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Pleiotrophin: Activity and mechanism
Open accessAbstract
Pleiotrophin (PTN) is a potent mitogenic cytokine with a high affinity for the polysaccharide glycosaminoglycan (GAG). Although it is most strongly associated with neural development during embryogenesis and the neonatal period, its expression has also been linked to a plethora of other physiological events including cancer metastasis, angiogenesis, bone development, and inflammation. A considerable amount of research has been carried out to understand the mechanisms by which PTN regulates these events. In particular, PTN has now been shown to bind a diverse collection of receptors including many GAG-containing proteoglycans. These interactions lead to the activation of many intracellular kinases and, ultimately, activation and transformation of cells. Structural studies of PTN in complex with both GAG and domains from its non-proteoglycan receptors reveal a binding mechanism that relies on electrostatic interactions and points to PTN-induced receptor oligomerization as one of the possible ways PTN uses to control cellular functions.
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“This interaction facilitates the internalization of the Ptn-Ncl complex [Wang, 2020].”
From Cell signaling pathways discovery from multi-modal data (2025) · cites this paper as Wang, 2020
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Flagged first, then by citations
4 of the 166 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Garcia-Gutierrez, 2014, Pleiotrophin antagonizes Brd2 during neuronal differentiation, J. Cell Sci., 127, 2554
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Sorted by citations
The Active Role of Pericytes During Neuroinflammation in the Adult Brain
Medina‐Flores, F., Hurtado‐Alvarado, G., Deli, M. A., & Gómez‐González, B. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01208-5 · Cited by 63
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Kang, X., Zhang, K., Wang, Y., Yang, Z., & Lu, Y. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1099287 · Cited by 35
Brief Electrical Stimulation Promotes Recovery after Surgical Repair of Injured Peripheral Nerves
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Astrocyte-Derived Pleiotrophin Mitigates Late-Stage Autoimmune CNS Inflammation
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Metadata
- Authors
- Wang, X.
- Affiliations
- Arizona State University (US)
- Corresponding author
- Xu Wang
- ORCID
- Xu Wang
- Venue
- Advances in Clinical Chemistry
- Publisher
- Elsevier
- Published
- 2020
- Volume
- 98
- Pages
- 51-89
- ISSN
- 0065-2423 (ISSN-L)
- PMC
- PMC7672882
- OpenAlex
- W3011324370
- Cited by
- 98
- References
- 166
- Citations by year
- 2026: 22 · 2025: 16 · 2024: 26 · 2023: 22 · 2022: 10 · 2021: 2
- FWCI
- 14.22
- Type
- book chapter
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Advances in clinical chemistry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM118518)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Keywords
- pleiotrophin, glycosaminoglycan binding, proteoglycans, receptor oligomerization, electrostatic interactions, receptor activation, cell transformation, metastasis, angiogenesis, skeletal development, inflammation, neural development, protein structure
- MeSH terms
- Animals, Carrier Proteins, Cell Differentiation, Humans, Neoplasms, Cytokines
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