The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Central thermoreceptors
Abstract
Homeotherms maintain their core body temperature within a narrow range by employing multiple redundant mechanisms to control heat production and dissipation. Preoptic area/anterior hypothalamic (PO/AH) neurons receive thermal signals from peripheral and deep-body thermoreceptors as well as hormonal and metabolic signals. A population of PO/AH neurons termed warm-sensitive increase their firing temperature with warming and are considered central thermoreceptors. Electrophysiologic and pharmacologic experiments have provided descriptions of their characteristics and signaling mechanisms. These studies have also allowed insights into the mechanisms by which neurochemicals important in thermoregulation exert their influence. Finally, the cellular mechanism involved in the interactions between thermoregulation and other aspects of homeostasis, such as energy metabolism and osmoregulation, have started to be unraveled.
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“For example, thermoreceptors have been found in other areas, including the brain stem, and indeed in other central nervous system structures such as the spinal cord [30], underscoring the fact that the thermoregulatory system is diffuse [31].”
From Human thermal perception and time of day: A review (2021) · cites this paper as [30]
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The TRPM2 channel is a hypothalamic heat sensor that limits fever and can drive hypothermia
Song, K., Wang, H., Kamm, G. B., Pohle, J., Reis, F. D. C., Heppenstall, P. A., Wende, H., & Siemens, J. (2016) · Science · doi:10.1126/science.aaf7537 · Cited by 405
Warm-Sensitive Neurons that Control Body Temperature
Tan, C. L., Cooke, E. K., Leib, D. E., Lin, Y.-C., Daly, G. E., Zimmerman, C. A., & Knight, Z. A. (2016) · Cell · doi:10.1016/j.cell.2016.08.028 · Cited by 402
Central and peripheral thermal control of effectors in homeothermic temperature regulation.
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TEMPERATURE REGULATION IN MAMMALS AND OTHER VERTEBRATES
Spalding, J. M. K. (1974) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.37.3.362-c · Cited by 264
Thermal stimulation of electrical activity of single units of the preoptic region
Nakayama, T., Hammel, H. T., Hardy, J. D., & Eisenman, J. S. (1963) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1963.204.6.1122 · Cited by 260
Boulant, J. A., & Hardy, J. D. (1974) · The Journal of Physiology · doi:10.1113/jphysiol.1974.sp010627 · Cited by 241
Thermoregulatory responses to hypothalamic cooling in unanesthetized dogs
Hammel, H. T., Hardy, J. D., & Fusco, M. M. (1960) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1960.198.3.481 · Cited by 218
Single unit activity of anterior hypothalamus during local heating
Nakayama, T., Eisenman, J. S., & Hardy, J. D. (1961) · Science · doi:10.1126/science.134.3478.560 · Cited by 214
Neuronal basis of Hammel's model for set-point thermoregulation
Boulant, J. A. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01064.2005 · Cited by 213
Hypothalamic mechanisms in thermoregulation.
Boulant, J. (1981) · PubMed · Cited by 166
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A synaptic temperature sensor for body cooling
Kamm, G. B., Boffi, J. C., Zuza, K., Nencini, S., Campos, J., Schrenk-Siemens, K., Sonntag, I., Kabaoğlu, B., Hay, M. Y. A. E., Schwarz, Y. N., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.10.001 · Cited by 68
Human thermal perception and time of day: A review
Vellei, M., Chinazzo, G., Zitting, K.-M., & Hubbard, J. (2021) · Temperature · doi:10.1080/23328940.2021.1976004 · Cited by 45
Be cool to be far: Exploiting hibernation for space exploration
Cerri, M., Hitrec, T., Luppi, M., & Amici, R. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.03.037 · Cited by 38
From Low-Grade Inflammation in Osteoarthritis to Neuropsychiatric Sequelae: A Narrative Review
Naumovs, V., Groma, V., & Mednieks, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232416031 · Cited by 20
Fujimoto, T., Fujii, N., Dobashi, K., Cao, Y., Matsutake, R., Takayanagi, M., Kondo, N., & Nishiyasu, T. (2021) · Physiology & Behavior · doi:10.1016/j.physbeh.2021.113531 · Cited by 14
Metadata
- Authors
- Tabarean, I. V.
- Affiliations
- Scintillon Institute (US)
- Corresponding author
- Iustin V. Tabarean
- ORCID
- Iustin V. Tabarean
- Venue
- Handbook of Clinical Neurology
- Publisher
- Elsevier
- Published
- 2018
- Volume
- 156
- Pages
- 121-127
- ISSN
- 0072-9752 (ISSN-L)
- OpenAlex
- W4233709709
- Cited by
- 11
- References
- 55
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 4
- FWCI
- 3.32
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Handbook of clinical neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Physiology (medical) › Thermoregulation and physiological responses
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- warm-sensitive neurons, preoptic area, anterior hypothalamus, thermoregulation, homeothermy, core body temperature, energy metabolism, osmoregulation
- MeSH terms
- Animals, Body Temperature Regulation, Brain, Homeostasis, Humans, Thermoreceptors
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