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Cited by 215Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisOccupational and environmental lung diseasesTransplantation: Methods and Outcomes

The DOI matches its Crossref record; 23 of the 24 references it cites were found in a registry or an index.

Interleukin 1 receptor antagonist (IL-1ra) prevents or cures pulmonary fibrosis elicited in mice by bleomycin or silica

Piguet, Pierre F., Vesin, Christian, Grau, Georges E., Thompson, Robert C.·1993·Cytokine
DOI 10.1016/1043-4666(93)90024-y
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Abstract

We explored the role of interleukin 1 (IL-1) in two models of pulmonary fibrosis (PF), elicited in mice by the intra-tracheal instillation of bleomycin or silica. In both models, administration of IL-1 receptor antagonist (IL-1ra) by an osmotic minipump implanted i.p., at a rate of 0.5 microgram/h, completely prevented the collagen deposition, as evaluated by the lung hydroxyproline content on day 15 after instillation. IL-1ra had little or no influence on the number of cells recovered from the broncho-alveolar lavage. Study of histological sections suggests that IL-1ra globally decreased the proportion of damaged lung and particularly in silica the formation of nodules with a rich content in collagen fibrils. IL-1ra was also effective in reducing the lung hydroxyproline content when given on day 25 after instillation of bleomycin or silica, indicating that it may reverse established PF. This study indicates that IL-1ra might be useful for the treatment of incipient or established pulmonary fibrosis.

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Crossref · 10.1016/1043-4666(93)90024-y

Cites

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Research works printed but not linked: 1

  1. Thrall, 1979, Bleomycin-induced pulmonary fibrosis in the rat, Am J Pathol, 95, 117

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Metadata

Authors
Piguet, P. F., Vesin, C., Grau, G. E., & Thompson, R. C.
Affiliations
University of Geneva (CH)
Corresponding author
Piguet, Pierre F.
ORCID
Venue
Cytokine
Publisher
Elsevier BV
Published
1993-01
Volume
5
Issue
1
Pages
57-61
ISSN
1043-4666 (ISSN-L)
DOI
10.1016/1043-4666(93)90024-y
OpenAlex
W2001796665
Cited by
215
References
24
Citations by year
2026: 1 · 2025: 3 · 2024: 3 · 2023: 6 · 2022: 2 · 2021: 7 · 2020: 2 · 2019: 9 · 2018: 5 · 2017: 3 · 2016: 7 · 2015: 8 · 2014: 5 · 2013: 6 · 2012: 10
FWCI
10.21
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Cytokine (publishedVersion)
  • PubMed (publishedVersion)
Funders
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
  • Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
Keywords
interleukin-1 receptor antagonist, pulmonary fibrosis, bleomycin-induced lung injury, silica-induced lung injury, interleukin-1, collagen deposition, hydroxyproline, lung hydroxyproline, pulmonary nodules, bronchoalveolar lavage, anti-inflammatory therapy
MeSH terms
Animals, Bleomycin, Bronchoalveolar Lavage Fluid, Hydroxyproline, Interleukin-1, Lung, Mice, Inbred CBA, Mice, Inbred C57BL, Pulmonary Fibrosis, RNA, Messenger, Silicon Dioxide, Tumor Necrosis Factor-alpha, Receptors, Interleukin-1, Mice

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