Varicella-zoster
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T cell memory established in humans during early age can deteriorate during the second half of life.
“However, the memory responses can be unsustained, because T cell memory established in humans during early age can deteriorate during the second half of life.”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [49]
The most obvious example of unsustained memory responses is the reactivation of latent varicella zoster virus (VZV) infection that manifests as herpes zoster.
“The most obvious example of unsustained memory responses is the reactivation of latent varicella zoster virus (VZV) infection that manifests as herpes zoster.”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [49]
A steady decline of VZV-specific CD4+ T cells over time has been documented, which is only very transiently boosted with zoster vaccination or reactivation.
“A steady decline of VZV-specific CD4+ T cells over time has been documented, which is only very transiently boosted with zoster vaccination or reactivation (49).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [49]
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Self-citationHERPES ZOSTER WITH DYSFUNCTION OF BLADDER AND ANUS
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- Authors
- Gilden, D., Nagel, M. A., & Cohrs, R. J.
- Affiliations
- University of Colorado Anschutz (US)
- Corresponding author
- Don Gilden
- Venue
- Handbook of clinical neurology
- Publisher
- Elsevier
- Published
- 2014
- Volume
- 123
- Pages
- 265-283
- ISSN
- 0072-9752 (ISSN-L)
- PMC
- PMC5489072
- OpenAlex
- W155530366
- Cited by
- 51
- References
- 187
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 5 · 2022: 6 · 2021: 6 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 6 · 2014: 1
- FWCI
- 14.36
- Type
- book chapter
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Handbook of clinical neurology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (AG 006127, R37AG006127, AG032958, R01AG006127, P01AG032958)
- National Institute of Neurological Disorders and Stroke (K08NS067070, R01NS082228, NS 067070, NS082228)
- Topics
- Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Keywords
- varicella-zoster virus, herpes zoster, varicella, viral reactivation, neurological complications, postherpetic neuralgia, zoster sine herpete, meningoencephalitis, cerebellitis, cranial nerve palsy, viral latency, pathogenesis, cell-mediated immunity, herpes zoster vaccination
- MeSH terms
- Herpes Zoster, Humans, Nervous System Diseases, Herpesvirus 3, Human
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