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Different Pathways to the Lysosome

·2015·International Review of Cell and Molecular Biology
DOI 10.1016/bs.ircmb.2015.07.008
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Abstract

Considerable research supports a model in which hydrolytic enzymes of mammalian lysosomes are sorted to their destinations in a receptor-dependent mechanism. The ligand for the mammalian sorting receptors is mannose 6-phosphate (M6P). Two M6P receptors have been defined in mammals. Here, we review the foundational evidence supporting this mechanism and highlight the remaining gaps in our understanding of the mammalian mechanism, including evidence for M6P-independent sorting, and its relevance to lysosomal enzyme sorting in metazoa.

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  • Retromer and its receptors, SORLA and CIMPR, function to traffic mature lysosomal hydrolases from the TGN via endosomes to lysosomes.

    “In particular, retromer and its receptors, SORLA and the cation‐independent mannose‐6 phosphate receptor (CIMPR), function to traffic mature lysosomal hydrolases from the TGN via endosomes to lysosomes (Cui et al. 2019; Hasanagic et al. 2015; Nielsen et al. 2007).”

    From The Alzheimer's Disease Gene <i>SORL1</i> Regulates Lysosome Function in Human Microglia (2025) · cites this paper as Hasanagic et al. 2015

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Metadata

Venue
International Review of Cell and Molecular Biology
Publisher
Elsevier
Published
2015
Pages
75-101
ISSN
1937-6448
DOI
10.1016/bs.ircmb.2015.07.008
Cited by
18
References
4
Language
en
Licence

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

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