?-Ergothioneine modulates oxidative damage in the kidney and liver of rats in vivo: studies upon the profile of polyunsaturated fatty acids
Abstract
Background & aims L-ergothioneine is a fungal metabolite exhibiting antioxidant functions in cells. The aim of this study was to assess the effect of oral administration of L-ergothioneine on the oxidative damage in vivo caused by the Fenton reagent ferric-nitrilotriacetate. Methods Rats were supplemented with L-ergo prior to the administration of acute dose of ferric-nitrilotriacetate. Kidney and liver levels of L-ergothioneine, glutathione, alpha-tocopherol, polyunsaturated fatty acids and conjugated dienes were assessed. Results Oral administration of 70 mg L-ergo/kg body weight of rats for 7 days prior to the injection of ferric-nitrilotriacetate protected the fatty acids against oxidation, with notable protections directed to: 20:5 (eicosapentaenoic acid) (23%), 22:6 (docosahexaenoinic acid) (30%), 20:3 n6 (eicosatrienoic acid) (22%), 20:4 (arachidonic acid) (25%), 18:2 linoleic acid (25%) and 18:1 oleic acid (14%) in the kidney. The protection of 20:5, 20:3 n6 and 18:1 in the liver by 32%, 20% and 11%, respectively, were statistically significant. L-ergothioneine significantly reduced kidney and liver levels of conjugated dienes and conserved the concentrations of alpha-tocopherol and glutathione in the kidney and liver in the ferric-nitrilotriacetate/L-ergothioneine treated rats. Conclusion Supplementation with L-ergothioneine not only protects the organs against the lipid peroxidation but conserves the consumption of endogenous glutathione and alpha-tocopherol. However consumption of mushrooms may have better promise as dietary sources of L-ergothioneine to humans.
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ERG has been shown to protect against a range of oxidative and toxic insults, including decreasing oxidative stress in rat liver and kidney, rescuing cells from β-amyloid-induced apoptotic death, protecting against palmitic acid-induced cell death, mercuric chloride-induced cellular dysfunction, and Cu-induced oxidative DNA damage.
“ERG has been shown to decrease oxidative stress in the liver and kidney of rats(469), rescued cells from β-amyloid-induced apoptotic death(231), protected against palmitic acid-induced cell death(470), mercuric chloride-induced cellular dysfunction(471), and prevented Cu-induced oxidative damage to DNA(472,473).”
From The biology of ergothioneine, an antioxidant nutraceutical (2020) · cites this paper as [469]
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Thiol-induced hydroxyl radical formation and scavenger effect of thiocarbamides on hydroxyl radicals
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The biology of ergothioneine, an antioxidant nutraceutical
Borodina, I., Kenny, L. C., McCarthy, C. M., Paramasivan, K., Pretorius, E., Roberts, T. J., van der Hoek, S. A., & Kell, D. B. (2020) · Nutrition Research Reviews · doi:10.1017/s0954422419000301 · Cited by 296 · see citing works
“tive stress in the liver and kidney of rats(469), rescued cells from β-amyloid-induced apoptotic death(231), protected against pal-”
BackgroundErgothioneine protects against neuronal injury induced by β-amyloid in mice
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- Authors
- Deiana, M.
- Affiliations
- University of Cagliari (IT)
- Corresponding author
- Deiana, M
- ORCID
- Deiana, M
- Venue
- Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2004-04
- Volume
- 23
- Issue
- 2
- Pages
- 183-193
- ISSN
- 0261-5614 (ISSN-L)
- OpenAlex
- W1997892133
- Cited by
- 92
- References
- 3
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 6 · 2023: 2 · 2022: 8 · 2021: 7 · 2020: 5 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 8 · 2015: 3 · 2014: 4 · 2013: 7 · 2012: 4
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion)
- Funders
- Regione Autonoma della Sardegna
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- L-ergothioneine, oxidative damage, lipid peroxidation, polyunsaturated fatty acids, ferric nitrilotriacetate, Fenton reaction, kidney, liver, glutathione, alpha-tocopherol, conjugated dienes, eicosapentaenoic acid, docosahexaenoic acid, dietary supplementation, mushrooms, antioxidants
- MeSH terms
- Animals, Antioxidants, Chromatography, High Pressure Liquid, Ergothioneine, Fatty Acids, Unsaturated, Ferric Compounds, Glutathione, Kidney, Lipids, Liver, Male, Nitrilotriacetic Acid, Oxidation-Reduction, Rats, Wistar, Oxidative Stress, alpha-Tocopherol, Rats
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