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Biophysical and Molecular Mechanisms of Shaker Potassium Channel Inactivation
Abstract
The potassium channels encoded by the Drosophila Shaker gene activate and inactivate rapidly when the membrane potential becomes more positive. Site-directed mutagenesis and single-channel patch-clamp recording were used to explore the molecular transitions that underlie inactivation in Shaker potassium channels expressed in Xenopus oocytes. A region near the amino terminus with an important role in inactivation has now been identified. The results suggest a model where this region forms a cytoplasmic domain that interacts with the open channel to cause inactivation.
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Cites
Interaction of Tetraethylammonium Ion Derivatives with the Potassium Channels of Giant Axons
Armstrong, C. M. (1971) · The Journal of General Physiology · doi:10.1085/jgp.58.4.413 · Cited by 929
Cited by
Calcium-activated potassium channels
Vergara, C., Latorre, R., Marrion, N. V., & Adelman, J. P. (1998) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(98)80056-1 · Cited by 954
Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling
Uversky, V. N., Oldfield, C. J., & Dunker, A. K. (2005) · Journal of Molecular Recognition · doi:10.1002/jmr.747 · Cited by 847
Membrane Phospholipid Control of Nucleotide Sensitivity of K ATP Channels
Shyng, S.-L., & Nichols, C. G. (1998) · Science · doi:10.1126/science.282.5391.1138 · Cited by 559
Mechanism by which Liddle's syndrome mutations increase activity of a human epithelial Na+ channel
Snyder, P. M., Price, M. P., McDonald, F. J., Adams, C. M., Volk, K. A., Zeiher, B. G., Stokes, J. B., & Welsh, M. J. (1995) · Cell · doi:10.1016/0092-8674(95)90212-0 · Cited by 350
Contributions of Kv3 Channels to Neuronal Excitability
RUDY, B., CHOW, A., LAU, D., AMARILLO, Y., OZAITA, A., SAGANICH, M., MORENO, H., NADAL, M. S., HERNANDEZ‐PINEDA, R., HERNANDEZ‐CRUZ, A., et al. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb11295.x · Cited by 305
Metadata
- Authors
- Hoshi, T., Zagotta, W. N., & Aldrich, R. W.
- Venue
- Science
- Published
- 1990-10-26
- Volume
- 250
- Issue
- 4980
- Pages
- 533-538
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1966667742
- Cited by
- 1,538
- References
- 1
- FWCI
- 22.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hoshi, T., Zagotta, W. N., & Aldrich, R. W. (1990). Biophysical and Molecular Mechanisms of Shaker Potassium Channel Inactivation. Science. https://doi.org/10.1126/science.2122519
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
