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Structure, Function, and Regulation of Desmosomes

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Kowalczyk, Andrew P., Green, Kathleen J.·2013·Progress in Molecular Biology and Translational Science
DOI 10.1016/b978-0-12-394311-8.00005-4PMC PMC4336551
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Abstract

Desmosomes are adhesive intercellular junctions that mechanically integrate adjacent cells by coupling adhesive interactions mediated by desmosomal cadherins to the intermediate filament cytoskeletal network. Desmosomal cadherins are connected to intermediate filaments by densely clustered cytoplasmic plaque proteins comprising members of the armadillo gene family, including plakoglobin and plakophilins, and members of the plakin family of cytolinkers, such as desmoplakin. The importance of desmosomes in tissue integrity is highlighted by human diseases caused by mutations in desmosomal genes, autoantibody attack of desmosomal cadherins, and bacterial toxins that selectively target desmosomal cadherins. In addition to reviewing the well-known roles of desmosomal proteins in tissue integrity, this chapter also highlights the growing appreciation for how desmosomal proteins are integrated with cell signaling pathways to contribute to vertebrate tissue organization and differentiation.

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Metadata

Authors
Kowalczyk, A. P., & Green, K. J.
Affiliations
  • Emory University (US)
  • Northwestern University (US)
Corresponding author
Kowalczyk, Andrew P.
ORCID
Venue
Progress in Molecular Biology and Translational Science
Publisher
Elsevier
Published
2013
Volume
116
Pages
95-118
ISSN
1877-1173 (ISSN-L)
DOI
10.1016/b978-0-12-394311-8.00005-4
PMC
PMC4336551
OpenAlex
W39042124
Cited by
270
References
2
Citations by year
2026: 14 · 2025: 28 · 2024: 25 · 2023: 26 · 2022: 18 · 2021: 22 · 2020: 32 · 2019: 23 · 2018: 22 · 2017: 20 · 2016: 12 · 2015: 14 · 2014: 13 · 2013: 1
FWCI
17.32
Type
book chapter
Language
en
Open access
Locations
  • Progress in molecular biology and translational science (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Fondation Leducq
  • National Institutes of Health
  • National Cancer Institute (R01CA122151)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR048266, R01AR050501, R37AR043380, R01AR041836)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connexins and lens biology
Keywords
desmosomes, desmosomal cadherins, intermediate filaments, desmoplakin, plakoglobin, plakophilin, armadillo proteins, desmosomal autoantibodies, desmosomal gene mutations, bacterial toxins, tissue integrity, signal transduction, tissue organization, histogenesis
MeSH terms
Animals, Cytoskeleton, Desmosomes, Humans, Signal Transduction, Desmosomal Cadherins

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CoChat. (2026). Citation check: Structure, Function, and Regulation of Desmosomes. https://app.cochat.ai/papers/10.1016/b978-0-12-394311-8.00005-4
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Kowalczyk, A. P., & Green, K. J. (2013). Structure, Function, and Regulation of Desmosomes. Progress in Molecular Biology and Translational Science. https://doi.org/10.1016/b978-0-12-394311-8.00005-4