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Oxidative DNA damage by crystalline silica

Daniel, Lambert N., Mao, Yan, Umberto, Saffiotti·1993·Free Radical Biology and Medicine
DOI 10.1016/0891-5849(93)90103-2
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Abstract

Using a simple DNA strand breakage assay, we detected the production of oxidant species, probably hydroxyl free radicals, in buffered suspensions of crystalline silica at pH 7.4. DNA damage was affected by the presence of oxygen and was accelerated by superoxide dismutase and by hydrogen peroxide. Deferoxamine blocked damage by hydrogen peroxide and silica but accelerated DNA damage by silica alone and by superoxide dismutase and silica. DNA damage was blocked by catalase and by the scavenging agents dimethyl sulfoxide and sodium benzoate. Chemical etching of crystalline silica to remove impurities by treatment of the surface with hydrofluoric acid resulted in markedly diminished DNA damaging ability. Even preparations of crystalline silica previously characterized as highly pure contained trace iron impurities in amounts significant enough to produce oxygen free radicals in aqueous suspension. Both superoxide and Fenton reaction oxidants were produced. We conclude that silica is able to mediate DNA strand breakage in vitro and that this DNA damage may be an important factor in silica toxicity.

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Research works printed but not linked: 31

  1. Saffiotti, 1988, Lung cancer induction by crystalline silica: Relationships to granulomatous reactions and host factors, Envir. Carcino, Revs., C6, 197
  2. Nolan, 1981, Quartz hemolysis as related to its surface functionalities, Environ. Res., 26, 503, 10.1016/0013-9351(81)90226-7 · DOI
  3. Brown, 1988, Fibroblast proliferation induced by silica exposed human alveolar macrophages, Am. Res. Respir., 138, 85
  4. Miller, 1987, Progression of type II cell hypertrophy and hyperplasia during silica-induced pulmonary inflammation, Lab. Invest., 57, 546
  5. Lesur, 1992, Silica exposure induces cytotoxicity and proliferative activity of type II pneumocytes, Exp. Lung Res., 18, 173, 10.3109/01902149209031679 · DOI
  6. Hesterberg, 1984, Dependence of asbestos- and mineral dust-induced transformation of mammalian cells in culture on fiber dimension, Cancer Res., 44, 2170
  7. Pairon, 1990, Sister chromatid exchanges in human lymphocytes treated with silica, British J. Indus. Med., 47, 110
  8. Khan, 1988, Strand breakage in DNA by silicic acid, Mutat Res., 208, 27, 10.1016/0165-7992(88)90016-4 · DOI
  9. Hochstrasser, 1972, Surfaces states of pristine silica surfaces, Surface Sci., 32, 644, 10.1016/0039-6028(72)90192-6 · DOI
  10. Karmanova, 1984, Mechanism of the emission of singlet oxygen molecules from a disordered quartz surface, Zhurnal Fizichestoi Khimii, 58, 1958
  11. Vallyathan, 1988, Generation of free radicals from freshly fractured silica dust, Am. Rev. Respir. Dis., 138, 1213, 10.1164/ajrccm/138.5.1213 · DOI · Paper page
  12. Doelman, 1990, Mineral dust exposure and free radical-mediated lung damage, Exp. Lung. Res., 16, 41, 10.3109/01902149009064698 · DOI
  13. Holley, 1992, Increased manganese superoxide dismutase protein in type II epithelial cells of rat lungs after inhalation of crocidolite asbestos or cristobalite silica, Am. J. Path., 141, 475
  14. Janssen, 1992, Expression of antioxidant enzymes in rat lungs after inhalation of asbestos or silica, J. Biol. Chem., 267, 10625, 10.1016/S0021-9258(19)50063-1 · DOI · Paper page
  15. Saffiotti, 1962, The histogenesis of experimental silicosis, Med. Lavoro, 53, 5
  16. Aust, 1990, Iron redox reactions and lipid peroxidation, Meth. Enzymol., 186, 457, 10.1016/0076-6879(90)86140-Q · DOI
  17. Winterbourn, 1975, The estimation of red cell superoxide dismutase activity, J. Lab. Clin. Med., 85, 337
  18. Marklund, 1974, Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase, Eur. J. Biochem., 47, 469, 10.1111/j.1432-1033.1974.tb03714.x · DOI
  19. Keele, 1970, Superoxide dismutase from Escherichia coli B, J. Biol. Chem., 245, 6176, 10.1016/S0021-9258(18)62675-4 · DOI
  20. Meneghini, 1988, Genotoxicity of active oxygen species in mammalian cells, Mut. Res., 195, 215, 10.1016/0165-1110(88)90001-2 · DOI
  21. Hertzberg, 1984, Cleavage of DNA with methidiumpropyl-EDTA-rion II: Reaction conditions and product analyses, Biochemistry, 23, 3934, 10.1021/bi00312a022 · DOI
  22. Halliwell, 1987, The deoxyribose method: A simple “test tube” assay for determination of rate constants for reactions of hydroxyl radicals, Anal. Biochem., 165, 215, 10.1016/0003-2697(87)90222-3 · DOI
  23. Winterbourn, 1991, Factors that influence the deoxyribose oxidation assay for Fenton reaction products, Free Radic. Biol. Med., 11, 353, 10.1016/0891-5849(91)90151-R · DOI
  24. Contopoulou, 1987, Analysis of DNA double strnd breakage and repair using orthogonal field alternating gel electrophoresis, Yeast, 3, 71, 10.1002/yea.320030203 · DOI
  25. Chen, 1989, Gel electrophoresis method for quantitation of gamma ray induced single- and double-strand breaks in DNA irradiated in vitro, Electrophoresis, 10, 318, 10.1002/elps.1150100509 · DOI
  26. Stamato, 1990, Assymetric field inversion gel electrophoresis: A new method for detecting DNA double strand breaks in mammalian cells, Radiat. Res., 121, 196, 10.2307/3577504 · DOI
  27. Ager, 1990, Measurement of radiation-induced DNA double-strand breaks by pulse-field gel electrophoresis, Radiat. Res., 122, 181, 10.2307/3577604 · DOI
  28. Blocher, 1990, DNA double strand break analysis by CHEF electrophoresis, Int. J. Radiat. Biol., 58, 23, 10.1080/09553009014551411 · DOI
  29. Finkelstein, 1982, Production of hydroxyl radical by decomposition of superoxide spin trapped adducts, Mol. Pharmacol., 21, 262, 10.1016/S0026-895X(25)14604-X · DOI
  30. Kolbanev, 1980, Mechanochemistry of quartz surface, Kinetika i Kataliz, 21, 1154
  31. Lund, 1991, Mobilization of iron from crocidolite asbestos by certain chelators results in enhanced crocidolite-dependent oxygen consumption, Arch. Biochem. Biophys., 287, 91, 10.1016/0003-9861(91)90392-V · DOI

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Metadata

Authors
Daniel, L. N., Mao, Y., & Umberto, S.
Venue
Free Radical Biology and Medicine
Publisher
Elsevier BV
Published
1993-05
Volume
14
Issue
5
Pages
463-472
ISSN
0891-5849
DOI
10.1016/0891-5849(93)90103-2
Cited by
64
References
1
Language
en
Licence

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CoChat. (2026). Citation check: Oxidative DNA damage by crystalline silica. https://app.cochat.ai/papers/10.1016/0891-5849(93)90103-2
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Daniel, L. N., Mao, Y., & Umberto, S. (1993). Oxidative DNA damage by crystalline silica. Free Radical Biology and Medicine. https://doi.org/10.1016/0891-5849(93)90103-2