Oxygen‐based free radical generation by ferrous ions and deferoxamine

Superoxide Dismutase

McCord, J. M., & Fridovich, I. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63504-5 · Cited by 12,952 · see citing works

LXXIII.—Oxidation of tartaric acid in presence of iron

Fenton, H. J. H. (1894) · J. Chem. Soc., Trans. · doi:10.1039/ct8946500899 · Cited by 3,179 · see citing works

The catalytic decomposition of hydrogen peroxide by iron salts

Haber, F., & Weiss, J. (1934) · Proceedings of the Royal Society of London. Series A - Mathematical and Physical Sciences · doi:10.1098/rspa.1934.0221 · Cited by 2,571 · see citing works

Inflammation. Basic principles and clinical correlates

(1989) · Biomedicine & Pharmacotherapy · doi:10.1016/0753-3322(89)90156-x · Cited by 2,388 · see citing works

Spin Trapping: ESR parameters of spin adducts 1474 1528V

Buettner, G. R. (1987) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(87)80033-3 · Cited by 1,827 · see citing works

Oxidation of tartaric acid in presence of iron

Fenton, H. J. H. (1894) · Journal of the Chemical Society (Resumed) · Cited by 1,498 · see citing works

Superoxide‐dependent production of hydroxyl radical catalyzed by iron—EDTA complex

McCord, J. M., & Day, E. D. (1978) · FEBS Letters · doi:10.1016/0014-5793(78)80116-1 · Cited by 870 · see citing works

Iron-catalyzed hydroxyl radical formation. Stringent requirement for free iron coordination site.

Graf, E., Mahoney, J. R., Bryant, R. G., & Eaton, J. W. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)43139-5 · Cited by 855 · see citing works

Superoxide‐dependent formation of hydroxyl radicals in the presence of iron chelates

Halliwell, B. B. (1978) · FEBS Letters · doi:10.1016/0014-5793(78)80779-0 · Cited by 743 · see citing works

H2O2 release from human granulocytes during phagocytosis. I. Documentation, quantitation, and some regulating factors.

Root, R. K., Metcalf, J. A., Oshino, N., & Chance, B. (1975) · Journal of Clinical Investigation · doi:10.1172/jci108024 · Cited by 646 · see citing works

Inhibition of the iron-catalysed formation of hydroxyl radicals from superoxide and of lipid peroxidation by desferrioxamine

Gutteridge, J. M. C., Richmond, R., & Halliwell, B. B. (1979) · Biochemical Journal · doi:10.1042/bj1840469 · Cited by 629 · see citing works

The Biochemistry of Desferrioxamine and its Relation to Iron Metabolism

Keberle, H. (1964) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1965.tb54077.x · Cited by 615 · see citing works

An Electron Spin Resonance Study of the Spin Adducts of OH and HO 2 Radicals with Nitrones in the Ultraviolet Photolysis of Aqueous Hydrogen Peroxide Solutions

Harbour, J. R., Chow, V., & Bolton, J. R. (1974) · Canadian Journal of Chemistry · doi:10.1139/v74-527 · Cited by 414 · see citing works

Evidence for reactive oxygen intermediates causing hemolysis and parasite death in malaria

Clark, I. A., & Hunt, N. H. (1983) · Infection and Immunity · doi:10.1128/iai.39.1.1-6.1983 · Cited by 359 · see citing works

Evidence for role of hydroxyl radical in complement and neutrophil-dependent tissue injury.

Ward, P. A., Till, G. O., Kunkel, R., & Beauchamp, C. (1983) · Journal of Clinical Investigation · doi:10.1172/jci111050 · Cited by 336 · see citing works

Evidence suggesting a role for hydroxyl radical in gentamicin-induced acute renal failure in rats.

Walker, P. D., & Shah, S. V. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113325 · Cited by 298 · see citing works

OCULAR TOXICITY OF HIGH-DOSE INTRAVENOUS DESFERRIOXAMINE

Davies, S., Hungerford, J. L., Arden, G. B., Marcus, R. E., Miller, M. H., & Huehns, E. R. (1983) · The Lancet · doi:10.1016/s0140-6736(83)90170-8 · Cited by 270 · see citing works

Systemic complement activation, lung injury, and products of lipid peroxidation.

Ward, P. A., Till, G. O., Hatherill, J. R., Annesley, T. M., & Kunkel, R. G. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112001 · Cited by 232 · see citing works

[52] Antimicrobial activity of myeloperoxidase

Klebanoff, S. J., Waltersdorph, A. M., & Rosen, H. (1984) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(84)05055-2 · Cited by 210 · see citing works

Lipid peroxidation and acute lung injury after thermal trauma to skin. Evidence of a role for hydroxyl radical.

Till, G. O., Hatherill, J. R., Tourtellotte, W. W., Lutz, M. J., & Ward, P. A. (1985) · PubMed Central · Cited by 188 · see citing works

Use of desferrioxamine as a ‘probe’ for iron-dependent formation of hydroxyl radicals

Halliwell, B. B. (1985) · Biochemical Pharmacology · doi:10.1016/0006-2952(85)90129-7 · Cited by 184 · see citing works

Cerebral and Ocular Toxicity Induced by Desferrioxamine

Blake, D. R., Winyard, P. G., Lunec, J., Williams, A. C., Good, P. A., Crewes, S. J., Gutteridge, J. M. C., ROWLEY, D., Halliwell, B. B., Cornish, A. L., et al. (1985) · QJM · doi:10.1093/oxfordjournals.qjmed.a067880 · Cited by 180 · see citing works

[73] Determination of nonheme iron, total iron, and copper

Brumby, P. E., & Massey, V. (1967) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(67)10078-5 · Cited by 174 · see citing works

Facilitation of Fe(II) antoxidation by Fe(III) complexing agents

Harris, D. C., & Aisen, P. (1973) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(73)90019-6 · Cited by 168 · see citing works

On spin trapping hydroxyl and hydroperoxyl radicals

Janzen, E. G., Nutter, D. E., Davis, E. R., Blackburn, B. J., Poyer, J. L., & McCay, P. B. (1978) · Canadian Journal of Chemistry · doi:10.1139/v78-368 · Cited by 156 · see citing works

Hydroxyl radical production involved in lipid peroxidation of rat liver microsomes

Lai, C.-S., & Piette, L. H. (1977) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(77)91220-7 · Cited by 150 · see citing works

Reactions of ferrioxamine and desferrioxamine with the hydroxyl radical

Hoe, S. T., Rowley, D. A., & Halliwell, B. B. (1982) · Chemico-Biological Interactions · doi:10.1016/0009-2797(82)90018-7 · Cited by 149 · see citing works

Über eisenhaltige Wachstumsfaktoren, die Sideramine, und ihre Antagonisten, die eisenhaltigen Antibiotika Sideromycine

Bickel, H., Gäumann, E., KELLER‐SCHIERLEIN, W., Prelog, V., Vischer, E., Wettstein, A., & Zähner, H. (1960) · Cellular and Molecular Life Sciences · doi:10.1007/bf02157712 · Cited by 141 · see citing works

Iodination by human polymorphonuclear leukocytes: a re-evaluation.

Klebanoff, S. J., & Clark, R. A. (1977) · PubMed · Cited by 131 · see citing works

Effect of a specific iron chelating agent on animal models of inflammation.

Blake, D. R., Hall, N. D., BACON, P. A., Dieppe, P. A., Halliwell, B. B., & Gutteridge, J. M. C. (1983) · Annals of the Rheumatic Diseases · doi:10.1136/ard.42.1.89 · Cited by 125 · see citing works

Deferoxamine inhibition of malaria is independent of host iron status.

Hershko, C., & Peto, T. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.168.1.375 · Cited by 124 · see citing works

Role of iron and ethylenediaminetetraacetic acid in the bactericidal activity of a superoxide anion-generating system

Rosen, H., & Klebanoff, S. J. (1981) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(81)90539-7 · Cited by 122 · see citing works

The enzymatic oxidation of Desferal to a nitroxide free radical

Morehouse, K. M., Flitter, W. D., & Mason, R. P. (1987) · FEBS Letters · doi:10.1016/0014-5793(87)80379-4 · Cited by 112 · see citing works

Detection of the Production of Oxygen-Centered Free Radicals by Human Neutrophils Using Spin Trapping Techniques: A Critical Perspective

Britigan, B. E., Cohen, M. S., & Rosen, G. M. (1987) · Journal of Leukocyte Biology · doi:10.1002/jlb.41.4.349 · Cited by 108 · see citing works

Oxygen Oxidation of Ferrous Ions Induced by Chelation

Kurimura, Y., Ochiai, R., & Matsuura, N. (1968) · Bulletin of the Chemical Society of Japan · doi:10.1246/bcsj.41.2234 · Cited by 94 · see citing works

Chelation of Ferrous Sulphate Solutions by Desferrioxamine B

Goodwin, J. F., & Whitten, C. F. (1965) · Nature · doi:10.1038/205281b0 · Cited by 94 · see citing works

Evidence for a role of hydroxyl radical in immune-complex-induced vasculitis.

Fligiel, S., Ward, P. A., Johnson, K. J., & Till, G. O. (1984) · PubMed Central · Cited by 88 · see citing works

Inhibition of microsomal oxidation of alcohols and of hydroxyl-radical-scavenging agents by the iron-chelating agent desferrioxamine

Cederbaum, A. I., & Dicker, E. (1983) · Biochemical Journal · doi:10.1042/bj2100107 · Cited by 86 · see citing works

Hydroxyl radical mediation of immune renal injury by desferrioxamine

Boyce, N., & Holdsworth, S. R. (1986) · Kidney International · doi:10.1038/ki.1986.260 · Cited by 84 · see citing works

Desferrioxamine: a scavenger of superoxide radicals?

Sinaceur, J., Ribière, C., Nordmann, J., & Nordmann, R. (1984) · Biochemical Pharmacology · doi:10.1016/0006-2952(84)90296-x · Cited by 79 · see citing works

Desferrioxamine as an Electron Donor. Inhibition of Membranal Lipid Peroxidation Initiated by H202–Activated Metmyoglobin and Other Peroxidizing Systems

Kanner, J., & Harel, S. (1987) · Free Radical Research Communications · doi:10.3109/10715768709069798 · Cited by 69 · see citing works

Mechanism of oxygenation of ferrous ion in neutral solution

Goto, K., Tamura, H., & Nagayama, M. (1970) · Inorganic Chemistry · doi:10.1021/ic50086a055 · Cited by 63 · see citing works

Mediation of IgA induced lung injury in the rat. Role of macrophages and reactive oxygen products.

Johnson, K. J., Ward, P. A., Kunkel, R. G., & Bs, W. (1986) · PubMed · Cited by 63 · see citing works

Inhibition of peroxidase-catalyzed reactions by deferoxamine

Klebanoff, S. J., & Waltersdorph, A. M. (1988) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(88)90326-8 · Cited by 37 · see citing works

Stimulation and inhibition of iron-dependent lipid peroxidation by desferrioxamine

Braughler, J. M., Chase, R. L., & Pregenzer, J. F. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(88)81317-2 · Cited by 32 · see citing works

Iodination catalyzed by the xanthine oxidase system: role of hydroxyl radicals

Klebanoff, S. J. (1982) · Biochemistry · doi:10.1021/bi00260a030 · Cited by 28 · see citing works

Reduction in the rate of ethanol elimination in vivo by desferrioxamine and diethylenetriaminepentaacetic acid: Suggestion for involvement of hydroxyl radicals in ethanol oxidation

Sinaceur, J., Ribière, C., Abu-Murad, C., Nordmann, J., & Nordmann, R. (1983) · Biochemical Pharmacology · doi:10.1016/0006-2952(83)90192-2 · Cited by 23 · see citing works

Opposite effects of two metal-chelators on alloxan-induced diabetes in mice

Grankvist, K., & Marklund, S. L. (1983) · Life Sciences · doi:10.1016/0024-3205(83)90163-7 · Cited by 21 · see citing works

Mössbauer spectroscopy of iron chelated by deferoxamine

Bock, J. L., & Lang, G. (1972) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(72)90288-7 · Cited by 20 · see citing works

Macrophage defense mechanisms against intracellular bacteria

Weiss, G., & Schaible, U. E. (2015) · Immunological Reviews · doi:10.1111/imr.12266 · Cited by 989 · see citing works

Mutagenic spectrum resulting from DNA damage by oxygen radicals

McBride, T. J., Preston, B. D., & Loeb, L. A. (1991) · Biochemistry · doi:10.1021/bi00215a030 · Cited by 239 · see citing works

Contribution of hepatic cytochrome P450 systems to the generation of reactive oxygen species

Bondy, S. C., & Naderi, S. (1994) · Biochemical Pharmacology · doi:10.1016/0006-2952(94)90235-6 · Cited by 237 · see citing works

The oxidative modification of low-density lipoproteins by macrophages

Leake, D. S., & Rankin, S. M. (1990) · Biochemical Journal · doi:10.1042/bj2700741 · Cited by 165 · see citing works

Oxidative stress in microorganisms—I

Sigler, K., Chaloupka, J., Brozmanová, J., Stadler, N., & Höfer, M. (1999) · Folia Microbiologica · doi:10.1007/bf02825650 · Cited by 149 · see citing works

Combined mannitol and deferoxamine therapy for myohemoglobinuric renal injury and oxidant tubular stress. Mechanistic and therapeutic implications.

Zager, R. A. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115942 · Cited by 149 · see citing works

Dextran-Coupled Deferoxamine Improves Outcome in a Murine Model of Head Injury

Panter, S. S., Braughler, J. M., & Hall, E. D. (1992) · Journal of Neurotrauma · doi:10.1089/neu.1992.9.47 · Cited by 144 · see citing works

Promotion of transition metal-induced reactive oxygen species formation by β-amyloid

Bondy, S. C., Guo‐Ross, S. X., & Truong, A. T. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00461-2 · Cited by 139 · see citing works

Effects of inorganic iron and myoglobin on in vitro proximal tubular lipid peroxidation and cytotoxicity.

Zager, R. A., & Foerder, C. A. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115682 · Cited by 115 · see citing works

Benefits and Risks of Deferiprone in Iron Overload in Thalassaemia and Other Conditions

Kontoghiorghes, G. J., Neocleous, K., & Kolnagou, A. (2003) · Drug Safety · doi:10.2165/00002018-200326080-00003 · Cited by 112 · see citing works

Egg Yolk Phosvitin Inhibits Hydroxyl Radical Formation from the Fenton Reaction

ISHIKAWA, S.-I., Yano, Y., Arihara, K., & Makoto, I. T. O. H. (2004) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.68.1324 · Cited by 108 · see citing works

The Involvement of Iron in Traumatic Brain Injury and Neurodegenerative Disease

Daglas, M., & Adlard, P. A. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00981 · Cited by 111 · see citing works

Role of oxidants and proteases in glomerular injury

Johnson, R. J., Lovett, D. H., Lehrer, R. I., Couser, W. G., & Klebanoff, S. J. (1994) · Kidney International · doi:10.1038/ki.1994.45 · Cited by 90 · see citing works

Oxidative DNA damage by crystalline silica

Daniel, L. N., Mao, Y., & Saffiotti, U. (1993) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(93)90103-2 · Cited by 88 · see citing works

Iron detoxifying activity of ferritin

Cozzi, A., Santambrogio, P., Levi, S., & Arosio, P. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)80823-2 · Cited by 85 · see citing works

Generation of active oxygen species from advanced glycation end-products (AGEs) during ultraviolet light A (UVA) irradiation and a possible mechanism for cell damaging

Masaki, H., Okano, Y., & Sakurai, H. (1999) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(99)00056-2 · Cited by 84 · see citing works

Cytochrome Oxidase Deficiency in Alzheimer's Diseasea

Parker, W. D. (1991) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1991.tb00191.x · Cited by 79 · see citing works

Reactive oxygen species dependent degradation pathway of 4-chlorophenol with Fe@Fe2O3 core–shell nanowires

Huang, Q., Cao, M., Ai, Z., & Zhang, L. (2014) · Applied Catalysis B: Environmental · doi:10.1016/j.apcatb.2014.06.046 · Cited by 78 · see citing works

Ascorbate does not act as a pro-oxidant towards lipids and proteins in human plasma exposed to redox-active transition metal ions and hydrogen peroxide

Suh, J. H., Zhu, B., & Frei, B. B. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00147-3 · Cited by 73 · see citing works

Ferrous ion autoxidation and its chelation in iron-loaded human liver HepG2 cells

Huang, X., Dai, J., Fournier, J., Ali, A., Zhang, Q., & Frenkel, K. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00770-5 · Cited by 72 · see citing works

Photochemical Cycling of Iron Mediated by Dicarboxylates: Special Effect of Malonate

Wang, Z., Chen, X., Ji, H., Ma, W., Chen, C., & Zhao, J. (2009) · Environmental Science & Technology · doi:10.1021/es901956x · Cited by 69 · see citing works

Deferoxamine Promotes MDA-MB-231 Cell Migration and Invasion through Increased ROS-Dependent HIF-1a Accumulation

Liu, Y., Cui, Y., Shi, M., Zhang, Q., Wang, Q., & Chen, X. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000358674 · Cited by 69 · see citing works

Effect of reactive oxygen species on the biosynthesis and structure of newly synthesized proteoglycans

Panasyuk, A., Frati, E., Ribault, D., & Mitrovic, D. R. (1994) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)90139-2 · Cited by 69 · see citing works

The Autoxidation of Iron(Ii) in Aqueous Systems: The Effects of Iron Chelation by Physiological, Non-Physiological and Therapeutic Chelators on the Generation of Reactive Oxygen Species and the Inducement of Biomolecular Damage

Burkitt, M. J., & Gilbert, B. C. (1991) · Free Radical Research Communications · doi:10.3109/10715769109094123 · Cited by 64 · see citing works

Effect of Dietary Iron Concentration, Age, and Length of Iron Feeding on Feed Intake and Tissue Iron Concentration of Broiler Chicks for Use as a Bioassay of Supplemental Iron Sources

Cao, J., Luo, X., Henry, P. R., Ammerman, C. B., Littell, R. C., & MILES, R. D. (1996) · Poultry Science · doi:10.3382/ps.0750495 · Cited by 63 · see citing works

Does Heat Shock Enhance Oxidative Stress? Studies with Ferrous and Ferric Iron

Freeman, M. L., Spitz, D. R., & Meredith, M. J. (1990) · Radiation Research · doi:10.2307/3577841 · Cited by 63 · see citing works

On the pro‐oxidant effects of haemozoin

de Oliveira, M. F., Timm, B. L., Machado, E. A., de Miranda, K. R., Attias, M., da Silva, J. R., Dansa‐Petretski, M., de Oliveira, M. A., de Souza, W., Pinhal, N. M., et al. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)02243-3 · Cited by 61 · see citing works

New Modes of Action of Desferrioxamine

Zhu, B., Har-El, R., Kitrossky, N., & Chevion, M. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00220-7 · Cited by 60 · see citing works

Increased generation of hydrogen peroxide possibly from mitochondrial respiratory chain after UVB irradiation of murine fibroblasts

Masaki, H., & Sakurai, H. (1997) · Journal of Dermatological Science · doi:10.1016/s0923-1811(96)00576-2 · Cited by 59 · see citing works

Rapid decomposition of diclofenac in a magnetic field enhanced zero-valent iron/EDTA Fenton-like system

Zhou, T., Feng, K., Xiang, W., Lv, Y., Wu, X., Mao, J., & He, C. (2017) · Chemosphere · doi:10.1016/j.chemosphere.2017.11.090 · Cited by 57 · see citing works

Cell cycle-dependent inhibition of the proliferation of human neural tumor cell lines by iron chelators

Renton, F. J., & Jeitner, T. M. (1996) · Biochemical Pharmacology · doi:10.1016/0006-2952(96)00099-8 · Cited by 57 · see citing works

Comparison of the protective effects of desferrioxamine and ICRF-187 against doxorubicin-induced toxicity in spontaneously hypertensive rats

Herman, E., Zhang, J., & Ferrans, V. J. (1994) · Cancer Chemotherapy and Pharmacology · doi:10.1007/bf00686629 · Cited by 56 · see citing works

Effects of the Spermicidal Agent Nonoxynol-9 on Vaginal Microbial Flora

Klebanoff, S. J. (1992) · The Journal of Infectious Diseases · doi:10.1093/infdis/165.1.19 · Cited by 55 · see citing works

Extracellular hemoglobin: the case of a friend turned foe

Quaye, I. K. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00096 · Cited by 53 · see citing works

Prooxidant activity of transferrin and lactoferrin.

Klebanoff, S. J., & Waltersdorph, A. M. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.172.5.1293 · Cited by 54 · see citing works

Effects of metals, ligands and antioxidants on the reaction of oxygen with 1,2,4-benzenetriol

Zhang, L., Bandy, B., & Davison, A. J. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)02089-6 · Cited by 54 · see citing works

Chelation Therapy in Cardiovascular Disease: Ethylenediaminetetraacetic Acid, Deferoxamine, and Dexrazoxane

Elihu, N., Anandasbapathy, S., & Frishman, W. H. (1998) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1998.tb04397.x · Cited by 52 · see citing works

Chelation therapy for iron overload

Barton, J. C. (2007) · Current Gastroenterology Reports · doi:10.1007/s11894-008-0024-9 · Cited by 51 · see citing works

Iron chelation in myocardial preservation after ischemia-reperfusion injury: The importance of pretreatment and toxicity

DeBoer, D. A., & Clark, R. E. (1992) · The Annals of Thoracic Surgery · doi:10.1016/0003-4975(92)90260-b · Cited by 51 · see citing works

Neurological complications in β-thalassemia

Zafeiriou, D., Economou, M. P., & Athanasiou-Metaxa, M. (2006) · Brain and Development · doi:10.1016/j.braindev.2006.02.005 · Cited by 50 · see citing works

Mechanism of in vitro heme‐induced LDL oxidation: effects of antioxidants

Klouche, K., Morena-Carrere, M., Canaud, B., Descomps, B., Beraud, J. J., & Cristol, J. (2004) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2004.01395.x · Cited by 50 · see citing works

Bactericidal effect of Fe2+, ceruloplasmin, and phosphate

Klebanoff, S. J. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90522-x · Cited by 49 · see citing works

Evidence against transition metal-independent hydroxyl radical generation by xanthine oxidase.

Lloyd, R. V., & Mason, R. P. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44820-4 · Cited by 42 · see citing works

Oxidation of Low-Density Lipoprotein by Iron at Lysosomal pH: Implications for Atherosclerosis

Satchell, L., & Leake, D. S. (2012) · Biochemistry · doi:10.1021/bi2017975 · Cited by 37 · see citing works

EPR spin trapping and 2-deoxyribose degradation studies of the effect of pyridoxal isonicotinoyl hydrazone (PIH) on ∙OH formation by the Fenton reaction

Hermes‐Lima, M. (1999) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(98)00167-6 · Cited by 37 · see citing works

Assay of creatinine using the peroxidase activity of copper-creatinine complexes

Pugia, M. J., Lott, J. A., Wallace, J. F., Cast, T. K., & Bierbaum, L. D. (2000) · Clinical Biochemistry · doi:10.1016/s0009-9120(99)00086-7 · Cited by 36 · see citing works

Sensorimotor Neurotoxicity Associated with High-Dose Deferoxamine Treatment

Levine, J. E., Cohen, A. R., MacQueen, M., Martin, M., & Giardina, P. J. (1997) · The American journal of pediatric hematology/oncology · doi:10.1097/00043426-199703000-00008 · Cited by 34 · see citing works

Effects of deferrioxamine on iron-catalyzed lipid peroxidation

Miller, D. M., Spear, N., & Aust, S. D. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90513-v · Cited by 34 · see citing works

Key factors in the ligand effects on the photo redox cycling of aqueous iron species

Wu, B., Zhang, G., Zhang, L., Song, X., Zhang, S., & Zhu, B. (2020) · Geochimica et Cosmochimica Acta · doi:10.1016/j.gca.2020.05.004 · Cited by 32 · see citing works

Effects of reactive oxygen species on eicosanoid metabolism in human endothelial cells

Schimke, I., Griesmacher, A., Weigel, G. J., Müller, M. M., & Holzhütter, H. (1992) · Prostaglandins · doi:10.1016/0090-6980(92)90096-c · Cited by 32 · see citing works

Mechanism of ascaridole activation in Leishmania

Geroldinger, G., Tonner, M., Hettegger, H., Bacher, M., Monzote, L., Walter, M., Staniek, K., Rosenau, T., & Gille, L. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.02.023 · Cited by 30 · see citing works

Phase I study using desferrioxamine and iron sorbitol citrate in an attempt to modulate the iron status of tumor cells to enhance doxorubicin activity

Voest, E. E., Neijt, J. P., KEUNEN, J. E. E., Dekker, A. W., van Asbeck, B. S., Nortier, J. W. R., Ros, F. E., & Marx, J. J. M. (1993) · Cancer Chemotherapy and Pharmacology · doi:10.1007/bf00686148 · Cited by 29 · see citing works

Diverse redox chemistry of photo/ferrioxalate system

Wang, Z., Xiao, D., & Liu, J. (2014) · RSC Advances · doi:10.1039/c4ra07153k · Cited by 28 · see citing works

Effects of glutathione, Trolox and desferrioxamine on hemoglobin-induced protein oxidative damage: Anti-oxidant or pro-oxidant?

Lu, N., Chen, W., & Peng, Y. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.03.009 · Cited by 28 · see citing works

Iron Toxicosis

Aisen, P., COHEN, G., & KANG, J. O. (1990) · International review of experimental pathology · doi:10.1016/b978-0-12-364931-7.50006-9 · Cited by 28 · see citing works

Pentosidine in advanced glycation end-products (AGEs) during UVA irradiation generates active oxygen species and impairs human dermal fibroblasts

Okano, Y., Masaki, H., & Sakurai, H. (2001) · Journal of Dermatological Science · doi:10.1016/s0923-1811(01)00114-1 · Cited by 27 · see citing works

Desferrioxamine (DFX) induces apoptosis through the p38-caspase8-Bid-Bax pathway in PHA-stimulated human lymphocytes

Kim, B.-M., & Chung, H.-W. (2007) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2007.11.022 · Cited by 27 · see citing works

Mechanism of reaction of a suggested superoxide-dismutase mimic, Fe(II)-N,N,N′,N′-tetrakis(2-pyridylmethyl) ethylenediamine

Iuliano, L., Pedersen, J. Z., Ghiselli, A., Praticò, D., Rotilio, G., & Violi, F. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90378-a · Cited by 27 · see citing works

Catalysis of the Haber-Weiss reaction by iron-diethylenetriaminepentaacetate

Egan, T. (1992) · Journal of Inorganic Biochemistry · doi:10.1016/0162-0134(92)84051-n · Cited by 25 · see citing works

Inhibition of the erythrocyte (Ca2+ + Mg2+)-ATPase by nonheme iron

Leclerc, L., Marden, M. C., & Poyart, C. (1991) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(91)90331-2 · Cited by 24 · see citing works

Spin trapping study on the kinetics of Fe2+ autoxidation: Formation of spin adducts and their destruction by superoxide

Kosaka, H., Katsuki, Y., & Shiga, T. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90412-p · Cited by 22 · see citing works

Microfluidic dissociation and clearance of Alzheimer’s β-amyloid aggregates

Lee, J., & Park, C. B. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.05.033 · Cited by 21 · see citing works

Desmethyl tirilazad improves neurologic function after hypoxic ischemic brain injury in piglets

Feng, Y., LeBlanc, M. H., LeBlanc, E. B., Parker, C. C., Fratkin, J. D., Qian, X.-B., Patel, D. M., Huang, M. H., Smith, E. E., & Vig, P. J. S. (2000) · Critical Care Medicine · doi:10.1097/00003246-200005000-00029 · Cited by 21 · see citing works

Opposite modulation of time course of quantal release in two parts of the same synapse by reactive oxygen species

Tsentsevitsky, A., Nikolsky, E. E., Giniatullin, R. A., & Bukharaeva, E. A. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.05.033 · Cited by 19 · see citing works

The in vitro response of human tumour cells to desferrioxamine is growth medium dependent

Voest, E. E., Rooth, H., Neijt, J. P., van Asbeck, B. S., & Marx, J. J. M. (1993) · Cell Proliferation · doi:10.1111/j.1365-2184.1993.tb00008.x · Cited by 19 · see citing works

Mechanisms ofSaccharomyces CerevisiaePMA1 H+-ATPase inactivation by Fe2+, H2O2and Fenton reagents

Stadler, N., Höfer, M., & Sigler, K. (2001) · Free Radical Research · doi:10.1080/10715760100301171 · Cited by 19 · see citing works

Ferrous ion formation by ferrioxamine prepared from aged desferrioxamine: A potential prooxidant property

Gutteridge, J. M. C., Quinlan, G. J., Swain, J., & Cox, J. H. (1994) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)90188-0 · Cited by 18 · see citing works

Effect of iron chelators on the cytotoxic and genotoxic action of hyperoxia in Chinese hamster ovary cells

Gille, J. J. P., van Berkel, C. G. M., & Joenje, H. (1992) · Mutation Research/DNAging · doi:10.1016/0921-8734(92)90006-b · Cited by 17 · see citing works

Deferoxamine effect on selenite-induced cataract formation in rats.

Wang, Z., Hess, J. L., & Bunce, G. E. (1992) · PubMed · Cited by 16 · see citing works

Malaria pigment and extracellular iron

van Zyl, R. L., Havlík, I., Hempelmann, E., MacPhaiI, A. P., & McNamara, L. (1993) · Biochemical Pharmacology · doi:10.1016/0006-2952(93)90042-u · Cited by 16 · see citing works

Desferrioxamine decreases NAD redox potential of intact red blood cells: evidence for desferrioxamine as an inducer of oxidant stress in red blood cells

Niihara, Y., Ge, J., Shalev, O., Wu, H., Tu, A., & Tanaka, K. R. (2002) · BMC Clinical Pharmacology · doi:10.1186/1472-6904-2-8 · Cited by 15 · see citing works

Increased Release of Free Fe Ions in Human Erythrocytes During Aging in the Circulation

Ando, K., Ogawa, K., Misaki, S., & Kikugawa, K. (2002) · Free Radical Research · doi:10.1080/1071576021000028307 · Cited by 15 · see citing works

Cottonseed Oil in Diets for Broilers in the Pre-Starter and Starter Phases

Lima, V. B. D. S., Dourado, L. R. B., Machado, L. P., Biagiotti, D., de Lima, S. B. P., Ferreira, G. J. B. D. C., Farias, L. A., de Sousa, F. A., Acácio, R. M., & Silva, D. R. S. E. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147695 · Cited by 14 · see citing works

Mechanism of hyperoxia‐induced chromosomal breakage in chinese hamster cells

Gille, J. J. P., van Berkel, C. G. M., & Joenje, H. (1993) · Environmental and Molecular Mutagenesis · doi:10.1002/em.2850220414 · Cited by 14 · see citing works

Mechanism of lysozyme inactivation and degradation by iron

Sellak, H., Franzini, E., Hakim, J., & Pasquier, C. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90259-y · Cited by 14 · see citing works

N-acetilcisteína e deferoxamina protegem contra insuficiência renal aguda induzida por isquemia/reperfusão em ratos

Bernardi, R. M., Constantino, L. D. S., Machado, R. A., Vuolo, F. S., Budni, P., Ritter, C., & Dal‐Pizzol, F. (2012) · Revista Brasileira de Terapia Intensiva · doi:10.1590/s0103-507x2012000300003 · Cited by 13 · see citing works

Reductive inactivation of yeast glutathione reductase by Fe(II) and NADPH

Cardoso, L. A., Ferreira, S. T., & Hermes‐Lima, M. (2007) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2007.03.025 · Cited by 13 · see citing works

The hypoxic preconditioning agent deferoxamine induces poly(ADP-ribose) polymerase-1-dependent inhibition of the mitochondrial respiratory chain

Cañuelo, A., Martínez‐Romero, R., Martínez‐Lara, E., Sánchez-Alcázar, J. A., & Siles, E. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-011-1162-1 · Cited by 13 · see citing works

Prooxidant Activity of Ferrioxamine in Isolated Rat Hepatocytes and Linoleic Acid Micelles

Bergamini, S., Rota, C., Staffieri, M., Tomasi, A., & Iannone, A. (1999) · Chemical Research in Toxicology · doi:10.1021/tx980149c · Cited by 13 · see citing works

The interaction between desferrioxamine and hemin: A potential toxicological implication

Lu, N., Yi, L., Deng, Q., Li, J., Gao, Z., & Li, H. (2012) · Toxicology in Vitro · doi:10.1016/j.tiv.2012.03.006 · Cited by 12 · see citing works

The past, present and future of RNA respiratory viruses: influenza and coronaviruses

Makarov, V., Riabova, O., Ekins, S., Pluzhnikov, N., & Chepur, S. (2020) · Pathogens and Disease · doi:10.1093/femspd/ftaa046 · Cited by 12 · see citing works

Effects of Some Naturally Occurring Iron Ion Chelators on In Vitro Superoxide Radical Formation

Hirai, T., Fukushima, K., Kumamoto, K., & Iwahashi, H. (2005) · Biological Trace Element Research · doi:10.1385/bter:108:1-3:077 · Cited by 12 · see citing works

2′,7′-dichlorofluorescin-based analysis of Fenton chemistry reveals auto-amplification of probe fluorescence and albumin as catalyst for the detection of hydrogen peroxide

Gonzalez, T., Peiretti, F., Defoort, C., Borel, P., & Govers, R. (2020) · Biochemical Journal · doi:10.1042/bcj20200602 · Cited by 11 · see citing works

Toxic Effects and Detection of Oxygen Free Radicals on Cultured Articular Chondrocytes Generated by Menadione

Michel, C., Vincent-Hubert, F., Duval, C., Poelman, M.-C., & Adolphe, M. (1992) · Free Radical Research Communications · doi:10.3109/10715769209079520 · Cited by 11 · see citing works

Completely Different Effects of Desferrioxamine on Hemin/Nitrite/H2O2-Induced Bovine Serum Albumin Nitration and Oxidation

Lu, N., Zhang, M., Li, H., & Gao, Z. (2008) · Chemical Research in Toxicology · doi:10.1021/tx800013e · Cited by 10 · see citing works

An overview of complications associated with deferoxamine therapy in thalassemia

Keikhaei, B., Anoosheh, N. F., Bahadoram, M., Mahmoudian‐Sani, M., Alikhani, K., & Helalinasab, A. (2020) · Journal of Nephropharmacology · doi:10.34172/npj.2021.05 · Cited by 9 · see citing works

Contribution of ferrous iron to maintenance of the gastric colonization of Helicobacter pylori in miniature pigs

Koga, T., Shimada, Y., Sato, K., Takahashi, K., Kikuchi, I., Okazaki, Y., Miura, T., Katsuta, M., & Iwata, M. (2002) · Microbiological Research · doi:10.1078/0944-5013-00169 · Cited by 7 · see citing works

Desferrioxamine dehydrogenates bilirubin in two stages, leading to a 1:1 red‐coloured adduct. Characterization of the products by high‐performance liquid chromatography/electrospray ionization mass spectrometry

Matteis, F. D., & Lord, G. A. (2008) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.3822 · Cited by 6 · see citing works

Possible mechanism of action of desferrioxamine and 2,2′-bipyridyl on inhibiting the in vitro growth of Plasmodium falciparum (FCR 3 strain)

Jairam, K., Havlík, I., & Monteagudo, F. S. E. (1991) · Biochemical Pharmacology · doi:10.1016/0006-2952(91)90434-7 · Cited by 6 · see citing works

Determination of non-protein-bound iron in rat tissue by ion chromatoraphy with electrochemical detection

Kawasaki, N., Tanimoto, T., & Tanaka, A. (1991) · Analytical Biochemistry · doi:10.1016/0003-2697(91)90192-v · Cited by 5 · see citing works

Generation of Reactive Oxygen Species by Interaction between Antioxidants Used as Food Additive and Metal Ions

Iwasaki, Y., Oda, M., Tsukuda, Y., Nagamori, Y., Nakazawa, H., Ito, R., & Saito, K. (2014) · Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi) · doi:10.3358/shokueishi.55.167 · Cited by 4 · see citing works

Mast cell disease associated with acute myeloid leukemia: Detection of a newc-kit mutation Asp816His

Pullarkat, V. A., Pullarkat, S. T., Calverley, D. C., & Brynes, R. K. (2000) · American Journal of Hematology · doi:10.1002/1096-8652(200012)65:4 · Cited by 56 · see citing works

Respiratory RNA Viruses: How to Be Prepared for an Encounter with New Pandemic Virus Strains

Chepur, S. V., Nn, P., Chubar, O. V., Сергеевна, Б. Л., Litvinenko, I., Makarov, V., Gogolevsky, A. S., Myasnikov, V. A., Myasnikova, I. A., & Al-Shekhadat, R. I. (2021) · Biology Bulletin Reviews · doi:10.1134/s207908642102002x · Cited by 3 · see citing works

Desferrioxamine enhances the reactivity of vanadium (IV) and vanadium (V) toward ferri- and ferrocytochrome c

Stern, A., Davison, A. J., Wu, Q., & Moon, J. (1992) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(92)90086-v · Cited by 3 · see citing works

Antioxidant Protection and Ixygen Radical Signaling

Gutteridge, J. M. C., & Halliwell, B. B. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-306-46806-9_8 · Cited by 2 · see citing works

Effect of donor fasting on survival of pancreas and heart grafts after warm ischemia.

Nishihara, M., Sumimoto, R., Asahara, T., Fukuda, Y., Southard, J. H., & Dohi, K. (1996) · PubMed · Cited by 2 · see citing works

Peroxynitrite and heme protein – Mediated nitrative/oxidative modification of human plasma protein: The role of free radical scavenging vs. complex forming

Lu, N., Zhou, G., Pei, D., Yi, L., & Gao, Z. (2009) · Toxicology in Vitro · doi:10.1016/j.tiv.2009.07.034 · Cited by 2 · see citing works

Hydrothermal treatment of yeast cell wall generates potent anti-proliferative agents targeting MCF7 breast cancer cells effectively even under culture conditions separated by a plastic wall

Kitagawa, T. (2025) · PLoS ONE · doi:10.1371/journal.pone.0313379 · Cited by 1 · see citing works

Comparative drug influence on peroxide mediated increase of cytosolic calcium in human endothelial cells

David, M., Horváth, G., Schimke, I., Nagy, I., & Mueller, M. (1993) · Clinica Chimica Acta · doi:10.1016/0009-8981(93)90057-b · Cited by 1 · see citing works

Non-Chelation Dependent Redox Actions of Desferrioxamine

Zhu, B., Har-El, R., Kitrossky, N., & Chevion, M. (1998) · Springer eBooks · doi:10.1007/978-1-4757-2907-8_2 · Cited by 1 · see citing works

Desferal-catalysed generation of superoxide radicals under oxidation of Fe(II) by oxygen

Vladimrov, Y. A., Kozlov, A. V., & Osipov, A. N. (1990) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(90)90831-3 · Cited by 1 · see citing works

Dual effect of deferoxamine on free radical formation and reoxygenation injury in isolated hepatocytes

Caraceni, P., Thiel, D. H. V., & Borle, A. B. (1995) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1995.269.1.g132 · Cited by 22 · see citing works

Inhibition of peroxidase-catalyzed reactions by deferoxamine

Klebanoff, S. J., & Waltersdorph, A. M. (1988) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(88)90326-8 · Cited by 37 · see citing works

Electron spin resonance spin-trapping investigation into the effects of paraquat and desferrioxamine on hydroxyl radical generation during acute iron poisoning.

Burkitt, M. J., Kadiiska, M. B., Hanna, P. M., Jordan, S. J., & Mason, R. P. (1993) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13607-9 · Cited by 54 · see citing works

Prooxidant action of desferrioxamine: Fenton-like production of hydroxyl radicals by reduced ferrioxamine

Borg, D. C., & Schaich, K. M. (1986) · Journal of Free Radicals in Biology & Medicine · doi:10.1016/s0748-5514(86)80004-6 · Cited by 70 · see citing works