The DOI matches its Crossref record; 411 of the 411 references it cites were found in a registry or an index.
Organokines in disease
Abstract
Studies have linked obesity, metabolic syndrome, type 2 diabetes, cardiovascular disease (CVD), nonalcoholic fatty liver disease (NAFLD) and dementia. Their relationship to the incidence and progression of these disease states suggests an interconnected pathogenesis involving chronic low-grade inflammation and oxidative stress. Metabolic syndrome represents comorbidities of central obesity, insulin resistance, dyslipidemia, hypertension and hyperglycemia associated with increased risk of type 2 diabetes, NAFLD, atherosclerotic CVD and neurodegenerative disease. As the socioeconomic burden for these diseases has grown signficantly with an increasing elderly population, new and alternative pharmacologic solutions for these cardiometabolic diseases are required. Adipose tissue, skeletal muscle and liver are central endocrine organs that regulate inflammation, energy and metabolic homeostasis, and the neuroendocrine axis through synthesis and secretion of adipokines, myokines, and hepatokines, respectively. These organokines affect each other and communicate through various endocrine, paracrine and autocrine pathways. The ultimate goal of this review is to provide a comprehensive understanding of organ crosstalk. This will include the roles of novel organokines in normal physiologic regulation and their pathophysiological effect in obesity, metabolic syndrome, type 2 diabetes, CVD, NAFLD and neurodegenerative disorders.
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“It also stimulates insulin release by increasing the expression of the glucagon-1-like peptide (GLP-1) [11,59].”
From Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions (2021) · cites this paper as [59]
In the citing paper
“These cytokines, especially TNF-α and leptin, seem to aggravate hypertension, which, together with visceral obesity, dyslipidemia, and hyperglycemia, configure the metabolic syndrome scenario [59,93].”
From Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions (2021) · cites this paper as [59]
Citations
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Cited by
Sorted by citations
Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions
de Oliveira dos Santos, A. R., de Oliveira Zanuso, B., Miola, V. F. B., Barbalho, S. M., Santos Bueno, P. C., Flato, U. A. P., Detregiachi, C. R. P., Buchaim, D. V., Buchaim, R. L., Tofano, R. J., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052639 · Cited by 189
Physical Exercise and Myokines: Relationships with Sarcopenia and Cardiovascular Complications
Barbalho, S. M., Flato, U. A. P., Tofano, R. J., Goulart, R. D. A., Guiguer, E. L., Detregiachi, C. R. P., Buchaim, D. V., Araújo, A. C., Buchaim, R. L., Reina, F. T. R., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103607 · Cited by 156
Metadata
- Authors
- Chung, H. S., & Choi, K. M.
- Affiliations
- Hallym University (KR)
- Korea University (KR)
- Corresponding author
- Kyung Mook Choi
- Venue
- Advances in clinical chemistry
- Publisher
- Elsevier
- Published
- 2020
- Volume
- 94
- Pages
- 261-321
- ISSN
- 0065-2423 (ISSN-L)
- OpenAlex
- W2967080190
- Cited by
- 46
- References
- 411
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 9 · 2023: 5 · 2022: 9 · 2021: 7 · 2020: 3
- FWCI
- 17.66
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Advances in clinical chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Korea University
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- adipokines, myokines, hepatokines, obesity, metabolic syndrome, type 2 diabetes, cardiovascular disease, non-alcoholic fatty liver disease, dementia, neurodegenerative diseases, low-grade inflammation, oxidative stress, organ crosstalk, insulin resistance, adipose tissue, skeletal muscle, liver, cardiometabolic disease
- MeSH terms
- Cardiovascular Diseases, Diabetes Mellitus, Type 2, Humans, Obesity, Neurodegenerative Diseases, Metabolic Syndrome, Adipokines
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