Cited by 17Pituitary Gland Disorders and TreatmentsGrowth Hormone and Insulin-like Growth FactorsElectrolyte and hormonal disorders

Hypopituitarisme post-traumatisme crânien: À propos de trois cas

Mariani, R, Bortoluzzi, M.N, Richelme, C, El Barbary, M, Coussement, A·1996·Archives de Pédiatrie

Abstract

Background Hypopituitarism is a rare but well-known complication of cranial trauma. In the absence of overt diabetes insipidus, its recognition is difficult as the onset of clinical symptoms can be very progressive, up to several years.Case reports Three children, aged 8, 9 and 2 years, respectively, were admitted after a cranial trauma. Manifestations of diabetes insipidus occurred a few days later in two patients; one of them developed secondary growth hormone deficiency, hypothyroidism and hypogonadism, only evidenced at the age of 14 years. The third patient also developed manifestations of hypothalamic and/or pituitary hormone deficiencies without diabetes insipidus at the age of 12 years-6 months. MRI showed complete severance of the pituitary stalk in two patients and absence of posterior pituitary signal in one of the two patients with diabetes insipidus.Conclusion Growth disorders and/or hypogonadism may occur many years after a trauma that may have been forgetten. Search for such an etiology and dynamic MRI are necessary in identifying heterogenous hypophyseal lesions.

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Crossref · 10.1016/0929-693x(96)82164-6

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20 of 20 references verified0 citation errors · 0 not checkable

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  • In one of Mariani et al.'s patients, DI was an isolated defect, whereas in the other it was accompanied by multiple pituitary hormone deficiencies, including growth hormone, thyroid, and gonadal insufficiencies.

    “In one patient, DI was an isolated defect, whereas in the other it was accompanied by multiple pituitary hormone deficiencies, including growth hormone, thyroid, and gonadal insufficiencies [66].”
  • Mariani et al. reported three cases of post-traumatic hypopituitarism in children, two of whom developed DI within days of the injury.

    “Mariani et al. reported three cases of post-traumatic hypopituitarism in children, two of whom developed DI within days of the injury.”

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Authors
Mariani, R., Bortoluzzi, M. N., Richelme, C., El Barbary, M., & Coussement, A.
Affiliations
Centre Hospitalier Universitaire de Nice (FR)
Venue
Archives de Pédiatrie
Publisher
Elsevier BV
Published
1996-08
Volume
3
Issue
8
Pages
796-801
ISSN
0929-693X (ISSN-L)
OpenAlex
W2049741491
Cited by
17
References
20
Citations by year
2025: 1 · 2019: 2 · 2018: 1 · 2016: 1 · 2012: 1
FWCI
0.27
Type
journal article
Language
fr
Open access
closed
Locations
  • Archives de Pédiatrie (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Electrolyte and hormonal disorders
Keywords
post-traumatic hypopituitarism, cranial trauma, diabetes insipidus, hypothyroidism, hypogonadism, pituitary stalk interruption syndrome, neurohypophysis, pediatric trauma, dynamic MRI
MeSH terms
Child, Female, Craniocerebral Trauma, Humans, Hypopituitarism, Infant, Magnetic Resonance Imaging, Male

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