Scrapie in Mice Deficient in Apolipoprotein E or Glial Fibrillary Acidic Protein
Abstract
In the prion diseases, extensive reactive gliosis is often found to be out of proportion to the degree of apparent neuronal damage. To evaluate the role of astrocytic gliosis in experimental scrapie of the mouse, we inoculated mice deficient in apolipoprotein E (apoE) or the glial fibrillary acidic protein (GFAP) with mouse prions. The expression of both apoE and GFAP in astrocytes increases as part of the reactive gliosis that accompanies scrapie. Null mice deficient in either apoE or GFAP inoculated with prions exhibited incubation times indistinguishable from untargeted control mice. The level of PrPSc and its regional deposition in the brains of ill mice deficient in either protein were also similar to control mice. Our findings demonstrate that neither apoE nor GFAP participates in the pathogenesis of the disease or in the production of PrPSc.
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Both ApoE and TREM2 are upregulated in prion disease and affect the expression of pro-inflammatory proteins during the disease course in murine models, but their depletion did not change survival times.
“Both proteins are upregulated in prion disease and affect the expression of pro-inflammatory proteins during the disease course in murine models. However, their depletion did not change survival times [102,103,104].”
From Loss of Homeostatic Microglia Signature in Prion Diseases (2022) · cites this paper as [102]
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- Authors
- Tatzelt, J., Maeda, N., Pekny, M., Yang, S.-L., Betsholtz, C., Eliasson, C., Cayetano, J., Camerino, A. P., DeArmond, S. J., & Prusiner, S. B.
- Affiliations
- University of California, San Francisco (US)
- University of Gothenburg (SE)
- Venue
- Neurology
- Published
- 1996-08
- Volume
- 47
- Issue
- 2
- Pages
- 449-453
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2118548006
- Cited by
- 59
- References
- 42
- Citations by year
- 2022: 1 · 2021: 3 · 2020: 6 · 2019: 2 · 2017: 3 · 2015: 5 · 2014: 1 · 2012: 3
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Prion Diseases and Protein Misfolding
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- scrapie, prion disease, apolipoprotein E, glial fibrillary acidic protein, astrocytes, incubation time, prion pathogenesis, knockout mice
- MeSH terms
- Animals, Apolipoproteins E, Glial Fibrillary Acidic Protein, Scrapie, Mice
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