Cited by 48Mitochondrial Function and PathologyAutophagy in Disease and TherapyATP Synthase and ATPases Research

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Mitochondrial Dynamics in Aging and Disease

Bereiter-Hahn, Jürgen·2014·Progress in molecular biology and translational science

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Abstract

Mitochondria are self-replicating organelles but nevertheless strongly depend on supply coded in nuclear genes. They serve many physiological demands in living cells. Supply of the cytoplasm with ATP and engagement in Ca(2+) regulation belong to the main functions of mitochondria. In large eukaryotic cells, in particular in neurons, with their long dendrites and axons, mitochondria have to move to the sites of their action. This trafficking involves several motor molecules and mechanisms to sense the sites of requirements of mitochondria. With aging and as a consequence of some diseases, mitochondrial components may be rendered dysfunctional, and mtDNA mutations arise during the course of replication and by the action of reactive oxygen species. Mutants in motor molecules engaged in trafficking and in the machinery of fusion and fission are causing severe deficiencies on the cellular level; they support neurodegeneration and, thus, cause many diseases. Frequent fusion and fission events mediate the elimination of impaired parts from mitochondria which finally will be degraded by autophagosomes. Extensive fusion provides a basis for functional complementation. Mobility of proteins and small molecules within the mitochondria is necessary to reach the functional goals of fusion and fission, although cristae and a large fraction of proteins of the respiratory complexes proved to be stable for hours after fusion and perform slow exchange of material.

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Authors: Bereiter-Hahn, J.
Venue: Progress in molecular biology and translational science
Publisher: Elsevier
Published: 2014
Volume: 127
Pages: 93-131
ISSN: 1877-1173 (ISSN-L)
DOI: 10.1016/b978-0-12-394625-6.00004-0
OpenAlex: W2405770350
Cited by: 48
References: 246
Citations by year: 2026: 3 · 2025: 4 · 2024: 5 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 6 · 2018: 3 · 2017: 6 · 2016: 9 · 2015: 4
FWCI: 8.04
Type: book chapter
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Progress in molecular biology and translational science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
Keywords: mitochondrial dynamics, mitochondrial fusion, mitochondrial fission, mitochondrial biogenesis, mitochondrial trafficking, motor proteins, mitochondrial DNA mutations, reactive oxygen species, neurodegeneration, aging, autophagy, calcium regulation, ATP production, electron transport chain
MeSH terms: Aging, Animals, Humans, Mitochondrial Proteins, Mitochondrial Diseases, Mitochondrial Membranes, Mitochondrial Size, Mitochondrial Dynamics

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