Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice

Coleman, D. L.

doi:10.1007/bf00429772

Cited by 1,307Pancreatic function and diabetesDiabetes and associated disordersRegulation of Appetite and Obesity

Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice

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Coleman, D. L.·1978·Diabetologia

DOI 10.1007/bf00429772

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Mice with genetic leptin deficiency or leptin receptor deficiency exhibit hyperphagia, obesity, insulin resistance, and diabetes.
“Such animals exhibit not only hyperphagia and obesity, but insulin resistance and diabetes as well (37, 57, 181, 212).”
From Leptin and the Central Nervous System Control of Glucose Metabolism (2011) · cites this paper as [37]
Absence of leptin or leptin receptors in Lepob/ob or Leprdb/db mice results in morbid obesity, hyperphagia, severe hyperglycemia and insulin resistance, and marked hypoactivity.
“The absence of leptin or leptin receptors in Lepob/ob mice or Leprdb/db mice respectively, results in morbid obesity, hyperphagia, severe hyperglycemia and insulin resistance, and marked hypoactivity (Chen et al., 1996; Coleman, 1978; Lee et al., 1996; Pelleymounter et al., 1995; Tartaglia et al., 1995; Zhang et al., 1994).”
From Leptin-Dependent Control of Glucose Balance and Locomotor Activity by POMC Neurons (2009) · cites this paper as Coleman, 1978

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“Such animals exhibit not only hyperphagia and obesity, but insulin resistance and diabetes as well (37, 57, 181, 212).”
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Authors: Coleman, D. L.
Affiliations: Jackson Laboratory (US)
Corresponding author: Coleman, D. L.
ORCID: Coleman, D. L.
Venue: Diabetologia
Publisher: Springer Science and Business Media LLC
Published: 1978-03
Volume: 14
Issue: 3
Pages: 141-148
ISSN: 0012-186X (ISSN-L)
1432-0428
DOI: 10.1007/bf00429772
OpenAlex: W2091085717
Cited by: 1,307
References: 35
Citations by year: 2026: 18 · 2025: 32 · 2024: 20 · 2023: 27 · 2022: 24 · 2021: 33 · 2020: 34 · 2019: 38 · 2018: 28 · 2017: 39 · 2016: 37 · 2015: 28 · 2014: 52 · 2013: 35 · 2012: 36
FWCI: 3.70
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Diabetologia (publishedVersion)
PubMed (publishedVersion)
The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
Funders: Université de Genève
National Cancer Institute
Topics: Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: single-gene mutations, beta-cell hyperplasia, beta-cell hypertrophy, islet atrophy, hyperphagia, hyperinsulinemia, hyperglycemia, genetic modifiers, type 1 diabetes, maturity-onset diabetes, insulin secretion
MeSH terms: Animals, Body Weight, Chromosomes, Diabetes Mellitus, Diabetes Mellitus, Experimental, Genes, Mice, Inbred Strains, Mice, Obese, Mutation, Obesity, Mice, Rats

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