Interleukin 1 receptor antagonist (IL-1ra) prevents or cures pulmonary fibrosis elicited in mice by bleomycin or silica
Abstract
We explored the role of interleukin 1 (IL-1) in two models of pulmonary fibrosis (PF), elicited in mice by the intra-tracheal instillation of bleomycin or silica. In both models, administration of IL-1 receptor antagonist (IL-1ra) by an osmotic minipump implanted i.p., at a rate of 0.5 microgram/h, completely prevented the collagen deposition, as evaluated by the lung hydroxyproline content on day 15 after instillation. IL-1ra had little or no influence on the number of cells recovered from the broncho-alveolar lavage. Study of histological sections suggests that IL-1ra globally decreased the proportion of damaged lung and particularly in silica the formation of nodules with a rich content in collagen fibrils. IL-1ra was also effective in reducing the lung hydroxyproline content when given on day 25 after instillation of bleomycin or silica, indicating that it may reverse established PF. This study indicates that IL-1ra might be useful for the treatment of incipient or established pulmonary fibrosis.
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In mice with bleomycin- or silica-induced lung fibrosis, giving IL-1 receptor antagonist lowered the fraction of damaged lung.
“Moreover, in a mouse model of bleomycin-or silica-induced pulmonary fibrosis, treatment with IL-1 receptor antagonist (IL-1ra) reduces the proportion of damaged lung (25).”
From Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica (2008) · cites this paper as [25]
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- Authors
- Piguet, P. F., Vesin, C., Grau, G. E., & Thompson, R. C.
- Affiliations
- University of Geneva (CH)
- Corresponding author
- Piguet, Pierre F.
- Venue
- Cytokine
- Publisher
- Elsevier BV
- Published
- 1993-01
- Volume
- 5
- Issue
- 1
- Pages
- 57-61
- ISSN
- 1043-4666 (ISSN-L)
- OpenAlex
- W2001796665
- Cited by
- 215
- References
- 24
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 6 · 2022: 2 · 2021: 7 · 2020: 2 · 2019: 9 · 2018: 5 · 2017: 3 · 2016: 7 · 2015: 8 · 2014: 5 · 2013: 6 · 2012: 10
- FWCI
- 10.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cytokine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Keywords
- interleukin-1 receptor antagonist, pulmonary fibrosis, bleomycin-induced lung injury, silica-induced lung injury, interleukin-1, collagen deposition, hydroxyproline, lung hydroxyproline, pulmonary nodules, bronchoalveolar lavage, anti-inflammatory therapy
- MeSH terms
- Animals, Bleomycin, Bronchoalveolar Lavage Fluid, Hydroxyproline, Interleukin-1, Lung, Mice, Inbred CBA, Mice, Inbred C57BL, Pulmonary Fibrosis, RNA, Messenger, Silicon Dioxide, Tumor Necrosis Factor-alpha, Receptors, Interleukin-1, Mice
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