Cited by 156Nutrition and Health in AgingMuscle Physiology and DisordersExercise and Physiological Responses

Physical Exercise and Myokines: Relationships with Sarcopenia and Cardiovascular Complications

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Barbalho, Sandra Maria, Flato, Uri Adrian Prync, Tofano, Ricardo José, Goulart, Ricardo de Alvares, Guiguer, Elen Landgraf, Detregiachi, Cláudia Rucco P., Buchaim, Daniela Vieira, Araújo, Adriano Cressoni +5 more·2020·International Journal of Molecular Sciences

Abstract

Skeletal muscle is capable of secreting different factors in order to communicate with other tissues. These mediators, the myokines, show potentially far-reaching effects on non-muscle tissues and can provide a molecular interaction between muscle and body physiology. Sarcopenia is a chronic degenerative neuromuscular disease closely related to cardiomyopathy and chronic heart failure, which influences the production and release of myokines. Our objective was to explore the relationship between myokines, sarcopenia, and cardiovascular diseases (CVD). The autocrine, paracrine, and endocrine actions of myokines include regulation of energy expenditure, insulin sensitivity, lipolysis, free fatty acid oxidation, adipocyte browning, glycogenolysis, glycogenesis, and general metabolism. A sedentary lifestyle accelerates the aging process and is a risk factor for developing sarcopenia, metabolic syndrome, and CVD. Increased adipose tissue resulting from the decrease in muscle mass in patients with sarcopenia may also be involved in the pathology of CVD. Myokines are protagonists in the complex condition of sarcopenia, which is associated with adverse clinical outcomes in patients with CVD. The discovery of new pathways and the link between myokines and CVD remain a cornerstone toward multifaceted interventions and perhaps the minimization of the damage resulting from muscle loss induced by factors such as atherosclerosis.

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Authors
Barbalho, S. M., Flato, U. A. P., Tofano, R. J., Goulart, R. D. A., Guiguer, E. L., Detregiachi, C. R. P., Buchaim, D. V., Araújo, A. C., Buchaim, R. L., Reina, F. T. R., Biteli, P., Reina, D. O. B. R., & Bechara, M. D.
Affiliations
  • Faculdade de Medicina de Marília (BR)
  • Postgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marilia (UNIMAR), Avenue Hygino Muzzy Filho, 1001, Marília 17525-902, São Paulo, Brazil
  • Universidade de Marília (BR)
  • Universidade de São Paulo (BR)
Corresponding author
Barbalho, Sandra Maria
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2020-05-20
Volume
21
Issue
10
Pages
3607
ISSN
1422-0067 (ISSN-L)
OpenAlex
W3028055237
Cited by
156
References
107
Citations by year
2026: 18 · 2025: 23 · 2024: 26 · 2023: 27 · 2022: 40 · 2021: 20 · 2020: 2
FWCI
2.84
Type
journal article
Language
en
Open access
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords
myokines, sarcopenia, cardiovascular disease, physical activity, skeletal muscle, sedentary lifestyle, cardiomyopathy, chronic heart failure, metabolic syndrome, adipose tissue, muscle mass loss, atherosclerosis, insulin sensitivity, energy expenditure
MeSH terms
Animals, Cardiovascular Diseases, Cell Communication, Humans, Exercise, Cytokines, Muscle, Skeletal, Adipokines, Sarcopenia

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