The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
Mice devoid of the glial fibrillary acidic protein develop normally and are susceptible to scrapie prions
Open accessAbstract
Glial fibrillary acidic protein (GFAP) is an intermediate filament protein specifically expressed in astrocytes in the CNS. To examine the function of GFAP in vivo, the Gfap gene was disrupted by gene targeting in embryonic stem cells. Mice homozygous for the mutation were completely devoid of GFAP but exhibited normal development and showed no obvious anatomical abnormalities in the CNS. When inoculated with infectious scrapie prions, the mutant mice exhibited neuropathological changes typical of prion diseases. Infectious prions accumulated in brains of the mutant mice to a degree similar to that in control littermates. These results suggest that GFAP is not essential for the morphogenesis of the CNS or for astrocytic responses against neuronal injury. The results argue against the hypothesis that GFAP plays a crucial role in the pathogenesis of prion diseases.
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“Absence of GFAP and/or Vim in mice has no major effect under physiological conditions (17–20), reflecting the role of intermediate filament (nanofilament) system as a signaling platform in situations connected with cellular stress (21).”
From Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice (2013) · cites this paper as [18]
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Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Novel Proteinaceous Infectious Particles Cause Scrapie
Prusiner, S. B. (1982) · Science · doi:10.1126/science.6801762 · Cited by 5,221
CNS stem cells express a new class of intermediate filament protein
Lendahl, U., Zimmerman, L. B., & McKay, R. D. G. (1990) · Cell · doi:10.1016/0092-8674(90)90662-x · Cited by 3,164
FINE STRUCTURAL LOCALIZATION OF A BLOOD-BRAIN BARRIER TO EXOGENOUS PEROXIDASE
Reese, T. S., & Karnovsky, M. J. (1967) · The Journal of Cell Biology · doi:10.1083/jcb.34.1.207 · Cited by 2,629
Mode of cell migration to the superficial layers of fetal monkey neocortex
Rakic, P. (1972) · Journal of Comparative Neurology · doi:10.1002/cne.901450105 · Cited by 2,170
Mice devoid of PrP are resistant to scrapie
Büeler, H., Aguzzi, A., Sailer, A. W., Greiner, R., Autenried, P., Aguet, M., & Weissmann, C. (1993) · Cell · doi:10.1016/0092-8674(93)90360-3 · Cited by 2,107
Altering the Genome by Homologous Recombination
Capecchi, M. R. (1989) · Science · doi:10.1126/science.2660260 · Cited by 2,037
Molecular Biology of Prion Diseases
Prusiner, S. B. (1991) · Science · doi:10.1126/science.1675487 · Cited by 1,975
Astrocytes induce blood–brain barrier properties in endothelial cells
Janzer, R. C., & RAFF, M. C. (1987) · Nature · doi:10.1038/325253a0 · Cited by 1,613
(1991) · Medical Entomology and Zoology · Cited by 1,512
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Fu, M., Chang, Y., Lin, N., Yang, A., Chang, C., Liu, J., Peng, C., Wu, K. L. H., Perng, M., & Lan, M. (2020) · Movement Disorders · doi:10.1002/mds.28099 · Cited by 8
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Naor, D., Nedvetzki, S., Assayag, N., Thurmond, R. L., Huang, J.-F., & Turley, E. A. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1313.007 · Cited by 8
Role of glial filaments in cells and tumors of glial origin: a review
Rutka, J. T., Murakami, M., Dirks, P. B., Hubbard, S. L., Becker, L. E., Fukuyama, K., Jung, S., & Matsuzawa, K. (1997) · Neurosurgical FOCUS · doi:10.3171/foc.1997.3.1.2 · Cited by 8
Furuya, S., Nagata, R., Ozaki, Y., Furuya, K., Nakayama, T., & Nagahama, M. (1997) · Anatomy and Embryology · doi:10.1007/s004290050030 · Cited by 8
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Luque, J. M., & y Ribotta, M. G. (2004) · PubMed · doi:10.14670/hh-19.271 · Cited by 7
Gubler, E., Hilbe, M., & Ehrensperger, F. (2007) · Schweizer Archiv für Tierheilkunde · doi:10.1024/0036-7281.149.3.111 · Cited by 6
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Perrot, R., & Eyer, J. (2013) · InTech eBooks · doi:10.5772/54676 · Cited by 5
Winkler, U., Hirrlinger, P., Sestu, M., Wilhelm, F., Besser, S., Zemljic-Harpf, A. E., Ross, R., Bornschein, G., Krügel, U., Ziegler, W., et al. (2013) · Glia · doi:10.1002/glia.22495 · Cited by 3
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Thomsen, R., Daugaard, T. F., Holm, I. E., & Nielsen, A. L. (2013) · PLoS ONE · doi:10.1371/annotation/5b23b7fc-e140-471e-ac62-c0f59bfcc337 · Cited by 5
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Messing, A., & Brenner, M. (2004) · Elsevier eBooks · doi:10.1016/b978-012439510-7/50099-1 · Cited by 2
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Alexander disease: a primary disease of astrocytes
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Eng, D. L., & Eng, L. F. (2010) · Advances in neurobiology · doi:10.1007/978-1-4419-6787-9_20 · Cited by 2
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Sontheimer, H. W., & Fernandez-Marques, E. (1997) · Springer eBooks · doi:10.1007/978-3-642-60669-4_10 · Cited by 2
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Lal, P. G., Ghirnikar, R. S., & Eng, L. F. (1996) · Molecular and Chemical Neuropathology · doi:10.1007/bf02815196 · Cited by 2
Kobayashi, K., Kobayashi, H., Ueda, M., & Honda, Y. (1996) · Brain Research · doi:10.1016/s0006-8993(96)00852-9 · Cited by 2
Inducible expression of glial fibrillary acidic protein in HT-1080 human fibrosarcoma cells.
Murakami, M., Fukuyama, K., Hubbard, S. L., Matsuzawa, K., Dirks, P. B., & Rutka, J. T. (1996) · PubMed · Cited by 2
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Guilfoyle, E. (2013) · doi:10.7916/d8902b0q · Cited by 1
Singh, V., Mittal, L. K., & Ashoka, R. K. (2017) · Journal of Anatomical Society of India · doi:10.1016/j.jasi.2017.12.005 · Cited by 1
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Perrot, R., & Julien, J. (2012) · Humana Press eBooks · doi:10.1007/978-1-61779-788-0_20 · Cited by 1
An Overview of Mouse Models in Neuroscience Research
Popko, B. (1999) · Springer eBooks · doi:10.1007/978-1-4615-4887-4_1 · Cited by 1
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Ware, C. B., & Hunt, J. S. (1998) · doi:10.1007/978-1-4757-2753-1_18 · Cited by 1
Chapter 7 Intermediate filaments: A medical overview
Klymkowsky, M. W., & Evans, R. M. (1995) · Principles of medical biology · doi:10.1016/s1569-2582(06)80040-1 · Cited by 1
PDGF in cerebellar development and tumorigenesis.
Andræ, J. (2001) · Uppsala University Publications (Uppsala University) · Cited by 1
Duka, T., Leshchins’ka, I., & Chornaya, V. I. (2002) · Biopolymers and Cell · doi:10.7124/bc.0005fd · Cited by 1
The astrocyte response to neural injury
O'Callaghan, J. P., & Little, A. R. (2002) · CRC Press eBooks · doi:10.1201/9780203219096.ch13 · Cited by 1
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Hundt, C. (2002) · Elektronische Hochschulschriften der LMU München (Ludwig-Maximilians-Universität München) · doi:10.5282/edoc.218
Bae, M., Kim, S.-R., Wee, H., Yoo, M., Oh, S. O., Baek, S., Kim, B.-S., Kim, J.-B., Sik-Yoon, & Bae, S. (2006) · Vascular Pharmacology · doi:10.1016/j.vph.2006.08.368
Gauczynski, S. (2002) · Elektronische Hochschulschriften der LMU München (Ludwig-Maximilians-Universität München) · doi:10.5282/edoc.224
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Moeton, M. (2014) · UvA-DARE (University of Amsterdam)
Doherty, J. P. (2009) · TSpace (University of Toronto)
Coelho‐Aguiar, J. D. M., Andreiuolo, F. D. M., Gebhardt, H., Geraldo, L. H., Pontes, B., Matias, D., Balça-Silva, J., Aguiar, D. P., do Carmo, A., Lopes, M. C., et al. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2904-7_4 · Cited by 1
Focal cerebral ischemia in GFAP-null mice.
Nawashiro, H. (2000) · Nosotchu · doi:10.3995/jstroke.22.478
The role of astrocytes in murine models of toxic demyelination
Menken, L. (2016) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-5792
Prionpatogenese - studier i dyremodeller
Bergström, A. A.-L., Heegaard, P. M. H., & Lind, P. (2005) · Dansk Veterinærtidsskrift
Heller, S. (2000) · Uppsala University Publications (Uppsala University)
Mak, T. W., Penninger, J. M., Roder, J., Rossant, J., & Saunders, M. E. (1998) · Elsevier eBooks · doi:10.1016/b978-012466044-1/50221-0
Loss of GFAP causes optico-retinal dysplasia and vision impairmentPreprint
Sarusie, M. V., Rönnbäck, C., Jespersgaard, C., Baungaard, S., Ali, Y., Kessel, L., Christensen, S. T., Brøndum‐Nielsen, K., Møllgård, K., Rosenberg, T., et al. (2022) · medRxiv · doi:10.1101/2022.11.09.22282105
Mutations in GFAP Alter Early Lineage Commitment of Organoids
Dykstra, W., Matusova, Z., Battaglia, R. A., Abaffy, P., Goya‐Iglesias, N., Pérez‐Sala, D., Ahlenius, H., Kubista, M., Pasterkamp, R. J., Li, L., et al. (2025) · Glia · doi:10.1002/glia.70049
Cellules Souches Neurales : modélisation et thérapie cellulaire des maladies à prions.
Delmouly, K. (2010) · theses.fr (ABES) · doi:10.70675/fe48cee8z3122z4589z864bzc06157231bf8
Role of intermediate filaments in mechanotransduction
Provenzano, G. D. (2021) · theses.fr (ABES) · doi:10.70675/dcc9ac33zf0b2z45b9zbd23z37f03e91208c
Optimizing RNA Delivery Strategies for Gilthead Seabream (Sparus aurata) SaB-1 Cells
Veiga-Rúa, S., Arana, Á. J., Salgado-Roo, A., Allegue, C., Cuesta, A., Martı́nez, P., Sanchez, L. E., & Robledo, D. (2026) · Fishes · doi:10.3390/fishes11080466
Colombo (1999) · doi:10.1002/(sici)1098-1136(19990101)25:1
Metadata
- Authors
- Gomi, H., Yokoyama, T., Fujimoto, K., Ikeda, T., Katoh, A., Itoh, T., & Itohara, S.
- Affiliations
- Kyoto University (JP)
- National Institute of Animal Health (JP)
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1995-01
- Volume
- 14
- Issue
- 1
- Pages
- 29-41
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2059028264
- Cited by
- 256
- References
- 67
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 4 · 2021: 6 · 2020: 5 · 2019: 1 · 2017: 8 · 2016: 4 · 2015: 6 · 2014: 4 · 2013: 6 · 2012: 6
- FWCI
- 7.99
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Science and Technology Agency
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Prion Diseases and Protein Misfolding
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Keywords
- glial fibrillary acidic protein, prion disease, astrocytes, intermediate filaments, gene targeting, central nervous system development, prion accumulation, neuropathology, prion pathogenesis
- MeSH terms
- Animals, Astrocytes, beta-Galactosidase, Brain, Brain Chemistry, Female, Glial Fibrillary Acidic Protein, Male, Mice, Inbred C57BL, Mice, Mutant Strains, Prions, RNA, Messenger, Scrapie, Spinal Cord, Vimentin, Mutagenesis, Gene Targeting, Mice
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