Wnt/β-catenin signaling and disease
Open accessAbstract
The WNT signal transduction cascade controls myriad biological phenomena throughout development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a wide range of pathologies in humans. In this Review, we provide an update of the core Wnt/β-catenin signaling pathway, discuss how its various components contribute to disease, and pose outstanding questions to be addressed in the future.
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In deregulated forms, the Wnt/β-catenin signaling pathway is involved in human cancers and developmental disorders.
“In deregulated forms, it is involved in human cancers and developmental disorders [26, 27].”
From Relating simulation studies by provenance—Developing a family of Wnt signaling models (2021) · cites this paper as [26]
Hotspot mutations of APC, Axin, and β-catenin drive tumorigenesis.
“hotspot mutations of APC, Axin, and β-catenin have been found to drive tumorigenesis2”
From A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer (2020) · cites this paper as [2]
Aberrant activation of Wnt signaling is highly implicated in various types of cancer, including colorectal cancer.
“Aberrant activation of Wnt signaling is highly implicated in various types of cancer, including colorectal cancer, in human, for example, hotspot mutations of APC, Axin, and β-catenin have been found to drive tumorigenesis2.”
From A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer (2020) · cites this paper as [2]
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Kowalczyk, A. P., & Green, K. J. (2013) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-394311-8.00005-4 · Cited by 270 · see citing works
YTHDF1 Regulates Tumorigenicity and Cancer Stem Cell-Like Activity in Human Colorectal Carcinoma
Bai, Y., Yang, C., Wu, R., Huang, L., Song, S., Li, W., Yan, P., Lin, C., Li, D., & Zhang, Y. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00332 · Cited by 267 · see citing works
Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin
Grossmann, T. N., Yeh, J. T.-H., Bowman, B. R., Chu, Q., Moellering, R. E., & Verdine, G. L. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1208396109 · Cited by 268 · see citing works
- Authors
- Clevers, H., & Nusse, R.
- Affiliations
- Royal Netherlands Academy of Arts and Sciences (NL)
- Corresponding author
- Clevers, Hans
- ORCID
- Clevers, Hans
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2012-06
- Volume
- 149
- Issue
- 6
- Pages
- 1192-1205
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2006419043
- Cited by
- 5,554
- References
- 180
- Citations by year
- 2026: 252 · 2025: 296 · 2024: 318 · 2023: 333 · 2022: 418 · 2021: 498 · 2020: 442 · 2019: 399 · 2018: 432 · 2017: 486 · 2016: 458 · 2015: 454 · 2014: 364 · 2013: 347 · 2012: 52
- FWCI
- 35.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
- Keywords
- Wnt/β-catenin signaling, Wnt signaling, signal transduction, developmental biology, pathogenesis, aberrant signaling
- MeSH terms
- Animals, Disease, Humans, Wnt Proteins, beta Catenin, Wnt Signaling Pathway
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