The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Simple Sugars to Complex Disease—Mucin-Type O-Glycans in Cancer
Open accessAbstract
Mucin-type O-glycans are a class of glycans initiated with N-acetylgalactosamine (GalNAc) α-linked primarily to Ser/Thr residues within glycoproteins and often extended or branched by sugars or saccharides. Most secretory and membrane-bound proteins receive this modification, which is important in regulating many biological processes. Alterations in mucin-type O-glycans have been described across tumor types and include expression of relatively small-sized, truncated O-glycans and altered terminal structures, both of which are associated with patient prognosis. New discoveries in the identity and expression of tumor-associated O-glycans are providing new avenues for tumor detection and treatment. This chapter describes mucin-type O-glycan biosynthesis, altered mucin-type O-glycans in primary tumors, including mechanisms for structural changes and contributions to the tumor phenotype, and clinical approaches to detect and target altered O-glycans for cancer treatment and management.
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Cites
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Self-citationLoss of intestinal core 1–derived O-glycans causes spontaneous colitis in mice
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Cited by
Glycosylation in cancer: mechanisms and clinical implications
Pinho, S. S., & Reis, C. A. (2015) · Nature Reviews Cancer · doi:10.1038/nrc3982 · Cited by 3,083
Global view of human protein glycosylation pathways and functions
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Hallmarks of glycosylation in cancer
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Intestinal epithelial glycosylation in homeostasis and gut microbiota interactions in IBD
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Glycosylation in cancer: mechanisms, diagnostic markers, and therapeutic applications
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Metadata
- Venue
- Advances in Cancer Research
- Publisher
- Elsevier
- Published
- 2015
- Volume
- 126
- Pages
- 53-135
- ISSN
- 0065-230X (ISSN-L)
- OpenAlex
- W197316820
- Cited by
- 260
- References
- 19
- FWCI
- 24.09
- Type
- book chapter
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
