life, fatigue, pain, weight loss, appetite loss, nausea, symptom management, quality of life
MeSH terms: Mental Disorders, Gastrointestinal Diseases, Humans, Neoplasms, Pain, Palliative Care, Skin Diseases, Prevalence

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Symptom Prevalence in Patients with Incurable Cancer: A Systematic Review

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