Sex-related responses after traumatic brain injury: Considerations for preclinical modeling

Späni, Claudia B.; Braun, David J.; Van Eldik, Linda J.

doi:10.1016/j.yfrne.2018.03.006

Cited by 195Traumatic Brain Injury and Neurovascular DisturbancesTraumatic Brain Injury ResearchAutomotive and Human Injury Biomechanics

Sex-related responses after traumatic brain injury: Considerations for preclinical modeling

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Späni, Claudia B., Braun, David J., Van Eldik, Linda J.·2018·Frontiers in Neuroendocrinology

DOI 10.1016/j.yfrne.2018.03.006PMC PMC6139061

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Abstract

Traumatic brain injury (TBI) has historically been viewed as a primarily male problem, since men are more likely to experience a TBI because of more frequent participation in activities that increase risk of head injuries. This male bias is also reflected in preclinical research where mostly male animals have been used in basic and translational science. However, with an aging population in which TBI incidence is increasingly sex-independent due to falls, and increasing female participation in high-risk activities, the attention to potential sex differences in TBI responses and outcomes will become more important. These considerations are especially relevant in designing preclinical animal models of TBI that are more predictive of human responses and outcomes. This review characterizes sex differences following TBI with a special emphasis on the contribution of the female sex hormones, progesterone and estrogen, to these differences. This information is potentially important in developing and customizing TBI treatments.

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A recent review reported that 93-95% of preclinical studies have failed to include biological sex as a variable.
“For example, a recent review reported that 93-95% of preclinical studies have failed to include biological sex as a variable.”
From Sex Differences in Traumatic Brain Injury: What We Know and What We Should Know (2019) · cites this paper as [20]

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Authors: Späni, C. B., Braun, D. J., & Van Eldik, L. J.
Affiliations: University of Kentucky (US)
ORCID: Späni, Claudia B.
Braun, David J.
Venue: Frontiers in Neuroendocrinology
Publisher: Elsevier BV
Published: 2018-07
Volume: 50
Pages: 52-66
ISSN: 0091-3022 (ISSN-L)
DOI: 10.1016/j.yfrne.2018.03.006
PMC: PMC6139061
OpenAlex: W2804503506
Cited by: 195
References: 195
Citations by year: 2026: 12 · 2025: 20 · 2024: 32 · 2023: 24 · 2022: 24 · 2021: 35 · 2020: 27 · 2019: 18 · 2018: 2
FWCI: 3.23
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Frontiers in Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (NS093920)
Topics: Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Automotive and Human Injury Biomechanics
Keywords: traumatic brain injury, sex differences, preclinical animal models, progesterone, estrogen, sex hormones, female sex hormones, translational research, sex bias in research
MeSH terms: Brain Injuries, Traumatic, Animals, Female, Humans, Male, Sex Characteristics, Gonadal Steroid Hormones, Models, Animal

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Sex-related responses after traumatic brain injury: Considerations for preclinical modeling

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