A phase I/IItrial of MYO‐029 in adult subjects with muscular dystrophy
Open accessAbstract
Objective: Myostatin is an endogenous negative regulator of muscle growth and a novel target for muscle diseases. We conducted a safety trial of a neutralizing antibody to myostatin, MYO‐029, in adult muscular dystrophies (Becker muscular dystrophy, facioscapulohumeral dystrophy, and limb‐girdle muscular dystrophy). Methods: This double‐blind, placebo‐controlled, multinational, randomized study included 116 subjects divided into sequential dose‐escalation cohorts, each receiving MYO‐029 or placebo (Cohort 1 at 1mg/kg; Cohort 2 at 3mg/kg; Cohort 3 at 10mg/kg; Cohort 4 at 30mg/kg). Safety and adverse events were assessed by reported signs and symptoms, as well as by physical examinations, laboratory results, echocardiograms, electrocardiograms, and in subjects with facioscapulohumeral dystrophy, funduscopic and audiometry examinations. Biological activity of MYO‐029 was assessed through manual muscle testing, quantitative muscle testing, timed function tests, subject‐reported outcomes, magnetic resonance imaging studies, dual‐energy radiographic absorptiometry studies, and muscle biopsy. Results: MYO‐029 had good safety and tolerability with the exception of cutaneous hypersensitivity at the 10 and 30mg/kg doses. There were no improvements noted in exploratory end points of muscle strength or function, but the study was not powered to look for efficacy. Importantly, bioactivity of MYO‐029 was supported by a trend in a limited number of subjects toward increased muscle size using dual‐energy radiographic absorptiometry and muscle histology. Interpretation: This trial supports the hypothesis that systemic administration of myostatin inhibitors provides an adequate safety margin for clinical studies. Further evaluation of more potent myostatin inhibitors for stimulating muscle growth in muscular dystrophy should be considered. Ann Neurol 2008
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Myostatin inhibitors display important side effects when tested in humans.
“However, myostatin inhibitors display important side effects when tested in humans93 or display no significant improvement of survival in cancer patients94.”
From Mechanisms of muscle atrophy and hypertrophy: implications in health and disease (2021) · cites this paper as [93]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
(1992) · PubMed · Cited by 33,716 · see citing works
The MOS 36-ltem Short-Form Health Survey (SF-36): I. Conceptual Framework and Item Selection
Ware, J. E., & Sherbourne, C. D. (1992) · Medical Care · doi:10.1097/00005650-199206000-00002 · Cited by 30,033 · see citing works
(1994) · Medical Entomology and Zoology · Cited by 4,156 · see citing works
Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member
McPherron, A. C., Lawler, A. M., & Lee, S.-J. (1997) · Nature · doi:10.1038/387083a0 · Cited by 4,013 · see citing works
Double muscling in cattle due to mutations in the myostatin gene
McPherron, A. C., & Lee, S.-J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.23.12457 · Cited by 2,039 · see citing works
Jaretzki, A., Barohn, R. J., Ernstoff, R. M., Kaminski, H. J., Keesey, J., Penn, A. S., & Sanders, D. B. (2000) · Neurology · doi:10.1212/wnl.55.1.16 · Cited by 1,660 · see citing works
Self-citationA deletion in the bovine myostatin gene causes the double–muscled phenotype in cattle
Grobet, L., Royo Martin, L. J., Poncelet, D., Pirottin, D., Brouwers, B., Riquet, J., Schoeberlein, A., Dunner, S., Ménissier, F., Massabanda, J., et al. (1997) · Nature Genetics · doi:10.1038/ng0997-71 · Cited by 1,556 · see citing works
Myostatin Mutation Associated with Gross Muscle Hypertrophy in a Child
Schuelke, M., Wagner, K. R., Stolz, L. E., Hübner, C., Riebel, T., Kömen, W., Braun, T., Tobin, J. F., & Lee, S.-J. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040933 · Cited by 1,399 · see citing works
Self-citationClop, A., Marcq, F., Takeda, H., Pirottin, D., Tordoir, X., Bibé, B., Bouix, J., Caiment, F., Elsen, J.-M., Eychenne, F., et al. (2006) · Nature Genetics · doi:10.1038/ng1810 · Cited by 1,260 · see citing works
Review of MR image segmentation techniques using pattern recognition
Bezdek, J. C., Hall, L., & Clarke, L. P. (1993) · Medical Physics · doi:10.1118/1.597000 · Cited by 956 · see citing works
Functional improvement of dystrophic muscle by myostatin blockade
Bogdanovich, S., Krag, T. O. B., Barton, E. R., Morris, L. D., Whittemore, L.-A., Ahima, R. S., & Khurana, T. S. (2002) · Nature · doi:10.1038/nature01154 · Cited by 831 · see citing works
Mosher, D. S., Quignon, P., Bustamante, C. D., Sutter, N. B., Mellersh, C. S., Parker, H. G., & Ostrander, E. A. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030079 · Cited by 826 · see citing works
Myasthenia gravis activities of daily living profile
Wolfe, G. I., Herbelin, L. L., Nations, S., Foster, B., Bryan, W. W., & Barohn, R. J. (1999) · Neurology · doi:10.1212/wnl.52.7.1487 · Cited by 577 · see citing works
Self-citationRandomized, Double-Blind Six-Month Trial of Prednisone in Duchenne's Muscular Dystrophy
Mendell, J. R., Moxley, R. T., Griggs, R. C., Brooke, M. H., Fenichel, G. M., Miller, J. P., King, W. M., Signore, L., Pandya, S., Florence, J. M., et al. (1989) · New England Journal of Medicine · doi:10.1056/nejm198906153202405 · Cited by 520 · see citing works
Self-citationGuidelines for treatment of autoimmune neuromuscular transmission disorders
SKEIE, G. O., Apostolski, S., Evoli, A., Gilhus, N. E., Illa, I., Harms, L., Hilton‐Jones, D., Melms, A., Verschuuren, J. J. G. M., & Horge, H. W. (2010) · European Journal of Neurology · doi:10.1111/j.1468-1331.2010.03019.x · Cited by 513 · see citing works
Inhibition of myostatin in adult mice increases skeletal muscle mass and strength
Whittemore, L.-A., Song, K., Li, X., Aghajanian, J. D., Davies, M. V., Girgenrath, S., Hill, J. J., Jalenak, M., Kelley, P. E., Knight, A., et al. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02953-4 · Cited by 503 · see citing works
A randomized double‐blind trial of prednisolone alone or with azathioprine in myasthenia gravis
Palace, J. A., Newsom–Davis, J., Lecky, B. R. F., & Myasthenia Gravis Study Group (1998) · Neurology · doi:10.1212/wnl.50.6.1778 · Cited by 471 · see citing works
Reliability Testing of the Quantitative Myasthenia Gravis Score a
Barohn, R. J., McIntire, D. D., Herbelin, L. L., Wolfe, G. I., Nations, S., & Bryan, W. W. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb11015.x · Cited by 417 · see citing works
Self-citationLoss of myostatin attenuates severity of muscular dystrophy in mdx mice
Wagner, K. R., McPherron, A. C., Winik, N., & Lee, S. (2002) · Annals of Neurology · doi:10.1002/ana.10385 · Cited by 378 · see citing works
Self-citationBrooke, M. H., Fenichel, G. M., Griggs, R. C., Mendell, J. R., Moxley, R. T., Miller, J. P., & Province, M. A. (1983) · Muscle & Nerve · doi:10.1002/mus.880060204 · Cited by 353 · see citing works
Self-citationAdverse Gastrointestinal Effects of Mycophenolate Mofetil
Behrend, M. (2001) · Drug Safety · doi:10.2165/00002018-200124090-00002 · Cited by 325 · see citing works
Mycophenolate mofetil: A safe and promising immunosuppressant in neuromuscular diseases
Chaudhry, V., Cornblath, D. R., Griffin, J. W., O’Brien, R., & Drachman, D. B. (2001) · Neurology · doi:10.1212/wnl.56.1.94 · Cited by 258 · see citing works
Girgenrath, S., Song, K., & Whittemore, L.-A. (2004) · Muscle & Nerve · doi:10.1002/mus.20175 · Cited by 228 · see citing works
Immunosuppressive agents for myasthenia gravis
Hart, I. K., Sathasivam, S., & Sharshar, T. (2007) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005224.pub2 · Cited by 212 · see citing works
Randomized, double-blind, placebo-controlled trial of albuterol in facioscapulohumeral dystrophy
Kissel, J. T., McDermott, M. P., Mendell, J. R., King, W. M., Pandya, S. K., Griggs, R. C., Tawil, R., & the FSH-DY Group (2001) · Neurology · doi:10.1212/wnl.57.8.1434 · Cited by 190 · see citing works
Self-citationMuscle regeneration in the prolonged absence of myostatin
Wagner, K. R., Liu, X., Chang, X., & Allen, R. E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408729102 · Cited by 186 · see citing works
Self-citationMycophenolate mofetil for myasthenia gravis: An open-label pilot study
Ciafaloni, E., Massey, J. M., Lipscomb, B., & Sanders, D. B. (2001) · Neurology · doi:10.1212/wnl.56.1.97 · Cited by 183 · see citing works
Limb-Girdle Muscular Dystrophy in the United States
Moore, S. A., Shilling, C. J., Westra, S., Wall, C., Wicklund, M., Stolle, C. A., Brown, C. A., Michele, D. E., Piccolo, F., Winder, T. L., et al. (2006) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000235854.77716.6c · Cited by 179 · see citing works
Self-citationCorticosteroids for myasthenia gravis
Schneider‐Gold, C., Gajdos, P., Toyka, K. V., & Hohlfeld, R. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002828.pub2 · Cited by 174 · see citing works
Creatine monohydrate in muscular dystrophies: A double-blind, placebo-controlled clinical study
Walter, M. C., Lochmüller, H., Reilich, P., Klopstock, T., Huber, R., Hartard, M., Hennig, M., Pongratz, D. E., & Müller‐Felber, W. (2000) · Neurology · doi:10.1212/wnl.54.9.1848 · Cited by 169 · see citing works
Phase I Study of Dystrophin Plasmid-Based Gene Therapy in Duchenne/Becker Muscular Dystrophy
Romero, N. B., Braun, S., Benvéniste, O., Leturcq, F., Hogrel, J., Morris, G. E., Barois, A., Eymard, B., Payan, C., Ortega, V., et al. (2004) · Human Gene Therapy · doi:10.1089/hum.2004.15.1065 · Cited by 153 · see citing works
Mycophenolate mofetil for myasthenia gravis
Meriggioli, M. N., Ciafaloni, E., Al‐Hayk, K., Rowin, J., Lipscomb, B., Massey, J. M., & Sanders, D. B. (2003) · Neurology · doi:10.1212/01.wnl.0000094122.88929.0b · Cited by 146 · see citing works
Martinez Elizondo, P. (1952) · PubMed · Cited by 135 · see citing works
(1997) · Neurology · doi:10.1212/wnl.48.1.38 · Cited by 131 · see citing works
Mowzoon, N., Sussman, A. T., & Bradley, W. G. (2001) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(01)00478-6 · Cited by 124 · see citing works
Mycophenolate Mofetil for Myasthenia Gravis A Double‐Blind, Placebo‐Controlled Pilot Study
Meriggioli, M. N., Rowin, J., RICHMAN, J. G., & Leurgans, S. E. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1254.064 · Cited by 110 · see citing works
A Pilot Trial of Prednisone in Facioscapulohumeral Muscular Dystrophy
Tawil, R., McDermott, M., Pandya, S. K., King, W. M., Kissel, J. T., Mendell, J. R., & Griggs, R. C. (1997) · Neurology · doi:10.1212/wnl.48.1.46 · Cited by 103 · see citing works
Self-citationMyostatin inhibition slows muscle atrophy in rodent models of amyotrophic lateral sclerosis
Holzbaur, E. L. F., Howland, D., Weber, N., Wallace, K. E., She, Y., Kwak, S., Tchistiakova, L. A., Murphy, E. K., Hinson, J., Karim, R., et al. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.05.009 · Cited by 101 · see citing works
Facioscapulohumeral muscular dystrophy (FSHD)
Tawil, R., McDermott, M. P., Mendell, J. R., Kissel, J. T., Griggs, R. C., & FSH-DY Group (1994) · Neurology · doi:10.1212/wnl.44.3_part_1.442 · Cited by 98 · see citing works
Self-citationInflammation and response to steroid treatment in limb-girdle muscular dystrophy 2I
Darín, N., Kroksmark, A., Ahlander, A., Moslemi, A. ‐., Oldfors, A., & Tulinius, M. (2007) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2007.02.018 · Cited by 96 · see citing works
Pilot trial of albuterol in facioscapulohumeral muscular dystrophy
Kissel, J. T., McDermott, M. P., Natarajan, R., Mendell, J. R., Pandya, S., King, W. M., Griggs, R. C., Tawil, R., & The FSH-DY Group* (1998) · Neurology · doi:10.1212/wnl.50.5.1402 · Cited by 86 · see citing works
Self-citationPublic health impact of adverse bone effects of oral corticosteroids
van Staa, T. P., Abenhaim, L., Cooper, C. C., Zhang, B., & Leufkens, H. G. M. (2001) · British Journal of Clinical Pharmacology · doi:10.1046/j.0306-5251.2001.1385.x · Cited by 74 · see citing works
Angelini, C. I., Fanin, M., Menegazzo, E., Freda, M. P., Duggan, D. J., & Hoffman, E. P. (1998) · Muscle & Nerve · doi:10.1002/(sici)1097-4598(199806)21:6 · Cited by 71 · see citing works
Hauser, R. A., Malek, A. R., & Rosen, R. (1998) · Neurology · doi:10.1212/wnl.51.3.912-a · Cited by 71 · see citing works
Creatine monohydrate in myotonic dystrophy
Walter, M. C., Reilich, P., Lochmüller, H., Kohnen, R., Schlotter, B., Hautmann, H., Dunkl, E., Pongratz, D. E., & M�ller-Felber, W. (2002) · Journal of Neurology · doi:10.1007/s00415-002-0923-x · Cited by 61 · see citing works
Valeriani, M., Pera, D. L., Niddam, D. M., Arendt‐Nielsen, L., & Chen, A. C. N. (2000) · Muscle & Nerve · doi:10.1002/1097-4598(200008)23:8 · Cited by 51 · see citing works
Mycophenolate Mofetil in the Therapy of Severe Myasthenia gravis
Schneider‐Gold, C., Gold, R., Reiners, K., & Toyka, K. V. (2001) · European Neurology · doi:10.1159/000050768 · Cited by 48 · see citing works
?Liver function tests? are not always tests of liver function
Korones, D. N., Brown, M. R., & Palis, J. (2000) · American Journal of Hematology · doi:10.1002/1096-8652(200101)66:1 · Cited by 47 · see citing works
Meriggioli, M. N., & Rowin, J. (2003) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-200309000-00011 · Cited by 36 · see citing works
Rózsa, C., Lovas, G., Fornádi, L., Szabó, G., & Komoly, S. (2006) · European Journal of Neurology · doi:10.1111/j.1468-1331.2006.01382.x · Cited by 28 · see citing works
PILOT TRIAL OF DILTIAZEM IN FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY
Elsheikh, B., Bollman, E., Peruggia, M., King, W. M., Galloway, G., & Kissel, J. T. (2007) · Neurology · doi:10.1212/01.wnl.0000264017.08217.39 · Cited by 28 · see citing works
Self-citationEpidemiology of allergic drug reactions.
Hoigné, R., Schlumberger, H. P., VERVLOET, D., & Zoppi, M. (1993) · PubMed · Cited by 25 · see citing works
Unsupervised statistical segmentation of multispectral volumetric MRI images
Tamez‐Peña, J. G., Totterman, S. M. S., & Parker, K. J. (1999) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.348585 · Cited by 23 · see citing works
The natural course of myasthenia gravis.
Fonseca, V., & Havard, C. W. H. (1990) · BMJ · doi:10.1136/bmj.300.6737.1409 · Cited by 22 · see citing works
Caponnetto, C., Rossi, E. G., & Primavera, A. (2001) · European Neurology · doi:10.1159/000050759 · Cited by 19 · see citing works
Mycophenolate mofetil and myasthenia gravis
Ciafaloni, E. (2005) · Lupus · doi:10.1191/0961203305lu2118oa · Cited by 19 · see citing works
Kotani, A., Takahashi, A., Koga, H., Morita, R., Fukuyama, H., Ichinohe, T., Ishikawa, T., Hori, T., & Uchiyama, T. (2002) · European Journal Of Haematology · doi:10.1034/j.1600-0609.2002.02789.x · Cited by 14 · see citing works
Prakash, K. M., Ratnagopal, P., Puvanendran, K., & Lo, Y. L. (2006) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2005.12.008 · Cited by 13 · see citing works
Motor unit discharge behaviors in stroke patients
Yan, K., Fang, J., & Shahani, B. T. (1998) · Muscle & Nerve · doi:10.1002/(sici)1097-4598(199811)21:11 · Cited by 12 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 3
- Tawil R, McDermott MP, Mendell J, et al. Facioscapulo- humeral muscular dystrophy (FSHD): design of natural history study and results of baseline testing. FSH-DY Group. Neurol- ogy 1994;44:442-446.
- Ware JE, Sherbourne CD. The MOS 36-Item Short-Form Health Survey (SF-36). Med Care 1992;30:473-483.
- Connolly AM, Pestronk A, Mehta S, Al-Lozi M. Primary alpha-sarcoglycan deficiency responsive to immunosuppression over three years. Muscle Nerve 1998;21:1549 -1553.
Cited by
Sorted by citations
Dent, E., Morley, J. E., Cruz-Jentoft, A. J., Arai, H., Kritchevsky, S. B., Guralnik, J., Bauer, J. M., Pahor, M., Clark, B. C., Cesari, M., et al. (2018) · The Journal of nutrition, health and aging · doi:10.1007/s12603-018-1139-9 · Cited by 1,130 · see citing works
Maltais, F., Decramer, M., Casaburi, R. H., Barreiro, E., Burelle, Y., Debigaré, R., Dekhuijzen, P. N. R., Franssen, F. M. E., Gayan‐Ramirez, G., Gea, J., et al. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201402-0373st · Cited by 1,113 · see citing works
Mechanisms of muscle atrophy and hypertrophy: implications in health and disease
Sartori, R., Romanello, V., & Sandri, M. (2021) · Nature Communications · doi:10.1038/s41467-020-20123-1 · Cited by 940 · see citing works
Exercise is the real polypill.
Fiuza-Luces, C., Garatachea, N., Berger, N. A., & Lucia, A. (2013) · Physiology · doi:10.1152/physiol.00019.2013 · Cited by 791 · see citing works
Mechanisms of muscle wasting in chronic kidney disease
Wang, X. H., & Mitch, W. E. (2014) · Nature Reviews Nephrology · doi:10.1038/nrneph.2014.112 · Cited by 630 · see citing works
Smad2 and 3 transcription factors control muscle mass in adulthood
Sartori, R., Milan, G., Patron, M., Mammucari, C., Blaauw, B., Abraham, R., & Sandri, M. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00104.2009 · Cited by 517 · see citing works
Role of Skeletal Muscle in Insulin Resistance and Glucose Uptake
Merz, K. E., & Thurmond, D. C. (2020) · Comprehensive Physiology · doi:10.1002/cphy.c190029 · Cited by 494 · see citing works
Ryanodine receptor oxidation causes intracellular calcium leak and muscle weakness in aging
Andersson, D. C., Betzenhauser, M. J., Reiken, S., Meli, A. C., Umanskaya, A., Xie, W., Shiomi, T., Zalk, R., Lacampagne, A., & Marks, A. R. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.05.014 · Cited by 424 · see citing works
Skeletal muscle atrophy: From mechanisms to treatments
Yin, L., Li, N., Jia, W., Wang, N., Liang, M., Yang, X., & Du, G. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105807 · Cited by 408 · see citing works
The role of myostatin in muscle wasting: an overview
Elkina, Y., von Haehling, S., Anker, S. D., & Springer, J. (2011) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1007/s13539-011-0035-5 · Cited by 349 · see citing works
Zhang, L., Rajan, V. R., Lin, E., Hu, Z., Han, H. Q., Zhou, X., Song, Y., Min, H., Wang, X., Du, J., et al. (2011) · The FASEB Journal · doi:10.1096/fj.10-176917 · Cited by 317 · see citing works
Lach-Trifilieff, E., Minetti, G. C., Sheppard, K., Ibebunjo, C., Feige, J. N., Hartmann, S., Brachat, S., Rivet, H., Koelbing, C., Morvan, F., et al. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.01307-13 · Cited by 306 · see citing works
Optimal management of sarcopenia
Sumukadas, D. (2010) · Clinical Interventions in Aging · doi:10.2147/cia.s11473 · Cited by 303 · see citing works
The Pathogenesis and Therapy of Muscular Dystrophies
Guiraud, S., Aartsma-Rus, A. M., Vieira, N. M., Davies, K. E., van Ommen, G. B., & Kunkel, L. M. (2015) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-090314-025003 · Cited by 297 · see citing works
A review of sarcopenia: Enhancing awareness of an increasingly prevalent disease
Marty, E., Liu, Y., Samuel, A. M., Or, O., & Lane, J. (2017) · Bone · doi:10.1016/j.bone.2017.09.008 · Cited by 291 · see citing works
Role of Skeletal Muscle in Insulin Resistance and Glucose Uptake
Merz, K. E., & Thurmond, D. C. (2020) · Comprehensive physiology · doi:10.1002/j.2040-4603.2020.tb00136.x · Cited by 283 · see citing works
A Phase 1/2a Follistatin Gene Therapy Trial for Becker Muscular Dystrophy
Mendell, J. R., Sahenk, Z., Malik, V., Gomez, A. M., Flanigan, K. M., Lowes, L. P., Alfano, L. N., Berry, K., Meadows, E., Lewis, S., et al. (2014) · Molecular Therapy · doi:10.1038/mt.2014.200 · Cited by 246 · see citing works
Self-citationCampbell, C., McMillan, H. J., Mah, J. K., Tarnopolsky, M. A., Selby, K. A., McClure, T., Wilson, D. M., Sherman, M. L., Escolar, D. M., & Attie, K. M. (2016) · Muscle & Nerve · doi:10.1002/mus.25268 · Cited by 240 · see citing works
Self-citationPharmacologic Options for the Treatment of Sarcopenia
Morley, J. E. (2016) · Calcified Tissue International · doi:10.1007/s00223-015-0022-5 · Cited by 225 · see citing works
Muscle hypertrophy driven by myostatin blockade does not require stem/precursor-cell activity
Amthor, H., Otto, A., Vulin, A., Rochat, A., Dumonceaux, J., Garcı́a, L., Mouisel, É., Hourdé, C., Macharia, R., Friedrichs, M., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811129106 · Cited by 195 · see citing works
Inhibition of myostatin with emphasis on follistatin as a therapy for muscle disease
Rodino‐Klapac, L. R., Haidet, A. M., Kota, J., Handy, C., Kaspar, B. K., & Mendell, J. R. (2009) · Muscle & Nerve · doi:10.1002/mus.21244 · Cited by 194 · see citing works
Self-citationCurrent status of pharmaceutical and genetic therapeutic approaches to treat DMD.
Pichavant, C., Aartsma-Rus, A., Clemens, P., Davies, K., Dickson, G., Takeda, S., Wilton, S., Wolff, J., Wooddell, C., Xiao, X., et al. (2011) · Molecular Therapy · doi:10.1038/mt.2011.59 · Cited by 202 · see citing works
Pathogenesis of the Limb Manifestations and Exercise Limitations in Peripheral Artery Disease
Hiatt, W. R., Armstrong, E. J., Larson, C. J., & Brass, E. P. (2015) · Circulation Research · doi:10.1161/circresaha.116.303566 · Cited by 192 · see citing works
Carlier, P. G., Marty, B., Scheidegger, O., Loureiro de Sousa, P., Baudin, P.-Y., Snezhko, E., & Vlodavets, D. (2016) · Journal of Neuromuscular Diseases · doi:10.3233/jnd-160145 · Cited by 186 · see citing works
Activin A more prominently regulates muscle mass in primates than does GDF8
Latres, E., Mastaitis, J., Fury, W., Miloscio, L., Trejos, J., Pangilinan, J., Okamoto, H., Cavino, K., Na, E., Papatheodorou, A., et al. (2017) · Nature Communications · doi:10.1038/ncomms15153 · Cited by 185 · see citing works
The central role of myostatin in skeletal muscle and whole body homeostasis
Elliott, B., Renshaw, D. W., Getting, S. J., & Mackenzie, R. (2012) · Acta Physiologica · doi:10.1111/j.1748-1716.2012.02423.x · Cited by 183 · see citing works
TGFβ and BMP signaling in skeletal muscle: potential significance for muscle-related disease
Sartori, R., Gregorevic, P., & Sandri, M. (2014) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2014.06.002 · Cited by 177 · see citing works
A single ascending‐dose study of muscle regulator ace‐031 in healthy volunteers
Attie, K. M., Borgstein, N. G., Yang, Y., Condon, C. H., Wilson, D. M., Pearsall, A. E., Kumar, R., Willins, D. A., Seehra, J. S., & Sherman, M. L. (2012) · Muscle & Nerve · doi:10.1002/mus.23539 · Cited by 176 · see citing works
Duchenne muscular dystrophy: disease mechanism and therapeutic strategies
Angulski, A. B. B., Hosny, N., Cohen, H., Martin, A. A., Hahn, D., Bauer, J., & Metzger, J. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1183101 · Cited by 166 · see citing works
Sex-specific differences in risk factors for sarcopenia amongst community-dwelling older adults
Tay, L. B. G., Ding, Y. Y., Leung, B. P. L., Ismail, N. H., Yeo, A., Yew, S., Tay, K. S., Tan, C. H., & Chong, M. S. (2015) · AGE · doi:10.1007/s11357-015-9860-3 · Cited by 174 · see citing works
Muscle–bone interactions: basic and clinical aspects
Cianferotti, L., & Brandi, M. L. (2013) · Endocrine · doi:10.1007/s12020-013-0026-8 · Cited by 168 · see citing works
Follistatin Gene Delivery Enhances Muscle Growth and Strength in Nonhuman Primates
Kota, J., Handy, C. R., Haidet, A. M., Montgomery, C. L., Eagle, A., Rodino‐Klapac, L. R., Tucker, D., Shilling, C. J., Therlfall, W. R., Walker, C. M., et al. (2009) · Science Translational Medicine · doi:10.1126/scitranslmed.3000112 · Cited by 166 · see citing works
Self-citationMechanisms Underlying Metabolic Syndrome-Related Sarcopenia and Possible Therapeutic Measures
Rubio-Ruiz, M. E., Guarner‐Lans, V., Pérez-Torres, I., & Soto, M. E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030647 · Cited by 166 · see citing works
Perturbed BMP signaling and denervation promote muscle wasting in cancer cachexia
Sartori, R., Hagg, A., Zampieri, S., Armani, A., Winbanks, C. E., Viana, L. R., Haidar, M., Watt, K. I., Qian, H., Pezzini, C., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.aay9592 · Cited by 158 · see citing works
Muscle-bone interactions: From experimental models to the clinic? A critical update
Laurent, M. R., Dubois, V., Claessens, F., Verschueren, S., Vanderschueren, D., Gielen, E., & Jardí, F. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.10.017 · Cited by 152 · see citing works
Myostatin inhibitors as therapies for muscle wasting associated with cancer and other disorders
Smith, R. C., & Lin, B. K. (2013) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0000000000000013 · Cited by 151 · see citing works
Targeting Fibrosis in Duchenne Muscular Dystrophy
Zhou, L., & Lu, H. (2010) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181e9a34b · Cited by 149 · see citing works
Targeting the myostatin signaling pathway to treat muscle loss and metabolic dysfunction
Lee, S. (2021) · Journal of Clinical Investigation · doi:10.1172/jci148372 · Cited by 147 · see citing works
Sarcopenic obesity: how do we treat it?
Bouchonville, M. F., & Villareal, D. T. (2013) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/01.med.0000433071.11466.7f · Cited by 141 · see citing works
Wang, L. H., & Tawil, R. (2016) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-016-0667-0 · Cited by 141 · see citing works
Self-citationSarcopenia and cachexia: the adaptations of negative regulators of skeletal muscle mass
Sakuma, K., & Yamaguchi, A. (2012) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1007/s13539-011-0052-4 · Cited by 137 · see citing works
Facioscapulohumeral muscular dystrophy
van der Maarel, S. M., Frants, R. R., & Padberg, G. W. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2006.05.009 · Cited by 137 · see citing works
Mariot, V., Joubert, R., Hourdé, C., Féasson, L., Hanna, M. G., Francesco Muntoni, A., Maisonobe, T., Servais, L., Bogni, C., Panse, R. L., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01486-4 · Cited by 136 · see citing works
Myostatin and its Regulation: A Comprehensive Review of Myostatin Inhibiting Strategies
Baig, M. H., Ahmad, K., Moon, J. S., Park, S.-Y., Ho Lim, J., Chun, H. J., Qadri, A. F., Hwang, Y. C., Jan, A. T., Ahmad, S. S., et al. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.876078 · Cited by 135 · see citing works
Cadena, S. M., Tomkinson, K. N., Monnell, T. E., Spaits, M. S., Kumar, R., Underwood, K. W., Pearsall, R. S., & Lachey, J. L. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00866.2009 · Cited by 135 · see citing works
Microdystrophin Ameliorates Muscular Dystrophy in the Canine Model of Duchenne Muscular Dystrophy
Shin, J., Pan, X., Hakim, C. H., Yang, H. T., Yue, Y., Zhang, K., Terjung, R. L., & Duan, D. (2013) · Molecular Therapy · doi:10.1038/mt.2012.283 · Cited by 133 · see citing works
Interaction Between Bone and Muscle in Older Persons with Mobility Limitations
Ferrucci, L., Baroni, M., Ranchelli, A., Lauretani, F., Maggio, M. G., Mecocci, P., & Ruggiero, C. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113196660690 · Cited by 132 · see citing works
Myostatin from the heart: local and systemic actions in cardiac failure and muscle wasting
Breitbart, A., Auger‐Messier, M., Molkentin, J. D., & Heineke, J. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00200.2011 · Cited by 131 · see citing works
Sarcopenia - Mechanisms and Treatments
Jones, T. E., Stephenson, K. W., King, J. G., Knight, K. R., Marshall, T. L., & Scott, W. B. (2009) · Journal of Geriatric Physical Therapy · doi:10.1519/00139143-200932020-00008 · Cited by 129 · see citing works
Facioscapulohumeral Muscular Dystrophy
Tawil, R. (2008) · Neurotherapeutics · doi:10.1016/j.nurt.2008.07.005 · Cited by 129 · see citing works
Self-citationRecent advances in the biology and therapy of muscle wasting
Glass, D. J., & Roubenoff, R. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05809.x · Cited by 127 · see citing works
Zhu, J., Li, Y., Lu, A., Gharaibeh, B., Ma, J., Kobayashi, T., Quintero, A., & Huard, J. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.04.008 · Cited by 124 · see citing works
Dimachkie, M. M., & Barohn, R. J. (2014) · Neurologic Clinics · doi:10.1016/j.ncl.2014.04.001 · Cited by 122 · see citing works
Self-citationFrailty, Sarcopenia, and Hormones
Morley, J. E., & Malmstrom, T. K. (2013) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2013.02.006 · Cited by 122 · see citing works
Limb–girdle muscular dystrophies
Guglieri, M., Straub, V. W., Bushby, K., & Lochmüller, H. (2008) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32830efdc2 · Cited by 122 · see citing works
Self-citationFacioscapulohumeral Muscular Dystrophy
Statland, J. M., & Tawil, R. (2016) · Continuum · doi:10.1212/con.0000000000000399 · Cited by 121 · see citing works
Self-citationGene therapy for muscular dystrophy: Lessons learned and path forward
Mendell, J. R., Rodino‐Klapac, L. R., Sahenk, Z., Malik, V., Kaspar, B. K., Walker, C. M., & Clark, K. R. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.04.078 · Cited by 120 · see citing works
Self-citationCan we identify a power-oriented polygenic profile?
Ruiz, J. R., Arteta, D., Buxens, A., Artieda, M., Gómez‐Gallego, F., Santiago, C., Yvert, T. P., Morán, M., & Lucía, A. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01242.2009 · Cited by 114 · see citing works
Lakshman, K. M., Bhasin, S., Corcoran, C., Collins‐Racie, L. A., Tchistiakova, L., Forlow, S. B., Ledger, K. S., Burczynski, M. E., Dorner, A. J., & LaVallie, E. R. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.12.019 · Cited by 113 · see citing works
Self-citationPistilli, E. E., Bogdanovich, S., Goncalves, M. D., Ahima, R. S., Lachey, J. L., Seehra, J. S., & Khurana, T. S. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2010.11.071 · Cited by 112 · see citing works
Specific inhibition of myostatin activation is beneficial in mouse models of SMA therapy
Long, K. K., O’Shea, K. M., Khairallah, R. J., Howell, K., Paushkin, S. V., Chen, K. S., Cote, S. M., Webster, M. T., Stains, J. P., Treece, E. R., et al. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy382 · Cited by 112 · see citing works
Myostatin/Activin Receptor Ligands in Muscle and the Development Status of Attenuating Drugs
Rodgers, B. D., & Ward, C. W. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnab030 · Cited by 111 · see citing works
Therapies for Musculoskeletal Disease: Can we Treat Two Birds with One Stone?
Girgis, C. M., Mokbel, N., & DiGirolamo, D. J. (2014) · Current Osteoporosis Reports · doi:10.1007/s11914-014-0204-5 · Cited by 110 · see citing works
Molecular Mechanisms and Treatment Options for Muscle Wasting Diseases
Rüegg, M. A., & Glass, D. J. (2011) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010510-100537 · Cited by 109 · see citing works
Elevated Myostatin Levels in Patients with Liver Disease
García, P. S., Cabbabe, A., Kambadur, R., Nicholas, G., & CSETE, M. E. (2010) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e3181eac1c9 · Cited by 107 · see citing works
Rose, F. F., Mattis, V. B., Rindt, H., & Lorson, C. L. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn426 · Cited by 106 · see citing works
Can Exercise Teach Us How to Treat Heart Disease?
Mann, N., & Rosenzweig, A. (2012) · Circulation · doi:10.1161/circulationaha.111.060376 · Cited by 105 · see citing works
Ratkevičius, A., Joyson, A., Selmer, I.-S., Dhanani, T., Grierson, C., Tommasi, A. M., DeVries, A., Rauchhaus, P., Crowther, D. J., Alesci, S., et al. (2011) · The Journals of Gerontology Series A · doi:10.1093/gerona/glr025 · Cited by 104 · see citing works
Cell–matrix interactions in muscle disease
Carmignac, V., & Durbeej, M. (2011) · The Journal of Pathology · doi:10.1002/path.3020 · Cited by 100 · see citing works
Andre, M. S., Johnson, M. C., Bansal, P. N., Wellen, J. W., Robertson, A. W., Opsahl, A., Burch, P. M., Bialek, P., Morris, C. A., & Owens, J. M. (2017) · Skeletal Muscle · doi:10.1186/s13395-017-0141-y · Cited by 101 · see citing works
Emerging drugs for Duchenne muscular dystrophy
Malik, V., Rodino‐Klapac, L. R., & Mendell, J. R. (2012) · Expert Opinion on Emerging Drugs · doi:10.1517/14728214.2012.691965 · Cited by 98 · see citing works
Self-citationMRI as outcome measure in facioscapulohumeral muscular dystrophy: 1-year follow-up of 45 patients
Andersen, G., Dahlqvist, J. R., Vissing, C. R., Heje, K., Thomsen, C. E., & Vissing, J. (2016) · Journal of Neurology · doi:10.1007/s00415-016-8361-3 · Cited by 98 · see citing works
Tawil, R., van der Maarel, S. M., Padberg, G. W., & van Engelen, B. G. M. (2010) · Neuromuscular Disorders · doi:10.1016/j.nmd.2010.04.007 · Cited by 97 · see citing works
Self-citationFacioscapulohumeral Muscular Dystrophy: Update on Pathogenesis and Future Treatments
Hamel, J., & Tawil, R. (2018) · Neurotherapeutics · doi:10.1007/s13311-018-00675-3 · Cited by 96 · see citing works
Self-citationBlocking extracellular activation of myostatin as a strategy for treating muscle wasting
Pirruccello, M., Jackson, J., Wawersik, S., Webster, M. T., Salta, L., Long, K. K., McConaughy, W., Capili, A. D., Boston, C., Carven, G. J., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-20524-9 · Cited by 94 · see citing works
Whole‐body magnetic resonance imaging evaluation of facioscapulohumeral muscular dystrophy
Leung, D. G., Carrino, J. A., Wagner, K. R., & Jacobs, M. A. (2015) · Muscle & Nerve · doi:10.1002/mus.24569 · Cited by 89 · see citing works
Self-citationShrikrishna, D., Astin, R., Kemp, P. R., & Hopkinson, N. S. (2012) · Clinical Science · doi:10.1042/cs20120081 · Cited by 89 · see citing works
Qiao, C., Li, J., Zheng, H., Bogan, J. R., Li, J., Yuan, Z., Zhang, C., Bogan, D., Kornegay, J. N., & Xiao, X. (2009) · Human Gene Therapy · doi:10.1089/hum.2008.135 · Cited by 90 · see citing works
Proserpio, V., Fittipaldi, R., Ryall, J. G., Sartorelli, V., & Caretti, G. (2013) · Genes & Development · doi:10.1101/gad.217240.113 · Cited by 90 · see citing works
Facioscapulohumeral Muscular Dystrophy
Statland, J. M., & Tawil, R. (2014) · Neurologic Clinics · doi:10.1016/j.ncl.2014.04.003 · Cited by 87 · see citing works
Self-citationMyostatin Inhibitors: Panacea or Predicament for Musculoskeletal Disorders?
Suh, J., & Lee, Y. (2020) · Journal of Bone Metabolism · doi:10.11005/jbm.2020.27.3.151 · Cited by 86 · see citing works
Finanger, E. L., Russman, B. S., Forbes, S. C., Rooney, W. D., Walter, G. A., & Vandenborne, K. (2011) · Physical Medicine and Rehabilitation Clinics of North America · doi:10.1016/j.pmr.2011.11.004 · Cited by 86 · see citing works
Myostatin: a skeletal muscle chalone
Lee, S.-J. (2023) · Annual Review of Physiology · doi:10.1146/annurev-physiol-012422-112116 · Cited by 84 · see citing works
Abati, E., Manini, A., Comi, G. P., & Corti, S. P. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04408-w · Cited by 84 · see citing works
Engelke, K., Chaudry, O., Gast, L. V., Eldib, M., Wang, L., Larédo, J.-D., Schett, G. A., & Nagel, A. M. (2023) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2023.07.005 · Cited by 82 · see citing works
Padhi, D., Higano, C. S., Shore, N. D., SIEBER, P. R., Rasmussen, E., & Smith, M. R. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1271 · Cited by 81 · see citing works
Leung, D. G. (2016) · Journal of Neurology · doi:10.1007/s00415-016-8350-6 · Cited by 80 · see citing works
Matsakas, A., Foster, K., Otto, A., Macharia, R., Elashry, M. I., Feist, S. A., Graham, I. R., Foster, H., Yaworsky, P. J., Walsh, F. S., et al. (2009) · Neuromuscular Disorders · doi:10.1016/j.nmd.2009.06.367 · Cited by 80 · see citing works
Kodippili, K., Hakim, C. H., Pan, X., Yang, H. T., Yue, Y., Zhang, Y., Shin, J., Yang, N. N., & Duan, D. (2017) · Human Gene Therapy · doi:10.1089/hum.2017.095 · Cited by 80 · see citing works
Advances in the Treatment of Duchenne Muscular Dystrophy: New and Emerging Pharmacotherapies
Reinig, A. M., Mirzaei, S., & Berlau, D. J. (2017) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.1909 · Cited by 79 · see citing works
Muscle and cardiac therapeutic strategies for Duchenne muscular dystrophy: past, present, and future
Łoboda, A., & Dulak, J. (2020) · Pharmacological Reports · doi:10.1007/s43440-020-00134-x · Cited by 80 · see citing works
Dumonceaux, J., Marie, S., Beley, C., Trollet, C., Vignaud, A., Ferry, A., Butler-Browne, G. S., & Garcı́a, L. (2010) · Molecular Therapy · doi:10.1038/mt.2009.322 · Cited by 79 · see citing works
Genes and the ageing muscle: a review on genetic association studies
Garatachea, N., & Lucía, A. (2011) · AGE · doi:10.1007/s11357-011-9327-0 · Cited by 79 · see citing works
The Physiology of Sports Injuries and Repair Processes
Kelc, R., Naranđa, J., Kuhta, M., & Vogrin, M. (2013) · InTech eBooks · doi:10.5772/54234 · Cited by 78 · see citing works
Genes, physical fitness and ageing
Garatachea, N., & Lucía, A. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.09.003 · Cited by 79 · see citing works
Hamrick, M. W., Arounleut, P., Kellum, E., Cain, M. A., Immel, D., & Liang, L. (2010) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0b013e3181c451f4 · Cited by 77 · see citing works
Mendias, C. L., Kayupov, E., Bradley, J. R., Brooks, S. V., & Claflin, D. R. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00126.2011 · Cited by 76 · see citing works
Inhibition of myostatin does not ameliorate disease features of severe spinal muscular atrophy mice
Sumner, C. J., Wee, C. D., Warsing, L. C., Choe, D. W., Ng, A. S., Lutz, C. M., & Wagner, K. R. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp253 · Cited by 76 · see citing works
Self-citationViña, J., Tarazona‐Santabalbina, F. J., Pérez‐Ros, P., Martínez‐Arnau, F. M., Borrás, C., González, G. O., Salvador‐Pascual, A., & Gómez‐Cabrera, M. C. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.04.005 · Cited by 75 · see citing works
Trevino, M. B., Zhang, X., Standley, R. A., Wang, M., Han, X., Reis, F. C. G., Periasamy, M., Yu, G., Kelly, D. P., Goodpaster, B. H., et al. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00161.2019 · Cited by 74 · see citing works
- Authors
- Wagner, K. R., Fleckenstein, J. L., Amato, A. A., Barohn, R. J., Bushby, K., Escolar, D. M., Flanigan, K. M., Pestronk, A., Tawil, R., Wolfe, G. I., Eagle, M., Florence, J. M., King, W. M., Pandya, S., Straub, V., Juneau, P., Meyers, K., Csimma, C., Araujo, T., Allen, R., Parsons, S. A., Wozney, J. M., LaVallie, E. R., & Mendell, J. R.
- Affiliations
- Johns Hopkins University (US)
- University of Oklahoma - Tulsa (US)
- Brigham and Women's Hospital (US)
- University of Kansas Medical Center (US)
- Newcastle University (GB)
- Children's National (US)
- University of Utah (US)
- Washington University in St. Louis (US)
- University of Rochester Medicine (US)
- The University of Texas Southwestern Medical Center (US)
- Abigail Wexner Research Institute (US)
- Wyeth (US)
- Corresponding author
- Wagner, Kathryn R.
- ORCID
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2008-05
- Volume
- 63
- Issue
- 5
- Pages
- 561-571
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2166485013
- Cited by
- 481
- References
- 59
- Citations by year
- 2026: 21 · 2025: 17 · 2024: 15 · 2023: 12 · 2022: 22 · 2021: 25 · 2020: 26 · 2019: 17 · 2018: 26 · 2017: 29 · 2016: 28 · 2015: 29 · 2014: 32 · 2013: 25 · 2012: 42
- FWCI
- 15.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- Medical Research Council
- National Center for Research Resources (M01RR000052, M01RR023940)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Genetics › Neurogenetic and Muscular Disorders Research
- Health Sciences › Medicine › Epidemiology › Inflammatory Myopathies and Dermatomyositis
- Keywords
- myostatin inhibition, muscular dystrophy, Becker muscular dystrophy, facioscapulohumeral muscular dystrophy, limb-girdle muscular dystrophy, neutralizing antibodies, dose escalation, drug safety, skin hypersensitivity, muscle growth, muscle strength
- MeSH terms
- Adult, Antibodies, Drug Eruptions, Double-Blind Method, Female, Humans, Male, Muscular Dystrophies, Risk Factors, Cohort Studies, Comorbidity, Placebo Effect, Incidence, Treatment Outcome, Risk Assessment, Internationality
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review