Hypopituitarisme post-traumatisme crânien: À propos de trois cas
Abstract
Background Hypopituitarism is a rare but well-known complication of cranial trauma. In the absence of overt diabetes insipidus, its recognition is difficult as the onset of clinical symptoms can be very progressive, up to several years.Case reports Three children, aged 8, 9 and 2 years, respectively, were admitted after a cranial trauma. Manifestations of diabetes insipidus occurred a few days later in two patients; one of them developed secondary growth hormone deficiency, hypothyroidism and hypogonadism, only evidenced at the age of 14 years. The third patient also developed manifestations of hypothalamic and/or pituitary hormone deficiencies without diabetes insipidus at the age of 12 years-6 months. MRI showed complete severance of the pituitary stalk in two patients and absence of posterior pituitary signal in one of the two patients with diabetes insipidus.Conclusion Growth disorders and/or hypogonadism may occur many years after a trauma that may have been forgetten. Search for such an etiology and dynamic MRI are necessary in identifying heterogenous hypophyseal lesions.
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In one of Mariani et al.'s patients, DI was an isolated defect, whereas in the other it was accompanied by multiple pituitary hormone deficiencies, including growth hormone, thyroid, and gonadal insufficiencies.
“In one patient, DI was an isolated defect, whereas in the other it was accompanied by multiple pituitary hormone deficiencies, including growth hormone, thyroid, and gonadal insufficiencies [66].”
From Endocrine Dysfunctions After Pediatric Traumatic Brain Injury: Present Insights and Future Directions (2025) · cites this paper as [66]
Mariani et al. reported three cases of post-traumatic hypopituitarism in children, two of whom developed DI within days of the injury.
“Mariani et al. reported three cases of post-traumatic hypopituitarism in children, two of whom developed DI within days of the injury.”
From Endocrine Dysfunctions After Pediatric Traumatic Brain Injury: Present Insights and Future Directions (2025) · cites this paper as [66]
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Hypopituitarism Secondary to Head Trauma
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“In one patient, DI was an isolated defect, whereas in the other it was accompanied by multiple pituitary hormone deficiencies, including growth hormone, thyroid, and gonadal insufficiencies [66].”
- Authors
- Mariani, R., Bortoluzzi, M. N., Richelme, C., El Barbary, M., & Coussement, A.
- Affiliations
- Centre Hospitalier Universitaire de Nice (FR)
- Venue
- Archives de Pédiatrie
- Publisher
- Elsevier BV
- Published
- 1996-08
- Volume
- 3
- Issue
- 8
- Pages
- 796-801
- ISSN
- 0929-693X (ISSN-L)
- OpenAlex
- W2049741491
- Cited by
- 17
- References
- 20
- Citations by year
- 2025: 1 · 2019: 2 · 2018: 1 · 2016: 1 · 2012: 1
- FWCI
- 0.27
- Type
- journal article
- Language
- fr
- Open access
- closed
- Locations
- Archives de Pédiatrie (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Electrolyte and hormonal disorders
- Keywords
- post-traumatic hypopituitarism, cranial trauma, diabetes insipidus, hypothyroidism, hypogonadism, pituitary stalk interruption syndrome, neurohypophysis, pediatric trauma, dynamic MRI
- MeSH terms
- Child, Female, Craniocerebral Trauma, Humans, Hypopituitarism, Infant, Magnetic Resonance Imaging, Male
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