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Trabecular bone remodeling and bone balance in hyperthyroidism
Abstract
In vivo tetracycline double-labeled iliac crest bone biopsies from 15 hyperthyroid patients were used for the reconstruction of curves describing the variation of resorption depth and formation thickness with time. The curves emerging were compared to curves reconstructed from 13 age- and sex-matched normal individuals (mean age 44 years). The median function period for resorptive cells in hyperthyroid patients (16 days) was about one-third the resorptive period in normals (51 days). No significant difference between the osteoclast-, mononuclear-, or preosteoblast-like cell resorption depths could be demonstrated between the two groups. Consequently, the median resorption rate in hyperthyroid patients (3.8 microns/day) was more than 3 times higher than the value in the control group (1.1 micron/day). Median Sigma, was shorter in the hyperthyroid group (109 days) than in the control group (151 days, P less than 0.05), as was the median initial mineralization lag time (5 and 16 days, respectively, P less than 0.01). No significant difference between the measured mean completed wall thickness (mcwT) values in the hyperthyroid groups and the control group could be demonstrated (58.1 and 60.5 micron respectively). Median initial mineralization rate in the hyperthyroid group (1.2 micron3/micron2 per day) was not significantly higher than the value calculated in the control group (0.9 micron3/micron2 per day), but median initial matrix appositional rate in hyperthyroid (4.8 microns3/micron2 per day) was 3 times higher than the value calculated for normals (1.6 micron3/micron2 per day) (P less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
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“which can decrease bone quality22 and bone mineral density,60 leading to a higher risk of fracture.”
From Levothyroxine dose and risk of fractures in older adults: nested case-control study (2011) · cites this paper as [60]
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Metadata
- Authors
- Eriksen, E. F., Mosekilde, L., & Melsen, F.
- Corresponding author
- Eriksen, E.F.
- Venue
- Bone
- Publisher
- Elsevier BV
- Published
- 1985-01
- Volume
- 6
- Issue
- 6
- Pages
- 421-428
- ISSN
- 1873-2763 (ISSN-L)
- 8756-3282
- OpenAlex
- W2051022943
- Cited by
- 172
- References
- 17
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 5 · 2023: 2 · 2022: 5 · 2021: 2 · 2020: 6 · 2019: 2 · 2018: 6 · 2017: 3 · 2016: 5 · 2015: 4 · 2014: 4 · 2013: 2 · 2012: 3
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Bone (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Keywords
- hyperthyroidism, trabecular bone remodeling, bone balance, tetracycline double labeling, iliac crest bone biopsy, bone resorption rate, bone formation rate, formation thickness, mineralization lag time, osteoclasts, bone turnover markers
- MeSH terms
- Adult, Aged, Bone Matrix, Bone Resorption, Female, Humans, Hyperthyroidism, Male, Middle Aged, Minerals, Osteogenesis, Regression Analysis, Time Factors
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