The DOI matches its Crossref record, with a small difference in title or year; 67 of the 67 references it cites were found in a registry or an index.
Cardiorespiratory Coupling
Open accessAbstract
Cardiorespiratory coupling is an encompassing term describing more than the well-recognized influences of respiration on heart rate and blood pressure. Our data indicate that cardiorespiratory coupling reflects a reciprocal interaction between autonomic and respiratory control systems, and the cardiovascular system modulates the ventilatory pattern as well. For example, cardioventilatory coupling refers to the influence of heart beats and arterial pulse pressure on respiration and is the tendency for the next inspiration to start at a preferred latency after the last heart beat in expiration. Multiple complementary, well-described mechanisms mediate respiration's influence on cardiovascular function, whereas mechanisms mediating the cardiovascular system's influence on respiration may only be through the baroreceptors but are just being identified. Our review will describe a differential effect of conditioning rats with either chronic intermittent or sustained hypoxia on sympathetic nerve activity but also on ventilatory pattern variability. Both intermittent and sustained hypoxia increase sympathetic nerve activity after 2 weeks but affect sympatho-respiratory coupling differentially. Intermittent hypoxia enhances sympatho-respiratory coupling, which is associated with low variability in the ventilatory pattern. In contrast, after constant hypobaric hypoxia, 1-to-1 coupling between bursts of sympathetic and phrenic nerve activity is replaced by 2-to-3 coupling. This change in coupling pattern is associated with increased variability of the ventilatory pattern. After baro-denervating hypobaric hypoxic-conditioned rats, splanchnic sympathetic nerve activity becomes tonic (distinct bursts are absent) with decreases during phrenic nerve bursts and ventilatory pattern becomes regular. Thus, conditioning rats to either intermittent or sustained hypoxia accentuates the reciprocal nature of cardiorespiratory coupling. Finally, identifying a compelling physiologic purpose for cardiorespiratory coupling is the biggest barrier for recognizing its significance. Cardiorespiratory coupling has only a small effect on the efficiency of gas exchange; rather, we propose that cardiorespiratory control system may act as weakly coupled oscillator to maintain rhythms within a bounded variability.
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“Briefly, researchers (Larsen et al., 2010; Thayer et al., 2011; Dick et al., 2014) suggest a common basis for HRV and respiration, with a bi-directional communication between the respiratory and cardiovascular systems (Thayer et al., 2012).”
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Metadata
- Authors
- Dick, T. E., Hsieh, Y.-H., Dhingra, R. R., Baekey, D. M., Galán, R. F., Wehrwein, E., & Morris, K. F.
- Affiliations
- Case Western Reserve University (US)
- University of Florida (US)
- Michigan State University (US)
- University of South Florida (US)
- Corresponding author
- Dick, Thomas E.
- ORCID
- Venue
- Progress in Brain Research
- Publisher
- Elsevier
- Published
- 2014
- Volume
- 209
- Pages
- 191-205
- ISSN
- 0079-6123 (ISSN-L)
- PMC
- PMC4052709
- OpenAlex
- W172191733
- Cited by
- 178
- References
- 67
- Citations by year
- 2026: 13 · 2025: 16 · 2024: 26 · 2023: 24 · 2022: 14 · 2021: 18 · 2020: 17 · 2019: 15 · 2018: 14 · 2017: 8 · 2016: 7 · 2015: 5 · 2014: 1
- FWCI
- 9.79
- Type
- book chapter
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Progress in brain research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL080318, HL007913, HL-080318, T32HL007913)
- National Institute of Neurological Disorders and Stroke (NS-069220, R01NS069220)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
- Keywords
- cardiorespiratory coupling, intermittent hypoxia, sustained hypoxia, hypobaric hypoxia, sympathetic activity, phrenic nerve activity, baroreceptors, respiratory control, heart rate, blood pressure, coupled oscillators
- MeSH terms
- Animals, Hemodynamics, Humans, Periodicity, Respiratory Physiological Phenomena, Sympathetic Nervous System, Rats
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