Myostatin

Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member

McPherron, A. C., Lawler, A. M., & Lee, S.-J. (1997) · Nature · doi:10.1038/387083a0 · Cited by 4,013

Double muscling in cattle due to mutations in the myostatin gene

McPherron, A. C., & Lee, S.-J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.23.12457 · Cited by 2,039

Regulation of myostatin activity and muscle growth

Lee, S.-J., & McPherron, A. C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151270098 · Cited by 1,616

A deletion in the bovine myostatin gene causes the double–muscled phenotype in cattle

Grobet, L., Royo Martin, L. J., Poncelet, D., Pirottin, D., Brouwers, B., Riquet, J., Schoeberlein, A., Dunner, S., Ménissier, F., Massabanda, J., et al. (1997) · Nature Genetics · doi:10.1038/ng0997-71 · Cited by 1,556

Myostatin Mutation Associated with Gross Muscle Hypertrophy in a Child

Schuelke, M., Wagner, K. R., Stolz, L. E., Hübner, C., Riebel, T., Kömen, W., Braun, T., Tobin, J. F., & Lee, S.-J. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040933 · Cited by 1,399

A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep

Clop, A., Marcq, F., Takeda, H., Pirottin, D., Tordoir, X., Bibé, B., Bouix, J., Caiment, F., Elsen, J.-M., Eychenne, F., et al. (2006) · Nature Genetics · doi:10.1038/ng1810 · Cited by 1,260

Mutations in myostatin ( GDF8 ) in Double-Muscled Belgian Blue and Piedmontese Cattle

Kambadur, R., Sharma, M., Smith, T. P. L., & Bass, J. J. (1997) · Genome Research · doi:10.1101/gr.7.9.910 · Cited by 1,204

Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival

Zhou, X., Wang, J. L., Lu, J., Song, Y., Kwak, K. S., Jiao, Q., Rosenfeld, R., Chen, Q., Boone, T. C., Simonet, W. S., et al. (2010) · Cell · doi:10.1016/j.cell.2010.07.011 · Cited by 960

Induction of Cachexia in Mice by Systemically Administered Myostatin

Zimmers, T. A., Davies, M. V., Koniaris, L. G., Haynes, P. A., Esquela‐Kerscher, A., Tomkinson, K. N., McPherron, A. C., Wolfman, N. M., & Lee, S. (2002) · Science · doi:10.1126/science.1069525 · Cited by 908

Activin-Binding Protein from Rat Ovary Is Follistatin

Nakamura, T., Takio, K., Eto, Y., Shibai, H., Titani, K., & Sugino, H. (1990) · Science · doi:10.1126/science.2106159 · Cited by 883

Functional improvement of dystrophic muscle by myostatin blockade

Bogdanovich, S., Krag, T. O. B., Barton, E. R., Morris, L. D., Whittemore, L.-A., Ahima, R. S., & Khurana, T. S. (2002) · Nature · doi:10.1038/nature01154 · Cited by 831

A Mutation in the Myostatin Gene Increases Muscle Mass and Enhances Racing Performance in Heterozygote Dogs

Mosher, D. S., Quignon, P., Bustamante, C. D., Sutter, N. B., Mellersh, C. S., Parker, H. G., & Ostrander, E. A. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030079 · Cited by 826

REGULATION OF MUSCLE MASS BY MYOSTATIN

Lee, S.-J. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.012103.135836 · Cited by 819

Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size

Trendelenburg, A. U., Meyer, A., Rohner, D., Boyle, J., Hatakeyama, S., & Glass, D. J. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00105.2009 · Cited by 792

Myostatin Signals through a Transforming Growth Factor β-Like Signaling Pathway To Block Adipogenesis

Rebbapragada, A., Benchabane, H., Wrana, J. L., Celeste, A. J., & Attisano, L. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.20.7230-7242.2003 · Cited by 573

Inhibition of myostatin in adult mice increases skeletal muscle mass and strength

Whittemore, L.-A., Song, K., Li, X., Aghajanian, J. D., Davies, M. V., Girgenrath, S., Hill, J. J., Jalenak, M., Kelley, P. E., Knight, A., et al. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02953-4 · Cited by 512

Suppression of body fat accumulation in myostatin-deficient mice

McPherron, A. C., & Lee, S.-J. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0213562 · Cited by 505

Regulation of muscle growth by multiple ligands signaling through activin type II receptors

Lee, S.-J., Reed, L. A., Davies, M. V., Girgenrath, S., Goad, M. E. P., Tomkinson, K. N., Wright, J. F., Barker, C., Ehrmantraut, G., Holmstrom, J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505996102 · Cited by 501

A phase I/IItrial of MYO‐029 in adult subjects with muscular dystrophy

Wagner, K. R., Fleckenstein, J. L., Amato, A. A., Barohn, R. J., Bushby, K., Escolar, D. M., Flanigan, K. M., Pestronk, A., Tawil, R., Wolfe, G. I., et al. (2008) · Annals of Neurology · doi:10.1002/ana.21338 · Cited by 481

Molecular definition of an allelic series of mutations disrupting the myostatin function and causing double-muscling in cattle

Grobet, L., Poncelet, D. A., Royo, L. J., Brouwers, B., Pirottin, D., Michaux, C., Ménissier, F., Zanotti, M., Dunner, S., & Georges, M. (1998) · Mammalian Genome · doi:10.1007/s003359900727 · Cited by 471

Activation of latent myostatin by the BMP-1/tolloid family of metalloproteinases

Wolfman, N. M., McPherron, A. C., Pappano, W. N., Davies, M. V., Song, K., Tomkinson, K. N., Wright, J. F., Zhao, L., Sebald, S. M., Greenspan, D. S., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2534946100 · Cited by 454

Isolation and partial characterization of follistatin: a single-chain Mr 35,000 monomeric protein that inhibits the release of follicle-stimulating hormone.

Ueno, N., LING, N. C., Ying, S. Y., Esch, F. S., Shimasaki, S., & Guillemin, R. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.23.8282 · Cited by 445

The Myostatin Propeptide and the Follistatin-related Gene Are Inhibitory Binding Proteins of Myostatin in Normal Serum

Hill, J. J., Davies, M. V., Pearson, A. A., Wang, J. H., Hewick, R. M., Wolfman, N. M., & Qiu, Y. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206379200 · Cited by 444

Lack of myostatin results in excessive muscle growth but impaired force generation

Amthor, H., Macharia, R., Navarrete, R., Schuelke, M., Brown, S., Otto, A., Voït, T., Muntoni, F., Vrbovà, G., Partridge, T. A., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604893104 · Cited by 438

The isolation of polypeptides with FSH suppressing activity from bovine follicular fluid which are structurally different to inhibin

Robertson, D. M., Klein, R., de Vos, F. L., McLachlan, R. I., Wettenhall, R. E. H., Hearn, M. T. W., Burger, H., & de Kretser, D. M. (1987) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(87)90430-x · Cited by 345

Functional and morphological recovery of dystrophic muscles in mice treated with deacetylase inhibitors

Minetti, G., Colussi, C., Adami, R., Serra, C., Mozzetta, C., Parente, V., Fortuni, S., Straino, S., Sampaolesi, M., Padova, M. D., et al. (2006) · Nature Medicine · doi:10.1038/nm1479 · Cited by 343

Pharmacological inhibition of myostatin suppresses systemic inflammation and muscle atrophy in mice with chronic kidney disease

Zhang, L., Rajan, V., Lin, E., Hu, Z., Han, H. Q., Zhou, X., Song, Y., Min, H., Wang, X., Du, J., et al. (2011) · The FASEB Journal · doi:10.1096/fj.10-176917 · Cited by 323

Quadrupling Muscle Mass in Mice by Targeting TGF-ß Signaling Pathways

Lee, S.-J. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000789 · Cited by 316

Regulation of Muscle Mass by Follistatin and Activins

Lee, S.-J., Lee, Y.-S., Zimmers, T. A., Soleimani, A., Matzuk, M. M., Tsuchida, K., Cohn, R. D., & Barton, E. R. (2010) · Molecular Endocrinology · doi:10.1210/me.2010-0127 · Cited by 273

Gdf-8 Propeptide Binds to GDF-8 and Antagonizes Biological Activity by Inhibiting GDF-8 Receptor Binding

Tries, R. S., Chen, T., Vies, M. V. D., Tomkinson, K. N., Pearson, A. A., Shakey, Q., & Wolfman, N. M. (2001) · Growth Factors · doi:10.3109/08977190109029114 · Cited by 270

Deacetylase Inhibitors Increase Muscle Cell Size by Promoting Myoblast Recruitment and Fusion through Induction of Follistatin

Iezzi, S., Padova, M. D., Serra, C., Caretti, G., Simone, C., Maklan, E., Minetti, G., Zhao, P., Hoffman, E. P., Puri, P., et al. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00107-8 · Cited by 245

Loss of myostatin expression alters fiber-type distribution and expression of myosin heavy chain isoforms in slow- and fast-type skeletal muscle

Girgenrath, S., Song, K., & Whittemore, L.-A. (2004) · Muscle & Nerve · doi:10.1002/mus.20175 · Cited by 238

Genetic deletion of myostatin from the heart prevents skeletal muscle atrophy in heart failure

Heineke, J., Auger-Messier, M., Xu, J., Sargent, M., York, A., Welle, S., & Molkentin, J. D. (2010) · Circulation · doi:10.1161/circulationaha.109.882068 · Cited by 238

Acute inhibition of myostatin-family proteins preserves skeletal muscle in mouse models of cancer cachexia

Klimek, M. B., Aydogdu, T., Link, M., Pons, M., Koniaris, L. G., & Zimmers, T. A. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.12.123 · Cited by 229

Regulation of Myostatin in Vivo by Growth and Differentiation Factor-Associated Serum Protein-1: A Novel Protein with Protease Inhibitor and Follistatin Domains

Hill, J. J., Qiu, Y., Hewick, R. M., & Wolfman, N. M. (2003) · Molecular Endocrinology · doi:10.1210/me.2002-0366 · Cited by 225

Myostatin, activin receptor IIb, and follistatin-like-3 gene expression are altered in adipose tissue and skeletal muscle of obese mice

Allen, D. L., Cleary, A. S., Speaker, K. J., Lindsay, S. F., Uyenishi, J., Reed, J. M., Madden, M. C., & Mehan, R. S. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00798.2007 · Cited by 183

Myostatin inhibition enhances the effects of exercise on performance and metabolic outcomes in aged mice

LeBrasseur, N. K., Schelhorn, T. M., Bernardo, B. L., Cosgrove, P. G., Loria, P. M., & Brown, T. A. (2009) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glp068 · Cited by 180

A Novel BMP Expressed in Developing Mouse Limb, Spinal Cord, and Tail Bud Is a Potent Mesoderm Inducer inXenopusEmbryos

Gamer, L. W., Wolfman, N. M., Celeste, A. J., Hattersley, G., Hewick, R. M., & Rosen, V. (1999) · Developmental Biology · doi:10.1006/dbio.1998.9191 · Cited by 170

Redundancy of myostatin and growth/differentiation factor 11 function

McPherron, A. C., Huynh, T. V., & Lee, S.-J. (2009) · BMC Developmental Biology · doi:10.1186/1471-213x-9-24 · Cited by 168

Decorin Gene Transfer Promotes Muscle Cell Differentiation and Muscle Regeneration

Li, Y., Li, J., Zhu, J., Sun, B., Branca, M. F., Tang, Y., Foster, W. H., Xiao, X., & Huard, J. (2007) · Molecular Therapy · doi:10.1038/sj.mt.6300250 · Cited by 162

Identification of a Novel Pool of Extracellular Pro-myostatin in Skeletal Muscle

Anderson, S. B., Goldberg, A. L., & Whitman, M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m706678200 · Cited by 159

FSTL3 deletion reveals roles for TGF-β family ligands in glucose and fat homeostasis in adults

Mukherjee, A., Sidis, Y., Mahan, A. L., Raher, M. J., Xia, Y. Y., Rosen, E. D., Bloch, K. D., Thomas, M. K., & Schneyer, A. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607966104 · Cited by 159

The effects of a soluble activin type IIB receptor on obesity and insulin sensitivity

Akpan, I., Goncalves, M. D., Dhir, R., Yin, X., Pistilli, E. E., Bogdanovich, S., Khurana, T. S., Ucran, J., Lachey, J., & Ahima, R. S. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.162 · Cited by 140

Administration of a soluble activin type IIB receptor promotes skeletal muscle growth independent of fiber type

Cadena, S. M., Tomkinson, K. N., Monnell, T. E., Spaits, M. S., Kumar, R., Underwood, K. W., Pearsall, R. S., & Lachey, J. L. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00866.2009 · Cited by 138

Impact of Exercise Training on Myostatin Expression in the Myocardium and Skeletal Muscle in a Chronic Heart Failure Model

Lenk, K., Schur, R., Linke, A., Erbs, S., Matsumoto, Y., Adams, V., & Schuler, G. C. (2009) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfp020 · Cited by 136

Genetic Analysis of the Role of Proteolysis in the Activation of Latent Myostatin

Lee, S.-J. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001628 · Cited by 114

Myostatin expression in ventricular myocardium in a rat model of volume‐overload heart failure

Shyu, K., Lu, M.-J., Wang, B. W., Sun, H.-Y., & Chang, H. (2006) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2006.01718.x · Cited by 100

Extracellular Regulation of Myostatin: A Molecular Rheostat for Muscle Mass

Lee, S. (2010) · Immunology Endocrine & Metabolic Agents - Medicinal Chemistry · doi:10.2174/187152210793663748 · Cited by 88

Molecular, cellular and physiological investigation of myostatin propeptide-mediated muscle growth in adult mice

Matsakas, A., Foster, K., Otto, A., Macharia, R., Elashry, M. I., Feist, S. A., Graham, I. R., Foster, H., Yaworsky, P. J., Walsh, F. S., et al. (2009) · Neuromuscular Disorders · doi:10.1016/j.nmd.2009.06.367 · Cited by 84

Both WFIKKN1 and WFIKKN2 Have High Affinity for Growth and Differentiation Factors 8 and 11

Kondás, K., Szláma, G., Trexler, M., & Patthy, L. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803025200 · Cited by 81

Building muscle, browning fat and preventing obesity by inhibiting myostatin

LeBrasseur, N. K. (2012) · Diabetologia · doi:10.1007/s00125-011-2361-8 · Cited by 46

Myostatin Is Upregulated Following Stress in an Erk-Dependent Manner and Negatively Regulates Cardiomyocyte Growth in Culture and in a Mouse Model

Bish, L. T., Morine, K., Sleeper, M. M., & Sweeney, H. L. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010230 · Cited by 45

Adeno-Associated Virus-8-Mediated Intravenous Transfer of Myostatin Propeptide Leads to Systemic Functional Improvements of Slow but Not Fast Muscle

Foster, K., Graham, I. R., Otto, A., Foster, H., Trollet, C., Yaworsky, P. J., Walsh, F. S., Bickham, D. C., Curtin, N. A., Kawar, S. L., et al. (2009) · Rejuvenation Research · doi:10.1089/rej.2008.0815 · Cited by 37

Morphology and Myofiber Composition of Skeletal Musculature of the Forelimb in Young and Aged Wild Type and Myostatin Null Mice

Elashry, M. I., Otto, A., Matsakas, A., El-Morsy, S. E., & Patel, K. (2009) · Rejuvenation Research · doi:10.1089/rej.2009.0870 · Cited by 30

Clinical Applications of Myostatin Inhibitors for Neuromuscular Diseases

Wagner, K. R. (2010) · Immunology Endocrine & Metabolic Agents - Medicinal Chemistry · doi:10.2174/187152210793663775 · Cited by 3

Role of Myostatin Signaling in Aging: Applications for Age-Related Sarcopenia

Wilkinson, H. A. (2010) · Immunology Endocrine & Metabolic Agents - Medicinal Chemistry · doi:10.2174/187152210793663801 · Cited by 2

Untitled work

Allen (1999) · doi:10.1002/(sici)1097-4652(199907)180:1

Myostatin and its Regulation: A Comprehensive Review of Myostatin Inhibiting Strategies

Baig, M. H., Ahmad, K., Moon, J. S., Park, S.-Y., Ho Lim, J., Chun, H. J., Qadri, A. F., Hwang, Y. C., Jan, A. T., Ahmad, S. S., et al. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.876078 · Cited by 135

Targeting myostatin/activin A protects against skeletal muscle and bone loss during spaceflight

Lee, S.-J., Lehar, A., Meir, J. U., Koch, C., Morgan, A., Warren, L. E., Rydzik, R., Youngstrom, D. W., Chandok, H., George, J., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2014716117 · Cited by 115

Functional redundancy of type I and type II receptors in the regulation of skeletal muscle growth by myostatin and activin A

Lee, S.-J., Lehar, A., Liu, Y., Ly, C. H., Pham, Q.-M., Michaud, M., Rydzik, R., Youngstrom, D. W., Shen, M. M., Kaartinen, V., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2019263117 · Cited by 59

FHL1 activates myostatin signalling in skeletal muscle and promotes atrophy

Lee, J. Y., Lori, D., Wells, D. J., & Kemp, P. R. (2015) · FEBS Open Bio · doi:10.1016/j.fob.2015.08.011 · Cited by 30

Myostatin expression levels in neuromuscular diseases participates in anti-myostatin clinical failure

Mariot, V., Joubert, R., Hourdé, C., et al. (2017) · Neuromuscular Disorders · doi:10.1016/j.nmd.2017.06.490

Past, Present, and Future Perspective of Targeting Myostatin and Related Signaling Pathways to Counteract Muscle Atrophy

Hoogaars, W. M. H., & Jaspers, R. T. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-1435-3_8 · Cited by 44

Muscle regeneration in the prolonged absence of myostatin

Wagner, K. R., Liu, X., Chang, X., & Allen, R. E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408729102 · Cited by 193

Role of myostatin in metabolism

González-Cadavid, N. F., & Bhasin, S. (2004) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/01.mco.0000134365.99523.7f · Cited by 89