Chromosomal localization of the gastric and brain receptors for cholecystokinin (CCKAR and CCKBR) in human and mouse
Open accessAbstract
Receptors for cholcystokinin (CCK) can be pharmacologically classified into at least two distinct subtypes, CCKAR and CCKBR. In an effort to determine whether the CCKA and CCKB receptors may be associated with certain CNS or gastrointestinal diseases, we have localized and compared the human and mouse chromosomal loci encoded by the CCKAR and CCKBR genes. The gene encoding the CCKA receptor maps to a syntenic region of human chromosome 4 and mouse chromosome 5. The CCKB receptor gene, on the other hand, resides on a syntenic region of human chromosome 11 and distal mouse chromosome 7. Localization of the CCK receptors with two dopamine receptors, DRD5 (4p15.1-p15.3) and DRD4 (11p15), provides the interesting possibility of coinvolvement in neuropsychiatric or CNS illnesses.
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- Authors
- Huppi, K., Siwarski, D., Pisegna, J. R., & Wank, S.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Huppi, K.
- Venue
- Genomics
- Publisher
- Elsevier BV
- Published
- 1995-02
- Volume
- 25
- Issue
- 3
- Pages
- 727-729
- ISSN
- 0888-7543 (ISSN-L)
- PMC
- PMC6736545
- OpenAlex
- W2023417188
- Cited by
- 42
- References
- 28
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 1 · 2021: 2 · 2018: 2 · 2016: 2 · 2015: 1 · 2014: 3 · 2013: 4
- FWCI
- 0.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genomics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, public-domain)
- Funders
- U.S. Department of Veterans Affairs (I01 BX004560, I01 RX000194)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK041301)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- CCK-A receptor, cholecystokinin B receptor, chromosomal localization, gene mapping, human chromosome 4, mouse chromosome 5, human chromosome 11, mouse chromosome 7, dopamine D4 receptor, syntenic regions, neuropsychiatric disorders, gastrointestinal diseases
- MeSH terms
- Animals, Base Sequence, Brain Chemistry, Chromosome Mapping, Chromosomes, Human, Pair 4, Cricetinae, Humans, Hybrid Cells, Mice, Inbred BALB C, Molecular Sequence Data, Receptors, Cholecystokinin, Receptors, Dopamine, Stomach, Polymerase Chain Reaction, DNA Primers, Receptor, Cholecystokinin A, Receptor, Cholecystokinin B, Mice
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