Thiols as potential UV radiation protectors: An in vitro study

van den Broeke, L.T.; van Henegouwen, G.M.J.Beyersbergen

doi:10.1016/1011-1344(93)80026-6

Cited by 34Skin Protection and AgingFree Radicals and AntioxidantsPhotochemistry and Electron Transfer Studies

Thiols as potential UV radiation protectors: An in vitro study

van den Broeke, L.T., van Henegouwen, G.M.J.Beyersbergen·1993·Journal of Photochemistry and Photobiology B: Biology

DOI 10.1016/1011-1344(93)80026-6

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Abstract

The following thiols were investigated with regard to their possible UV-radiation protective properties: captopril, cysteamine, ergothioneine, mesna, mercaptopropionylglycine, N-acetylcysteine, and penicillamine. As a measure for protection, the inhibition of in vitro irreversible photobinding of the labeled phototoxic drugs chlorpromazine (CPZ) and 8-methoxypsoralen (8-MOP) to protein and DNA was used. Besides photobinding to biomacromolecules, the photodegradation of CPZ and the formation of promazine (PZH) and hydroxypromazine (PZOH) were measured as well. Because of the H-atom and electron donating capacity of the thiols, the ratio [PZOH]/[PZH] was expected to be decreased and the photodegradation of CPZ was expected to be higher in the presence of thiols. Maximum inhibition of CPZ photobinding ranged for the different thiols between 21-100% (DNA) and 17-87% (human serum albumin). All thiols enhanced the photodegradation of CPZ (19-84%) and inhibited the ratio [PZOH]/[PZH] (90-97%). 8-MOP photobinding to human serum albumin was also clearly inhibited (75-96%), but remarkably less to DNA (2-41%). This study indicates that thiols are able to cope with a variety of reactive species. Scavenging of radicals, quenching of singlet molecular oxygen species and reaction with excited states seem to be essential mechanisms involved with this process.

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ERG can react with and detoxify, or prevent the formation of, hydroxyl radicals, singlet oxygen, ozone, superoxide, peroxide, hypochlorite and peroxynitrite.
“Although the literature is somewhat scattered and heterogeneous, it seems clear that as well as hydroxyl radicals(228–232), ERG can also react with and detoxify, or prevent the formation of, singlet oxygen(233–242), ozone(243), superoxide(231,241,244–246), peroxide(32,124,247,248), hypochlorite(32,232,249) and peroxynitrite(224,231,250,251).”
From The biology of ergothioneine, an antioxidant nutraceutical (2020) · cites this paper as [236]

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UVB photoprotection by thiourea and (thio)semicarbazone derivatives: cellular and molecular evidence
Rana, S., Bhatti, A. A., Nawaz, H., Yaqoob, S., & Hameed, A. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-12754-2

Authors: van den Broeke, L. T., & van Henegouwen, G. M. J. B.
Venue: Journal of Photochemistry and Photobiology B: Biology
Publisher: Elsevier BV
Published: 1993-03
Volume: 17
Issue: 3
Pages: 279-286
ISSN: 1011-1344 (ISSN-L)
DOI: 10.1016/1011-1344(93)80026-6
OpenAlex: W1971240868
Cited by: 34
References: 46
Citations by year: 2026: 2 · 2025: 1 · 2020: 2 · 2019: 1 · 2018: 1 · 2015: 1
FWCI: 3.03
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Photochemistry and Photobiology B Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Photochemistry and Electron Transfer Studies
Keywords: thiols, UV protection, photoprotection, chlorpromazine, 8-methoxypsoralen, photodegradation, human serum albumin, reactive oxygen species scavenging, singlet oxygen quenching, captopril, cysteamine, N-acetylcysteine, D-penicillamine, ergothioneine, mesna
MeSH terms: Chlorpromazine, DNA, Humans, Methoxsalen, Radiation-Protective Agents, Serum Albumin, Sulfhydryl Compounds, Ultraviolet Rays

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Thiols as potential UV radiation protectors: An in vitro study

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