The DOI matches its Crossref record.
Retention and retrieval in the endoplasmic reticulum and the Golgi apparatus
Open accessAbstract
Resident proteins of the exocytic pathway contain at least two types of information in their primary sequence for determining their subcellular location. The first type of information is found at the carboxyl terminus of soluble proteins of the endoplasmic reticulum (ER) and in the cytoplasmic domain of some ER and Golgi membrane proteins. It acts as a retrieval signal, returning proteins that have left the compartment in which they reside. The second type of information has been found in the membrane-spanning domain of several ER and Golgi proteins and, though the mechanism by which it operates is still unclear, it acts as a retention signal, keeping the protein at a particular location within the organelle. The presence of both a retrieval signal and a retention signal in a trans-Golgi network resident protein suggests that more than one mechanism operates to ensure correct localization of resident proteins along the exocytic pathway.
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Cited by
Shen, J., Chen, X., Hendershot, L., & Prywes, R. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00203-4 · Cited by 1,456
Characterization of a cis-Golgi matrix protein, GM130.
Nakamura, N., Rabouille, C., Watson, R., Nilsson, T., Hui, N., Slusarewicz, P., Kreis, T. E., & Warren, G. (1995) · The Journal of cell biology · doi:10.1083/jcb.131.6.1715 · Cited by 819
Self-citationGlycosyltransferase activity of Fringe modulates Notch–Delta interactions
Brückner, K., Perez, L., Clausen, H., & Cohen, S. (2000) · Nature · doi:10.1038/35019075 · Cited by 694
Mellman, I., & Warren, G. (2000) · Cell · doi:10.1016/s0092-8674(00)81687-6 · Cited by 441
Self-citationSmith, A. N., Skaug, J., Choate, K. A., Nayir, A., Bakkaloglu, A., Ozen, S., Hulton, S. A., Sanjad, S. A., Al-Sabban, E. A., Lifton, R. P., et al. (2000) · Nature Genetics · doi:10.1038/79208 · Cited by 425
Metadata
- Authors
- Nilsson, T., & Warren, G.
- Venue
- Current Opinion in Cell Biology
- Publisher
- Elsevier BV
- Published
- 1994-08
- Volume
- 6
- Issue
- 4
- Pages
- 517-521
- ISSN
- 0955-0674 (ISSN-L)
- OpenAlex
- W2062044807
- Cited by
- 246
- References
- 0
- FWCI
- 1.88
- Type
- journal article
- Language
- en
- Open access
- green
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