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Cited by 416Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationCongenital heart defects research

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Constructing the cerebral cortex: Neurogenesis and fate determination

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McConnell, Susan K.·1995·Neuron
DOI 10.1016/0896-6273(95)90168-x
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Abstract

Sitting at the apex of neural processing in the mammalian brain is the cerebral cortex, the convoluted sheet of neurons covering the two cerebral hemispheres. Neurons within the neocortex underlie our most sophisticated cognitive and perceptual abilities and are thus highly specialized for the analysis of sensory inputs or the generation of motor outputs. The position, connectivity, and morphology of each neuron reflect its particular function. Although neurons in the adult brain are organized in highly ordered and differentiated arrays, these cells arise from dividing progenitor cells of a simple neuroepithelium in which cells appear morphologically indistinguishable. This review addresses the question of how diverse neuronal phenotypes are generated from apparently homogeneous progenitors in appropriate numbers, times, and positions during the development of the cerebral cortex, focusing on key steps in neurogenesis including the molecular control of cell number, the decision to generate a neuron, and cell type specification. Overview of Cortical Organization and Development

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Metadata

Authors
McConnell, S. K.
Affiliations
Stanford University (US)
Corresponding author
McConnell, Susan K.
ORCID
McConnell, Susan K.
Venue
Neuron
Publisher
Elsevier BV
Published
1995-10
Volume
15
Issue
4
Pages
761-768
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/0896-6273(95)90168-x
OpenAlex
W2114843411
Cited by
416
References
76
Citations by year
2025: 5 · 2024: 4 · 2023: 6 · 2022: 9 · 2021: 12 · 2020: 15 · 2019: 5 · 2018: 14 · 2017: 13 · 2016: 7 · 2015: 9 · 2014: 10 · 2013: 8 · 2012: 12
FWCI
2.79
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuron (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • National Science Foundation
  • National Institutes of Health
  • National Institute of Mental Health (MH51864)
  • National Eye Institute (EY 08411, R01EY008411)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
Keywords
cortical development, neurogenesis, neuronal fate determination, cortical progenitor cells, cell specification, neuronal differentiation, neocortex
MeSH terms
Animals, Cell Differentiation, Cell Division, Cell Movement, Cerebral Cortex, Neurons, Phenotype, Stem Cells

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