The ontogeny of gene expression of progestin receptors in the female rat brain
Abstract
The postnatal development of the progestin receptor (PR) system in the rat brain is a region-specific and stage-related process. In an attempt to analyze the molecular mechanism by which the dramatic change of gene expression of the PR occurs we have examined the level of PR mRNAs in the hypothalamus-preoptic area (HPOA) and cerebral cortex in development from fetal to postnatal stages of female rats. We used polymerase chain reaction to clone, from uterine cDNA, the cDNA corresponding to the steroid-binding domain of the PR forms 'A' and 'B' mRNA as well as the region around the translation-initiation site (ATG1) of the putative PR form 'B' mRNA. A quantitative reverse transcription-polymerase chain reaction assay was used to measure the level of mRNAs for PR forms 'A' and 'B' (total PR mRNAs) and PR form 'B'. There was a regional difference in the intracerebral distribution between the total and form 'B' mRNAs, indicating possible distinct mechanisms responsible for regulating the expression of the PR mRNAs. The PR mRNAs in the brain, already detectable 2 days before birth, increased at early neonatal stages. The total PR mRNAs in the cortex developed in a manner essentially similar to the PR protein at the early stages, but, surprisingly, unlike the receptor, the messages remained high at the later stages from day 18 to 8 weeks of life. On the other hand, the ontogeny of the cortical mRNA for form 'B', which predominantly existed in the region, resembled that of the cortical PR protein. In the HPOA the postnatal development of the form 'B' mRNAs was also roughly similar to the PR. These results suggest region-specific and stage-related gene expression of the PR isoform system in the developing brain: gene expression of form 'B' seems to be predominantly, first, "turned on" around birth, followed by form 'A' mRNA expression around days 8-12. Moreover, lowered levels of the cortical PR mRNAs in the propylthiouracil-induced hypothyroid rat, together with suppressed PR level, indicate a possible regulatory role of thyroid hormone on gene expression of the cortical receptor.
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In one study of mRNA from homogenized tissue, expression of the PR B isoform peaked at P8 and then declined to basal values before weaning, while the A isoform rose, resulting in total PR expression in the cortex remaining into adulthood.
“They found that expression of the B isoform peaked at P8 and then declined to basal values before weaning, while the A isoform rose, resulting in total PR expression in the cortex remaining into adulthood (Kato et al., 1993).”
From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Kato et al., 1993
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- Authors
- Kato, J., Hirata, S., Nozawa, A., & Mouri, N.
- Affiliations
- University of Yamanashi Hospital (JP)
- University of Yamanashi (JP)
- Corresponding author
- Kato, Junzo
- Venue
- The Journal of Steroid Biochemistry and Molecular Biology
- Publisher
- Elsevier BV
- Published
- 1993-12
- Volume
- 47
- Issue
- 1-6
- Pages
- 173-182
- ISSN
- 0960-0760 (ISSN-L)
- OpenAlex
- W2049608201
- Cited by
- 68
- References
- 28
- Citations by year
- 2024: 1 · 2023: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 1 · 2013: 3 · 2012: 1
- FWCI
- 0.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Steroid Biochemistry and Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Keywords
- progestin receptor, cerebral cortex, steroid-binding domain, postnatal brain development, thyroid hormone regulation, propylthiouracil-induced hypothyroidism, region-specific gene expression
- MeSH terms
- Amino Acid Sequence, Animals, Animals, Newborn, Base Sequence, Brain, Cerebral Cortex, Female, Hypothalamus, Hypothyroidism, Molecular Sequence Data, Preoptic Area, Receptors, Progesterone, RNA, Messenger, Tissue Distribution, Gene Expression, Polymerase Chain Reaction, Rats, Wistar, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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