Neocortical histogenesis in normal and reeler mice: A developmental study based upon [3H]thymidine autoradiography
Abstract
The relative positions of the principal neuronal classes of neocortex are inverted in the reeler mutant mouse. Neurons formed at 48-hourly intervals throughout the period of neocortical cytogenesis between E11 and E17 are labeled by [3H]thymidine. The positions of the labeled cells during and subsequent to their migrations are traced by autoradiography. Simultaneously-formed cohorts reach the neocortex at the same time in normal and reeler animals. After E13, subsequent to the appearance of the cortical plate, cohorts of migrating cells in the normal animal ascend to the interface of the cortical plate and marginal layer where they come to rest in a narrow laminar zone. In reeler, by contrast, migration is arrested in the depths of the cortex. The migrating cell appears unable to ascend through the zone occupied by the preceding cohorts. At the completion of migration neurons of both genotypes become fixed in position and undergo little subsequent shift in their relative positions in the course of future cortical growth. Despite the anomaly of migrations and the post-migratory positions of neurons in reeler, cohorts of cells formed at the same time in the two genotypes give rise to the same neuronal classes.
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The reeler mouse mutant has neurons generated normally but abnormally placed, resulting in disorganization of cortical laminar layers in the CNS.
“The reeler is an autosomal recessive mouse mutant, in which neurons are generated normally but are abnormally placed, resulting in disorganization of cortical laminar layers in the CNS (7–12).”
From Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody (2000) · cites this paper as [10]
In the reeler mouse model, lamination of principal cells in cortex is inverted and the s.p. of the hippocampus is split in region CA1.
“in the reeler mouse model, in which expression of reelin or associated proteins is disrupted, the lamination of PCs in cortex is inverted and the s.p. of the hippocampus is split in region CA1”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [178]
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- Authors
- Caviness, V. S.
- Affiliations
- Harvard University (US)
- Corresponding author
- Caviness, Verne S.
- Venue
- Developmental Brain Research
- Publisher
- Elsevier BV
- Published
- 1982-07
- Volume
- 4
- Issue
- 3
- Pages
- 293-302
- ISSN
- 0165-3806 (ISSN-L)
- OpenAlex
- W1979060895
- Cited by
- 639
- References
- 37
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 12 · 2023: 6 · 2022: 11 · 2021: 11 · 2020: 10 · 2019: 6 · 2018: 6 · 2017: 12 · 2016: 12 · 2015: 11 · 2014: 11 · 2013: 13 · 2012: 25
- FWCI
- 3.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Developmental Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R01NS012005)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Keywords
- neuronal migration, cortical lamination, cortical plate, cortical development, 3H-thymidine labeling
- MeSH terms
- Animals, Autoradiography, Cerebral Cortex, DNA Replication, Female, Mice, Inbred Strains, Mice, Neurologic Mutants, Pregnancy, Species Specificity, Thymidine, Mice
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