G Protein-Coupled Receptor Heterocomplexes in Neuropsychiatric Disorders
Open accessAbstract
G protein-coupled receptors (or GPCRs) represent the largest family of membrane proteins in the human genome and are the target of approximately half of all therapeutic drugs. GPCRs contain a conserved structure of seven transmembrane domains. Their amino terminus is located extracellularly, whereas the carboxy terminus extends into the cytoplasm. Accumulating evidence suggests that GPCRs exist and function as monomeric entities. Nevertheless, more recent findings indicate that GPCRs can also form dimers or even higher order oligomers. The differential pharmacological and signaling properties of GPCR heteromeric complexes hint that their physiological effects may be different as compared to those obtained in tissue cultures that express a particular GPCR. In this chapter, we review current data on the role of GPCR heteromerization in receptor signaling, as well as its potential implication in neuropsychiatric disorders such as schizophrenia, depression, and Parkinson's disease.
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GPCRs form homodimers, heterodimers, oligomers, or complexes in the signalsomes of the membrane.
“GPCRs form homodimers, heterodimers, oligomers, or complexes in the signalsomes of the membrane [54].”
From G-protein-coupled receptor participates in 20-hydroxyecdysone signaling on the plasma membrane (2014) · cites this paper as [54]
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Self-citationSaha, S., & González‐Maeso, J. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110427
Self-citation
- Authors
- Moreno, J. L., Holloway, T., & González-Maeso, J.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Venue
- Progress in Molecular Biology and Translational Science
- Publisher
- Elsevier
- Published
- 2013
- Volume
- 117
- Pages
- 187-205
- ISSN
- 1877-1173 (ISSN-L)
- PMC
- PMC4844024
- OpenAlex
- W2461236563
- Cited by
- 30
- References
- 146
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2020: 1 · 2019: 1 · 2018: 4 · 2017: 5 · 2016: 5 · 2015: 3 · 2014: 5
- FWCI
- 5.68
- Type
- book chapter
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Progress in molecular biology and translational science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (R01MH084894)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- G protein-coupled receptors, receptor oligomerization, receptor dimerization, receptor signaling, neuropsychiatric disorders, schizophrenia, depression, Parkinson's disease
- MeSH terms
- Animals, Mental Disorders, Humans, Models, Molecular, Receptors, G-Protein-Coupled, Multiprotein Complexes
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