Acquired growth hormone deficiency due to pituitary stalk transection after head trauma in childhood
Abstract
Two patients are reported with growth hormone deficiency due to head trauma in childhood. Although their injuries were outwardly only slight and there was no loss of consciousness and no subsequent neurological deficits, they exhibited gradual growth retardation from the time of the trauma. Provocative endocrinological tests showed growth hormone deficiency and MRI showed transection of the pituitary stalk. These findings suggest that ordinary head trauma, as well as perinatal insult and congenital abnormalities, could be a cause of growth hormone deficiency.
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The absence of standardized screening protocols and consensus guidelines likely contributes to underrecognition of post-traumatic pituitary dysfunction, with a median diagnostic delay of five years after injury.
“The absence of standardized screening protocols and consensus guidelines likely contributes to underrecognition, with a median diagnostic delay of five years after injury, thereby underestimating the true prevalence [14,15].”
From Endocrine Dysfunctions After Pediatric Traumatic Brain Injury: Present Insights and Future Directions (2025) · cites this paper as [15]
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“The absence of standardized screening protocols and consensus guidelines likely contributes to underrecognition, with a median diagnostic delay of five years after injury, thereby underestimating the true prevalence [14,15].”
- Authors
- Yamanaka, C., Momoi, T., Fujisawa, I., Kikuchi, K., Kaji, M., Sasaki, H., Yorifuji, T., & Mikawa, H.
- Affiliations
- Kyoto University (JP)
- Shimane Medical University (JP)
- Venue
- European Journal of Pediatrics
- Published
- 1993-02
- Volume
- 152
- Issue
- 2
- Pages
- 99-101
- ISSN
- 0340-6199 (ISSN-L)
- 1432-1076
- OpenAlex
- W2023518142
- Cited by
- 50
- References
- 14
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 1 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 2 · 2014: 1 · 2013: 2 · 2012: 1
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- pituitary stalk transection, head trauma, pediatric head injury, growth retardation, magnetic resonance imaging, perinatal injury
- MeSH terms
- Child, Choristoma, Growth Disorders, Craniocerebral Trauma, Humans, Magnetic Resonance Imaging, Male, Pituitary Gland, Pituitary Gland, Posterior, Pituitary Neoplasms, Growth Hormone
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