The DOI matches its Crossref record; 311 of the 311 references it cites were found in a registry or an index.
Phosphatidylethanolamine Metabolism in Health and Disease
Open accessAbstract
Phosphatidylethanolamine (PE) is the second most abundant glycerophospholipid in eukaryotic cells. The existence of four only partially redundant biochemical pathways that produce PE, highlights the importance of this essential phospholipid. The CDP-ethanolamine and phosphatidylserine decarboxylase pathways occur in different subcellular compartments and are the main sources of PE in cells. Mammalian development fails upon ablation of either pathway. Once made, PE has diverse cellular functions that include serving as a precursor for phosphatidylcholine and a substrate for important posttranslational modifications, influencing membrane topology, and promoting cell and organelle membrane fusion, oxidative phosphorylation, mitochondrial biogenesis, and autophagy. The importance of PE metabolism in mammalian health has recently emerged following its association with Alzheimer's disease, Parkinson's disease, nonalcoholic liver disease, and the virulence of certain pathogenic organisms.
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Cites
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Background
Cited by
van der Veen, J. N., Kennelly, J. P., Wan, S., Vance, J. E., Vance, D. E., & Jacobs, R. L. (2017) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2017.04.006 · Cited by 1,514
Fatty Acid– and Lipid-Mediated Signaling in Plant Defense
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APOE2 orchestrated differences in transcriptomic and lipidomic profiles of postmortem AD brain
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Recent advances in metabolism and toxicity of tyrosine kinase inhibitors
Zhao, Q., Wu, Z. E., Li, B., & Li, F. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108256 · Cited by 57
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Metadata
- Venue
- International Review of Cell and Molecular Biology
- Publisher
- Elsevier
- Published
- 2016
- Volume
- 321
- Pages
- 29-88
- ISSN
- 0074-7696 (ISSN-L)
- 1937-6448
- OpenAlex
- W2411561471
- Cited by
- 526
- References
- 311
- FWCI
- 10.45
- Type
- book chapter
- Language
- en
- Open access
- green
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