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Cited by 79Stress Responses and CortisolImmune Response and InflammationAdrenal Hormones and Disorders

Neuro-hormonal host defence in endotoxin shock

Ramachandra, Rangappa N., Sehon, Alec H., Berczi, Istvan·1992·Brain, Behavior, and Immunity
DOI 10.1016/0889-1591(92)90015-g
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Abstract

The sensitivity (LD100) of mice to lipopolysaccharide (LPS) endotoxin and to its toxic moiety, lipid A (LA), increased 500-fold after adrenalectomy (ADX). Inhibition of glucocorticoid synthesis in intact mice by metyrapone had a similar, though less dramatic, sensitizing effect to LPS. In ADX mice, the serum level of tumor necrosis factor-alpha (TNF) was 40-60 times higher than that in controls at 2 h after LPS/LA treatment. In intact mice the serum corticosterone level fell 1 h after lipid A injection to below detectable levels, which was followed by a brisk increase reaching the peak level of 48-50 micrograms/100 ml at 2 h. Both TNF production and the lethal effect of PLS/LA could be inhibited in ADX mice by glucocorticoid treatment. Plasma prolactin was increased significantly 1 h after endotoxin administration in both intact and ADX animals.

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  • A deficient or blunted HPA axis is commonly observed in autoimmune and inflammatory diseases, and disrupting the HPA axis compromises survival of normally resistant mice to septic shock.

    “On the other hand, a deficient or blunted HPA axis is commonly observed in the clinic in a wide range of autoimmune and inflammatory diseases. Likewise, disrupting the HPA axis surgically (through adrenalectomy) or pharmacologically (with GR antagonists) compromises the survival of normally resistant mice to septic shock (23–27).”

    From The HPA – Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain (2014) · cites this paper as [26]

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Authors
Ramachandra, R. N., Sehon, A. H., & Berczi, I.
Affiliations
University of Manitoba (CA)
Corresponding author
Berczi, Istvan
Venue
Brain, Behavior, and Immunity
Publisher
Elsevier BV
Published
1992-06
Volume
6
Issue
2
Pages
157-169
ISSN
0889-1591 (ISSN-L)
DOI
10.1016/0889-1591(92)90015-g
OpenAlex
W2081984658
Cited by
79
References
44
Citations by year
2026: 1 · 2023: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 4 · 2014: 1 · 2012: 5
FWCI
1.42
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Brain Behavior and Immunity (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
endotoxic shock, lipopolysaccharide, lipid A, adrenalectomy, glucocorticoids, metyrapone, TNF-α, corticosterone, prolactin, endotoxin sensitivity, glucocorticoid resistance
MeSH terms
Adrenalectomy, Animals, Corticosterone, Dexamethasone, Disease Susceptibility, Dose-Response Relationship, Drug, Female, Lipid A, Lipopolysaccharides, Metyrapone, Mice, Inbred BALB C, Pituitary-Adrenal System, Prolactin, Shock, Septic, Tumor Necrosis Factor-alpha, Mice

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