Cited by 48Mitochondrial Function and PathologyAutophagy in Disease and TherapyATP Synthase and ATPases Research

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Mitochondrial Dynamics in Aging and Disease

Bereiter-Hahn, Jürgen·2014·Progress in molecular biology and translational science

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Abstract

Mitochondria are self-replicating organelles but nevertheless strongly depend on supply coded in nuclear genes. They serve many physiological demands in living cells. Supply of the cytoplasm with ATP and engagement in Ca(2+) regulation belong to the main functions of mitochondria. In large eukaryotic cells, in particular in neurons, with their long dendrites and axons, mitochondria have to move to the sites of their action. This trafficking involves several motor molecules and mechanisms to sense the sites of requirements of mitochondria. With aging and as a consequence of some diseases, mitochondrial components may be rendered dysfunctional, and mtDNA mutations arise during the course of replication and by the action of reactive oxygen species. Mutants in motor molecules engaged in trafficking and in the machinery of fusion and fission are causing severe deficiencies on the cellular level; they support neurodegeneration and, thus, cause many diseases. Frequent fusion and fission events mediate the elimination of impaired parts from mitochondria which finally will be degraded by autophagosomes. Extensive fusion provides a basis for functional complementation. Mobility of proteins and small molecules within the mitochondria is necessary to reach the functional goals of fusion and fission, although cristae and a large fraction of proteins of the respiratory complexes proved to be stable for hours after fusion and perform slow exchange of material.

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Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
Twig, G., Elorza, A., Molina, A. J. A., Mohamed, H., Wikstrom, J. D., Walzer, G., Stiles, L., Haigh, S. E., Katz, S., Las, G., et al. (2008) · The EMBO Journal · doi:10.1038/sj.emboj.7601963 · Cited by 3,082
Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development
Chen, H., Detmer, S. A., Ewald, A. J., Griffin, E. E., Fraser, S. E., & Chan, D. C. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200211046 · Cited by 2,601
ER Tubules Mark Sites of Mitochondrial Division
Friedman, J. R., Lackner, L. L., West, M., DiBenedetto, J. R., Nunnari, J., & Voeltz, G. K. (2011) · Science · doi:10.1126/science.1207385 · Cited by 2,072
The Biologic Clock: The Mitochondria?
Harman, D. (1972) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1972.tb00787.x · Cited by 2,026
Mitochondria: Dynamic Organelles in Disease, Aging, and Development
Chan, D. C. (2006) · Cell · doi:10.1016/j.cell.2006.06.010 · Cited by 1,987
Mitochondria: More Than Just a Powerhouse
McBride, H. M., Neuspiel, M., & Wasiak, S. (2006) · Current Biology · doi:10.1016/j.cub.2006.06.054 · Cited by 1,985
Dynamin-related Protein Drp1 Is Required for Mitochondrial Division in Mammalian Cells
Smirnova, E., Griparić, L., Shurland, D., & van der Bliek, A. M. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.8.2245 · Cited by 1,938
The Role of Dynamin-Related Protein 1, a Mediator of Mitochondrial Fission, in Apoptosis
Frank, S., Gaume, B., Bergmann-Leitner, E. S., Leitner, W. W., Robert, E. G., Catez, F., Smith, C. L., & Youle, R. J. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00055-7 · Cited by 1,755
During autophagy mitochondria elongate, are spared from degradation and sustain cell viability
Gomes, L. C., Benedetto, G. D., & Scorrano, L. (2011) · Nature Cell Biology · doi:10.1038/ncb2220 · Cited by 1,735
OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion
Frezza, C., Cipolat, S., Martins de Brito, O., Micaroni, M., Beznoussenko, G. V., Rudka, T., Bartoli, D., Polishuck, R. S., Danial, N. N., De Strooper, B., et al. (2006) · Cell · doi:10.1016/j.cell.2006.06.025 · Cited by 1,673
Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A
Züchner, S., Mersiyanova, I. V., Muglia, M., Bissar-Tadmouri, N., Rochelle, J., Dadali, E. L., Zappia, M., Nelis, E., Patitucci, A., Senderek, J., et al. (2004) · Nature Genetics · doi:10.1038/ng1341 · Cited by 1,572
Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases
Chen, H., & Chan, D. C. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp326 · Cited by 1,506
The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses
Li, Z., Okamoto, K.-I., Hayashi, Y., & Sheng, M. (2004) · Cell · doi:10.1016/j.cell.2004.11.003 · Cited by 1,498
Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy
Delettre, C., Lenaers, G., Griffoin, J.-M., Gigarel, N., Lorenzo, C., Belenguer, P., Pelloquin, L., Grosgeorge, J., Turc-Carel, C., Perret, E., et al. (2000) · Nature Genetics · doi:10.1038/79936 · Cited by 1,446
Disruption of Fusion Results in Mitochondrial Heterogeneity and Dysfunction
Chen, H., Chomyn, A., & Chan, D. C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503062200 · Cited by 1,376
OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28
Alexander, C., Votruba, M., Pesch, U. E. A., Thiselton, D. L., Mayer, S., Moore, A., Rodriguez, M., Kellner, U., Leo-Kottler, B., Auburger, G., et al. (2000) · Nature Genetics · doi:10.1038/79944 · Cited by 1,330
OPA1 requires mitofusin 1 to promote mitochondrial fusion
Cipolat, S., de Brito, O. M., Dal Zilio, B., & Scorrano, L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407043101 · Cited by 1,300
Mitochondrial dynamics and apoptosis
Suen, D.-F., Norris, K. L., & Youle, R. J. (2008) · Genes & Development · doi:10.1101/gad.1658508 · Cited by 1,270
Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology
Yu, T., Robotham, J. L., & Yoon, Y. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511154103 · Cited by 1,246
Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission.
Taguchi, N., Ishihara, N., Jofuku, A., Oka, T., & Mihara, K. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m607279200 · Cited by 1,226
Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease
Wang, X., Su, B., Lee, H.-G., Li, X., Perry, G., Smith, M. A., & Zhu, X. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1357-09.2009 · Cited by 1,224
The axonal transport of mitochondria
Saxton, W. M., & Hollenbeck, P. J. (2012) · Journal of Cell Science · doi:10.1242/jcs.053850 · Cited by 1,218
Fusion and fission: interlinked processes critical for mitochondrial health
Chan, D. C. (2012) · Annual Review of Genetics · doi:10.1146/annurev-genet-110410-132529 · Cited by 1,196
Loss of OPA1 Perturbates the Mitochondrial Inner Membrane Structure and Integrity, Leading to Cytochrome c Release and Apoptosis
Olichon, A., Baricault, L., Gas, N., Guillou, E., Valette, A., Belenguer, P., & Lenaers, G. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c200677200 · Cited by 1,168
Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria
Cereghetti, G. M., Stangherlin, A., de Brito, O. M., Chang, C. R., Blackstone, C., Bernardi, P., & Scorrano, L. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808249105 · Cited by 1,129
Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells
Otera, H., Wang, C., Cleland, M. M., Setoguchi, K., Yokota, S., Youle, R. J., & Mihara, K. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201007152 · Cited by 1,110
S-Nitrosylation of Drp1 Mediates β-Amyloid-Related Mitochondrial Fission and Neuronal Injury
Cho, D.-H., Nakamura, T., Fang, J., Cieplak, P., Godzik, A., Gu, Z., & Lipton, S. A. (2009) · Science · doi:10.1126/science.1171091 · Cited by 1,092
Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice
Ishihara, N., Nomura, M., Jofuku, A., Kato, H., Suzuki, S. O., Masuda, K., Otera, H., Nakanishi, Y., Nonaka, I., Goto, Y.-I., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1907 · Cited by 1,066
Reversible phosphorylation of Drp1 by cyclic AMP‐dependent protein kinase and calcineurin regulates mitochondrial fission and cell death
Cribbs, J. T., & Strack, S. (2007) · EMBO Reports · doi:10.1038/sj.embor.7401062 · Cited by 1,061
Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis
Lee, Y.-J., Jeong, S.-Y., Karbowski, M., Smith, C. L., & Youle, R. J. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-04-0294 · Cited by 1,042
Differential Regulation of Dynein and Kinesin Motor Proteins by Tau
Dixit, R., Ross, J. L., Goldman, Y. E., & Holzbaur, E. L. F. (2008) · Science · doi:10.1126/science.1152993 · Cited by 1,012
Mutant dynactin in motor neuron disease
Puls, I., Jonnakuty, C., LaMonte, B. H., Holzbaur, E. L. F., Tokito, M. K., MANN, E. A., Floeter, M. K., Bidus, K., Drayna, D. T., Oh, S. J., et al. (2003) · Nature Genetics · doi:10.1038/ng1123 · Cited by 973
Mitochondrial Fusion and Fission in Mammals
Chan, D. C. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.22.010305.104638 · Cited by 972
Mitochondria take center stage in aging and neurodegeneration
Beal, M. F. (2005) · Annals of Neurology · doi:10.1002/ana.20624 · Cited by 957
Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration
Sheng, Z., & Cai, Q. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3156 · Cited by 940
Mitochondrial fusion protects against neurodegeneration in the cerebellum
Chen, H., McCaffery, J. M., & Chan, D. C. (2007) · Cell · doi:10.1016/j.cell.2007.06.026 · Cited by 924
Dynamics of mitochondria in living cells: Shape changes, dislocations, fusion, and fission of mitochondria
Bereiter‐Hahn, J., & Vöth, M. (1994) · Microscopy Research and Technique · doi:10.1002/jemt.1070270303 · Cited by 900
Self-citation
Regulation of mitochondrial morphology through proteolytic cleavage of OPA1
Ishihara, N., Fujita, Y., Oka, T., & Mihara, K. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601184 · Cited by 899
Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age
Corral-Debrinski, M., Horton, T., Lott, M. T., Shoffner, J. M., Flint Beal, M., & Wallace, D. C. (1992) · Nature Genetics · doi:10.1038/ng1292-324 · Cited by 890
Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress
Stamer, K., Vogel, R., Thies, E., Mandelkow, E., & Mandelkow, E.-M. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200108057 · Cited by 885
The Mechanism of Ca2+-Dependent Regulation of Kinesin-Mediated Mitochondrial Motility
Wang, X., & Schwarz, T. L. (2009) · Cell · doi:10.1016/j.cell.2008.11.046 · Cited by 871
Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis
Karbowski, M., Lee, Y.-J., Gaume, B., Jeong, S.-Y., Frank, S., Nechushtan, A., Santel, A., Fuller, M., Smith, C. L., & Youle, R. J. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200209124 · Cited by 846
Cyclic AMP-dependent Protein Kinase Phosphorylation of Drp1 Regulates Its GTPase Activity and Mitochondrial Morphology
Chang, C., & Blackstone, C. D. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.c700083200 · Cited by 824
OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L
Song, Z., Chen, H., Fiket, M., Alexander, C., & Chan, D. C. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200704110 · Cited by 818
An Actin-Dependent Step in Mitochondrial Fission Mediated by the ER-Associated Formin INF2
Korobova, F., Ramabhadran, V., & Higgs, H. N. (2013) · Science · doi:10.1126/science.1228360 · Cited by 817
SLP‐2 is required for stress‐induced mitochondrial hyperfusion
Tondera, D., Grandemange, S., Jourdain, A. A., Karbowski, M., Mattenberger, Y., Herzig, S., Cruz, S. D., Clerc, P., Lauria, I., Merkwirth, C., et al. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.89 · Cited by 796
Mitochondria, oxidative stress and neurodegeneration
Federico, A., Cardaioli, E., Pozzo, P. D., Formichi, P., Gallus, G. N., & Radi, E. (2012) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2012.05.030 · Cited by 790
The Machines that Divide and Fuse Mitochondria
Hoppins, S., Lackner, L., & Nunnari, J. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.071905.090048 · Cited by 790
MAM: more than just a housekeeper
Hayashi, T., Rizzuto, R., Hajnoczky, G., & Su, T.-P. (2009) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.12.002 · Cited by 787
Charcot-Marie-Tooth Disease Type 2A Caused by Mutation in a Microtubule Motor KIF1Bβ
Zhao, C., Takita, J., Tanaka, Y., Setou, M., Nakagawa, T., Takeda, S., Yang, H. W., Terada, S., Nakata, T., Takei, Y., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00363-4 · Cited by 765
A Lethal Defect of Mitochondrial and Peroxisomal Fission
Waterham, H. R., Koster, J., van Roermund, C. W. T., Mooyer, P. A. W., Wanders, R. J. A., & Leonard, J. V. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa064436 · Cited by 749
Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS
Bosco, D. A., Morfini, G. A., Karabacak, M., Song, Y., Gros‐Louis, F., Pasinelli, P., Goolsby, H., Fontaine, B. A., Lemay, N., McKenna-Yasek, D. M., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2660 · Cited by 685
Mitochondrial Fusion in Human Cells Is Efficient, Requires the Inner Membrane Potential, and Is Mediated by Mitofusins
Legros, F., Lombès, A., Frachon, P., & Rojo, M. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-06-0330 · Cited by 676
Mitofusin 2 Is Necessary for Transport of Axonal Mitochondria and Interacts with the Miro/Milton Complex
Misko, A. L., Jiang, S., Wegorzewska, I., Milbrandt, J., & Baloh, R. H. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.6248-09.2010 · Cited by 653
Axonal Transport of Mitochondria to Synapses Depends on Milton, a Novel Drosophila Protein
Stowers, R. S., Megeath, L. J., Górska‐Andrzejak, J., Meinertzhagen, I. A., & Schwarz, T. L. (2002) · Neuron · doi:10.1016/s0896-6273(02)01094-2 · Cited by 643
Whole-cell 3D STORM reveals interactions between cellular structures with nanometer-scale resolution
Huang, B., Jones, S. A., Brandenburg, B., & Zhuang, X. (2008) · Nature Methods · doi:10.1038/nmeth.1274 · Cited by 626
Dnm1 forms spirals that are structurally tailored to fit mitochondria
Ingerman, E., Perkins, E. M., Marino, M., Mears, J. A., McCaffery, J. M., Hinshaw, J. E., & Nunnari, J. (2005) · Journal of Cell Biology · doi:10.1083/jcb.200506078 · Cited by 621
Mitochondrial calcium signalling and cell death: Approaches for assessing the role of mitochondrial Ca2+ uptake in apoptosis
Hajnóczky, G., Csordás, G., Das, S., Garcı́a-Pérez, C., Saotome, M., Roy, S. S., & Yi, M. (2006) · Cell Calcium · doi:10.1016/j.ceca.2006.08.016 · Cited by 613
Docking of Axonal Mitochondria by Syntaphilin Controls Their Mobility and Affects Short-Term Facilitation
Kang, J.-S., Tian, J.-H., Pan, P.-Y., Zald, P., Li, C., Deng, C., & Sheng, Z.-H. (2008) · Cell · doi:10.1016/j.cell.2007.11.024 · Cited by 598
Mitochondrial fission and remodelling contributes to muscle atrophy
Romanello, V., Guadagnin, E., Gomes, L., Roder, I., Sandri, C., Petersen, Y., Milan, G., Masiero, E., Del Piccolo, P., Foretz, M., et al. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.60 · Cited by 596
Solute and macromolecule diffusion in cellular aqueous compartments
Verkman, A. S. (2002) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(01)02003-5 · Cited by 578
Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity
Song, W., Chen, J., Petrilli, A. M., Liot, G., Klinglmayr, E., Zhou, Y., Poquiz, P., Tjong, J., Pouladi, M. A., Hayden, M. R., et al. (2011) · Nature Medicine · doi:10.1038/nm.2313 · Cited by 575
Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo
Rojo, M., Legros, F., Chateau, D., & Lombès, A. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.8.1663 · Cited by 555
Axonal transport of mitochondria along microtubules and F-actin in living vertebrate neurons.
Morris, R. L., & Hollenbeck, P. J. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.131.5.1315 · Cited by 541
Bidirectional Ca 2+ -dependent control of mitochondrial dynamics by the Miro GTPase
Saotome, M., Safiulina, D., Szabadkai, G., Das, S., Fransson, Å., Aspenstrom, P., Rizzuto, R., & Hajnóczky, G. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808953105 · Cited by 538
Bax/Bak promote sumoylation of DRP1 and its stable association with mitochondria during apoptotic cell death
Wasiak, S., Zunino, R., & McBride, H. M. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200610042 · Cited by 537
Quality control of mitochondria: protection against neurodegeneration and ageing
Tatsuta, T., & Langer, T. (2008) · The EMBO Journal · doi:10.1038/sj.emboj.7601972 · Cited by 525
New insights into the role of mitochondria in aging: mitochondrial dynamics and more
Seo, A. Y., Joseph, A.-M., Dutta, D., Hwang, J. C. Y., Aris, J. P., & Leeuwenburgh, C. (2010) · Journal of Cell Science · doi:10.1242/jcs.070490 · Cited by 522
Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro
Trushina, E., Dyer, R. B., Badger, J. D., Ure, D., Eide, L., Tran, D. D., Vrieze, B. T., Legendre-Guillemin, V., McPherson, P. S., Mandavilli, B. S., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.18.8195-8209.2004 · Cited by 520
Mitochondrial Fusion is Essential for Organelle Function and Cardiac Homeostasis
Chen, Y., Liu, Y., & Dorn, G. W. (2011) · Circulation Research · doi:10.1161/circresaha.111.258723 · Cited by 515
Axonal mitochondrial transport and potential are correlated
Miller, K. E., & Sheetz, M. P. (2004) · Journal of Cell Science · doi:10.1242/jcs.01130 · Cited by 512
Vesicular Glycolysis Provides On-Board Energy for Fast Axonal Transport
Zala, D., Hinckelmann, M.-V., Yu, H., da Cunha, M. M. L., Liot, G., Cordelières, F. P., Marco, S., & Saudou, F. (2013) · Cell · doi:10.1016/j.cell.2012.12.029 · Cited by 494
Mitochondrial turnover and aging of long-lived postmitotic cells: the mitochondrial-lysosomal axis theory of aging
Terman, A., Kurz, T., Navratil, M., Arriaga, E. A., & Brunk, U. T. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2598 · Cited by 490
Tau Reduction Prevents Aβ-Induced Defects in Axonal Transport
Vossel, K. A., Zhang, K., Brodbeck, J., Daub, A. C., Sharma, P., Finkbeiner, S., Cui, B., & Mucke, L. (2010) · Science · doi:10.1126/science.1194653 · Cited by 486
The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division
Karbowski, M., Neutzner, A., & Youle, R. J. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200611064 · Cited by 485
The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking.
Fransson, S., Ruusala, A., & Aspenström, P. (2006) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2006.03.163 · Cited by 479
A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis
Choi, S., Huang, P., Jenkins, G. M., Chan, D. C., Schiller, J., & Frohman, M. A. (2006) · Nature Cell Biology · doi:10.1038/ncb1487 · Cited by 476
Loss of the Intermembrane Space Protein Mgm1/OPA1 Induces Swelling and Localized Constrictions along the Lengths of Mitochondria
Griparić, L., van der Wel, N. N., Orozco, I. J., Peters, P. J., & van der Bliek, A. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400920200 · Cited by 468
Drp-1-Dependent Division of the Mitochondrial Network Blocks Intraorganellar Ca2+ Waves and Protects against Ca2+-Mediated Apoptosis
Szabadkai, G., Simoni, A. M., Chami, M., Wieckowski, M. R., Youle, R. J., & Rizzuto, R. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.09.026 · Cited by 468
Ions and energy in mammalian brain
Erecińska, M., & Silver, I. A. (1994) · Progress in Neurobiology · doi:10.1016/0301-0082(94)90015-9 · Cited by 464
Opa1 deficiency in a mouse model of autosomal dominant optic atrophy impairs mitochondrial morphology, optic nerve structure and visual function
Davies, V. J., Hollins, A. J., Piechota, M. J., Yip, W., Davies, J. R., White, K. E., Nicols, P. P., Boulton, M. E., & Votruba, M. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm079 · Cited by 449
N-Terminal Mutant Huntingtin Associates with Mitochondria and Impairs Mitochondrial Trafficking
Orr, A. L., Li, S., Wang, C.-E., Li, H., Wang, J., Rong, J., Xu, X., Mastroberardino, P. G., Greenamyre, J. T., & Li, X. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0106-08.2008 · Cited by 429
Mitochondrial Diseases of the Brain
Chaturvedi, R. K., & Beal, M. F. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.03.018 · Cited by 426
Human cells are protected from mitochondrial dysfunction by complementation of DNA products in fused mitochondria
Ono, T., Isobe, K., Nakada, K., & Hayashi, J.-I. (2001) · Nature Genetics · doi:10.1038/90116 · Cited by 420
Imaging axonal transport of mitochondria in vivo
Misgeld, T., Kerschensteiner, M., Bareyre, F. M., Burgess, R. W., & Lichtman, J. W. (2007) · Nature Methods · doi:10.1038/nmeth1055 · Cited by 419
The actin cytoskeleton: a key regulator of apoptosis and ageing?
Gourlay, C. W., & Ayscough, K. R. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1682 · Cited by 405
Ganglioside-induced differentiation associated protein 1 is a regulator of the mitochondrial network
Niemann, A., Rüegg, M., Padula, V. L., Schenone, A. E., & Suter, U. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200507087 · Cited by 402
Atypical Rho GTPases Have Roles in Mitochondrial Homeostasis and Apoptosis
Fransson, Å., Ruusala, A., & Aspenström, P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208609200 · Cited by 396
Perinuclear Mitochondrial Clustering Creates an Oxidant-Rich Nuclear Domain Required for Hypoxia-Induced Transcription
Al‐Mehdi, A., Pastukh, V. M., Swiger, B. M., Reed, D., Patel, M., Bardwell, G. C., Pastukh, V. V., ALEXEYEV, M. F., & Gillespie, M. N. (2012) · Science Signaling · doi:10.1126/scisignal.2002712 · Cited by 396
Mitochondrial Trafficking to Synapses in Cultured Primary Cortical Neurons
Chang, D. T. W., Honick, A. S., & Reynolds, I. J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1012-06.2006 · Cited by 391
Composition and dynamics of human mitochondrial nucleoids.
Garrido, N., Griparić, L., Jokitalo, E., Wartiovaara, J., van der Bliek, A. M., & Spelbrink, J. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-07-0399 · Cited by 390
Organization and dynamics of human mitochondrial DNA
Legros, F., Malka, F., Frachon, P., Lombès, A., & Rojo, M. (2004) · Journal of Cell Science · doi:10.1242/jcs.01134 · Cited by 383
RALA and RALBP1 regulate mitochondrial fission at mitosis
Kashatus, D. F., Lim, K.-H., Brady, D. C., Pershing, N. L. K., Cox, A. D., & Counter, C. M. (2011) · Nature Cell Biology · doi:10.1038/ncb2310 · Cited by 380
Control of mitochondrial transport and localization in neurons
MacAskill, A. F., & Kittler, J. T. (2009) · Trends in Cell Biology · doi:10.1016/j.tcb.2009.11.002 · Cited by 372
Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission
Zhao, J., Liu, T., Jin, S., Wang, X., Qu, M., Uhlén, P., Tomilin, N., Shupliakov, O., Lendahl, U., & Nistér, M. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.198 · Cited by 370
Oxidative Stress and Neurodegeneration
Moreira, P. I., Smith, M. A., Zhu, X., Nunomura, A., Castellani, R. J., & Perry, G. L. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1333.062 · Cited by 370
Dysregulation of HSG triggers vascular proliferative disorders
Chen, K.-H., Guo, X., Ma, D., Guo, Y., Li, Q., Yang, D., Li, P., Qiu, X., Wen, S., Xiao, R.-P., et al. (2004) · Nature Cell Biology · doi:10.1038/ncb1161 · Cited by 370
High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain
Lin, M. T. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.2.133 · Cited by 366
Mitochondrial ‘kiss‐and‐run’: interplay between mitochondrial motility and fusion–fission dynamics
Liu, X., Weaver, D., Shirihai, O. S., & Hajnóczky, G. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.255 · Cited by 360
Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons
Colin, E., Zala, D., Liot, G., Rangone, H., Borrell-Pagés, M., Li, X., Saudou, F., & Humbert, S. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.133 · Cited by 360
Mitochondrial Fusion Directs Cardiomyocyte Differentiation via Calcineurin and Notch Signaling
Kasahara, A., Cipolat, S., Chen, Y., Dorn, G. W., & Scorrano, L. (2013) · Science · doi:10.1126/science.1241359 · Cited by 354
T cell activation requires mitochondrial translocation to the immunological synapse
Quintana, A., Schwindling, C., Wenning, A. S., Becherer, U., Rettig, J., Schwarz, E. C., & Hoth, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703126104 · Cited by 347
Mitochondrial Function and Actin Regulate Dynamin-Related Protein 1-Dependent Mitochondrial Fission
Vos, K. J. D., Allan, V., Grierson, A. J., & Sheetz, M. P. (2005) · Current Biology · doi:10.1016/j.cub.2005.02.064 · Cited by 345
Reducing mitochondrial fission results in increased life span and fitness of two fungal ageing models
Scheckhuber, C. Q., Erjavec, N., Tinazli, A., Hamann, A., Nyström, T., & Osiewacz, H. D. (2007) · Nature Cell Biology · doi:10.1038/ncb1524 · Cited by 344
Tau regulates the attachment/detachment but not the speed of motors in microtubule-dependent transport of single vesicles and organelles
Trinczek, B., Ebneth, A., Mandelkow, E.-M., & Mandelkow, E. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.14.2355 · Cited by 344
Fzo1, a Protein Involved in Mitochondrial Fusion, Inhibits Apoptosis
Sugioka, R., Shimizu, S., & Tsujimoto, Y. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408910200 · Cited by 341
Glutamate Decreases Mitochondrial Size and Movement in Primary Forebrain Neurons
Rintoul, G. L., Filiano, A. J., Brocard, J. B., Kress, G. J., & Reynolds, I. J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-21-07881.2003 · Cited by 326
ER-Associated Mitochondrial Division Links the Distribution of Mitochondria and Mitochondrial DNA in Yeast
Murley, A., Lackner, L. L., Osman, C., West, M., Voeltz, G. K., Walter, P., & Nunnari, J. (2013) · eLife · doi:10.7554/elife.00422 · Cited by 326
Orchestration of lymphocyte chemotaxis by mitochondrial dynamics
Campello, S., Lacalle, R. A., Bettella, M., Mañes, S., Scorrano, L., & Viola, A. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061877 · Cited by 325
Mitochondrial dynamics controlled by mitofusins regulate Agrp neuronal activity and diet-induced obesity
Dietrich, M. O., Liu, Z.-W., & Horvath, T. L. (2013) · Cell · doi:10.1016/j.cell.2013.09.004 · Cited by 306
Microtubule motors at the intersection of trafficking and transport
Caviston, J. P., & Holzbaur, E. L. F. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.08.002 · Cited by 303
Mitochondria (and other cytoplasmic structures) in tissue cultures
Lewis, M. R., & Lewis, W. H. (1915) · American Journal of Anatomy · doi:10.1002/aja.1000170304 · Cited by 301
Association of mitochondria with microtubules in cultured cells.
Heggeness, M. H., Simon, M., & Singer, S. J. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.8.3863 · Cited by 298
Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence
Lee, S., Jeong, S.-Y., Lim, W.-C., Kim, S., Park, Y.-Y., Sun, X., Youle, R. J., & Cho, H. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700679200 · Cited by 298
Nerve Growth Factor Signaling Regulates Motility and Docking of Axonal Mitochondria
Chada, S. R., & Hollenbeck, P. J. (2004) · Current Biology · doi:10.1016/j.cub.2004.07.027 · Cited by 296
Axonal Transport and Alzheimer's Disease
Stokin, G. B., & Goldstein, L. S. B. (2006) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.75.103004.142637 · Cited by 296
Mammalian Dynamin-like Protein DLP1 Tubulates Membranes
Yoon, Y., Pitts, K. R., & McNiven, M. A. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.9.2894 · Cited by 285
A protein complex containing Mdm10p, Mdm12p, and Mmm1p links mitochondrial membranes and DNA to the cytoskeleton-based segregation machinery.
Boldogh, I., Nowakowski, D. W., Yang, H.-C., Chung, H., Karmon, S., Royes, P., & Pon, L. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-04-0225 · Cited by 283
A splice site mutation in the murine Opa1 gene features pathology of autosomal dominant optic atrophy
Alavi, M. V., Bette, S. J., Schimpf, S., Schuettauf, F., Schraermeyer, U., Wehrl, H. F., Rüttiger, L., Beck, S. C., Tonagel, F., Pichler, B. J., et al. (2006) · Brain · doi:10.1093/brain/awm005 · Cited by 278
Mutant huntingtin and mitochondrial dysfunction
Bossy‐Wetzel, E., Petrilli, A. M., & Knott, A. B. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.09.004 · Cited by 276
Molecular mechanisms and physiologic functions of mitochondrial dynamics
Otera, H., & Mihara, K. (2011) · The Journal of Biochemistry · doi:10.1093/jb/mvr002 · Cited by 265
The SUMO protease SENP5 is required to maintain mitochondrial morphology and function
Zunino, R., Schauss, A. C., Rippstein, P. U., Andrade-Navarro, M. A., & McBride, H. M. (2007) · Journal of Cell Science · doi:10.1242/jcs.03418 · Cited by 262
Decreased expression of Drp1 and Fis1 mediates mitochondrial elongation in senescent cells and enhances resistance to oxidative stress through PINK1
Mai, S., Klinkenberg, M., Auburger, G., Bereiter-Hahn, J., & Jendrach, M. (2010) · Journal of Cell Science · doi:10.1242/jcs.059246 · Cited by 256
Self-citation
Redistribution of mitochondria leads to bursts of ATP production during spontaneous mouse oocyte maturation
Yu, Y., Dumollard, R., Rossbach, A. M., Lai, F. A., & Swann, K. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22171 · Cited by 256
Mitochondrial division ensures the survival of postmitotic neurons by suppressing oxidative damage
Kageyama, Y., Zhang, Z., Roda, R. H., Fukaya, M., Wakabayashi, J., Wakabayashi, N., Kensler, T. W., Reddy, P. H., Iijima, M., & Sesaki, H. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201110034 · Cited by 256
Acute Impairment of Mitochondrial Trafficking by β-Amyloid Peptides in Hippocampal Neurons
Rui, Y., Tiwari, P., Xie, Z., & Zheng, J. Q. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3231-06.2006 · Cited by 255
Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1
Park, Y.-Y., Lee, S., Karbowski, M., Neutzner, A., Youle, R. J., & Cho, H. (2010) · Journal of Cell Science · doi:10.1242/jcs.061481 · Cited by 244
The mitochondrial protein MTP18 contributes to mitochondrial fission in mammalian cells
Tondera, D., Czauderna, F., Paulick, K., Schwarzer, R., Kaufmann, J., & Santel, A. (2005) · Journal of Cell Science · doi:10.1242/jcs.02415 · Cited by 239
Mitochondrial dynamics and disease, OPA1
Olichon, A., Guillou, E., Delettre, C., Landes, T., Pelloquin, L., Emorine, L. J., Mils, V., Daloyau, M., Hamel, C., Amati‐Bonneau, P., et al. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.04.003 · Cited by 238
Mitochondria at the Synapse
Ly, C. V., & Verstreken, P. (2006) · The Neuroscientist · doi:10.1177/1073858406287661 · Cited by 234
Separate fusion of outer and inner mitochondrial membranes
Malka, F., Guillery, O., Cifuentes-Díaz, C., Guillou, E., Belenguer, P., Lombès, A., & Rojo, M. (2005) · EMBO Reports · doi:10.1038/sj.embor.7400488 · Cited by 233
Dynamics of nucleoid structure regulated by mitochondrial fission contributes to cristae reformation and release of cytochrome c
Ban-Ishihara, R., Ishihara, T., Sasaki, N., Mihara, K., & Ishihara, N. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1301951110 · Cited by 231
OPA1 alternate splicing uncouples an evolutionary conserved function in mitochondrial fusion from a vertebrate restricted function in apoptosis
Olichon, A., Elachouri, G., Baricault, L., Delettre, C., Belenguer, P., & Lenaers, G. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402048 · Cited by 228
Rapid Diffusion of Green Fluorescent Protein in the Mitochondrial Matrix
Partikian, A., Ölveczky, B. P., Swaminathan, R., Li, Y., & Verkman, A. S. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.140.4.821 · Cited by 228
Short- and long-term alterations of mitochondrial morphology, dynamics and mtDNA after transient oxidative stress
Jendrach, M., Mai, S., Pohl, S., Vöth, M., & Bereiter‐Hahn, J. (2008) · Mitochondrion · doi:10.1016/j.mito.2008.06.001 · Cited by 225
Self-citation
Mitochondrial Localization and the Persistent Migration of Epithelial Cancer cells
Desai, S. P., Bhatia, S. N., Toner, M., & Irimia, D. (2013) · Biophysical Journal · doi:10.1016/j.bpj.2013.03.025 · Cited by 223
The role of free radicals in the aging brain and Parkinson’s Disease: Convergence and parallelism
Kumar, H., Lim, H.-W., More, S. V., Kim, B.-W., Koppula, S., Kim, I. S., & Choi, D.-K. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms130810478 · Cited by 212
Interactions between the endoplasmic reticulum, mitochondria, plasma membrane and other subcellular organelles
Lebiedzińska, M., Szabadkai, G., Jones, A. W. E., Duszyński, J., & Wieckowski, M. R. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.02.017 · Cited by 207
Human Myo19 Is a Novel Myosin that Associates with Mitochondria
Quintero, O. A., DiVito, M. M., Adikes, R. C., Kortan, M. B., Case, L. B., Lier, A., Panaretos, N. S., Slater, S. Q., Rengarajan, M., Feliu, M., et al. (2009) · Current Biology · doi:10.1016/j.cub.2009.10.026 · Cited by 204
STED super-resolution microscopy reveals an array of MINOS clusters along human mitochondria
Jans, D. C., Wurm, C. A., Riedel, D., Wenzel, D., Stagge, F., Deckers, M., Rehling, P., & Jakobs, S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1301820110 · Cited by 197
Myelination and Axonal Electrical Activity Modulate the Distribution and Motility of Mitochondria at CNS Nodes of Ranvier
Ohno, N., Kidd, G. J., Mahad, D., Kiryu‐Seo, S., Avishai, A., Komuro, H., & Trapp, B. D. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0095-11.2011 · Cited by 194
The mitochondrial fission factor dynamin‐related protein 1 modulates T‐cell receptor signalling at the immune synapse
Baixauli, F., Martin-Cofreces, N. B., Morlino, G., Carrasco, Y. R., Calabia-Linares, C., Veiga, E., Serrador, J. M., & Sánchez‐Madrid, F. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.25 · Cited by 191
Hydrogen peroxide induces apoptosis in HeLa cells through mitochondrial pathway
Singh, M. K., Sharma, H., & Singh, N. (2007) · Mitochondrion · doi:10.1016/j.mito.2007.07.003 · Cited by 191
Mitofusin-2 Is a Major Determinant of Oxidative Stress-mediated Heart Muscle Cell Apoptosis
Shen, T., Zheng, M., Cao, C., Chen, C., Tang, J., Zhang, W., Cheng, H., Chen, K., & Xiao, R. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702657200 · Cited by 189
Mitofusin 2 Protects Cerebellar Granule Neurons against Injury-induced Cell Death
Jahani‐Asl, A., Cheung, E. C., Neuspiel, M., MacLaurin, J. G., Fortin, A., Park, D. S., McBride, H. M., & Slack, R. S. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703812200 · Cited by 187
Reverse of Age-Dependent Memory Impairment and Mitochondrial DNA Damage in Microglia by an Overexpression of Human Mitochondrial Transcription Factor A in Mice
Hayashi, Y., Yoshida, M., Yamato, M., Ide, T., Wu, Z., Ochi-Shindou, M., Kanki, T., Kang, D., Sunagawa, K., Tsutsui, H., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1957-08.2008 · Cited by 181
Human gelsolin prevents apoptosis by inhibiting apoptotic mitochondrial changes via closing VDAC
Kusano, H., Shimizu, S., Koya, R. C., Fujita, H., Kamada, S., Kuzumaki, N., & Tsujimoto, Y. (2000) · Oncogene · doi:10.1038/sj.onc.1203868 · Cited by 178
Mitochondria form a filamentous reticular network in hippocampal dendrites but are present as discrete bodies in axons: A three-dimensional ultrastructural study
Popov, V. I., Medvedev, N. I., Davies, H. A., & Stewart, M. G. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20682 · Cited by 175
Functional organization of mammalian mitochondrial DNA in nucleoids: history, recent developments, and future challenges
Spelbrink, J. N. (2010) · IUBMB Life · doi:10.1002/iub.282 · Cited by 171
Live Cell Imaging of Mitochondrial Movement along Actin Cables in Budding Yeast
Fehrenbacher, K. L., Yang, H., Gay, A. C., Huckaba, T. M., & Pon, L. A. (2004) · Current Biology · doi:10.1016/j.cub.2004.11.004 · Cited by 170
Morpho-dynamic changes of mitochondria during ageing of human endothelial cells
Jendrach, M., Pohl, S., Vöth, M., Kowald, A., Hammerstein, P., & Bereiter‐Hahn, J. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.03.002 · Cited by 170
Self-citation
Why size matters – balancing mitochondrial dynamics in Alzheimer's disease
DuBoff, B., Feany, M. Β., & Götz, J. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.03.002 · Cited by 168
Mitochondrial biogenesis in the axons of vertebrate peripheral neurons
Amiri, M., & Hollenbeck, P. J. (2008) · Developmental Neurobiology · doi:10.1002/dneu.20668 · Cited by 165
Frequency and Selectivity of Mitochondrial Fusion Are Key to Its Quality Maintenance Function
Mouli, P. K., Twig, G., & Shirihai, O. S. (2009) · Biophysical Journal · doi:10.1016/j.bpj.2008.12.3959 · Cited by 164
Convergence of Amyloid-β and Tau Pathologies on Mitochondria In Vivo
Eckert, A., Schulz, K. L., Rhein, V. F., & Götz, J. (2010) · Molecular Neurobiology · doi:10.1007/s12035-010-8109-5 · Cited by 160
The Micro-Architecture of Mitochondria at Active Zones: Electron Tomography Reveals Novel Anchoring Scaffolds and Cristae Structured for High-Rate Metabolism
Perkins, G. A., Tjong, J., Brown, J. M., Poquiz, P., Scott, R. T., Kolson, D. R., Ellisman, M. H., & Spirou, G. A. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1517-09.2010 · Cited by 160
Role of mitofusin 2 mutations in the physiopathology of Charcot–Marie–Tooth disease type 2A
Cartoni, R., & Martinou, J. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.05.003 · Cited by 157
Role of MINOS in mitochondrial membrane architecture and biogenesis
van der Laan, M., Bohnert, M., Wiedemann, N., & Pfanner, N. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2012.01.004 · Cited by 156
The 4977bp deletion of mitochondrial DNA in human skeletal muscle, heart and different areas of the brain: A useful biomarker or more?
Meißner, C., Bruse, P., Mohamed, S. A., Schulz, A., Warnk, H., Storm, T., & Oehmichen, M. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.03.004 · Cited by 156
Syntabulin–Kinesin-1 Family Member 5B-Mediated Axonal Transport Contributes to Activity-Dependent Presynaptic Assembly
Cai, Q., Pan, P., & Sheng, Z. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0731-07.2007 · Cited by 152
Mitochondrial network morphology: building an integrative, geometrical view
Rafelski, S. M. (2013) · BMC Biology · doi:10.1186/1741-7007-11-71 · Cited by 151
Mitochondrial Membrane Potential in Axons Increases with Local Nerve Growth Factor or Semaphorin Signaling
Verburg, J., & Hollenbeck, P. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2614-08.2008 · Cited by 150
The molecular mechanism of mitochondrial fusion
Hoppins, S. C., & Nunnari, J. M. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.07.005 · Cited by 148
Mitochondria and calcium in health and disease
Duchen, M. R., Verkhratsky, A., & Muallem, S. (2008) · Cell Calcium · doi:10.1016/j.ceca.2008.02.001 · Cited by 147
Retarded diffusion of ADP in cardiomyocytes: possible role of mitochondrial outer membrane and creatine kinase in cellular regulation of oxidative phosphorylation
Saks, V. A., Vasil'eva, E., Belikova, Y., Kuznetsov, A. V., Lyapina, S., Petrova, L., & Perov, N. A. (1993) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(93)90166-d · Cited by 145
Dynamics, structure, and function are coupled in the mitochondrial matrix.
Scalettar, B. A., Abney, J. R., & Hackenbrock, C. R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.18.8057 · Cited by 143
MARF and Opa1 Control Mitochondrial and Cardiac Function in Drosophila
Dorn, G. W., Clark, C. F., Eschenbacher, W. H., Kang, M., Engelhard, J. T., Warner, S. J., Matkovich, S. J., & Jowdy, C. C. (2010) · Circulation Research · doi:10.1161/circresaha.110.236745 · Cited by 139
Restricted diffusion of OXPHOS complexes in dynamic mitochondria delays their exchange between cristae and engenders a transitory mosaic distribution
Wilkens, V., Kohl, W., & Busch, K. B. (2012) · Journal of Cell Science · doi:10.1242/jcs.108852 · Cited by 139
Nanoscale Organization of Mitochondrial Microcompartments Revealed by Combining Tracking and Localization Microscopy
Dellmann, T., Richter, C. P., Wilkens, V., Hess, S. T., Piehler, J., & Busch, K. B. (2011) · Nano Letters · doi:10.1021/nl203343a · Cited by 137
ROMO1 Is an Essential Redox-Dependent Regulator of Mitochondrial Dynamics
Norton, M., Ng, A. C., Baird, S. D., Dumoulin, A., Shutt, T. E., Mah, N., Andrade-Navarro, M. A., McBride, H. M., & Screaton, R. A. (2014) · Science Signaling · doi:10.1126/scisignal.2004374 · Cited by 134
High- and low-calcium-dependent mechanisms of mitochondrial calcium signalling
Spät, A., Szanda, G., Csordás, G., & Hajnóczky, G. (2008) · Cell Calcium · doi:10.1016/j.ceca.2007.11.015 · Cited by 131
Mitochondrial Dynamics: Functional Link with Apoptosis
Otera, H., & Mihara, K. (2012) · International Journal of Cell Biology · doi:10.1155/2012/821676 · Cited by 131
Dynactin Is Required for Coordinated Bidirectional Motility, but Not for Dynein Membrane Attachment
Haghnia, M., Cavalli, V., Shah, S. B., Schimmelpfeng, K., Brusch, R., Yang, G., Herrera, C. M., Pilling, A. D., & Goldstein, L. S. B. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-08-0695 · Cited by 128
Evolution of the mitochondrial fusion–fission cycle and its role in aging
Kowald, A., & Kirkwood, T. B. L. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1101604108 · Cited by 126
Interplay between mitochondria and cellular calcium signalling
Jacobson, J., & Duchen, M. R. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000009869.29827.df · Cited by 123
Activity-Dependent Regulation of Mitochondrial Motility by Calcium and Na/K-ATPase at Nodes of Ranvier of Myelinated Nerves
Zhang, C. L., Ho, P. L., Kintner, D. B., Sun, D., & Chiu, S. Y. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4551-09.2010 · Cited by 123
Androgen receptor with elongated polyglutamine tract forms aggregates that alter axonal trafficking and mitochondrial distribution in motoneuronal processes
Piccioni, F., Pinton, P., Simeoni, S., Pozzi, P., Fascio, U., Vismara, G., Martini, L., Rizzuto, R., & Poletti, A. (2002) · The FASEB Journal · doi:10.1096/fj.01-1035fje · Cited by 123
WAVE1 controls neuronal activity-induced mitochondrial distribution in dendritic spines
Sung, J. Y., Engmann, O., Teylan, M. A., Nairn, A. C., Greengard, P., & Kim, Y. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712180105 · Cited by 117
Mitochondria are morphologically heterogeneous within cells
Collins, T. J., & Bootman, M. D. (2003) · Journal of Experimental Biology · doi:10.1242/jeb.00244 · Cited by 116
What can mitochondrial heterogeneity tell us about mitochondrial dynamics and autophagy?
Wikström, J. D., Twig, G., & Shirihai, O. S. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.06.006 · Cited by 114
The rescue of microtubule-dependent traffic recovers mitochondrial function in Parkinson's disease
Esteves, A. R., Gozes, I., & Cardoso, S. M. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.10.003 · Cited by 110
Ca2+-dependent regulation of mitochondrial dynamics by the Miro–Milton complex
Liu, X., & Hajnóczky, G. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.05.013 · Cited by 107
Mitochondrial reticulum network dynamics in relation to oxidative stress, redox regulation, and hypoxia
Ježek, P., & Plecitá‐Hlavatá, L. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.02.014 · Cited by 106
Mitochondrial membrane dynamics, cristae remodelling and apoptosis
Heath-Engel, H. M., & Shore, G. C. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.02.006 · Cited by 104
Regulation of mitochondria distribution by RhoA and formins
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Vimentin supports mitochondrial morphology and organization
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How mitochondria fuse
Meeusen, S., & Nunnari, J. M. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.06.014 · Cited by 97
Molecular landmarks along the axonal route: axonal transport in health and disease
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Partial uncoupling of oxidative phosphorylation induces premature senescence in human fibroblasts and yeast mother cells
Stöckl, P., Zankl, C., Hütter, E., Unterluggauer, H., Laun, P., Heeren, G., Bogengruber, E., Herndler‐Brandstetter, D., Breitenbach, M., & Jansen‐Dürr, P. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.06.005 · Cited by 95
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Self-citation
Mitochondrial DNA alterations and reduced mitochondrial function in aging
Hebert, S. L., Lanza, I. R., & Nair, K. S. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.03.007 · Cited by 92
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Modulating Mitochondrial Intracellular Location as a Redox Signal
Murphy, M. P. (2012) · Science Signaling · doi:10.1126/scisignal.2003386 · Cited by 88
Calcium microdomains and oxidative stress
Davidson, S. M., & Duchen, M. R. (2006) · Cell Calcium · doi:10.1016/j.ceca.2006.08.017 · Cited by 88
Agonist-induced regulation of mitochondrial and endoplasmic reticulum motility
Brough, D., Schell, M. J., & Irvine, R. F. (2005) · Biochemical Journal · doi:10.1042/bj20050738 · Cited by 83
Emergence of the Mitochondrial Reticulum from Fission and Fusion Dynamics
Sukhorukov, V. M., Dikov, D., Reichert, A. S., & Meyer‐Hermann, M. (2012) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002745 · Cited by 80
Ca2+ signaling, mitochondria and sensitivity to oxidative stress in aging astrocytes
Lin, D., Wu, J., Holstein, D. M., Upadhyay, G., Rourk, W., Muller, E., & Lechleiter, J. D. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.11.004 · Cited by 75
Diffusion of Tricarboxylic Acid Cycle Enzymes in the Mitochondrial Matrix in Vivo
Haggie, P. M., & Verkman, A. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207456200 · Cited by 75

Research works printed but not linked: 1

Lombe, 2002, Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins, Mol Biol Cell, 13, 4343, 10.1091/mbc.E02-06-0330 · DOI

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See all 48

Authors: Bereiter-Hahn, J.
Venue: Progress in molecular biology and translational science
Publisher: Elsevier
Published: 2014
Volume: 127
Pages: 93-131
ISSN: 1877-1173 (ISSN-L)
DOI: 10.1016/b978-0-12-394625-6.00004-0
OpenAlex: W2405770350
Cited by: 48
References: 246
Citations by year: 2026: 3 · 2025: 4 · 2024: 5 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 6 · 2018: 3 · 2017: 6 · 2016: 9 · 2015: 4
FWCI: 8.04
Type: book chapter
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Progress in molecular biology and translational science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
Keywords: mitochondrial dynamics, mitochondrial fusion, mitochondrial fission, mitochondrial biogenesis, mitochondrial trafficking, motor proteins, mitochondrial DNA mutations, reactive oxygen species, neurodegeneration, aging, autophagy, calcium regulation, ATP production, electron transport chain
MeSH terms: Aging, Animals, Humans, Mitochondrial Proteins, Mitochondrial Diseases, Mitochondrial Membranes, Mitochondrial Size, Mitochondrial Dynamics

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