Cited by 415Occupational and environmental lung diseasesInterstitial Lung Diseases and Idiopathic Pulmonary FibrosisSarcoidosis and Beryllium Toxicity Research

Silica binding and toxicity in alveolar macrophages

Open access
Hamilton, Raymond F., Thakur, Sheetal A., Holian, Andrij·2008·Free Radical Biology and Medicine

Abstract

Inhalation of the crystalline form of silica is associated with a variety of pathologies, from acute lung inflammation to silicosis, in addition to autoimmune disorders and cancer. Basic science investigators looking at the mechanisms involved with the earliest initiators of disease are focused on how the alveolar macrophage interacts with the inhaled silica particle and the consequences of silica-induced toxicity on the cellular level. Based on experimental results, several rationales have been developed for exactly how crystalline silica particles are toxic to the macrophage cell that is functionally responsible for clearance of the foreign particle. For example, silica is capable of producing reactive oxygen species (ROS) either directly (on the particle surface) or indirectly (produced by the cell as a response to silica), triggering cell-signaling pathways initiating cytokine release and apoptosis. With murine macrophages, reactive nitrogen species are produced in the initial respiratory burst in addition to ROS. An alternative explanation for silica toxicity includes lysosomal permeability, by which silica disrupts the normal internalization process leading to cytokine release and cell death. Still other research has focused on the cell surface receptors (collectively known as scavenger receptors) involved in silica binding and internalization. The silica-induced cytokine release and apoptosis are described as the function of receptor-mediated signaling rather than free radical damage. Current research ideas on silica toxicity and binding in the alveolar macrophage are reviewed and discussed.

Integrity signals

Registry

Crossref · 10.1016/j.freeradbiomed.2007.12.027

Cites

121 of 121 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

3 of the 124 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Hamilton, R. F., Thakur, S. A., & Holian, A.
Affiliations
University of Montana (US)
Corresponding author
Holian, Andrij
Venue
Free Radical Biology and Medicine
Publisher
Elsevier BV
Published
2008-04
Volume
44
Issue
7
Pages
1246-1258
ISSN
0891-5849 (ISSN-L)
OpenAlex
W2044353844
Cited by
415
References
124
Citations by year
2026: 19 · 2025: 16 · 2024: 25 · 2023: 33 · 2022: 32 · 2021: 33 · 2020: 23 · 2019: 21 · 2018: 24 · 2017: 22 · 2016: 23 · 2015: 16 · 2014: 19 · 2013: 23 · 2012: 18
FWCI
2.11
Type
journal article
Language
en
Open access
Locations
  • Free Radical Biology and Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of General Medical Sciences (P30GM103338)
  • National Institute of Environmental Health Sciences (R01ES015294, ES-015294)
  • National Center for Research Resources (P20RR017670)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
  • Health Sciences › Medicine › Physiology › Sarcoidosis and Beryllium Toxicity Research
Keywords
crystalline silica, silica toxicity, alveolar macrophages, reactive oxygen species, reactive nitrogen species, respiratory burst, cytokine production, apoptosis, scavenger receptors, silicosis, particle clearance
MeSH terms
Animals, Free Radicals, Humans, Lung, Lysosomes, Macrophages, Models, Biological, Protein Binding, Silicon Dioxide, Surface-Active Agents, Signal Transduction, Macrophages, Alveolar, Apoptosis, Reactive Nitrogen Species, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review