The DOI matches its Crossref record; 177 of the 177 references it cites were found in a registry or an index.
CB 1 and CB 2 Receptor Pharmacology
Open accessAbstract
The CB1 and CB2 cannabinoid receptors (CB1R, CB2R) are members of the G protein coupled receptor (GPCR) family that were identified over 20 years ago. CB1Rs and CB2Rs mediate the effects of Δ9-tetrahydrocannabinol (Δ9-THC), the principal psychoactive constituent of marijuana and subsequently identified endogenous cannabinoids (endocannabinoids) anandamide and 2-arachidonoyl glycerol. CB1Rs and CB2Rs have both similarities and differences in their pharmacology. Both receptors recognize multiple classes of agonist and antagonist compounds and produce an array of distinct downstream effects. Natural polymorphisms and alternative splice variants may also contribute to their pharmacological diversity. As our knowledge of the distinct differences grows, we may be able to target select receptor conformations and their corresponding pharmacological responses. This chapter will discuss their pharmacological characterization, distribution, phylogeny and signaling pathways. In addition, the effects of extended agonist exposure and how that affects signaling and expression patterns of the receptors is considered.
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Cites
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Goods and Bads of the Endocannabinoid System as a Therapeutic Target: Lessons Learned after 30 Years
Maccarrone, M., Di Marzo, V., Gertsch, J., Grether, U., Howlett, A. C., Hua, T., Makriyannis, A., Piomelli, D., Ueda, N., & van der Stelt, M. (2023) · Pharmacological Reviews · doi:10.1124/pharmrev.122.000600 · Cited by 183
Self-citationRole of the endocannabinoid system in the regulation of intestinal homeostasis
Cuddihey, H., MacNaughton, W. K., & Sharkey, K. A. (2022) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2022.05.015 · Cited by 79
Fairhurst, C., Kumar, R., Checketts, D., Tayo, B., & Turner, S. (2020) · Developmental Medicine & Child Neurology · doi:10.1111/dmcn.14548 · Cited by 53
Metadata
- Authors
- Howlett, A. C., & Abood, M. E.
- Venue
- Advances in Pharmacology
- Publisher
- Elsevier
- Published
- 2017
- Volume
- 80
- Pages
- 169-206
- ISSN
- 1054-3589 (ISSN-L)
- OpenAlex
- W2626033047
- Cited by
- 375
- References
- 177
- FWCI
- 49.53
- Type
- book chapter
- Language
- en
- Open access
- green
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