Vitamin D Endocrine System and the Immune Response in Rheumatic Diseases
Abstract
Epidemiological evidence indicates a significant association between vitamin D deficiency and an increased incidence of autoimmune diseases. The presence of vitamin D receptors (VDRs) in the cells of the immune system and the fact that several of these cells produce the vitamin D hormone suggested that vitamin D could have immunoregulatory properties, and now potent immunomodulatory activities on dendritic cells, Th1 and Th17 cells, as well as B cells have been confirmed. Serum levels of vitamin D have been found to be significantly lower in patients with systemic lupus erythematosus, undifferentiated connective tissue disease, and type-1 diabetes mellitus than in the healthy population. In addition, it was also found that lower levels of vitamin D were associated with higher disease activity in rheumatoid arthritis. Promising clinical results together with evidence for the regulation of multiple immunomodulatory mechanisms by VDR agonists represent a sound basis for further exploration of their potential in the treatment of rheumatic autoimmune disorders.
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Vitamin D fosters many aspects of innate immunity but inhibits adaptive immunity toward a T helper type 1 and T helper type 17 direction.
“Vitamin D was described to foster many aspects of innate immunity but inhibits adaptive immunity toward a T helper type 1 and T helper type 17 direction [100].”
From Interaction of the endocrine system with inflammation: a function of energy and volume regulation (2014) · cites this paper as [100]
Hypovitaminosis D is a general phenomenon in many chronic inflammatory diseases.
“Hypovitaminosis D is a general phenomenon in many CIDs [100].”
From Interaction of the endocrine system with inflammation: a function of energy and volume regulation (2014) · cites this paper as [100]
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Interaction of the endocrine system with inflammation: a function of energy and volume regulation
Straub, R. H. (2014) · Arthritis Research & Therapy · doi:10.1186/ar4484 · Cited by 121 · see citing works
“Hypovitaminosis D is a general phenomenon in many CIDs [100].”
Background
- Authors
- Cutolo, M., Plebani, M., Shoenfeld, Y., Adorini, L., & Tincani, A.
- Affiliations
- University of Genoa (IT)
- University of Padua (IT)
- Tel Aviv University (IL)
- Venue
- Vitamins & Hormones
- Publisher
- Elsevier
- Published
- 2011
- Volume
- 86
- Pages
- 327-351
- ISSN
- 0083-6729 (ISSN-L)
- OpenAlex
- W1599146062
- Cited by
- 86
- References
- 84
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 6 · 2022: 4 · 2021: 12 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 4 · 2016: 7 · 2015: 6 · 2014: 8 · 2013: 8 · 2012: 20
- FWCI
- 45.75
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Vitamins and hormones (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Keywords
- vitamin D, vitamin D receptor, immunomodulation, autoimmune disease, rheumatic diseases, systemic lupus erythematosus, connective tissue diseases, type 1 diabetes, rheumatoid arthritis, dendritic cells, Th1 cells, Th17 cells, B cells, VDR agonists, vitamin D deficiency
- MeSH terms
- Animals, Autoimmune Diseases, Combined Modality Therapy, Endocrine System Diseases, Endocrine System, Humans, Immunity, Psoriasis, Rheumatic Diseases, Vitamin D, Receptors, Calcitriol, Antirheumatic Agents, Dietary Supplements, Immunomodulation
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