EULAR recommendations for the management of systemic lupus erythematosus. Report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics

Bertsias, G; Ioannidis, J P A; Boletis, J; Bombardieri, S; Cervera, R; Dostal, C; Font, J; Gilboe, I M; Houssiau, F; Huizinga, T; Isenberg, D; Kallenberg, C G M; Khamashta, M; Piette, J C; Schneider, M; Smolen, J; Sturfelt, G; Tincani, A; van Vollenhoven, R; Gordon, C; Boumpas, D T

doi:10.1136/ard.2007.070367

Cited by 762Systemic Lupus Erythematosus ResearchSystemic Sclerosis and Related DiseasesClinical practice guidelines implementation

EULAR recommendations for the management of systemic lupus erythematosus. Report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics

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Bertsias, G, Ioannidis, J P A, Boletis, J, Bombardieri, S, Cervera, R, Dostal, C, Font, J, Gilboe, I M +13 more·2008·Annals of the Rheumatic Diseases

DOI 10.1136/ard.2007.070367

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Abstract

Objective Systemic lupus erythematosus (SLE) is a complex disease with variable presentations, course and prognosis. We sought to develop evidence-based recommendations addressing the major issues in the management of SLE. Methods The EULAR Task Force on SLE comprised 19 specialists and a clinical epidemiologist. Key questions for the management of SLE were compiled using the Delphi technique. A systematic search of PubMed and Cochrane Library Reports was performed using McMaster/Hedges clinical queries' strategies for questions related to the diagnosis, prognosis, monitoring and treatment of SLE. For neuropsychiatric, pregnancy and antiphospholipid syndrome questions, the search was conducted using an array of relevant terms. Evidence was categorised based on sample size and type of design, and the categories of available evidence were identified for each recommendation. The strength of recommendation was assessed based on the category of available evidence, and agreement on the statements was measured across the 19 specialists. Results Twelve questions were generated regarding the prognosis, diagnosis, monitoring and treatment of SLE, including neuropsychiatric SLE, pregnancy, the antiphospholipid syndrome and lupus nephritis. The evidence to support each proposition was evaluated and scored. After discussion and votes, the final recommendations were presented using brief statements. The average agreement among experts was 8.8 out of 10. Conclusion Recommendations for the management of SLE were developed using an evidence-based approach followed by expert consensus with high level of agreement among the experts.

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Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial
Navarra, S., Guzmán, R., Gallacher, A., Hall, S., Levy, R. A., Jimenez, R., Li, E. K., Thomas, M., Kim, H., Leon, M. G., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(10)61354-2 · Cited by 2,078 · see citing works
2019 update of the EULAR recommendations for the management of systemic lupus erythematosus
Fanouriakis, A., Kostopoulou, M., Alunno, A., Aringer, M., Bajema, I., Boletis, J. N., Cervera, R., Doria, A., Gordon, C., Govoni, M., et al. (2019) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2019-215089 · Cited by 2,011 · see citing works
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Systemic lupus erythematosus
Kaul, A., Gordon, C., Crow, M. K., Touma, Z., Urowitz, M. B., van Vollenhoven, R., Ruiz‐Irastorza, G., & Hughes, G. R. V. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.39 · Cited by 1,449 · see citing works
EULAR recommendations for the management of systemic lupus erythematosus: 2023 update
Fanouriakis, A., Kostopoulou, M., Andersen, J., Aringer, M., Arnaud, L., Bae, S., Boletis, J., Bruce, I. N., Cervera, R., Doria, A., et al. (2023) · Annals of the Rheumatic Diseases · doi:10.1136/ard-2023-224762 · Cited by 1,107 · see citing works
Joint European League Against Rheumatism and European Renal Association–European Dialysis and Transplant Association (EULAR/ERA-EDTA) recommendations for the management of adult and paediatric lupus nephritis
Bertsias, G. K., Tektonidou, M. G., Amoura, Z., Aringer, M., Bajema, I. M., Berden, J. H. M., Boletis, J., Cervera, R., Dörner, T., Doria, A., et al. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2012-201940 · Cited by 1,008 · see citing works
Clinical efficacy and side effects of antimalarials in systemic lupus erythematosus: a systematic review
Ruiz-Irastorza, G., Ramos-Casals, M., Brito-Zeron, P., & Khamashta, M. A. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2008.101766 · Cited by 978 · see citing works
Update οn the diagnosis and management of systemic lupus erythematosus
Fanouriakis, A., Tziolos, N., Bertsias, G. K., & Boumpas, D. T. (2020) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2020-218272 · Cited by 775 · see citing works
EULAR recommendations for the management of systemic lupus erythematosus with neuropsychiatric manifestations: report of a task Force of the EULAR standing Committee for clinical Affairs
Bertsias, G. K., Ioannidis, J. P. A., Aringer, M., Bollen, E., Bombardieri, S., Bruce, I. N., Cervera, R., Dalakas, M., Doria, A., Hanly, J. G., et al. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.130476 · Cited by 742 · see citing works
EULAR recommendations for the management of Behçet disease
Hatemi, G., Silman, A. J., Bang, D., Bodaghi, B., Chamberlain, A. M., Gül, A., Houman, M. H., Kötter, I., Olivieri, I., Salvarani, C., et al. (2008) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2007.080432 · Cited by 705 · see citing works
Novel paradigms in systemic lupus erythematosus
Dörner, T., & Furie, R. A. (2019) · The Lancet · doi:10.1016/s0140-6736(19)30546-x · Cited by 572 · see citing works
EFNS guidelines on diagnosis and management of neuromyelitis optica
Sellner, J., Boggild, M., Clanet, M., Hintzen, R. Q., Illés, Z., Montalbán, X., Pasquier, R. D., Polman, C. H., Sørensen, P. S., & Hemmer, B. (2010) · European Journal of Neurology · doi:10.1111/j.1468-1331.2010.03066.x · Cited by 460 · see citing works
Methods of Formal Consensus in Classification/Diagnostic Criteria and Guideline Development
Nair, R., Aggarwal, R., & Khanna, D. (2011) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2010.12.001 · Cited by 441 · see citing works
Antiphospholipid syndrome
Schreiber, K. I., Sciascia, S., de Groot, P. G., Devreese, K. M. J., Jacobsen, S., Ruiz‐Irastorza, G., Salmon, J. E., Shoenfeld, Y., Shovman, O., & Hunt, B. J. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.103 · Cited by 437 · see citing works
Belimumab in the treatment of systemic lupus erythematosus: high disease activity predictors of response
van Vollenhoven, R., Petri, M., Cervera, R., Roth, D. A., Ji, B., Kleoudis, C. S., Zhong, Z. J., & Freimuth, W. W. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2011-200937 · Cited by 411 · see citing works
Cardiac Complications Attributed to Chloroquine and Hydroxychloroquine: A Systematic Review of the Literature
Chatre, C., Roubille, F., Vernhet, H., Jørgensen, C., & Pers, Y. (2018) · Drug Safety · doi:10.1007/s40264-018-0689-4 · Cited by 398 · see citing works
European League Against Rheumatism recommendations for monitoring patients with systemic lupus erythematosus in clinical practice and in observational studies
Mosca, M., Tani, C., Aringer, M., Bombardieri, S., Boumpas, D., Brey, R. L., Cervera, R., Doria, A., Jayne, D. R. W., Khamashta, M. A., et al. (2009) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2009.117200 · Cited by 377 · see citing works
The British Society for Rheumatology guideline for the management of systemic lupus erythematosus in adults
Gordon, C., Amissah-Arthur, M.-B., Gayed, M., Brown, S., Bruce, I. N., D’Cruz, D. P., Empson, B., Griffiths, B., Jayne, D. R. W., Khamashta, M. A., et al. (2017) · Lara D. Veeken · doi:10.1093/rheumatology/kex286 · Cited by 365 · see citing works
Risk factors for thrombosis and primary thrombosis prevention in patients with systemic lupus erythematosus with or without antiphospholipid antibodies
Tektonidou, M. G., Laskari, K., Panagiotakos, D. B., & Moutsopoulos, H. M. (2009) · Arthritis Care & Research · doi:10.1002/art.24232 · Cited by 356 · see citing works
Efficacy and safety of ustekinumab, an IL-12 and IL-23 inhibitor, in patients with active systemic lupus erythematosus: results of a multicentre, double-blind, phase 2, randomised, controlled study
van Vollenhoven, R., Hahn, B. H., Tsokos, G. C., Wagner, C. L., Lipsky, P. E., Touma, Z., Werth, V. P., Gordon, R. M., Zhou, B., Hsu, B. L., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)32167-6 · Cited by 331 · see citing works
Physical activity and autoimmune diseases: Get moving and manage the disease
Sharif, Κ., Watad, ‬., Bragazzi, N. L., Lichtbroun, M., Amital, H., & Shoenfeld, Y. (2017) · Autoimmunity Reviews · doi:10.1016/j.autrev.2017.11.010 · Cited by 325 · see citing works
A pivotal phase III, randomised, placebo-controlled study of belimumab in patients with systemic lupus erythematosus located in China, Japan and South Korea
Zhang, F., Bae, S., Bass, D., Chu, M., Egginton, S., Gordon, D., Roth, D. A., Zheng, J., & Tanaka, Y. (2018) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2017-211631 · Cited by 306 · see citing works
Rituximab in systemic lupus erythematosusA systematic review of off-label use in 188 cases
Ramos‐Casals, M., Soto, M., Cuadrado, M., & Khamashta, M. A. (2009) · Lupus · doi:10.1177/0961203309106174 · Cited by 304 · see citing works
Pathogenesis, diagnosis and management of neuropsychiatric SLE manifestations
Bertsias, G. K., & Boumpas, D. T. (2010) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2010.62 · Cited by 283 · see citing works
Efficacy of rituximab in 164 patients with biopsy-proven lupus nephritis: Pooled data from European cohorts
Díaz‐Lagares, C., Croca, S. C., Sangle, S. R., Vital, E. M. J., Catapano, F., Martínez-Berriotxoa, A., Hernández, F. J. G., Callejas-Rubio, J. L., Rascón, J., D’Cruz, D. P., et al. (2011) · Autoimmunity Reviews · doi:10.1016/j.autrev.2011.10.009 · Cited by 246 · see citing works
Efficacy and Safety of Atacicept in Patients With Systemic Lupus Erythematosus
Merrill, J. T., Wallace, D. J., Wax, S. D., Kao, A. H., Fraser, P. A., Chang, P., Isenberg, D. A., & on behalf of the ADDRESS II Investigators (2017) · Arthritis & Rheumatology · doi:10.1002/art.40360 · Cited by 246 · see citing works
Sifalimumab, a Human Anti–Interferon‐α Monoclonal Antibody, in Systemic Lupus Erythematosus: A Phase I Randomized, Controlled, Dose‐Escalation Study
Petri, M., Wallace, D. J., Spindler, A. J., Chindalore, V. L., KALUNIAN, K. C., Mysler, E., Neuwelt, C. M., Robbie, G. J., White, W. I., Higgs, B. W., et al. (2013) · Arthritis & Rheumatism · doi:10.1002/art.37824 · Cited by 238 · see citing works
Management of Neuropsychiatric Systemic Lupus Erythematosus: Current Approaches and Future Perspectives
Checa, C. M., Zirkzee, E. J. M., Huizinga, T. W. J., & Steup‐Beekman, G. M. (2016) · Drugs · doi:10.1007/s40265-015-0534-3 · Cited by 240 · see citing works
The Diagnosis and Treatment of Systemic Lupus Erythematosus
Kuhn, A., Bonsmann, G., Anders, H., Herzer, P., Tenbrock, K., & Schneider, M. (2015) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2015.0423 · Cited by 230 · see citing works
Lupus nephritis: A critical review
Borchers, A. T., Leibushor, N., Naguwa, S. M., Cheema, G. S., Shoenfeld, Y., & Gershwin, M. E. (2012) · Autoimmunity Reviews · doi:10.1016/j.autrev.2012.08.018 · Cited by 229 · see citing works
Prolonged remission in Caucasian patients with SLE: prevalence and outcomes
Zen, M., Iaccarino, L., Gatto, M., Bettio, S., Nalotto, L., Ghirardello, A., Punzi, L., & Doria, A. (2015) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2015-207347 · Cited by 227 · see citing works
Guidelines on the use of extracorporeal photopheresis
Knobler, R., Berlin, G., Calzavara‐Pinton, P., Greinix, H., Jaksch, P., Laroche, L., Ludvigsson, J., Quaglino, P., Reinisch, W., Scarisbrick, J. J., et al. (2013) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.12311 · Cited by 219 · see citing works
Review: Lupus nephritis: pathologic features, epidemiology and a guide to therapeutic decisions
Ortega, L., Schultz, D., Lenz, O., Pardo, V., & Contreras, G. (2010) · Lupus · doi:10.1177/0961203309358187 · Cited by 219 · see citing works
Inflammatory markers in systemic lupus erythematosus
Aringer, M. (2019) · Journal of Autoimmunity · doi:10.1016/j.jaut.2019.102374 · Cited by 221 · see citing works
European evidence-based recommendations for diagnosis and treatment of childhood-onset systemic lupus erythematosus: the SHARE initiative
Groot, N., de Graeff, N., Avčin, T., Bader‐Meunier, B., Brogan, P. A., Doležalová, P., Feldman, B. M., Koné‐Paut, I., Lahdenne, P., Marks, S. D., et al. (2017) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2016-210960 · Cited by 213 · see citing works
Systemic lupus erythematosus, lupus nephritis and end-stage renal disease: a pragmatic review mapping disease severity and progression
Mahajan, A., Amelio, J., Gairy, K., Kaur, G., Levy, R. A., Roth, D. A., & Bass, D. (2020) · Lupus · doi:10.1177/0961203320932219 · Cited by 212 · see citing works
Incidence and prevention of bladder toxicity from cyclophosphamide in the treatment of rheumatic diseases: A data‐driven review
Monach, P. A., Arnold, L. M., & Merkel, P. A. (2009) · Arthritis & Rheumatism · doi:10.1002/art.25061 · Cited by 210 · see citing works
The clinical significance of antiphospholipid antibodies in systemic lupus erythematosus
Ünlü, O., Zuily, S., & Erkan, D. (2015) · European Journal of Rheumatology · doi:10.5152/eurjrheum.2015.0085 · Cited by 210 · see citing works
Hydroxychloroquine retinopathy — implications of research advances for rheumatology care
Jorge, A. M., Ung, C., YOUNG, L. H. Y., Melles, R. B., & Choi, H. K. (2018) · Nature Reviews Rheumatology · doi:10.1038/s41584-018-0111-8 · Cited by 206 · see citing works
Pregnancy Outcomes in Patients with Autoimmune Diseases and Anti-Ro/SSA Antibodies
Brucato, A. L., Cimaz, R., Caporali, R. F., Ramoni, V. L., & Buyon, J. P. (2009) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-009-8190-6 · Cited by 201 · see citing works
The impact of hydroxychloroquine treatment on pregnancy outcome in women with antiphospholipid antibodies
Sciascia, S., Hunt, B. J., Talavera-García, E., Lliso-Ribera, G., Khamashta, M. A., & Cuadrado, M. J. (2015) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2015.09.078 · Cited by 201 · see citing works
Antiphospholipid syndrome
Sammaritano, L. R. (2019) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2019.101463 · Cited by 201 · see citing works
S2k guideline for treatment of cutaneous lupus erythematosus – guided by the European Dermatology Forum (EDF) in cooperation with the European Academy of Dermatology and Venereology (EADV)
Kuhn, A., Aberer, E., Bata‐Csörgõ, Z., Caproni, M., Dreher, A., Francès, C., Gläser, R., Klötgen, H., Landmann, A., Marinović, B., et al. (2016) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.14053 · Cited by 188 · see citing works
New therapeutic strategies in systemic lupus erythematosus management
Gatto, M., Zen, M., Iaccarino, L., & Doria, A. (2018) · Nature Reviews Rheumatology · doi:10.1038/s41584-018-0133-2 · Cited by 186 · see citing works
Baseline Predictors of Systemic Lupus Erythematosus Flares: Data From the Combined Placebo Groups in the Phase III Belimumab Trials
Petri, M., van Vollenhoven, R., Buyon, J. P., Levy, R. A., Navarra, S., Cervera, R., Zhong, Z. J., Freimuth, W. W., & Groups, O. B. O. T. B. A. B. S. (2013) · Arthritis & Rheumatism · doi:10.1002/art.37995 · Cited by 181 · see citing works
Development and validation of a new algorithm for attribution of neuropsychiatric events in systemic lupus erythematosus
Bortoluzzi, A., Scirè, C. A., Bombardieri, S., Caniatti, L. M., Conti, F., Vita, S. D., Doria, A., Ferraccioli, G., Gremese, E., Mansutti, E., et al. (2014) · Lara D. Veeken · doi:10.1093/rheumatology/keu384 · Cited by 172 · see citing works
Disease activity and damage accrual during the early disease course in a multinational inception cohort of patients with systemic lupus erythematosus
Nossent, J. C., Kiss, E. V., Rozman, B., Pokorny, G., Vlachoyiannopoulos, P. G., Olesińska, M., Marchesoni, A., Mosca, M., Påi, S., Manger, K., et al. (2010) · Lupus · doi:10.1177/0961203310366572 · Cited by 169 · see citing works
First Latin American clinical practice guidelines for the treatment of systemic lupus erythematosus: Latin American Group for the Study of Lupus (GLADEL, Grupo Latino Americano de Estudio del Lupus)–Pan-American League of Associations of Rheumatology (PANLAR)
Pons‐Estel, B. A., Bonfá, E., Soriano, E. R., Cardiel, M. H., Izcovich, A., Popoff, F., Criniti, J. M., Vásquez, G. M., Massardo, L., Duarte, M., et al. (2018) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2018-213512 · Cited by 165 · see citing works
The NET-effect of combining rituximab with belimumab in severe systemic lupus erythematosus
Kraaij, T., Kamerling, S. W. A., de Rooij, E. N. M., van Daele, P. L. A., Bredewold, O. W., Bakker, J. A., Bajema, I. M., Scherer, H. U., Toes, R. E. M., Huizinga, T. W. J., et al. (2018) · Journal of Autoimmunity · doi:10.1016/j.jaut.2018.03.003 · Cited by 164 · see citing works
Belimumab: A Review in Systemic Lupus Erythematosus
Blair, H. A., & Duggan, S. T. (2018) · Drugs · doi:10.1007/s40265-018-0872-z · Cited by 161 · see citing works
The anti-viral facet of anti-rheumatic drugs: Lessons from COVID-19
Perricone, C., Triggianese, P., Bartoloni, E., Cafaro, G., Bonifacio, A. F., Bursi, R., Perricone, R., & Gerli, R. (2020) · Journal of Autoimmunity · doi:10.1016/j.jaut.2020.102468 · Cited by 157 · see citing works
Phase III trial results with blisibimod, a selective inhibitor of B-cell activating factor, in subjects with systemic lupus erythematosus (SLE): results from a randomised, double-blind, placebo-controlled trial
Merrill, J. T., Shanahan, W. R., Scheinberg, M. A., KALUNIAN, K. C., Wofsy, D., & Martin, R. S. (2018) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2018-213032 · Cited by 157 · see citing works
Diagnosis, Monitoring, and Treatment of Systemic Lupus Erythematosus: A Systematic Review of Clinical Practice Guidelines
Tunnicliffe, D. J., Singh‐Grewal, D., Kim, S., Craig, J. C., & Tong, A. (2015) · Arthritis Care & Research · doi:10.1002/acr.22591 · Cited by 154 · see citing works
Therapeutic opportunities in systemic lupus erythematosus: state of the art and prospects for the new decade
Bertsias, G. K., Salmon, J. E., & Boumpas, D. T. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.135186 · Cited by 152 · see citing works
Ethnicity in systemic lupus erythematosus (SLE): its influence on susceptibility and outcomes
González, L., Toloza, S., McGwin, G., & Alarcón, G. (2013) · Lupus · doi:10.1177/0961203313502571 · Cited by 150 · see citing works
European consensus statement on the terminology used in the management of lupus glomerulonephritis
Gordon, C., Jayne, D. R. W., Pusey, C. D., Adu, D., Amoura, Z., Aringer, M., Ballerin, J., Cervera, R., Alén, J. C., Chizzolini, C., et al. (2009) · Lupus · doi:10.1177/0961203308100481 · Cited by 150 · see citing works
Exercise and physical activity in systemic lupus erythematosus: A systematic review with meta-analyses
O’Dwyer, T., Durcan, L., & Wilson, F. (2017) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2017.04.003 · Cited by 150 · see citing works
Treating systemic lupus erythematosus in the 21st century: new drugs and new perspectives on old drugs
Ruiz‐Irastorza, G., & Bertsias, G. K. (2020) · Rheumatology · doi:10.1093/rheumatology/keaa403 · Cited by 148 · see citing works
Off-label use of rituximab in 196 patients with severe, refractory systemic autoimmune diseases.
Ramos‐Casals, M., Hernández, F. J. G., de Ramón, E., Callejas-Rubio, J. L., Martínez-Berriotxoa, A., Pallarés, L., Caminal‐Montero, L., Selva-O’Callaghan, A., Oristrell, J., Hidalgo, C., et al. (2010) · PubMed · Cited by 140 · see citing works
The value of glucocorticoid co-therapy in different rheumatic diseases - positive and adverse effects
van der Goes, M. C., Jacobs, J. W. G., & Bijlsma, J. W. J. (2014) · Arthritis Research & Therapy · doi:10.1186/ar4686 · Cited by 140 · see citing works
Optimizing outcome in SLE: treating-to-target and definition of treatment goals
Doria, A., Gatto, M., Zen, M., Iaccarino, L., & Punzi, L. (2014) · Autoimmunity Reviews · doi:10.1016/j.autrev.2014.01.055 · Cited by 137 · see citing works
Pharmacokinetics, tolerability, and preliminary efficacy of paquinimod (ABR‐215757), a new quinoline‐3‐carboxamide derivative: Studies in lupus‐prone mice and a multicenter, randomized, double‐blind, placebo‐controlled, repeat‐dose, dose‐ranging study in patients with systemic lupus erythematosus
Bengtsson, A. A., Sturfelt, G. K., Lood, C., Rönnblom, L., van Vollenhoven, R., Axelsson, B., Sparre, B., Tuvesson, H., Öhman, M. W., & Leanderson, T. (2011) · Arthritis & Rheumatism · doi:10.1002/art.33493 · Cited by 130 · see citing works
Predictors of cardiovascular events in patients with systemic lupus erythematosus (SLE): a systematic review and meta-analysis
Ballocca, F., D’Ascenzo, F., Moretti, C., Omedè, P., Cerrato, E., Barbero, U., Abbate, A., Bertero, M. T., Biondi‐Zoccai, G., & Gaïta, F. (2014) · European Journal of Preventive Cardiology · doi:10.1177/2047487314546826 · Cited by 130 · see citing works
Gut Microbiome and Metabolites in Systemic Lupus Erythematosus: Link, Mechanisms and Intervention
Zhang, L., Qing, P., Yang, H., Wu, Y., Liu, Y., & Luo, Y. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.686501 · Cited by 124 · see citing works
Diagnosis and management of the antiphospholipid syndrome
Cohen, D. B., Berger, S. P., Steup‐Beekman, G. M., Bloemenkamp, K. W. M., & Bajema, I. M. (2010) · BMJ · doi:10.1136/bmj.c2541 · Cited by 124 · see citing works
Consensus statement on blocking the effects of interleukin-6 and in particular by interleukin-6 receptor inhibition in rheumatoid arthritis and other inflammatory conditions
Smolen, J., Schoels, M., Nishimoto, N., Breedveld, F., Burmester, G., Dougados, M., Emery, P., Ferraccioli, G., Gabay, C., Gibofsky, A., et al. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2012-202469 · Cited by 14,041 · see citing works
Early Disease and Low Baseline Damage as Predictors of Response to Belimumab in Patients With Systemic Lupus Erythematosus in a Real‐Life Setting
Gatto, M., Saccon, F., Zen, M., Regola, F., Fredi, M., Andréoli, L., Tincani, A., Urban, M. L., Emmi, G., Ceccarelli, F., et al. (2020) · Arthritis & Rheumatology · doi:10.1002/art.41253 · Cited by 122 · see citing works
Lupus: an overview of the disease and management options.
Maidhof, W., & Hilas, O. (2012) · PubMed Central · Cited by 116 · see citing works
Chloroquine and hydroxychloroquine are associated with reduced cardiovascular risk: a systematic review and meta-analysis
Liu, D., Li, X., Zhang, Y., Kwong, J. S. W., Li, L., Zhang, Y., Xu, C., Li, Q., Sun, X., Tian, H., et al. (2018) · Drug Design Development and Therapy · doi:10.2147/dddt.s166893 · Cited by 114 · see citing works
Delayed diagnosis adversely affects outcome in systemic lupus erythematosus: Cross sectional analysis of the LuLa cohort
Kernder, A. L., Richter, J., Fischer‐Betz, R., Winkler-Rohlfing, B., Brinks, R., Aringer, M., Schneider, M., & Chehab, G. (2021) · Lupus · doi:10.1177/0961203320983445 · Cited by 121 · see citing works
Pragmatic approaches to therapy for systemic lupus erythematosus
Xiong, W., & Lahita, R. G. (2013) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2013.157 · Cited by 113 · see citing works
Systemic Lupus Erythematosus: A Review of the Disease and Treatment Options
Gurevitz, S. L., Snyder, J. A., Wessel, E. K., Frey, J., & Williamson, B. A. (2013) · The Consultant Pharmacist · doi:10.4140/tcp.n.2013.110 · Cited by 111 · see citing works
Treatment Algorithms in Systemic Lupus Erythematosus
Muangchan, C., van Vollenhoven, R., Bernatsky, S., Smith, C. D., Hudson, M., İnanç, M., Rothfield, N. F., Nash, P. T., Furie, R. A., Senécal, J., et al. (2015) · Arthritis Care & Research · doi:10.1002/acr.22589 · Cited by 109 · see citing works
Longterm Hydroxychloroquine Therapy and Low-dose Aspirin May Have an Additive Effectiveness in the Primary Prevention of Cardiovascular Events in Patients with Systemic Lupus Erythematosus
Fasano, S., Pierro, L., Pantano, I., Iudici, M., & Valentini, G. (2017) · The Journal of Rheumatology · doi:10.3899/jrheum.161351 · Cited by 110 · see citing works
Ovarian stimulation for ovulation induction and in vitro fertilization in patients with systemic lupus erythematosus and antiphospholipid syndrome
Bellver, J., & Pellicer, A. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.06.033 · Cited by 110 · see citing works
Systemic lupus erythematosus: state of the art on clinical practice guidelines
Tamirou, F., Arnaud, L., Talarico, R., Scirè, C. A., Alexander, T., Amoura, Z., Avčin, T., Bortoluzzi, A., Cervera, R., Conti, F., et al. (2018) · RMD Open · doi:10.1136/rmdopen-2018-000793 · Cited by 104 · see citing works
Lupus arthritis--do we have a clinically useful classification?
Ball, E., & Bell, A. L. (2011) · Lara D. Veeken · doi:10.1093/rheumatology/ker381 · Cited by 102 · see citing works
Association between chronic immune-mediated inflammatory diseases and cardiovascular risk
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Authors: Bertsias, G., Ioannidis, J. P. A., Boletis, J., Bombardieri, S., Cervera, R., Dostal, C., Font, J., Gilboe, I. M., Houssiau, F., Huizinga, T., Isenberg, D., Kallenberg, C. G. M., Khamashta, M., Piette, J. C., Schneider, M., Smolen, J., Sturfelt, G., Tincani, A., van Vollenhoven, R., Gordon, C., & Boumpas, D. T.
Affiliations: University of Crete (GR)
University of Ioannina (GR)
Laiko General Hospital of Athens (GR)
University of Pisa (IT)
Hospital Clínic de Barcelona (ES)
Oslo University Hospital (NO)
Cliniques Universitaires Saint-Luc (BE)
Leiden University Medical Center (NL)
University College Hospital (GB)
University Medical Center Groningen (NL)
St Thomas' Hospital (GB)
Heinrich Heine University Düsseldorf (DE)
Medical University of Vienna (AT)
Lund University (SE)
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT)
University of Birmingham (GB)
Corresponding author: Boumpas, D T
ORCID: Bertsias, G
Ioannidis, J P A
Bombardieri, S
Cervera, R
Huizinga, T
Isenberg, D
Khamashta, M
Schneider, M
Smolen, J
Tincani, A
Gordon, C
Boumpas, D T
Venue: Annals of the Rheumatic Diseases
Publisher: Elsevier BV
Published: 2008-02
Volume: 67
Issue: 2
Pages: 195-205
ISSN: 0003-4967 (ISSN-L)
DOI: 10.1136/ard.2007.070367
OpenAlex: W2157038471
Cited by: 762
References: 164
Citations by year: 2026: 14 · 2025: 17 · 2024: 19 · 2023: 26 · 2022: 19 · 2021: 58 · 2020: 56 · 2019: 53 · 2018: 70 · 2017: 62 · 2016: 47 · 2015: 53 · 2014: 43 · 2013: 53 · 2012: 46
FWCI: 18.49
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor)
Locations: Annals of the Rheumatic Diseases (publishedVersion)
PubMed (publishedVersion)
Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion, other-oa)
Lund University Publications (Lund University) (submittedVersion)
HighWire Press Open Archive (submittedVersion)
University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Funders: University of Crete
Topics: Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
Health Sciences › Medicine › Pathology and Forensic Medicine › Systemic Sclerosis and Related Diseases
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Clinical practice guidelines implementation
Keywords: systemic lupus erythematosus, clinical management, diagnosis, prognosis, disease surveillance, treatment, neuropsychiatric lupus, pregnancy, antiphospholipid syndrome, lupus nephritis, evidence-based recommendations, expert consensus
MeSH terms: Female, Humans, Lupus Erythematosus, Systemic, Lupus Nephritis, Male, Pregnancy, Pregnancy Complications, Antiphospholipid Syndrome, Evidence-Based Medicine

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EULAR recommendations for the management of systemic lupus erythematosus. Report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics

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