Physical Exercise and Myokines: Relationships with Sarcopenia and Cardiovascular Complications
Open accessAbstract
Skeletal muscle is capable of secreting different factors in order to communicate with other tissues. These mediators, the myokines, show potentially far-reaching effects on non-muscle tissues and can provide a molecular interaction between muscle and body physiology. Sarcopenia is a chronic degenerative neuromuscular disease closely related to cardiomyopathy and chronic heart failure, which influences the production and release of myokines. Our objective was to explore the relationship between myokines, sarcopenia, and cardiovascular diseases (CVD). The autocrine, paracrine, and endocrine actions of myokines include regulation of energy expenditure, insulin sensitivity, lipolysis, free fatty acid oxidation, adipocyte browning, glycogenolysis, glycogenesis, and general metabolism. A sedentary lifestyle accelerates the aging process and is a risk factor for developing sarcopenia, metabolic syndrome, and CVD. Increased adipose tissue resulting from the decrease in muscle mass in patients with sarcopenia may also be involved in the pathology of CVD. Myokines are protagonists in the complex condition of sarcopenia, which is associated with adverse clinical outcomes in patients with CVD. The discovery of new pathways and the link between myokines and CVD remain a cornerstone toward multifaceted interventions and perhaps the minimization of the damage resulting from muscle loss induced by factors such as atherosclerosis.
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This environment constitutes fertile soil for atherosclerosis's chronic inflammatory process, a prelude to several cardiovascular conditions.
“This environment constitutes fertile soil for atherosclerosis’s chronic inflammatory process, a prelude to several cardiovascular conditions [8].”
From Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions (2021) · cites this paper as [8]
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Sarcopenia: revised European consensus on definition and diagnosis
Cruz-Jentoft, A. J., Bahat, G., Bauer, J., Boirie, Y., Bruyère, O., Cederholm, T., Cooper, C., Landi, F., Rolland, Y., Sayer, A. A., et al. (2019) · Age and Ageing · doi:10.1093/ageing/afy169 · Cited by 13,818 · see citing works
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810 · see citing works
Sarcopenia: revised European consensus on definition and diagnosis
Cruz-Jentoft, A. J., Bahat, G., Bauer, J., Boirie, Y., Bruyère, O., Cederholm, T., Cooper, C., Landi, F., Rolland, Y., Sayer, A. A., et al. (2019) · Age and Ageing · doi:10.1093/ageing/afz046 · Cited by 3,803 · see citing works
Winstein, C. J., Stein, J., Arena, R., Bates, B., Cherney, L. R., Cramer, S. C., Deruyter, F., Eng, J. J., Fisher, B., Harvey, R. L., et al. (2016) · Stroke · doi:10.1161/str.0000000000000098 · Cited by 3,293 · see citing works
The anti-inflammatory effect of exercise
Petersen, A. M. W., & Pedersen, B. K. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00164.2004 · Cited by 3,100 · see citing works
Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6
Pedersen, B. K., & Febbraio, M. A. (2008) · Physiological Reviews · doi:10.1152/physrev.90100.2007 · Cited by 2,388 · see citing works
FoxO3 Controls Autophagy in Skeletal Muscle In Vivo
Mammucari, C., Milan, G., Romanello, V., Masiero, E., Rudolf, R., Del Piccolo, P., Burden, S. J., Di Lisi, R., Sandri, C., Zhao, J., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.001 · Cited by 1,953 · see citing works
Sarcopenia: Aging-Related Loss of Muscle Mass and Function
Larsson, L., Degens, H., Li, M., Salviati, L., Lee, Y. I., Thompson, W., Kirkland, J. L., & Sandri, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00061.2017 · Cited by 1,797 · see citing works
Zhao, J., Brault, J. J., Schild, A., Cao, P., Sandri, M., Schiaffino, S., Lecker, S. H., & Goldberg, A. L. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.004 · Cited by 1,489 · see citing works
Xu, J., Lloyd, D. J., Hale, C., Stanislaus, S., Chen, M., Sivits, G., Vonderfecht, S., Hecht, R., Li, Y.-S., Lindberg, R. A., et al. (2009) · Diabetes · doi:10.2337/db08-0392 · Cited by 1,151 · see citing works
Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size
Trendelenburg, A. U., Meyer, A., Rohner, D., Boyle, J., Hatakeyama, S., & Glass, D. J. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00105.2009 · Cited by 792 · see citing works
Sarcopenia: A Time for Action. An SCWD Position Paper
Bauer, J. M., Morley, J. E., Schols, A. M. W. J., Ferrucci, L., Cruz-Jentoft, A. J., Dent, E., Baracos, V. E., Crawford, J. A., Doehner, W., Heymsfield, S. B., et al. (2019) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12483 · Cited by 739 · see citing works
The diseasome of physical inactivity – and the role of myokines in muscle–fat cross talk
Pedersen, B. K. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.179515 · Cited by 631 · see citing works
Pedersen, B. K. (2013) · Comprehensive physiology · doi:10.1002/cphy.c120033 · Cited by 516 · see citing works
Skeletal muscle as an endocrine organ: PGC-1α, myokines and exercise
Schnyder, S., & Handschin, C. (2015) · Bone · doi:10.1016/j.bone.2015.02.008 · Cited by 419 · see citing works
The exerkine apelin reverses age-associated sarcopenia
Vinel, C., Lukjanenko, L., Batut, A., Deleruyelle, S., Pradère, J.-P., Le Gonidec, S., Dortignac, A., Geoffre, N., Pereira, O., Karaz, S., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0131-6 · Cited by 398 · see citing works
Leal, L. G., Lopes, M. A., & Batista, M. L. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01307 · Cited by 382 · cited 1× · see citing works
“During cachexia and sarcopenia, it can reduce the rate of protein degradation, which highlights the therapeutic importance of this cytokine [58,80].”
BackgroundSarcopenia and sarcopenic obesity
Choi, K. M. (2016) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2016.193 · Cited by 344 · see citing works
FGF21 as Modulator of Metabolism in Health and Disease
Tezze, C., Romanello, V., & Sandri, M. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00419 · Cited by 313 · see citing works
Irisin: A Hope in Understanding and Managing Obesity and Metabolic Syndrome
Arhire, L. I., Mihalache, L., & Covașă, M. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00524 · Cited by 306 · see citing works
Qiao, X., Nie, Y., Ma, Y., Chen, Y., Cheng, R., Yin, W., Hu, Y., Xu, W., & Xu, L. (2016) · Scientific Reports · doi:10.1038/srep18732 · Cited by 291 · see citing works
The Ever-Expanding Myokinome: Discovery Challenges and Therapeutic Implications
Whitham, M., & Febbraio, M. A. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.153 · Cited by 279 · see citing works
Resistance Exercise Training as a Primary Countermeasure to Age-Related Chronic Disease
Mcleod, J. C., Stokes, T., & Phillips, S. M. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00645 · Cited by 254 · see citing works
The role of exercise-induced myokines in regulating metabolism
Huh, J. Y. (2018) · Archives of Pharmacal Research · doi:10.1007/s12272-017-0994-y · Cited by 242 · see citing works
Trayhurn, P., Drevon, C. A., & Eckel, J. (2011) · Archives of Physiology and Biochemistry · doi:10.3109/13813455.2010.535835 · Cited by 214 · see citing works
Jeremic, N., Chaturvedi, P., & Tyagi, S. C. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25450 · Cited by 211 · see citing works
The myokine decorin is regulated by contraction and involved in muscle hypertrophy
Kanzleiter, T., Rath, M., Görgens, S. W., Jensen, J., Tangen, D. S., Kolnes, A. J., Kolnes, K. J., Lee, S., Eckel, J., Schürmann, A., et al. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.06.123 · Cited by 209 · see citing works
Tuena, C., Pedroli, E., Trimarchi, P. D., Gallucci, A., Chiappini, M., Goulene, K., Gaggioli, A., Riva, G., Lattanzio, F., Giunco, F., et al. (2020) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2020.00093 · Cited by 200 · see citing works
Raschke, S., Eckardt, K., Bjørklund Holven, K., Jensen, J., & Eckel, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062008 · Cited by 199 · see citing works
FGF21 as a Hepatokine, Adipokine, and Myokine in Metabolism and Diseases
Itoh, N. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00107 · Cited by 198 · see citing works
Exercise-Induced Myokines With Therapeutic Potential for Muscle Wasting
Piccirillo, R. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00287 · Cited by 190 · see citing works
Myonectin Is an Exercise-Induced Myokine That Protects the Heart From Ischemia-Reperfusion Injury
Otaka, N., Shibata, R., Ohashi, K., Uemura, Y., Kambara, T., Enomoto, T., Ogawa, H., Ito, M., Kawanishi, H., Maruyama, S., et al. (2018) · Circulation Research · doi:10.1161/circresaha.118.313777 · Cited by 189 · see citing works
Osteosarcopenia is more than sarcopenia and osteopenia alone
The FiAT intervention group, Drey, M., Sieber, C. C., Bertsch, T., Bauer, J. M., & Schmidmaier, R. (2015) · Aging Clinical and Experimental Research · doi:10.1007/s40520-015-0494-1 · Cited by 186 · see citing works
Therapeutic impact of follistatin-like 1 on myocardial ischemic injury in preclinical models
Ogura, Y., Ouchi, N., Ohashi, K., Shibata, R., Kataoka, Y., Kambara, T., Kito, T., Maruyama, S., Yuasa, D., Matsuo, K., et al. (2012) · Circulation · doi:10.1161/circulationaha.112.115089 · Cited by 183 · see citing works
VanderVeen, B. N., Fix, D. K., & Carson, J. A. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/3292087 · Cited by 182 · see citing works
Evolution of sarcopenia research
Janssen, I. (2010) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h10-067 · Cited by 181 · see citing works
Factors associated with sarcopenia: A cross-sectional analysis using UK Biobank
Petermann-Rocha, F., Chen, M., Gray, S. R., Ho, F. K., Pell, J. P., & Celis-Morales, C. (2020) · Maturitas · doi:10.1016/j.maturitas.2020.01.004 · Cited by 172 · see citing works
Impact of Skeletal Muscle Mass on Metabolic Health
Kim, G., & Kim, J. H. (2020) · Endocrinology and Metabolism · doi:10.3803/enm.2020.35.1.1 · Cited by 171 · see citing works
Durieux, A., Amirouche, A., Banzet, S., Koulmann, N., Bonnefoy, R., Pasdeloup, M., Mouret, C., Bigard, X. A., Peinnequin, A., & Freyssenet, D. G. (2007) · Endocrinology · doi:10.1210/en.2006-1500 · Cited by 162 · see citing works
Exercise-Released Myokines in the Control of Energy Metabolism
Laurens, C., Bergouignan, A., & Moro, C. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00091 · Cited by 159 · see citing works
New insights into the pathogenesis and treatment of sarcopenia in chronic heart failure
Yin, J., Lü, X., Qian, Z., Xu, W., & Zhou, X. (2019) · Theranostics · doi:10.7150/thno.33000 · Cited by 155 · see citing works
Fibroblast growth factor 21 and browning of white adipose tissue
Cuevas-Ramos, D., Mehta, R., & Aguilar-Salinas, C. A. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00037 · Cited by 149 · see citing works
Sarcopenia, Frailty, and Diabetes in Older Adults
Jang, H. C. (2016) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2016.40.3.182 · Cited by 138 · see citing works
Myokines in skeletal muscle physiology and metabolism: Recent advances and future perspectives
Das, D. K., Graham, Z. A., & Cardozo, C. P. (2020) · Acta Physiologica · doi:10.1111/apha.13367 · Cited by 129 · see citing works
Motoneuron Loss Is Associated With Sarcopenia
Drey, M., Krieger, B., Sieber, C. C., Bauer, J. M., Hettwer, S., Bertsch, T., Dahinden, P., Mäder, A., Vrijbloed, J. W., Schuster, G. M., et al. (2014) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2014.02.002 · Cited by 126 · see citing works
A Key Role for Leukemia Inhibitory Factor in C26 Cancer Cachexia
Seto, D. N., Kandarian, S. C., & Jackman, R. W. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.638411 · Cited by 123 · see citing works
The role of PGC‐1 coactivators in aging skeletal muscle and heart
Dillon, L. M., Rebelo, A. P., & Moraes, C. T. (2012) · IUBMB Life · doi:10.1002/iub.608 · Cited by 116 · see citing works
Serum myostatin levels and skeletal muscle wasting in chronic obstructive pulmonary disease
Ju, C., & Chen, R. (2011) · Respiratory Medicine · doi:10.1016/j.rmed.2011.07.016 · Cited by 114 · see citing works
An Overview of the Beneficial Effects of Exercise on Health and Performance
Krämer, A. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-1792-1_1 · Cited by 114 · see citing works
No pain, no gain? The effects of pain-promoting neuropeptides and neurotrophins on fracture healing
Sun, S., Diggins, N. H., Gunderson, Z. J., Fehrenbacher, J. C., White, F. A., & Kacena, M. A. (2019) · Bone · doi:10.1016/j.bone.2019.115109 · Cited by 106 · see citing works
On the Definition of Sarcopenia in the Presence of Aging and Obesity—Initial Results from UK Biobank
Linge, J., Heymsfield, S. B., & Dahlqvist Leinhard, O. (2020) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glz229 · Cited by 103 · see citing works
Bloch, S. A. A., Lee, J. Y., Wort, S. J., Polkey, M. I., Kemp, P. R., & Griffiths, M. (2013) · Critical Care Medicine · doi:10.1097/ccm.0b013e318274671b · Cited by 100 · see citing works
Garneau, L., & Aguer, C. (2019) · Diabetes & Metabolism · doi:10.1016/j.diabet.2019.02.006 · Cited by 92 · see citing works
Lai, S., Muscaritoli, M., Andreozzi, P., Sgreccia, A., Leo, S. D., Mazzaferro, S., Mitterhofer, A. P., Pasquali, M., Protopapa, P., Spagnoli, A., et al. (2018) · Nutrition · doi:10.1016/j.nut.2018.12.005 · Cited by 89 · see citing works
Alexandre, T. D. S., Duarte, Y. A. D. O., Santos, J. L. F., & Lebrão, M. L. (2018) · Revista Brasileira de Epidemiologia · doi:10.1590/1980-549720180009.supl.2 · Cited by 85 · see citing works
Hida, T., Imagama, S., Ando, K., Kobayashi, K., Muramoto, A., Ito, K., Ishikawa, Y., Tsushima, M., Nishida, Y., Ishiguro, N., et al. (2017) · Modern Rheumatology · doi:10.1080/14397595.2017.1349058 · Cited by 84 · see citing works
Effects of 12 Weeks Resistance Training on Serum Irisin in Older Male Adults
Zhao, J., Su, Z., Qu, C., & Dong, Y. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00171 · Cited by 82 · see citing works
Planella-Farrugia, C., Comas, F., Sabater, M., Moreno, M., Moreno‐Navarrete, J. M., Rovira, O., Ricart, W., & Fernández‐Real, J. M. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00871 · Cited by 74 · see citing works
Adropin and irisin in arterial hypertension, diabetes mellitus and chronic kidney disease
Maciorkowska, M., Musiałowska, D., & Małyszko, J. (2019) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/104551 · Cited by 72 · see citing works
Iron Metabolism of the Skeletal Muscle and Neurodegeneration
Hałoń, M., Borkowska, A., Herman-Antosiewicz, A., & Antosiewicz, J. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00165 · Cited by 69 · see citing works
If my muscle could talk: Myokines as a biomarker of frailty
Coelho‐Júnior, H. J., Picca, A., Calvani, R., Uchida, M. C., & Marzetti, E. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110715 · Cited by 69 · see citing works
Quinn, L. S., Anderson, B. G., Strait‐Bodey, L., & Wolden‐Hanson, T. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.10.012 · Cited by 68 · see citing works
Re Cecconi, A. D., Forti, M., Chiappa, M., Zhu, Z., Zingman, L. V., Cervo, L., Beltrame, L., Marchini, S., & Piccirillo, R. (2019) · Cancers · doi:10.3390/cancers11101541 · Cited by 66 · see citing works
Jia, D., Cai, M., Xi, Y., Du, S., & Tian, Z. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.12.009 · Cited by 64 · see citing works
Myokines as possible therapeutic targets in cancer cachexia
Manole, E., Ceafalan, L. C., Popescu, B. O., Dumitru, C., & Bastian, A. E. (2018) · Journal of Immunology Research · doi:10.1155/2018/8260742 · Cited by 60 · see citing works
Furihata, T., Kinugawa, S., Fukushima, A., Takada, S., Homma, T., Masaki, Y., Abe, T., Yokota, T., Oba, K., Okita, K., et al. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.06.231 · Cited by 59 · see citing works
Inhibition of the myostatin/Smad signaling pathway by short decorin-derived peptides
Shafey, N. E., Guesnon, M., Simon, F., Deprez, E., Cosette, J., Stockholm, D., Scherman, D., Bigey, P., & Kichler, A. (2016) · Experimental Cell Research · doi:10.1016/j.yexcr.2016.01.019 · Cited by 54 · see citing works
Delanaye, P., Bataille, S., Quinonez, K., Buckinx, F., Warling, X., Krzesinski, J.-M., Pottel, H., Burtey, S., Bruyère, O., & Cavalier, E. (2019) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2018.11.010 · Cited by 54 · see citing works
Nakajima, T., Shibasaki, I., Sawaguchi, T., Haruyama, A., Kaneda, H., Nakajima, T., Hasegawa, T., Arikawa, T., Obi, S., Sakuma, M., et al. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8101576 · Cited by 52 · see citing works
The prevalence of sarcopenia and subtypes in cardiovascular diseases, and a new diagnostic approach
Sasaki, K., Kakuma, T., Sasaki, M., Ishizaki, Y., Fukami, A., Enomoto, M., Adachi, H., Matsuse, H., Shiba, N. N., Ueno, T., et al. (2020) · Journal of Cardiology · doi:10.1016/j.jjcc.2020.03.004 · Cited by 50 · see citing works
Lower irisin levels in coronary artery disease: a meta-analysis
Guo, W., Zhang, B., & Wang, X. (2020) · Minerva Endocrinology · doi:10.23736/s0391-1977.17.02663-3 · Cited by 49 · see citing works
Sarcopenic obesity in fatty liver
Merli, M., Lattanzi, B., & Aprile, F. (2019) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000558 · Cited by 48 · see citing works
Effect of exercise intensity on circulating hepatokine concentrations in healthy men
Willis, S. A., Sargeant, J. A., Thackray, A. E., Yates, T. E., Stensel, D. J., Aithal, G. P., & King, J. A. (2019) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2018-0818 · Cited by 48 · see citing works
Park, S., Ryu, S. Y., Park, J., & Choi, S.-W. (2019) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2019.0059 · Cited by 48 · see citing works
(2020) · Advances in clinical chemistry · doi:10.1016/bs.acc.2019.07.012 · Cited by 46 · see citing works
Apelin promotes hepatic fibrosis through ERK signaling in LX-2 cells
Wang, Y., Song, J., Bian, H., Bo, J., Lv, S., Pan, W., & Lv, X. (2019) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-019-03581-0 · Cited by 45 · see citing works
The role of decorin in cardiovascular diseases: more than just a decoration
Vu, T. T., Marquez, J. C., Long, L. T., Nguyen, A. T. T., Kim, H. K., & Han, J. (2018) · Free Radical Research · doi:10.1080/10715762.2018.1516285 · Cited by 44 · see citing works
Protective Roles of Adipocytokines and Myokines in Cardiovascular Disease
Ouchi, N., Ohashi, K., Shibata, R., & Murohara, T. (2016) · Circulation Journal · doi:10.1253/circj.cj-16-0663 · Cited by 42 · see citing works
Targeting mitochondrial quality control for treating sarcopenia: lessons from physical exercise
Picca, A., Calvani, R., Leeuwenburgh, C., Coelho‐Júnior, H. J., Bernabei, R., Landi, F., & Marzetti, E. (2018) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2019.1559827 · Cited by 42 · see citing works
Prestroke Sarcopenia and Stroke Severity in Elderly Patients with Acute Stroke
Nozoe, M., Kanai, M., Kubo, H., Yamamoto, M., Shimada, S., & Mase, K. (2019) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2019.05.001 · Cited by 42 · see citing works
Rütti, S., Dusaulcy, R., Hansen, J. S., Howald, C., Dermitzakis, E. T., Pedersen, B. K., Pinget, M., Plomgaard, P., & Bouzakri, K. (2018) · Scientific Reports · doi:10.1038/s41598-018-28117-2 · Cited by 41 · see citing works
Chun, S., Shin, D. W., Han, K., Jung, J., Kim, B., Jung, H., Son, K. Y., Lee, S., & Lee, S. (2019) · European Journal of Preventive Cardiology · doi:10.1177/2047487319882118 · Cited by 41 · see citing works
The brown bear as a translational model for sedentary lifestyle‐related diseases
Fröbert, O., Frøbert, A. M., Kindberg, J., Arnemo, J. M., & Overgaard, M. T. (2019) · Journal of Internal Medicine · doi:10.1111/joim.12983 · Cited by 40 · see citing works
Exercise-induced myokines: a brief review of controversial issues of this decade
Son, J. S., Chae, S. A., Testroet, E. D., Du, ., & Jun, H.-P. (2017) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2018.1416290 · Cited by 38 · see citing works
Santana, N. D. M., Mendes, R. M. L., da Silva, N. F., & Pinho, C. P. S. (2019) · Einstein (São Paulo) · doi:10.31744/einstein_journal/2019ao4632 · Cited by 37 · see citing works
Role of irisin in androgen-deficient muscle wasting and osteopenia in mice
Iemura, S., Kawao, N., Okumoto, K., Akagi, M., & Kaji, H. (2019) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-019-01043-7 · Cited by 37 · see citing works
Association between reduced brain-derived neurotrophic factor concentration & coronary heart disease
Šustar, A., Perkovic, M. N., Erjavec, G. N., Strac, D. S., & Pivac, N. (2019) · The Indian Journal of Medical Research · doi:10.4103/ijmr.ijmr_1566_17 · Cited by 37 · see citing works
Updated concept of sarcopenia based on muscle–bone relationship
Yakabe, M., Hosoi, T., Akishita, M., & Ogawa, S. (2019) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-019-01048-2 · Cited by 36 · see citing works
Exercise and Cardiovascular Protection
Li, G., Li, J., & Gao, F. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-1792-1_14 · Cited by 36 · see citing works
Yamashita, M., Kamiya, K., Matsunaga, A., Kitamura, T., Hamazaki, N., Matsuzawa, R., Nozaki, K., Tanaka, S., Nakamura, T., Maekawa, E., et al. (2019) · Journal of Cardiology · doi:10.1016/j.jjcc.2019.02.010 · Cited by 35 · see citing works
Tibana, R. A., Nascimento, D. D. C., de Souza, N. M. F., de Souza, V. C., Neto, I. V. D. S., Voltarelli, F. A., Pereira, G. B., Navalta, J. W., & Prestes, J. (2016) · The journal of nutrition health & aging · doi:10.1007/s12603-016-0748-4 · Cited by 34 · see citing works
González-Gil, A. M., Peschard-Franco, M., Castillo, E. C., Gutierrez-DelBosque, G., Treviño, V., Silva‐Platas, C., Pérez-Villarreal, L. F., García‐Rivas, G., & Elizondo‐Montemayor, L. (2019) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-019-0458-2 · Cited by 34 · see citing works
Nakano, I., Kinugawa, S., Hori, H., Fukushima, A., Yokota, T., Takada, S., Kakutani, N., Obata, Y., Yamanashi, K., & Anzai, T. (2020) · International Heart Journal · doi:10.1536/ihj.19-400 · Cited by 33 · see citing works
Kim, J., Lee, Y., & Yi, H. (2016) · Experimental Physiology · doi:10.1113/ep085852 · Cited by 32 · see citing works
Time-restricted eating and age-related muscle loss
Tinsley, G. M., & Paoli, A. (2019) · Aging · doi:10.18632/aging.102384 · Cited by 24 · see citing works
Developing Insulin and BDNF Mimetics for Diabetes Therapy
Chan, C. B., Ahuja, P., & Ye, K. (2019) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026619666191010160643 · Cited by 23 · see citing works
Identification of decorin derived peptides with a zinc dependent anti-myostatin activity
Guiraud, S., van Wittenberghe, L., Georger, C., Scherman, D., & Kichler, A. (2012) · Neuromuscular Disorders · doi:10.1016/j.nmd.2012.07.002 · Cited by 19 · see citing works
Identification of CCL5/RANTES as a novel contraction-reducible myokine in mouse skeletal muscle
Ishiuchi, Y., Sato, H., Komatsu, N., Kawaguchi, H., Matsuwaki, T., Yamanouchi, K., Nishihara, M., & Nedachi, T. (2018) · Cytokine · doi:10.1016/j.cyto.2018.03.012 · Cited by 17 · see citing works
Ojima, K., Oe, M., Nakajima, I., Shibata, M., Muroya, S., CHIKUNI, K., Hattori, A., & Nishimura, T. (2014) · Animal Science Journal · doi:10.1111/asj.12310 · Cited by 16 · see citing works
Body Composition in Patients with Atrial Fibrillation.
Anaszewicz, M., Banaś, W., Wawrzeńczyk, A., & Budzyński, J. (2019) · PubMed Central · doi:10.6515/acs.201909_35(5).20190323a · Cited by 16 · see citing works
Abe, K., Yano, T., Katano, S., Ohori, K., Ishigo, T., Moniwa, N., & Miura, T. (2020) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.13876 · Cited by 15 · see citing works
Design and synthesis of potent myostatin inhibitory cyclic peptides
Rentier, C., Takayama, K., Saitoh, M., Nakamura, A., Ikeyama, H., Taguchi, A., Taniguchi, A., & Hayashi, Y. (2019) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2019.02.019 · Cited by 11 · see citing works
Circulating MicroRNAs as Diagnostic Biomarkers for Motor Neuron Disease
Wang, L., & Zhang, L. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00354 · Cited by 9 · see citing works
Myokines: A promising therapeutic target for hepatic encephalopathy
Yang, C., & Luo, A. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2016.10.040 · Cited by 8 · see citing works
Newly discovered myokines in chronic kidney disease
Ebert, T., & Kralisch, S. (2016) · Polskie Archiwum Medycyny Wewnętrznej · doi:10.20452/pamw.3473 · Cited by 6 · see citing works
Nguyen, T. V., Tran, K. D., Bui, K. X., Le, D., & Nguyen, T. N. (2020) · Australian Journal on Ageing · doi:10.1111/ajag.12789 · Cited by 4 · see citing works
Apelin affects the mouse aging urinary peptidome with minimal effects on kidney
Vinel, C., Schanstra, J. P., Boizard, F., Péreira, O., Auriau, J., Dortignac, A., Breuil, B., Feuillet, G., Nkuipou‐Kenfack, E., Zürbig, P., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-47109-4 · Cited by 3 · see citing works
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El Assar, M., Álvarez-Bustos, A., Sosa, P., Angulo, J., & Rodríguez-Mañas, L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158713 · Cited by 371 · see citing works
Metabolic Syndrome and Sarcopenia
Nishikawa, H., Asai, A., Fukunishi, S., Nishiguchi, S., & Higuchi, K. (2021) · Nutrients · doi:10.3390/nu13103519 · Cited by 333 · see citing works
Bilski, J., Pierzchalski, P., Szczepanik, M., Bonior, J., & Zoladz, J. A. (2022) · Cells · doi:10.3390/cells11010160 · Cited by 262 · see citing works
Links between metabolic syndrome and metabolic dysfunction-associated fatty liver disease
Lim, S. K., Kim, J., & Targher, G. (2021) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2021.04.008 · Cited by 216 · see citing works
Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions
de Oliveira dos Santos, A. R., de Oliveira Zanuso, B., Miola, V. F. B., Barbalho, S. M., Santos Bueno, P. C., Flato, U. A. P., Detregiachi, C. R. P., Buchaim, D. V., Buchaim, R. L., Tofano, R. J., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052639 · Cited by 189 · see citing works
Self-citationRelationship Between Sarcopenia and Cardiovascular Diseases in the Elderly: An Overview
He, N., Zhang, Y., Zhang, L., Zhang, S., & Ye, H. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.743710 · Cited by 164 · see citing works
Exercise therapy for people with sarcopenic obesity: myokines and adipokines as effective actors
Alizadeh Pahlavani, H. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.811751 · Cited by 145 · see citing works
Mechanisms by Which Skeletal Muscle Myokines Ameliorate Insulin Resistance
Balakrishnan, R., & Thurmond, D. C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094636 · Cited by 132 · see citing works
Muscle-to-tumor crosstalk: The effect of exercise-induced myokine on cancer progression
Huang, Q., Wu, M., Wu, X., Zhang, Y., & Xia, Y. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188761 · Cited by 118 · see citing works
Ginkgo biloba in the Aging Process: A Narrative Review
Barbalho, S. M., Direito, R., Laurindo, L. F., Marton, L. T., Guiguer, É. L., Goulart, R. D. Á., Tofano, R. J., de Carvalho, A. C. A., Flato, U. A. P., Tofano, V. A. C., et al. (2022) · Antioxidants · doi:10.3390/antiox11030525 · Cited by 110 · see citing works
Self-citationPanax ginseng and aging related disorders: A systematic review
Zanuso, B. D. O., dos Santos, A. R. D. O., Miola, V. F. B., Campos, L. M. G., Spilla, C. S. G., & Barbalho, S. M. (2022) · Experimental Gerontology · doi:10.1016/j.exger.2022.111731 · Cited by 106 · see citing works
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de Lima, E. P., Tanaka, M., Lamas, C. B., Quesada, K. R., Detregiachi, C. R. P., Araújo, A. C., Guiguer, É. L., Catharin, V. M. C. S., de Castro, M. V. M., Baldi, E., et al. (2024) · Biomedicines · doi:10.3390/biomedicines12092096 · Cited by 78 · see citing works
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Mellem, R. H., Girotto, O. S., Marques, E. B., Laurindo, L. F., Grippa, P. C., Mendes, C. G., Garcia, L. N. H., Bechara, M. D., Barbalho, S. M., Sinatora, R. V., et al. (2023) · Biomedicines · doi:10.3390/biomedicines11010136 · Cited by 67 · see citing works
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Xie, G., Jin, H., Mikhail, H., Pavel, V., Yang, G., Ji, B., Lu, B., & Li, Y. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115147 · Cited by 57 · see citing works
Lee, J. H., Jeon, J. H., & Lee, M. J. (2020) · Nutrients · doi:10.3390/nu12092597 · Cited by 56 · see citing works
Minniti, G., Pescinini-Salzedas, L. M., Minniti, G. A. D. S., Laurindo, L. F., Barbalho, S. M., Sinatora, R. V., Sloan, L. A., Haber, R. S. D. A., Araújo, A. C., Quesada, K. R., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113452 · Cited by 52 · see citing works
Self-citationHou, Y., Tang, Y., Wang, X., Ai, X., Wang, H., Li, X., Chen, X., Zhang, Y., Hu, Y., Meng, X., et al. (2020) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2020.9072 · Cited by 49 · see citing works
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dos Santos, J. P. M., de Maio, M. C., Lemes, M. A., Laurindo, L. F., Haber, J. F. D. S., Bechara, M. D., do Prado, P. S., Rauen, E. C., Costa, F., Pereira, B. C. D. A., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23010498 · Cited by 48 · see citing works
Self-citationShao, X., Gong, W., Wang, Q., Wang, P., Shi, T., Mahmut, A., Qin, J., Yao, Y., Yan, W., Chen, D., et al. (2022) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13106 · Cited by 42 · see citing works
Caldo‐Silva, A., Furtado, G. E., Chupel, M. U., Bachi, A. L. L., Barros, M. P., Neves, R. S., Marzetti, E., Massart, A. G. M., & Teixeira, A. M. (2021) · Nutrients · doi:10.3390/nu13041106 · Cited by 37 · see citing works
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Tanimura, R., Kobayashi, L., Shirai, T., & Takemasa, T. (2022) · Physiological Reports · doi:10.14814/phy2.15205 · Cited by 36 · see citing works
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Papadopetraki, A., Giannopoulos, A., Maridaki, M., Zagouri, F., Droufakou, S., Koutsilieris, M., & Philippou, A. (2023) · Cancers · doi:10.3390/cancers15245856 · Cited by 34 · see citing works
Ghanemi, A., Melouane, A., Yoshioka, M., & St‐Amand, J. (2022) · Metabolites · doi:10.3390/metabo12020125 · Cited by 31 · see citing works
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Ramírez‐Vélez, R., González, A., García‐Hermoso, A., Latasa, I., Izquierdo, M., & Dı́ez, J. (2022) · Metabolism · doi:10.1016/j.metabol.2022.155348 · Cited by 31 · see citing works
Cai, X., Hu, J., Wang, M., Wen, W., Wang, J., Yang, W., Dang, Y., Luo, Q., Hong, J., & Li, N. (2023) · Aging · doi:10.18632/aging.204587 · Cited by 29 · see citing works
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Araújo, L. P., Godoy, A. C. F., Frota, F. F., Lamas, C. B., Quesada, K. R., Detregiachi, C. R. P., Araújo, A. C., Miglino, M. A., Guiguer, É. L., Haber, R. S. D. A., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262412147 · Cited by 30 · see citing works
Self-citationHuerta, L. D. J., Marco-Alacid, C., Grande, C., & Andrés, C. V. (2024) · Nutrients · doi:10.3390/nu16162717 · Cited by 25 · see citing works
Navarro‐Lomas, G., Dote‐Montero, M., Alcántara, J. M. A., Plaza‐Florido, A., Castillo, M. J., & Amaro‐Gahete, F. J. (2022) · European Journal of Applied Physiology · doi:10.1007/s00421-022-04957-9 · Cited by 23 · see citing works
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Nasso, R., D’Errico, A., Motti, M. L., Masullo, M., & Arcone, R. (2024) · Clinics and Practice · doi:10.3390/clinpract14040117 · Cited by 22 · see citing works
The recent development, application, and future prospects of muscle atrophy animal models
Zhang, G., Hu, F., Huang, T., Ma, X., Cheng, Y., Liu, X., Jiang, W., Dong, B., & Fu, C. (2024) · MedComm – Future Medicine · doi:10.1002/mef2.70008 · Cited by 22 · see citing works
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Huang, W.-F., Chen, Y., Chang, C., & Wu, C. (2025) · Osteoporosis and Sarcopenia · doi:10.1016/j.afos.2025.05.004 · Cited by 22 · see citing works
Jia, S., Yu, Z., & Bai, L. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1302769 · Cited by 22 · see citing works
Wang, J., Yang, Y., Su, Q., Wang, J., Zeng, H., Chen, Y., Zhou, J., & Wang, Y. (2024) · BMC Public Health · doi:10.1186/s12889-024-19521-7 · Cited by 21 · see citing works
Yoshikoshi, S., Yamamoto, S., Suzuki, Y., Imamura, K., Harada, M., Osada, S., Kamiya, K., & Matsunaga, A. (2022) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13039 · Cited by 19 · see citing works
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Rutkove, S. B., Callegari, S., Concepcion, H. A., Mourey, T., Widrick, J. J., Nagy, J. A., & Nath, A. K. (2023) · Scientific Reports · doi:10.1038/s41598-023-34119-6 · Cited by 19 · see citing works
Aodah, A. H., Devi, S., Alkholifi, F. K., Yusufoglu, H. S., Foudah, A. I., & Alam, A. (2023) · Molecules · doi:10.3390/molecules28104089 · Cited by 19 · see citing works
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Nishikawa, R., Fukuda, T., Haruyama, A., Shibasaki, I., Yamaguchi, S., Arikawa, T., Obi, S., Amano, H., Yagi, H., Sakuma, M., et al. (2022) · IJC Heart & Vasculature · doi:10.1016/j.ijcha.2022.101114 · Cited by 17 · see citing works
Mechanisms of sarcopenia in liver cirrhosis and the role of myokines
Geladari, E. V. (2023) · Annals of Gastroenterology · doi:10.20524/aog.2023.0804 · Cited by 17 · see citing works
Exercise-Induced Biomarker Modulation in Sarcopenia: From Inflamm-Aging to Muscle Regeneration
Marmondi, F., Ferrando, V., Filipas, L., Codella, R., Ruggeri, P., Torre, A. L., Faelli, E. L., & Bonato, M. (2025) · Sports · doi:10.3390/sports13120444 · Cited by 16 · see citing works
Timofte, D. V., Tudor, R. C., Mocanu, V., & Labusca, L. S. (2024) · Nutrients · doi:10.3390/nu16234231 · Cited by 15 · see citing works
Lim, G., Lee, H., & Lim, Y. (2022) · Biomedicines · doi:10.3390/biomedicines10102529 · Cited by 15 · see citing works
Exerkines and myokines in aging sarcopenia
Wang, H., He, W., Chen, P., Wang, H., Wang, H., Zhu, L., & Liu, X. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1592491 · Cited by 14 · see citing works
Losasso, M. R., Parussolo, M. L. C., Silva, A. O., Direito, R., Quesada, K. R., Detregiachi, C. R. P., Bechara, M. D., Méndez‐Sánchez, N., Abenavoli, L., Araújo, A. C., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26104673 · Cited by 13 · see citing works
Self-citationZhang, M., Zhang, L., Hu, Y., Wang, Y., Xu, S., Xie, X., Tian, X., Li, Z., Jin, H., & Liu, H. (2022) · PeerJ · doi:10.7717/peerj.14429 · Cited by 14 · see citing works
Zhang, C., Peng, W., Liang, W., Guo, T., Hu, K., Su, W., Chen, Y., Ning, M., & Liu, Y. (2024) · Experimental Gerontology · doi:10.1016/j.exger.2024.112561 · Cited by 13 · see citing works
Palumbo, C., Antonelli, A., Triggiani, L., Volta, A. D., Maffezzoni, F., Zamboni, S., Borghetti, P., Rinaudo, L., Valcamonico, F., Maroldi, R., et al. (2021) · Prostate Cancer and Prostatic Diseases · doi:10.1038/s41391-021-00345-0 · Cited by 13 · see citing works
Circulating Myokines as Novel Biomarkers for Cardiovascular Diseases
Lyu, J.-X., Guo, D., Song, Y.-C., Zhang, M.-R., Ge, F.-Q., Zhao, J., Zhu, H., & Hang, P. (2024) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2502056 · Cited by 13 · see citing works
Barbalho, S. M., Tofano, R. J., Chagas, E. F. B., Detregiachi, C. R. P., Goulart, R. D. Á., & Flato, U. A. P. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111302 · Cited by 12 · see citing works
Self-citationMiyamoto, T., Shimizu, Y., Matsuo, Y., Otaru, T., Kanzawa, Y., Miyamae, N., Yamada, E., & Katsuno, T. (2021) · European Journal of Sport Science · doi:10.1080/17461391.2021.1953152 · Cited by 12 · see citing works
Wang, C., Jiao, X., Liang, J., & Lu, A. (2025) · Clinics · doi:10.1016/j.clinsp.2025.100784 · Cited by 11 · see citing works
Ding, K., Jiang, W., Zhangwang, J., Wang, Y., Zhang, J., & Lei, M. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02639-7 · Cited by 11 · see citing works
Zhang, M., Lin, H., & Xu, X. (2025) · BMC Public Health · doi:10.1186/s12889-025-21734-3 · Cited by 11 · see citing works
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Hwangbo, H., Kim, M. Y., Ji, S. Y., Kim, D. H., Park, B. S., Jeong, S. U., Yoon, J. H., Kim, T. H., Kim, G., & Choi, Y. H. (2023) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2306.06012 · Cited by 10 · see citing works
Cai, Z., & Dong, D. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1397429 · Cited by 10 · see citing works
The emerging role of exercise preconditioning in preventing skeletal muscle atrophy
Zhou, X., Li, S., Wang, L., Wang, J., Zhang, P., & Chen, X. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1559594 · Cited by 10 · see citing works
Li, Y., & Zhang, Z. (2024) · Medicine · doi:10.1097/md.0000000000041052 · Cited by 9 · see citing works
Peña, J. C., Becerra, D., Vásquez, F. J. R., & Castillo-Daza, C. A. (2021) · Fisioterapia · doi:10.1016/j.ft.2021.03.005 · Cited by 9 · see citing works
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Laube, W. (2021) · Manuelle Medizin · doi:10.1007/s00337-021-00801-x · Cited by 8 · see citing works
Knapik, M., Kuna, J., Chmielewski, G., Jaśkiewicz, Ł., & Krajewska–Włodarczyk, M. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14186527 · Cited by 7 · see citing works
Barbalho, S. M., Laurindo, L. F., Valenti, V. E., Méndez‐Sánchez, N., Ramírez-Mejía, M. M., & Goulart, R. D. Á. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262311547 · Cited by 7 · see citing works
Self-citationKhorasani, Z. M., Besharat, M., Mehrad‐Majd, H., Mohammadi, S. A., & Mahmoudinia, M. (2022) · Endocrinology Diabetes & Metabolism · doi:10.1002/edm2.370 · Cited by 7 · see citing works
Xuan, Y., Pang, S., Xie, W., He, R., Li, Q., & Yuan, J. (2023) · Medicine · doi:10.1097/md.0000000000035976 · Cited by 6 · see citing works
Buffoni, M., Volta, A. D., Valcamonico, F., Bergamini, M., Caramella, I., D'Apollo, D., Zivi, A., Procopio, G., Sepe, P., Conte, G. D., et al. (2025) · European Urology Oncology · doi:10.1016/j.euo.2025.02.006 · Cited by 6 · see citing works
Lee, T., Lee, H.-I., Roh, H., & Cho, S.-Y. (2025) · Life · doi:10.3390/life15111752 · Cited by 6 · see citing works
Workeneh, B., Kalantar‐Zadeh, K., & Moore, L. W. (2021) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2021.04.004 · Cited by 6 · see citing works
Primo, D., Izaola, O., Gómez, J. J. L., & de Luis, D. A. (2023) · Endocrinología Diabetes y Nutrición · doi:10.1016/j.endinu.2023.04.002 · Cited by 6 · see citing works
Song, H., Liu, C., Yang, Z., Liu, D., Li, J., Mei, Z., Xu, J., Pan, J., Zhang, X., Yan, C., et al. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156990 · Cited by 5 · see citing works
Der Muskulatur mehr Aufmerksamkeit schenken!
Laube, W. (2021) · Manuelle Medizin · doi:10.1007/s00337-021-00821-7 · Cited by 5 · see citing works
Curiel-Cervantes, V., Solís‐S, J. C., Camacho-Barrón, M., Aguilar-Galarza, A., Valencia, M. E., & Anaya‐Loyola, M. A. (2022) · Growth Factors · doi:10.1080/08977194.2022.2049262 · Cited by 5 · see citing works
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Güngör, Ö., Sevinç, M., Sena Memnune, U. L. U., & Kocyigit, I. D. (2022) · International Urology and Nephrology · doi:10.1007/s11255-022-03393-0 · Cited by 5 · see citing works
Tian, M., Lan, Q., Yuan, J., He, P., Yu, F., Long, C., & Zha, Y. (2023) · Cardiorenal Medicine · doi:10.1159/000534399 · Cited by 5 · see citing works
The Role of Sarcopenia in Heart Failure with Depression
Wang, R., Duan, J., Liu, W., Huang, K., Chen, Z., Yang, C., & Yang, L. (2022) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2309296 · Cited by 5 · see citing works
State-of-the-art insights into myokines as biomarkers of sarcopenia: a literature review
Moussaoui, O. R. (2025) · International Journal of Physiology Pathophysiology and Pharmacology · doi:10.62347/rneq8696 · Cited by 4 · see citing works
Wahid, M., Saqib, F., Abbas, G., Shah, S., Alshammari, A., Albekairi, T. H., Ali, A., Khurm, M., & Mubarak, M. S. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1277594 · Cited by 4 · see citing works
Meydanal, Y. E., Şenışık, S., & ŞİRİN, H. (2025) · Headache The Journal of Head and Face Pain · doi:10.1111/head.14951 · Cited by 4 · see citing works
Vasodilator Dysfunction in Human Obesity: Established and Emerging Mechanisms
Schinzari, F., Tesauro, M., & Cardillo, C. (2021) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000001108 · Cited by 5 · see citing works
Free fatty acids are associated with muscle dysfunction in Chinese adults with type 2 diabetes
Fu, J., Sun, L., Mu, Z., & Xiu, S. (2022) · Endocrine · doi:10.1007/s12020-022-03053-4 · Cited by 4 · see citing works
Teil 2: Muskeldysfunktionen – mit Training gegen Schmerz
Laube, W. (2022) · Man and medicine · doi:10.1007/s00337-022-00887-x
Rigor, J., Monteiro‐Soares, M., Barata, P., & Martins‐Mendes, D. (2024) · Sci · doi:10.3390/sci6040059 · Cited by 4 · see citing works
Кироненко, Т. А., Милованова, К. Г., Zakharova, A. N., Sidorenko, S. V., Климанова, Е. А., Dyakova, E. Y., Орлова, А. А., Negodenko, E. S., Kalinnikova, J. G., Orlov, S. N., et al. (2021) · Biochemistry (Moscow) · doi:10.1134/s0006297921030123 · Cited by 4 · see citing works
Nishio, R., Dohi, T., Fukase, T., Takeuchi, M., Takahashi, N., Endo, H., Doi, S., Okai, I., Iwata, H., Okazaki, S., et al. (2022) · IJC Heart & Vasculature · doi:10.1016/j.ijcha.2022.101163 · Cited by 6 · see citing works
Sun, Z., Wu, Z., Zhu, L., Li, X., Xu, D., Tian, X., & Mao, D. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1410068 · Cited by 5 · see citing works
Kim, Y., Kim, D., Kim, J., Yun, M., & Kang, E. S. (2024) · ESC Heart Failure · doi:10.1002/ehf2.15086 · Cited by 3 · see citing works
Yang, J., Zhong, J., Du, Y., Liu, J., Li, Z., & Liu, Y. (2025) · Experimental Gerontology · doi:10.1016/j.exger.2025.112811 · Cited by 3 · see citing works
Vargas-Pacheco, A., & Correa-López, L. E. (2021) · Revista de la Facultad de Medicina Humana · doi:10.25176/rfmh.v22i1.4129 · Cited by 3 · see citing works
Banitalebi, E., Banitalebi, E., Ghahfarrokhi, M. M., Rahimi, M., Laher, I., & Davison, K. (2023) · Journal of Aging and Physical Activity · doi:10.1123/japa.2022-0241 · Cited by 3 · see citing works
Sarcopenia and Cardiovascular Diseases in Individuals With Diabetes or Prediabetes
Wang, X., Zeng, Q., Yu, X., & Li, S. (2025) · Journal of Clinical Hypertension · doi:10.1111/jch.70024 · Cited by 3 · see citing works
Metabolic Syndrome and Metabolic Dysfunction‐Associated Fatty Liver Disease
Koo, B. K., & Lim, S. K. (2022) · Wiley eBooks · doi:10.1002/9781119695257.ch13 · Cited by 3 · see citing works
Exercise interventions for mitigating the persistent side effects of COVID-19
Gupta, S., Liu, K. R., Sandhu, S., & Gupta, A. (2024) · Sport Sciences for Health · doi:10.1007/s11332-024-01269-7 · Cited by 2 · see citing works
Laube, W. (2024) · Manuelle Medizin · doi:10.1007/s00337-024-01117-2 · Cited by 2 · see citing works
Chen, L., Li, A., Zhou, X., Chen, W., Zhou, Y., Wang, R., Kou, Y., & Zhou, J. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1838118 · Cited by 2 · see citing works
Laube, W. (2026) · Manuelle Medizin · doi:10.1007/s00337-026-01254-w · Cited by 2 · see citing works
Sui, Y., Huang, Z., Dong, S.-Y., & Zheng, Y. (2022) · Health · doi:10.4236/health.2022.148063 · Cited by 2 · see citing works
- Authors
- Barbalho, S. M., Flato, U. A. P., Tofano, R. J., Goulart, R. D. A., Guiguer, E. L., Detregiachi, C. R. P., Buchaim, D. V., Araújo, A. C., Buchaim, R. L., Reina, F. T. R., Biteli, P., Reina, D. O. B. R., & Bechara, M. D.
- Affiliations
- Faculdade de Medicina de Marília (BR)
- Postgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marilia (UNIMAR), Avenue Hygino Muzzy Filho, 1001, Marília 17525-902, São Paulo, Brazil
- Universidade de Marília (BR)
- Universidade de São Paulo (BR)
- Corresponding author
- Barbalho, Sandra Maria
- ORCID
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2020-05-20
- Volume
- 21
- Issue
- 10
- Pages
- 3607
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC7279354
- OpenAlex
- W3028055237
- Cited by
- 156
- References
- 107
- Citations by year
- 2026: 18 · 2025: 23 · 2024: 26 · 2023: 27 · 2022: 40 · 2021: 20 · 2020: 2
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- myokines, sarcopenia, cardiovascular disease, physical activity, skeletal muscle, sedentary lifestyle, cardiomyopathy, chronic heart failure, metabolic syndrome, adipose tissue, muscle mass loss, atherosclerosis, insulin sensitivity, energy expenditure
- MeSH terms
- Animals, Cardiovascular Diseases, Cell Communication, Humans, Exercise, Cytokines, Muscle, Skeletal, Adipokines, Sarcopenia
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