Role of magnesium in hypertension

Sontia, Bruno; Touyz, Rhian M.

doi:10.1016/j.abb.2006.05.005

Cited by 202Magnesium in Health and DiseaseBlood Pressure and Hypertension StudiesMagnesium Alloys: Properties and Applications

Role of magnesium in hypertension

Sontia, Bruno, Touyz, Rhian M.·2007·Archives of Biochemistry and Biophysics

DOI 10.1016/j.abb.2006.05.005

Open this paper in CoChat — free account

Abstract

Magnesium affects blood pressure by modulating vascular tone and reactivity. It acts as a calcium channel antagonist, it stimulates production of vasodilator prostacyclins and nitric oxide and it alters vascular responses to vasoactive agonists. Magnesium deficiency has been implicated in the pathogenesis of hypertension with epidemiological and experimental studies demonstrating an inverse correlation between blood pressure and serum magnesium levels. Magnesium also influences glucose and insulin homeostasis, and hypomagnesemia is associated with metabolic syndrome. Although most epidemiological and experimental studies support a role for low magnesium in the pathophysiology of hypertension, data from clinical studies have been less convincing. Furthermore, the therapeutic value of magnesium in the management of hypertension is unclear. The present review addresses the role of magnesium in the regulation of vascular function and blood pressure and discusses the implications of magnesium deficiency in experimental and clinical hypertension, in metabolic syndrome and in pre-eclampsia.

Integrity signals

Registry

Crossref · 10.1016/j.abb.2006.05.005

Cites

120 of 120 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Chia seeds contain omega-3 fatty acids, magnesium, potassium, calcium, and flavonoids (quercetin, chlorogenic acid, caffeic acid) that have been linked to reduced blood pressure.
“They are rich in crucial fatty acids, particularly with a high omega-3 to omega-6 ratio, linked to reduced BP and a lower risk of CVD [43–45]. A 100-g serving of chia provides significant amounts of magnesium, potassium, and calcium, all potent vasodilators and vascular smooth muscle contraction inhibitors, effectively reducing BP [46–49]. Additionally, chia seeds contain flavonoids such as querc”
From Effects of chia seed (Salvia hispanica L.) supplementation on cardiometabolic health in overweight subjects: a systematic review and meta-analysis of RCTs (2024) · cites this paper as [47]

Preeclampsia: an endothelial cell disorder
Roberts, J. M., Taylor, R. N., Musci, T. J., Rodgers, G. M., Hubel, C. A., & McLaughlin, M. K. (1989) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(89)90665-0 · Cited by 1,859 · see citing works
Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo-controlled trial
Altman, D. G., Carroli, G., Duley, L., Farrell, B., Moodley, J., Neilson, J., & Smith, D. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08778-0 · Cited by 1,488 · see citing works
Reactive Oxygen Species in the Vasculature
Taniyama, Y., & Griendling, K. K. (2003) · Hypertension · doi:10.1161/01.hyp.0000100443.09293.4f · Cited by 1,067 · see citing works
Which anticonvulsant for women with eclampsia? Evidence from the Collaborative Eclampsia Trial
The Eclampsia Trial Collaborative Group (1995) · The Lancet · doi:10.1016/s0140-6736(95)91034-4 · Cited by 836 · see citing works
"Which Anticonvulsant for Women with Eclampsia? Evidence from the Collaborative Eclampsia Trial."
(1995) · Studies in Family Planning · doi:10.2307/2138105 · Cited by 735 · see citing works
Reactive oxygen species in vascular biology: implications in hypertension
Touyz, R. M., & Schiffrin, E. L. (2004) · Histochemistry and Cell Biology · doi:10.1007/s00418-004-0696-7 · Cited by 646 · see citing works
Self-citation
A Comparison of Magnesium Sulfate with Phenytoin for the Prevention of Eclampsia
Lucas, M. J., Leveno, K. J., & Cunningham, F. G. (1995) · New England Journal of Medicine · doi:10.1056/nejm199507273330401 · Cited by 545 · see citing works
Role of magnesium in insulin action, diabetes and cardio-metabolic syndrome X
Barbagallo, M. (2003) · Molecular Aspects of Medicine · doi:10.1016/s0098-2997(02)00090-0 · Cited by 466 · see citing works
Magnesium Intake and Risk of Type 2 Diabetes in Men and Women
López‐Ridaura, R., Willett, W. C., Rimm, E. B., Liu, S., Stampfer, M. J., Manson, J. E., & Hu, F. B. (2004) · Diabetes Care · doi:10.2337/diacare.27.1.134 · Cited by 454 · see citing works
Serum and Dietary Magnesium and the Risk for Type 2 Diabetes Mellitus
Kao, W. H. L., Folsom, A. R., Nieto, F. J., Mo, J., Watson, R. L., & Brancati, F. L. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.18.2151 · Cited by 406 · see citing works
Prospective Study of Nutritional Factors, Blood Pressure, and Hypertension Among US Women
Ascherio, A., Hennekens, C. H., Willett, W. C., Sacks, F. M., ROSNER, B. A., Manson, J. E., Witteman, J. C. M., & Stampfer, M. J. (1996) · Hypertension · doi:10.1161/01.hyp.27.5.1065 · Cited by 403 · see citing works
A Cluster of Metabolic Defects Caused by Mutation in a Mitochondrial tRNA
Wilson, F. H., Hariri, A., Farhi, A., Zhao, H., Petersen, K. F., Toka, H. R., Nelson-Williams, C. J., Raja, K. M., Kashgarian, M. J., Shulman, G. I., et al. (2004) · Science · doi:10.1126/science.1102521 · Cited by 355 · see citing works
Magnesium Intake and Incidence of Metabolic Syndrome Among Young Adults
He, K., Liu, K., Daviglus, M. L., Morris, S. J., Loria, C. M., Horn, L. V., Jacobs, D. R., & Savage, P. J. (2006) · Circulation · doi:10.1161/circulationaha.105.588327 · Cited by 353 · see citing works
The effect of magnesium supplementation on blood pressure: a meta-analysis of randomized clinical trials
Jee, S. H., Miller, E. R., Güallar, E., Singh, V. K., Appel, L. J., & Klag, M. J. (2002) · American Journal of Hypertension · doi:10.1016/s0895-7061(02)02964-3 · Cited by 346 · see citing works
Relationship of magnesium intake and other dietary factors to blood pressure: the Honolulu heart study
Joffres, M. R., REED, D. M., & Yano, K. (1987) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/45.2.469 · Cited by 322 · see citing works
Magnesium Intake, C-Reactive Protein, and the Prevalence of Metabolic Syndrome in Middle-Aged and Older U.S. Women
Song, Y., Ridker, P. M., Manson, J. E., Cook, N. R., Buring, J. E., & Liu, S. (2005) · Diabetes Care · doi:10.2337/diacare.28.6.1438 · Cited by 315 · see citing works
Divalent Cations in Essential Hypertension
(1984) · New England Journal of Medicine · doi:10.1056/nejm198408303110924 · Cited by 302 · see citing works
Effect of magnesium on blood pressure.
Dyckner, T., & Wester, P. O. (1983) · BMJ · doi:10.1136/bmj.286.6381.1847 · Cited by 263 · see citing works
Divalent Cations in Essential Hypertension
Resnick, L. M., Laragh, J. H., Sealey, J. E., & Alderman, M. H. (1983) · New England Journal of Medicine · doi:10.1056/nejm198310133091504 · Cited by 260 · see citing works
Low serum magnesium levels and metabolic syndrome
Guerrero‐Romero, F., & Rodríguez‐Morán, M. (2002) · Acta Diabetologica · doi:10.1007/s005920200036 · Cited by 252 · see citing works
Magnesium-deficiency elevates circulating levels of inflammatory cytokines and endothelin
Weglicki, W. B., Phillips, T. M., Freedman, A. M., CASSIDY, M. M., & Dickens, B. F. (1992) · Molecular and Cellular Biochemistry · doi:10.1007/bf02454195 · Cited by 239 · see citing works
Oral Magnesium supplementation improves insulin sensitivity in non-diabetic subjects with insulin resistance. A double-blind placebo-controlled randomized trial
Guerrero‐Romero, F., Tamez-Pérez, H. E., González-González, G. M., Salinas-Martı́nez, A. M., Montes‐Villarreal, J., Treviño-Ortiz, J. H., & Rodríguez‐Morán, M. (2004) · Diabetes & Metabolism · doi:10.1016/s1262-3636(07)70116-7 · Cited by 235 · see citing works
High concentrations of magnesium modulate vascular endothelial cell behaviour in vitro
Maier, J. A. M., Bernardini, D., Rayssiguier, Y., & Mazur, A. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.02.004 · Cited by 227 · see citing works
Direct Magnetic Resonance Determination of Aortic Distensibility in Essential Hypertension
Resnick, L. M., Militianu, D., Cunnings, A. J., Pipe, J. G., Evelhoch, J. L., & Soulen, R. L. (1997) · Hypertension · doi:10.1161/01.hyp.30.3.654 · Cited by 193 · see citing works
A randomised controlled trial of intravenous magnesium sulphate versus placebo in the management of women with severe pre‐eclampsia
Coetzee, E. J., Dommisse, J., & Anthony, J. (1998) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1998.tb10090.x · Cited by 189 · see citing works
Effect of magnesium sulfate on maternal brain blood flow in preeclampsia: A randomized, placebo-controlled study
Belfort, M. A., & Moise, K. J. (1992) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(11)91567-1 · Cited by 189 · see citing works
Transient Receptor Potential Melastatin 7 Ion Channels Regulate Magnesium Homeostasis in Vascular Smooth Muscle Cells
He, Y., Yao, G., Savoia, C., & Touyz, R. M. (2005) · Circulation Research · doi:10.1161/01.res.0000152967.88472.3e · Cited by 186 · see citing works
Self-citation
Epithelial Ca2+ and Mg2+ Channels in Health and Disease
Hoenderop, J. G. J., & Bindels, R. J. M. (2004) · Journal of the American Society of Nephrology · doi:10.1681/asn.2004070523 · Cited by 182 · see citing works
Physiological and pathophysiological role of magnesium in the cardiovascular system
Laurant, P., & Touyz, R. M. (2000) · Journal of Hypertension · doi:10.1097/00004872-200018090-00003 · Cited by 170 · see citing works
Self-citation
Lack of effect of oral magnesium on high blood pressure: a double blind study.
Cappuccio, F. P., Markandu, N. D., Beynon, G., Shore, A. C., Sampson, B., & MacGregor, G. A. (1985) · BMJ · doi:10.1136/bmj.291.6490.235 · Cited by 168 · see citing works
Magnesium relaxes arterial smooth muscle by decreasing intracellular Ca2+ without changing intracellular Mg2+.
D'Angelo, E. K., Singer, H. A., & Rembold, C. M. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115807 · Cited by 142 · see citing works
Magnesium sulfate: rationale for its use in preeclampsia.
Watson, K., Moldow, C. F., Ogburn, P. L., & Jacob, H. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.4.1075 · Cited by 137 · see citing works
Magnesium regulates intracellular free ionized calcium concentration and cell geometry in vascular smooth muscle cells
Zhang, A., Cheng, T. P. ‐., & Altura, B. M. (1992) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(92)90024-6 · Cited by 136 · see citing works
Magnesium and blood pressure: Review of the epidemiologic and clinical trial experience
Whelton, P. K., & Klag, M. J. (1989) · The American Journal of Cardiology · doi:10.1016/0002-9149(89)90215-4 · Cited by 119 · see citing works
Nutrient Intake and Blood Pressure in the Dietary Intervention Study in Children
Simons‐Morton, D. G., Hunsberger, S., Horn, L. V., BARTON, B. A., Robson, A. M., McMahon, R. P., Muhonen, L. E., Kwiterovich, P. O., Lasser, N. L., Kimm, S. Y. S., et al. (1997) · Hypertension · doi:10.1161/01.hyp.29.4.930 · Cited by 114 · see citing works
Magnesium Inhibits Norepinephrine Release by Blocking N-Type Calcium Channels at Peripheral Sympathetic Nerve Endings
Shimosawa, T., Takano, K., Ando, K., & Fujita, T. (2004) · Hypertension · doi:10.1161/01.hyp.0000146536.68208.84 · Cited by 112 · see citing works
The effects of high oral magnesium supplementation on blood pressure, serum lipids and related variables in apparently healthy Japanese subjects
Itoh, K., Kawasaki, T., & Nakamura, M. (1997) · British Journal Of Nutrition · doi:10.1079/bjn19970191 · Cited by 109 · see citing works
Role of free radicals and substance P in magnesium deficiency
Weglicki, W. B., Mak, I. T., Kramer, J. H., Dickens, B. F., CASSIDY, M. M., STAFFORD, R., & Phillips, T. (1996) · Cardiovascular Research · doi:10.1016/s0008-6363(95)00196-4 · Cited by 107 · see citing works
Differential regulation of transient receptor potential melastatin 6 and 7 cation channels by ANG II in vascular smooth muscle cells from spontaneously hypertensive rats
Touyz, R. M., He, Y., Montezano, A. C. I., Yao, G., Chubanov, V., Gudermann, T. W., & Callera, G. E. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00515.2005 · Cited by 105 · see citing works
Self-citation
Hypomagnesemia Inhibits Nitric Oxide Release From Coronary Endothelium: Protective Role of Magnesium Infusion After Cardiac Operations
Pearson, P. J., Évora, P. R. B., Seccombe, J. F., & Schaff, H. V. (1998) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(98)00020-4 · Cited by 96 · see citing works
The Dose-Dependent Reduction in Blood Pressure Through Administration of Magnesium A Double Blind Placebo Controlled Cross-Over Study
Widman, L., Wester, P. O., Stegmayr, B., & Wirell, M. (1993) · American Journal of Hypertension · doi:10.1093/ajh/6.1.41 · Cited by 91 · see citing works
Intracellular ionic consequences of dietary salt loading in essential hypertension. Relation to blood pressure and effects of calcium channel blockade.
Resnick, L. M., Gupta, R. K., Difabio, B., Barbagallo, M., Mann, S. J., Marion, R. M., & Laragh, J. H. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117445 · Cited by 81 · see citing works
Hemodynamic effects of magnesium sulfate on the normal human heart
Vigorito, C., Giordano, A., Ferraro, P., Acanfora, D., Caprio, L. D., Naddeo, C., & Rengo, F. (1991) · The American Journal of Cardiology · doi:10.1016/0002-9149(91)90478-4 · Cited by 79 · see citing works
Effects of dietary magnesium on the development of hypertension in the spontaneously hypertensive rat.
Berthelot, A., & Esposito, J. (1983) · Journal of the American College of Nutrition · doi:10.1080/07315724.1983.10719931 · Cited by 76 · see citing works
Lack of blood pressure effect with calcium and magnesium supplementation in adults with high-normal blood pressure
Yamamoto, M. E., Applegate, W. B., Klag, M. J., Borhani, N. O., Cohen, J. D., Kirchner, K. A., Lakatos, E., Sacks, F. M., Taylor, J. O., & Hennekens, C. H. (1995) · Annals of Epidemiology · doi:10.1016/1047-2797(94)00054-w · Cited by 75 · see citing works
Antagonistic modulatory roles of magnesium and calcium on release of endothelium-derived relaxing factor and smooth muscle tone.
Gold, M. E., Buga, G. M., Wood, K. S., Byrns, R. E., Chaudhuri, G., & Ignarro, L. J. (1990) · Circulation Research · doi:10.1161/01.res.66.2.355 · Cited by 73 · see citing works
Calcium and magnesium in drinking water and the risk of death from hypertension
Yang, C. (1999) · American Journal of Hypertension · doi:10.1016/s0895-7061(99)00065-5 · Cited by 71 · see citing works
Dietary Calcium, Potassium, Magnesium and Blood Pressure in the Netherlands
Leer, E. M. V., Seidell, J. C., & Kromhout, D. (1995) · International Journal of Epidemiology · doi:10.1093/ije/24.6.1117 · Cited by 70 · see citing works
Modulation of vascular smooth muscle cell growth by magnesium—role of mitogen—activated protein kinases
Touyz, R. M., & Yao, G. (2003) · Journal of Cellular Physiology · doi:10.1002/jcp.10393 · Cited by 68 · see citing works
Self-citation
The 2005 Canadian Hypertension Education Program recommendations for the management of hypertension: part II - therapy.
Khan, N. A., McAlister, F. A., Rz, L., Touyz, R. M., Padwal, R. S., Rabkin, S. W., Leiter, L. A., Lebel, M., Herbert, C. P., Schiffrin, E. L., et al. (2005) · PubMed · Cited by 68 · see citing works
Self-citation
Definition of the Metabolic Syndrome: Current Proposals and Controversies
Reisin, E., & Alpert, M. (2005) · The American Journal of the Medical Sciences · doi:10.1097/00000441-200512000-00003 · Cited by 65 · see citing works
Magnesium, calcium, sodium and potassium status in normotensive and hypertensive Johannesburg residents.
Touyz, R. M., Milne, F. J., Seftel, H. C., & Reinach, S. G. (1987) · PubMed · Cited by 64 · see citing works
Self-citation
Effects of low dietary magnesium intake on development of hypertension in stroke-prone spontaneously hypertensive rats
Touyz, R. M., Pu, Q., He, G., Chen, X., Yao, G., Neves, M. F., & Viel, É. C. (2002) · Journal of Hypertension · doi:10.1097/00004872-200211000-00022 · Cited by 64 · see citing works
Self-citation
Effects of magnesium on prostacyclin synthesis and intracellular free calcium concentration in vascular cells.
Satake, K., Lee, J., Shimizu, H., Uzui, H., Mitsuke, Y., Yue, H., & Ueda, T. (2004) · PubMed · Cited by 63 · see citing works
Extracellular Mg 2+ Inhibits Capacitative Ca 2+ Entry in Vascular Smooth Muscle Cells
Yoshimura, M., Oshima, T., Matsuura, H., Ishida, T., Kambe, M., & Kajiyama, G. (1997) · Circulation · doi:10.1161/01.cir.95.11.2567 · Cited by 63 · see citing works
Serum ionized magnesium levels in normal and preeclamptic gestation
Handwerker, S. M., ALTURA, B., & ALTURA, B. (1997) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(97)80058-0 · Cited by 62 · see citing works
Blood Pressure Response During Long-Term Treatment With Magnesium Is Dependent on Magnesium Status
Lind, L., Lithell, H., Pollare, T., & Ljunghall, S. (1991) · American Journal of Hypertension · doi:10.1093/ajh/4.8.674 · Cited by 61 · see citing works
Serum Ionized Magnesium Relation to Blood Pressure and Racial Factors
Resnick, L. M. (1997) · American Journal of Hypertension · doi:10.1016/s0895-7061(97)00364-6 · Cited by 60 · see citing works
Long-Term Magnesium Supplementation in Essential Hypertension
Ferrara, L. A., Iannuzzi, R., Castaldo, A., Iannuzzi, A., Russo, D., & Mancini, M. (2008) · Cardiology · doi:10.1159/000175772 · Cited by 57 · see citing works
Magnesium supplementation attenuates, but does not prevent, development of hypertension in spontaneously hypertensive rats
Touyz, R. M. (1999) · American Journal of Hypertension · doi:10.1016/s0895-7061(99)00064-3 · Cited by 57 · see citing works
Self-citation
Effect of magnesium on vascular tone and reactivity in pressurized mesenteric resistance arteries from spontaneously hypertensive rats
Laurant, P., Touyz, R. M., & Schiffrin, E. L. (1997) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y97-044 · Cited by 56 · see citing works
Self-citation
Effects of Dietary Sodium and Magnesium on Cyclosporin A–Induced Hypertension and Nephrotoxicity in Spontaneously Hypertensive Rats
Mervaala, E. M. A., PERE, A.-K., Lindgren, L., Laakso, J. T., Teräväinen, T., Karjala, K., Vapaatalo, H., Ahonen, J. P., & Karppanen, H. (1997) · Hypertension · doi:10.1161/01.hyp.29.3.822 · Cited by 55 · see citing works
Effect of oral magnesium supplementation on blood pressure, platelet aggregation and calcium handling in deoxycorticosterone acetate induced hypertension in rats
Kh, R., Khullar, M., Kashyap, M. K., Pandhi, P., & Uppal, R. (2000) · Journal of Hypertension · doi:10.1097/00004872-200018070-00014 · Cited by 53 · see citing works
Daily Intake of Magnesium and Calcium From Drinking Water in Relation to Myocardial Infarction
Rosenlund, M., Berglind, N., Hallqvist, J., Bellander, T., & Bluhm, G. (2005) · Epidemiology · doi:10.1097/01.ede.0000165390.18798.62 · Cited by 52 · see citing works
Serum Ionized Magnesium Levels in Normal and Preeclamptic Gestation
Standley, C. A. (1997) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(96)00380-8 · Cited by 52 · see citing works
Relaxatory effect of magnesium on mesenteric vascular beds differs from normal and streptozotocin induced diabetic rats
Soltani, N., Keshavarz, M., Sohanaki, H., Zahediasl, S., & Dehpour, A. R. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.12.003 · Cited by 51 · see citing works
Dietary electrolyte intake and blood pressure in older subjects: the Rotterdam Study
Geleijnse, J. M., Witteman, J. C. M., den Breeijen, J. H., Albert Hofman, D., de Jong, P. T. V. M., Pols, H. A. P., & Grobbee, D. E. (1996) · Journal of Hypertension · doi:10.1097/00004872-199606000-00009 · Cited by 50 · see citing works
Reduction in Blood Pressure with a Sodium-Reduced, Potassium- and Magnesium-Enriched Mineral Salt in Subjects with Mild Essential Hypertension.
Kawasaki, T., Itoh, K., & Kawasaki, M. (1998) · Hypertension Research · doi:10.1291/hypres.21.235 · Cited by 48 · see citing works
Effect of Magnesium Deficiency on Blood Pressure and Mechanical Properties of Rat Carotid Artery
Laurant, P., Hayoz, D., Brunner, H. R., & Berthelot, A. (1999) · Hypertension · doi:10.1161/01.hyp.33.5.1105 · Cited by 47 · see citing works
Activation of the Na+-H+Exchanger Modulates Angiotensin II–Stimulated Na+-Dependent Mg2+Transport in Vascular Smooth Muscle Cells in Genetic Hypertension
Touyz, R. M., & Schiffrin, E. L. (1999) · Hypertension · doi:10.1161/01.hyp.34.3.442 · Cited by 45 · see citing works
Self-citation
Potassium, Magnesium, and Electrolyte Imbalance and Complications in Disease Management
Weglicki, W. B., Quamme, G. A., Tucker, K. L., Haigney, M. C., & Resnick, L. (2005) · Clinical and Experimental Hypertension · doi:10.1081/ceh-200044275 · Cited by 45 · see citing works
Intracellular free-magnesium levels in vascular smooth muscle and striated muscle cells of the spontaneously hypertensive rat
Ng, L. L., Davies, J. E., & Ameen, M. (1992) · Metabolism · doi:10.1016/0026-0495(92)90319-6 · Cited by 44 · see citing works
Intracellular Free Magnesium and High Energy Phosphates in the Perfused Normotensive and Spontaneously Hypertensive Rat Heart A 31P NMR Study
Jelicks, L. A., & Gupta, R. K. (1991) · American Journal of Hypertension · doi:10.1093/ajh/4.2.131 · Cited by 44 · see citing works
Abnormal magnesium status in patients with cardiovascular diseases
Sasaki, S., Oshima, T., Matsuura, H., Ozono, R., Higashi, Y., Sasaki, N., Matsumoto, T., Nakano, Y., Ueda, A., Yoshimizu, A., et al. (2000) · Clinical Science · doi:10.1042/cs19990119 · Cited by 42 · see citing works
Dietary Magnesium Supplementation Modifies Blood Pressure and Cardiovascular Function in Mineralocorticoid-Salt Hypertensive Rats but Not in Normotensive Rats
Laurant, P., Kantelip, J., & Berthelot, A. (1995) · Journal of Nutrition · doi:10.1093/jn/125.4.830 · Cited by 41 · see citing works
Endothelin‐1‐induced contraction in isolated aortae from normotensive and DOCA‐salt hypertensive rats: effect of magnesium
Laurant, P., & Berthelot, A. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb16048.x · Cited by 41 · see citing works
New European, American and International guidelines for hypertension management: agreement and disagreement
Stergiou, G. S., & Salgami, E. V. (2004) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.2.3.359 · Cited by 40 · see citing works
Serum and intracellular magnesium during normal pregnancy and in patients with pre‐eclampsia
Seydoux, J., Girardin, E. P., Paunier, L., & Béguin, F. (1992) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1992.tb14500.x · Cited by 36 · see citing works
Intracellular and Extracellular, Ionized and Total Magnesium in Pre-Eclampsia and Uncomplicated Pregnancy
Sanders, R., Konijnenberg, A., Huijgen, H. J., Wolf, H., Boer, K., & Sanders, G. T. (1999) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.1999.008 · Cited by 36 · see citing works
Plasma and intracellular Mg2+ concentrations in pre-eclampsia
Kisters, K., Niedner, W., Fafera, I., & Zidek, W. (1990) · Journal of Hypertension · doi:10.1097/00004872-199004000-00002 · Cited by 35 · see citing works
Oral magnesium administration prevents vascular complications in STZ-diabetic rats
Soltani, N., Keshavarz, M., Sohanaki, H., Dehpour, A. R., & Zahediasl, S. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.07.027 · Cited by 34 · see citing works
Effect of a mineral salt diet on 24-h blood pressure monitoring in elderly hypertensive patients
Katz, A., Rosenthal, T., RACHIMAMAOZ, C., Peleg, E., Zeidenstein, R., & Levi, Y. (1999) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1000837 · Cited by 33 · see citing works
Increased activity of the Mg2+/Na+ exchanger in red blood cells from essential hypertensive patients.
Picado, M. J., Sierra, À., Aguilera, M. T., Coca, A., & Urbano-Márquez, A. (1994) · Hypertension · doi:10.1161/01.hyp.23.6.987 · Cited by 33 · see citing works
Mechanisms responsible for vasodilation upon magnesium infusion in vivo: clinical evidence.
Teragawa, H., Matsuura, H., Chayama, K., & Oshima, T. (2002) · PubMed · Cited by 31 · see citing works
Effects of Magnesium Sulfate Infusion Upon Plasma Prostaglandins in Preeclampsia and Preterm Labor
Sipes, S. L., Weiner, C. P., Gellhaus, T. M., & Goodspeed, J. D. (1994) · Hypertension in Pregnancy · doi:10.3109/10641959409072231 · Cited by 31 · see citing works
Magnesium supplementation and deoxycorticosterone acetate – salt hypertension: effect on arterial mechanical properties and on activity of endothelin-1
Berthon, N., Laurant, P., Hayoz, D., FELLMANN, D., Brunner, H. R., & Berthelot, A. (2002) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y02-082 · Cited by 30 · see citing works
Modulation of the voltage-dependent K current by intracellular Mg in rat aortic smooth muscle cells
Tammaro, P., SMITH, A., CROWLEY, B., & Sv, S. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.10.035 · Cited by 30 · see citing works
Magnesium‐induced vasodilation in the dorsal hand vein⋆
Landau, R., Scott, J. A., & Smiley, R. M. (2004) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2004.00114.x · Cited by 29 · see citing works
Modulation of Ca2+ channel activity by ATP metabolism and internal Mg2+ in guinea‐pig basilar artery smooth muscle cells.
McHugh, D., & Beech, D. J. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021314 · Cited by 28 · see citing works
Fetal ionized magnesium levels parallel maternal levels during magnesium sulfate therapy for preeclampsia
Mason, B. A., Standley, C. A., Whitty, J. E., & Cotton, D. B. (1996) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(96)70277-6 · Cited by 28 · see citing works
Inhibitors of Na+/Mg2+ exchange activity attenuate the development of hypertension in angiotensin II-induced hypertensive rats
Touyz, R. M., & Yao, G. (2003) · Journal of Hypertension · doi:10.1097/00004872-200302000-00025 · Cited by 28 · see citing works
Self-citation
Low [Mg 2+ ] e Enhances Arterial Spontaneous Tone via Phosphatidylinositol 3-Kinase in DOCA-Salt Hypertension
Northcott, C. A., & Watts, S. W. (2003) · Hypertension · doi:10.1161/01.hyp.0000103631.68328.03 · Cited by 26 · see citing works
Uremia in Acute Glomerular Nephritis
(1925) · New England Journal of Medicine · doi:10.1056/nejm192510011931401 · Cited by 26 · see citing works
Inhibitors of Na+/Mg2+ exchange activity attenuate the development of hypertension in angiotensin II-induced hypertensive rats
Thomas, T. H. (2003) · Journal of Hypertension · doi:10.1097/00004872-200302000-00011 · Cited by 25 · see citing works
Membranes of magnesium deficiency induced neoplastic cells
Guenther, T., & Averdunk, R. (1985) · Journal of the American College of Nutrition · Cited by 25 · see citing works
Influence of endothelium on Mg2+-induced relaxation in noradrenaline-contracted aorta from DOCA-salt hypertensive rat
Laurant, P., & Berthelot, A. (1994) · European Journal of Pharmacology · doi:10.1016/0014-2999(94)90477-4 · Cited by 24 · see citing works
Disturbances of magnesium metabolism in the spontaneously hypertensive rat.
Berthelot, A., Luthringer, C., Meyers, E., & Exinger, A. (1987) · Journal of the American College of Nutrition · doi:10.1080/07315724.1987.10720195 · Cited by 22 · see citing works
Electrolyte content of serum, erythrocyte, kidney and heart tissue in salt induced hypertensive rats
Mahboob, T., Mumtaz, M., & Haleem, M. A. (1996) · Life Sciences · doi:10.1016/0024-3205(96)00359-1 · Cited by 21 · see citing works
L ‐NAME inhibits Mg2+‐induced rat aortic relaxation in the absence of endothelium
Das, R., Kravtsov, G. M., Ballard, H. J., & Kwan, C. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702737 · Cited by 20 · see citing works
Altered cations and muscle membrane ATPase activity in deoxycorticosterone acetate-salt spontaneously hypertensive rats
Touyz, R. M., Marshal, P. R., & Milne, F. J. (1991) · Journal of Hypertension · doi:10.1097/00004872-199108000-00007 · Cited by 20 · see citing works
Self-citation
Extracellular Mg2+ blocks endothelin-1-induced contraction through the inhibition of non-selective cation channels in coronary smooth muscle
Ko, E., Park, W. S., & Earm, Y. E. (2004) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-004-1319-9 · Cited by 20 · see citing works
Action of magnesium sulfate on platelet prostacyclin interaction and prostacyclin of blood vessels
Briel, R. C., Lippert, T. H., & Zahradnik, H. P. (1985) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(85)90124-3 · Cited by 19 · see citing works
Mineral Balance and Blood Pressure in the Young Spontaneously Hypertensive Rat
Jones, M., Martins, J. E., & Clemens, R. (1988) · Journal of Nutrition · doi:10.1093/jn/118.1.114 · Cited by 18 · see citing works
Intralymphocyte free magnesium and calcium and insulin tolerance test in a group of essential hypertensive patients
Delva, P., Pastori, C., Montesi, G., Degan, M., Micciolo, R., Paluani, F., & Lechi, A. (1998) · Life Sciences · doi:10.1016/s0024-3205(98)00407-x · Cited by 18 · see citing works
Abnormal magnesium metabolism in two rat models of genetic hypertension
Wells, I. C., & Agrawal, D. K. (1992) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y92-170 · Cited by 18 · see citing works
Early-onset increased calcium and decreased magnesium concentrations and an increased calcium/magnesium ratio in SHR versus WKY.
Kisters, K., Wessels, F., Tokmak, F., Krefting, E. R., Gremmler, B., Kosch, M., & Hausberg, M. (2004) · PubMed · Cited by 17 · see citing works
Responses in extracellular and intracellular calcium and magnesium in aldosteronism
Runyan, A. L., Sun, Y., Bhattacharya, S. K., Ahokas, R. A., Chhokar, V. S., Gerling, I., & Weber, K. T. (2005) · Journal of Laboratory and Clinical Medicine · doi:10.1016/j.lab.2005.04.008 · Cited by 17 · see citing works
Mononuclear Cell Magnesium Content Remains Unchanged in Various Hypertensive Disorders of Pregnancy
Frenkel, Y., Weiss, M., Shefi, M., Lusky, A., Mashiach, S., & Dolev, E. (2010) · Gynecologic and Obstetric Investigation · doi:10.1159/000292485 · Cited by 16 · see citing works
Reactive oxygen species
Bukoski, R. D. (2002) · Journal of Hypertension · doi:10.1097/00004872-200211000-00009 · Cited by 16 · see citing works
MAGNESIUM, CALCIUM AND TRACE ELEMENTS IN SPONTANEOUSLY HYPERTENSIVE RATS
Saito, N., Abbu, G. C., Konishi, Y., Nishiyama, S., & Okada, T. (1995) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1995.tb02887.x · Cited by 15 · see citing works
INTRALYMPHOCYTIC FREE CALCIUM AND MAGNESIUM IN STROKE‐PRONE SPONTANEOUSLY HYPERTENSIVE RATS AND EFFECTS OF BLOOD PRESSURE AND VARIOUS ANTIHYPERTENSIVE AGENTS
Adachi, M., Nara, Y., Mano, M., Ikeda, K., Horie, R., & Yamori, Y. (1993) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1993.tb01745.x · Cited by 15 · see citing works
Platelet magnesium depletion in normotensive and hypertensive obese subjects: the role of salt-regulating hormones and catecholamines.
Corica, F., Corsonello, A., Buemi, M., Gregorio, T. D., Malara, A., Mauro, V. N., Macaione, S., & Ientile, R. (1999) · PubMed · Cited by 15 · see citing works
Relations between magnesium, calcium, and plasma renin activity in black and white hypertensive patients.
Touyz, R. M., Panz, V. R., & Milne, F. J. (1995) · PubMed · Cited by 14 · see citing works
Self-citation
Expression of platelet-derived growth factor-A mRNA in human placenta: Effect of magnesium infusion in pre-eclampsia
Jur̀čovičová, J., Krueger, K., Nandy, I. M., Lewis, D. F., Brooks, G. G., & Brown, E. G. (1998) · Placenta · doi:10.1016/s0143-4004(98)90083-2 · Cited by 12 · see citing works
Effect of oral magnesium supplementation on blood pressure, platelet aggregation and calcium handling in deoxycorticosterone acetate-induced hypertension in rats
Kisters, K., Hausberg, M., & Kosch, M. (2001) · Journal of Hypertension · doi:10.1097/00004872-200101000-00023 · Cited by 12 · see citing works
Influence of endothelium in the in vitro vasorelaxant effect of magnesium on aortic basal tension in DOCA-salt hypertensive rat.
Laurant, P., & Berthelot, A. (1992) · PubMed · Cited by 11 · see citing works
A Comparison of Free Intracellular Calcium and Magnesium Levels in the Vascular Smooth Muscle and Striated Muscle Cells of the Spontaneously Hypertensive and Wistar Kyoto Normotensive Rat
Ameen, M., Davies, J. E., & Ng, L. L. (1991) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1991.tb17348.x · Cited by 9 · see citing works
Interferon for mixed cryoglobulinemia associated with hepatitis C
DISDIER, P., Harle, J. ‐., & Weiller, P. J. (1992) · The American Journal of Medicine · doi:10.1016/0002-9343(92)90700-l · Cited by 9 · see citing works
Magnesium Uptake by Intestinal Brush-Border Membranes of Spontaneously Hypertensive Rats
Gilles-Baillien, M., & Cogneau, M. (1992) · Experimental Biology and Medicine · doi:10.3181/00379727-201-43489 · Cited by 7 · see citing works
Role of the Na+/Mg2+ exchanger in hypertensions
Kisters, K. (2003) · American Journal of Hypertension · doi:10.1016/s0895-7061(02)03148-5 · Cited by 6 · see citing works

Flagged first, then by citations

Sorted by citations

Transient Receptor Potential Channels in the Vasculature
Earley, S., & Brayden, J. E. (2015) · Physiological Reviews · doi:10.1152/physrev.00026.2014 · Cited by 414 · see citing works
Suboptimal magnesium status in the United States: are the health consequences underestimated?
Rosanoff, A., Weaver, C. M., & Rude, R. K. (2012) · Nutrition Reviews · doi:10.1111/j.1753-4887.2011.00465.x · Cited by 371 · see citing works
Nutritional Deficiencies in Morbidly Obese Patients: A New Form of Malnutrition?: Part A: Vitamins
Kaidar-Person, O., Person, B., Szomstein, S., & Rosenthal, R. J. (2008) · Obesity Surgery · doi:10.1007/s11695-007-9349-y · Cited by 325 · see citing works
Mitochondrial Channels: Ion Fluxes and More
Szabó, I., & Zoratti, M. (2014) · Physiological Reviews · doi:10.1152/physrev.00021.2013 · Cited by 321 · see citing works
Role of Magnesium Deficiency in Promoting Atherosclerosis, Endothelial Dysfunction, and Arterial Stiffening as Risk Factors for Hypertension
Kostov, K. G., & Halacheva, L. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061724 · Cited by 206 · see citing works
Cell (patho)physiology of magnesium
Wolf, F. I., & Trapani, V. (2007) · Clinical Science · doi:10.1042/cs20070129 · Cited by 193 · see citing works
Proton-pump inhibitor use is associated with low serum magnesium concentrations
Danziger, J., William, J. H., Scott, D., Lee, J., Lehman, L.-W. H., Mark, R. G., Howell, M. D., Celi, L. A., & Mukamal, K. J. (2013) · Kidney International · doi:10.1038/ki.2012.452 · Cited by 184 · see citing works
Transient receptor potential melastatin 6 and 7 channels, magnesium transport, and vascular biology: implications in hypertension
Touyz, R. M. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00903.2007 · Cited by 161 · see citing works
Self-citation
Oxidative stress in preeclampsia and the role of free fetal hemoglobin
Hansson, S. R., Nääv, Å., & Erlandsson, L. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2014.00516 · Cited by 159 · see citing works
Cocoa consumption for 2 wk enhances insulin-mediated vasodilatation without improving blood pressure or insulin resistance in essential hypertension
Muniyappa, R., Hall, G., Kolodziej, T. L., Karne, R. J., Crandon, S. K., & Quon, M. J. (2008) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26457 · Cited by 155 · see citing works
Nutritional Deficiencies in Morbidly Obese Patients: A New Form of Malnutrition?
Kaidar‐Person, O., Person, B., Szomstein, S., & Rosenthal, R. J. (2008) · Obesity Surgery · doi:10.1007/s11695-007-9350-5 · Cited by 144 · see citing works
Magnesium and Vascular Changes in Hypertension
Cunha, A. R., Umbelino, B., Correia, M. L., & Neves, M. F. (2012) · International Journal of Hypertension · doi:10.1155/2012/754250 · Cited by 131 · see citing works
Magnesium in Hypertension, Cardiovascular Disease, Metabolic Syndrome, and Other Conditions: A Review
Champagne, C. M. (2008) · Nutrition in Clinical Practice · doi:10.1177/0884533608314533 · Cited by 128 · see citing works
Nut consumption and risk of hypertension in US male physicians
Djoussé, L., Rudich, T., & Gaziano, J. M. (2008) · Clinical Nutrition · doi:10.1016/j.clnu.2008.08.005 · Cited by 128 · see citing works
Mediterranean diet and blood pressure reduction in adults with and without hypertension: A systematic review and meta-analysis of randomized controlled trials
Filippou, C. D., Thomopoulos, C., Kouremeti, M., Sotiropoulou, L., Nihoyannopoulos, P., Tousoulis, D. M., & Tsioufis, C. P. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.01.030 · Cited by 122 · see citing works
Changes in Intestinal Bifidobacteria Levels Are Associated with the Inflammatory Response in Magnesium-Deficient Mice
Pachikian, B. D., Neyrinck, A. M., Deldicque, L., Backer, F. C. D., Catry, É., Dewulf, E. M., Sohet, F. M., Bindels, L. B., Everard, A., Francaux, M., et al. (2010) · Journal of Nutrition · doi:10.3945/jn.109.117374 · Cited by 111 · see citing works
Dietary Approaches to Stop Hypertension (DASH): potential mechanisms of action against risk factors of the metabolic syndrome
Akhlaghi, M. (2019) · Nutrition Research Reviews · doi:10.1017/s0954422419000155 · Cited by 103 · see citing works
Hypermagnesemia in Clinical Practice
AalHamad, A. H., Alawi, A. M. A., Kashoub, M. S., & Falhammar, H. (2023) · Medicina · doi:10.3390/medicina59071190 · Cited by 89 · see citing works
Nuts, hypertension and endothelial function
Casas‐Agustench, P., López-Uriarte, P. J., Ros, E., Bulló, M., & Salas‐Salvadó, J. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2011.01.009 · Cited by 87 · see citing works
Design and Synthesis of a FlAsH-Type Mg2+ Fluorescent Probe for Specific Protein Labeling
Fujii, T., Shindo, Y., Hotta, K., Citterio, D., Nishiyama, S., Suzuki, K. A. O., & Oka, K. (2014) · Journal of the American Chemical Society · doi:10.1021/ja410031n · Cited by 85 · see citing works
Relations Between Dairy Food Intake and Arterial Stiffness
Crichton, G. E., Elias, M. F., Dore, G. A., Abhayaratna, W. P., & Robbins, M. A. (2012) · Hypertension · doi:10.1161/hypertensionaha.111.190017 · Cited by 82 · see citing works
The effects of combined magnesium and zinc supplementation on metabolic status in patients with type 2 diabetes mellitus and coronary heart disease
Hamedifard, Z., Farrokhian, A., Reiner, Ž., Bahmani, F., Asemi, Z., Ghotbi, M., & Taghizadeh, M. (2020) · Lipids in Health and Disease · doi:10.1186/s12944-020-01298-4 · Cited by 77 · see citing works
Optimizing desalinated sea water blending with other sources to meet magnesium requirements for potable and irrigation waters
Avni, N., Eben‐Chaime, M., & Oron, G. (2013) · Water Research · doi:10.1016/j.watres.2013.01.018 · Cited by 76 · see citing works
Layered double hydroxide/poly-dopamine composite coating with surface heparinization on Mg alloys: improved anticorrosion, endothelialization and hemocompatibility
Li, H., Peng, F., Wang, D., Qiao, Y., Xu, D., & Liu, X. (2018) · Biomaterials Science · doi:10.1039/c8bm00298c · Cited by 75 · see citing works
Low cardiovascular risks in the middle aged males and females excreting greater 24-hour urinary taurine and magnesium in 41 WHO-CARDIAC study populations in the world
Yamori, Y., Taguchi, T., Mori, H., & Mori, M. (2010) · Journal of Biomedical Science · doi:10.1186/1423-0127-17-s1-s21 · Cited by 74 · see citing works
Oral magnesium supplementation improves endothelial function and attenuates subclinical atherosclerosis in thiazide-treated hypertensive women
Cunha, A. R., d’El-Rei, J., Medeiros, F., Umbelino, B., Oigman, W., Touyz, R. M., & Neves, M. F. (2016) · Journal of Hypertension · doi:10.1097/hjh.0000000000001129 · Cited by 73 · see citing works
Self-citation
Impact of Micronutrients on Hypertension: Evidence from Clinical Trials with a Special Focus on Meta-Analysis
Chiu, H., Venkatakrishnan, K., Головинская, О., & Wang, C. (2021) · Nutrients · doi:10.3390/nu13020588 · Cited by 72 · see citing works
Review of Dairy Consumption and Cognitive Performance in Adults: Findings and Methodological Issues
Crichton, G. E., Bryan, J., Murphy, K. J., & Buckley, J. D. (2010) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000320987 · Cited by 72 · see citing works
Oral Magnesium Supplementation Improves the Metabolic Profile of Metabolically Obese, Normal-weight Individuals: A Randomized Double-blind Placebo-controlled Trial
Rodríguez‐Morán, M., & Guerrero‐Romero, F. (2014) · Archives of Medical Research · doi:10.1016/j.arcmed.2014.05.003 · Cited by 70 · see citing works
Retracted: Magnesium supplementation affects metabolic status and pregnancy outcomes in gestational diabetes: a randomized, double-blind, placebo-controlled trial
Asemi, Z., Karamali, M., Jamilian, M., Foroozanfard, F., Bahmani, F., Heidarzadeh, Z., Benisi-Kohansal, S., Surkan, P. J., & Esmaillzadeh, A. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.098616 · Cited by 69 · see citing works
Retracted
Relation between dairy food intake and cognitive function: The Maine-Syracuse Longitudinal Study
Crichton, G. E., Elias, M. F., Dore, G. A., & Robbins, M. A. (2011) · International Dairy Journal · doi:10.1016/j.idairyj.2011.08.001 · Cited by 68 · see citing works
Pregnancy‐Related Risk Factors Are Associated With a Significant Burden of Treated Hypertension Within 10 Years of Delivery: Findings From a Population‐Based Norwegian Cohort
Egeland, G. M., Skurtveit, S. O., Staff, A. C., Eide, G. E., Daltveit, A. K., Klungsøyr, K., Trogstad, L., Magnus, P. M., Brantsæter, A. L., & Haugen, M. A. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.117.008318 · Cited by 67 · see citing works
Magnesium Reduces Blood-Brain Barrier Permeability and Regulates Amyloid-β Transcytosis
Zhu, D., Su, Y., Fu, B. M., & Xu, H. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-0896-0 · Cited by 64 · see citing works
Chia seed ( Salvia hispanica L.) supplementation to the diet of adults with type 2 diabetes improved systolic blood pressure: A randomized controlled trial
Alwosais, E. Z. M., Al‐Ozairi, E., Zafar, T. A., & Al-Kandari, S. (2021) · Nutrition and Health · doi:10.1177/0260106020981819 · Cited by 63 · see citing works
Nut consumption and risk of mortality in the Physicians’ Health Study
Hshieh, T. T., Petrone, A. B., Gaziano, J. M., & Djoussé, L. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.099846 · Cited by 63 · see citing works
The Effect of Electrolytes on Blood Pressure: A Brief Summary of Meta-Analyses
Iqbal, S., Klammer, N., & Ekmekçioğlu, C. (2019) · Nutrients · doi:10.3390/nu11061362 · Cited by 63 · see citing works
Magnesium homeostasis and alcohol consumption.
Romani, A. (2008) · PubMed · Cited by 62 · see citing works
Effect of magnesium supplementation on endothelial function: A systematic review and meta-analysis of randomized controlled trials
Mofrad, M. D., Djafarian, K., Mozaffari, H., & Shab‐Bidar, S. (2018) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2018.04.020 · Cited by 56 · see citing works
Newly Developed Mg2+–Selective Fluorescent Probe Enables Visualization of Mg2+ Dynamics in Mitochondria
Shindo, Y., Fujii, T., Komatsu, H., Citterio, D., Hotta, K., Suzuki, K. A. O., & Oka, K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023684 · Cited by 55 · see citing works
A novel chromo- and fluorogenic dual sensor for Mg 2+ and Zn 2+ with cell imaging possibilities and DFT studies
Alam, R., Mistri, T., Katarkar, A., Chaudhuri, K., Mandal, S. K., Khuda‐Bukhsh, A. R., Das, K. K., & Ali, M. (2014) · The Analyst · doi:10.1039/c3an02347h · Cited by 55 · see citing works
Magnesium transport in hypertension
Sontia, B., & Touyz, R. M. (2007) · Pathophysiology · doi:10.1016/j.pathophys.2007.09.005 · Cited by 52 · see citing works
Self-citation
Relationships between micronutrient losses in sweat and blood pressure among heat-exposed steelworkers
Tang, Y., Wang, D., Jun, L. I., Li, X., Wang, Q., Liu, N., Liu, W., & Li, Y. (2016) · Industrial Health · doi:10.2486/indhealth.2014-0225 · Cited by 50 · see citing works
Vascular biology of magnesium and its transporters in hypertension.
Yogi, Á., Callera, G. E., Antunes, T. T., Tostes, R. C., & Touyz, R. M. (2010) · PubMed · doi:10.1684/mrh.2010.0222 · Cited by 49 · see citing works
Self-citation
Effects of magnesium supplementation on carotid intima–media thickness and metabolic profiles in diabetic haemodialysis patients: a randomised, double-blind, placebo-controlled trial
Talari, H. R., Zakizade, M., Soleimani, A., Bahmani, F., Ghaderi, A., Mirhosseini, N. Z., Eslahi, M., Babadi, M., Mansournia, M. A., & Asemi, Z. (2019) · British Journal Of Nutrition · doi:10.1017/s0007114519000163 · Cited by 48 · see citing works
A Mediterranean Diet to Improve Cardiovascular and Cognitive Health: Protocol for a Randomised Controlled Intervention Study
Wade, A. T., Davis, C. R., Dyer, K. A., Hodgson, J. M., Woodman, R. J., Keage, H. A. D., & Murphy, K. J. (2017) · Nutrients · doi:10.3390/nu9020145 · Cited by 46 · see citing works
Serum magnesium in the metabolically-obese normal-weight and healthy-obese subjects
Guerrero‐Romero, F., & Rodríguez‐Morán, M. (2013) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2013.02.014 · Cited by 46 · see citing works
Posterior reversible encephalopathy syndrome (PRES) and hypomagnesemia: A frequent association?
Chardain, A., Mesnage, V., Alamowitch, S., Bourdain, F., Crozier, S., Lenglet, T., Psimaras, D., Demeret, S., Graveleau, P., Hoang‐Xuan, K., et al. (2016) · Revue Neurologique · doi:10.1016/j.neurol.2016.06.004 · Cited by 46 · see citing works
Renal function of cyclin M2 Mg2+ transporter maintains blood pressure
Funato, Y., Yamazaki, D., & Miki, H. (2016) · Journal of Hypertension · doi:10.1097/hjh.0000000000001211 · Cited by 46 · see citing works
The Influence of Polyphenols on Atherosclerosis Development
Ziółkiewicz, A., Kasprzak‐Drozd, K., Rusinek, R., Markut–Miotła, E., & Oniszczuk, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087146 · Cited by 45 · see citing works
Dairy consumption and working memory performance in overweight and obese adults
Crichton, G. E., Murphy, K. J., Howe, P. R. C., Buckley, J. D., & Bryan, J. (2012) · Appetite · doi:10.1016/j.appet.2012.03.019 · Cited by 44 · see citing works
Magnesium Replacement Does Not Improve Insulin Resistance in Patients With Metabolic Syndrome: A 12-Week Randomized Double-Blind Study
Silva, L. D. S. E. (2014) · Journal of Clinical Medicine Research · doi:10.14740/jocmr1580w · Cited by 43 · see citing works
Dysregulation of renal transient receptor potential melastatin 6/7 but not paracellin-1 in aldosterone-induced hypertension and kidney damage in a model of hereditary hypomagnesemia
Yogi, Á., Callera, G. E., O'Connor, S. E., He, Y., Corrêa, J. W. D. N., Tostes, R. C., Mazur, A., & Touyz, R. M. (2011) · Journal of Hypertension · doi:10.1097/hjh.0b013e32834786d6 · Cited by 41 · see citing works
Self-citation
A turn-on fluorescent sensor for highly selective recognition of Mg2+ based on new Schiff’s base derivative
Wang, G.-Q., Qin, J., Fan, L. F., Li, C.-R., & Yang, Z. (2015) · Journal of Photochemistry and Photobiology A Chemistry · doi:10.1016/j.jphotochem.2015.08.005 · Cited by 41 · see citing works
Mitochondrial energy conversion disturbance with decrease in ATP production as a source of systemic arterial hypertension
Postnov, Y. V., Orlov, S. N., Budnikov, Y., Doroschuk, A. D., & Postnov, A. Y. (2007) · Pathophysiology · doi:10.1016/j.pathophys.2007.09.002 · Cited by 40 · see citing works
Role of Dietary Components in Modulating Hypertension
Feyh, A., & Bracero, L. A. (2016) · doi:10.4172/2155-9880.1000433 · Cited by 40 · see citing works
Umbilical cord blood nutrients in low birth weight babies in relation to birth weight & gestational age.
Elizabeth, K., Krishnan, V., & Vijayakumar, T. (2008) · PubMed · Cited by 40 · see citing works
Serum magnesium concentrations and all-cause, cardiovascular, and cancer mortality among U.S. adults: Results from the NHANES I Epidemiologic Follow-up Study
Zhang, X., Xia, J., Gobbo, L. C. D., Hruby, A., Dai, Q., & Song, Y. (2017) · Clinical Nutrition · doi:10.1016/j.clnu.2017.08.021 · Cited by 39 · see citing works
Significance of platelet endothelial cell adhesion molecule-1 (PECAM-1) and intercellular adhesion molecule-1 (ICAM-1) expressions in preeclamptic placentae
Erol, A. Y. G., Nazli, M., & YILDIZ, S. E. (2012) · Endocrine · doi:10.1007/s12020-012-9644-9 · Cited by 39 · see citing works
Magnesium Deficiency Affects Mammary Epithelial Cell Proliferation: Involvement of Oxidative Stress
Wolf, F. I., Trapani, V., Simonacci, M., Boninsegna, A., Mazur, A., & Maier, J. A. M. (2008) · Nutrition and Cancer · doi:10.1080/01635580802376360 · Cited by 38 · see citing works
Severe Hypomagnesemia Associated With Reversible Subacute Ataxia and Cerebellar Hyperintensities on MRI
Boulos, M. I., Shoamanesh, A., Aviv, R. I., Gladstone, D. J., & Swartz, R. H. (2012) · The Neurologist · doi:10.1097/nrl.0b013e31825bbf07 · Cited by 37 · see citing works
Omeprazole use and risk of chronic kidney disease evolution
Guedes, J. V. M., Aquino, J. A., Castro, T. L. B., de Morais, F. A., Baldoni, A. O., Belo, V. S., & Otoni, A. (2020) · PLoS ONE · doi:10.1371/journal.pone.0229344 · Cited by 36 · see citing works
Common single nucleotide polymorphisms in transient receptor potential melastatin type 6 increase the risk for proton pump inhibitor-induced hypomagnesemia
Hess, M. W., de Baaij, J. H. F., Broekman, M. M. T. J., Bisseling, T. M., Haarhuis, B., Tan, A. C. I. T. L., Morsche, R. H. M. T., Hoenderop, J. G. J., Bindels, R. J. M., & Drenth, J. P. H. (2016) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0000000000000259 · Cited by 34 · see citing works
An inverse association between magnesium in 24-h urine and cardiovascular risk factors in middle-aged subjects in 50 CARDIAC Study populations
for the CARDIAC Study Group, Yamori, Y., Sagara, M., Mizushima, S., Liu, L., Ikeda, K., & Nara, Y. (2014) · Hypertension Research · doi:10.1038/hr.2014.158 · Cited by 33 · see citing works
Association of blood pressure and metabolic syndrome components with magnesium levels in drinking water in some Serbian municipalities
Rašić-Milutinović, Z., Peruničić-Peković, G., Jovanović, D., Gluvic, Z. M., & Čanković‐Kadijević, M. (2012) · Journal of Water and Health · doi:10.2166/wh.2012.028 · Cited by 32 · see citing works
Brazil and cashew nuts intake improve body composition and endothelial health in women at cardiometabolic risk (Brazilian Nuts Study): a randomised controlled trial
Caldas, A. P. S., Rocha, D. M. U. P., Dionísio, A. P., Hermsdorff, H. H. M., & Bressan, J. (2022) · British Journal Of Nutrition · doi:10.1017/s000711452100475x · Cited by 30 · see citing works
Magnesium Sulfate Normalizes Placental Interleukin-6 Secretion in Preeclampsia
Amash, A., Holcberg, G., Sheiner, E., & Huleihel, M. (2010) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2010.0011 · Cited by 29 · see citing works
Magnesium and FGF-23 are independent predictors of pulse pressure in pre-dialysis diabetic chronic kidney disease patients
Fragoso, A., Silva, A. P., Gundlach, K., Büchel, J., & Neves, P. L. (2014) · Clinical Kidney Journal · doi:10.1093/ckj/sfu003 · Cited by 28 · see citing works
Magnesium and the risk of all-cause and cardiac mortality in hemodialysis patients: agent provocateur or innocent bystander?
Courivaud, C., & Davenport, A. (2013) · Kidney International · doi:10.1038/ki.2013.301 · Cited by 27 · see citing works
Study of Magnesium Formulations on Intestinal Cells to Influence Myometrium Cell Relaxation
Uberti, F., Morsanuto, V., Ruga, S., Galla, R., Farghali, M., Notte, F., Bozzo, C., Magnani, C., Nardone, A., & Molinari, C. G. (2020) · Nutrients · doi:10.3390/nu12020573 · Cited by 27 · see citing works
Magnesium and stress
Cuciureanu, M. D., & Vink, R. (2011) · University of Adelaide Press eBooks · doi:10.1017/upo9780987073051.020 · Cited by 26 · see citing works
Effects of chia seed (Salvia hispanica L.) supplementation on cardiometabolic health in overweight subjects: a systematic review and meta-analysis of RCTs
Karimi, M., Pirzad, S., Shirsalimi, N., Ahmadizad, S., Hashemi, S. M., Karami, S., Kazemi, K., Shahir-Roudi, E., & Aminzadeh, A. (2024) · Nutrition & Metabolism · doi:10.1186/s12986-024-00847-3 · Cited by 25 · see citing works
Disorders of Calcium, Magnesium, and Phosphate Balance
Smogorzewski, M. J., Robert K. Rude, & Yu, A. S. L. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4160-6193-9.10018-1 · Cited by 25 · see citing works
Chia seeds ameliorate cardiac disease risk factors via alleviating oxidative stress and inflammation in rats fed high-fat diet
Aref, M., FaragAllah, E. M., Goda, N. I. A., Abu-Alghayth, M. H., Abomughaid, M. M., Mahboub, H. H. H., Alwutayd, K. M., & ELSHERBINI, H. A. (2024) · Scientific Reports · doi:10.1038/s41598-023-41370-4 · Cited by 24 · see citing works
Posterior reversible encephalopathy syndrome in preeclampsia and eclampsia: The role of hypomagnesemia
Fang, X., Wang, H., Liu, Z., Chen, J., Tan, H., Liang, Y., & Chen, D. (2020) · Seizure · doi:10.1016/j.seizure.2020.01.003 · Cited by 23 · see citing works
Low Calcium Intake in Midpregnancy Is Associated with Hypertension Development within 10 Years after Pregnancy: The Norwegian Mother and Child Cohort Study
Egeland, G. M., Skurtveit, S. O., Sakshaug, S., Daltveit, A. K., Vikse, B. E., & Haugen, M. A. (2017) · Journal of Nutrition · doi:10.3945/jn.117.251520 · Cited by 21 · see citing works
Structure-based differences between the metal ion selectivity of two siderophores desferrioxamine B (DFB) and desferricoprogen (DFC): Why DFC is much better Pb(II) sequestering agent than DFB?
Farkas, E., Bátka, D., Kremper, G., & Pócsi, I. (2008) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2008.03.006 · Cited by 21 · see citing works
Effects of Serum Calcium and Magnesium on Heart Rate Variability in Adult Women
Kim, Y.-H., Jung, K.-I., & Song, C.-H. (2012) · Biological Trace Element Research · doi:10.1007/s12011-012-9518-2 · Cited by 20 · see citing works
Insight into the molecular regulation of the epithelial magnesium channel TRPM6
Cao, G., Hoenderop, J. G. J., & Bindels, R. J. M. (2008) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0b013e328303e184 · Cited by 20 · see citing works
Altered vascular structure and wave reflection in hypertensive women with low magnesium levels
Cunha, A. R., Medeiros, F., Umbelino, B., Oigman, W., Touyz, R. M., & Neves, M. F. (2013) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2013.04.008 · Cited by 19 · see citing works
Self-citation
Dietary Mineral Intake from Nuts and Its Relationship to Hypertension Among Korean Adults
Bae, Y., Kim, M., & Choi, M. (2021) · Biological Trace Element Research · doi:10.1007/s12011-021-02952-3 · Cited by 19 · see citing works
[Nutrition, metabolic syndrome and morbid obesity].
Gil, M. R., Teruel, V. S., Aguirregoicoa, E., Gómez, L. C., López, Y., & García-Blanch, G. (2011) · PubMed · doi:10.1590/s0212-16112011000400014 · Cited by 18 · see citing works
Nut Consumption and Effects on Chronic Kidney Disease and Mortality in the United States
Wang, K., Qian, D., Hu, Y., Cheng, Y., Ge, S., & Yao, Y. (2022) · American Journal of Nephrology · doi:10.1159/000524382 · Cited by 18 · see citing works
Hypomagnesemia in Intracerebral Hemorrhage
Behrouz, R., Hafeez, S., Mutgi, S. A., Zakaria, A., & Miller, C. (2015) · World Neurosurgery · doi:10.1016/j.wneu.2015.08.036 · Cited by 18 · see citing works
Preeclampsia/eclampsia: Reto para el ginecoobstetra
Pacheco, J. (2006) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · Cited by 18 · see citing works
SLC41A1 knockdown inhibits angiotensin II-induced cardiac fibrosis by preventing Mg2+ efflux and Ca2+ signaling in cardiac fibroblasts
Yu, N., Jiang, J., Yu, Y., Li, H., Huang, X., Ma, Y., Zhang, L., Zou, J., Zhang, B., Chen, S., et al. (2014) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2014.09.013 · Cited by 16 · see citing works
Disorders of bone and bone mineral metabolism
Komoroski, M., Azad, N., & Camacho, P. M. (2013) · Handbook of clinical neurology · doi:10.1016/b978-0-7020-4087-0.00058-9 · Cited by 16 · see citing works
Importance of plant sources of magnesium for human health
Nielsen, F. H. (2015) · Australian Journal of Agricultural Research · doi:10.1071/cp15072 · Cited by 16 · see citing works
Effects of magnesium supplementation on electrophysiological remodeling of cardiac myocytes in L-NAME induced hypertensive rats
Öztürk, N., Olğar, Y., Aslan, M., & Özdemir, S. (2016) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-016-9666-8 · Cited by 16 · see citing works
Challenges of Changing Water Sources for Human Wellbeing in the Arctic Zone of Western Siberia
Bogdanova, E. N., Lobanov, A. A., Andronov, S. V., Soromotin, A. V., Popov, A., Skalny, A. V., Shaduyko, O. M., & Callaghan, T. V. (2023) · Water · doi:10.3390/w15081577 · Cited by 15 · see citing works
Auxologic, Biochemical and Clinical (ABC) Profile of Low Birth Weight Babies A 2-year Prospective Study
Elizabeth, K. E., Krishnan, V., & Zachariah, P. (2007) · Journal of Tropical Pediatrics · doi:10.1093/tropej/fmm048 · Cited by 14 · see citing works
Mg-supplementation attenuated lipogenic and oxidative/nitrosative gene expression caused by Combination Antiretroviral Therapy (cART) in HIV-1-transgenic rats
Elzohary, L., Weglicki, W. B., Chmielinska, J. J., Kramer, J. H., & Mak, I. T. (2019) · PLoS ONE · doi:10.1371/journal.pone.0210107 · Cited by 14 · see citing works
Recent Applications of Magnesium Chemical Sensors in Biological Samples
Algarra, M., Jiménez-Herrera, C. M., & da Silva, J. C. G. E. (2014) · Critical Reviews in Analytical Chemistry · doi:10.1080/10408347.2013.867229 · Cited by 14 · see citing works
Relationship of Sodium and Magnesium Intakes to Hypertension Proven by 24‐Hour Urianalysis in a South Indian Population
Chidambaram, N., Sethupathy, S., Saravanan, N., Mori, M., Yamori, Y., Garg, A., & Chockalingam, A. (2014) · Journal of Clinical Hypertension · doi:10.1111/jch.12361 · Cited by 13 · see citing works
Features of infratentorial-predominant posterior reversible encephalopathy syndrome
Fitzgerald, R. T., Samant, R. S., Kumar, M., Hemert, R. L. V., & Angtuaco, E. J. (2015) · Acta Neurologica Belgica · doi:10.1007/s13760-015-0431-2 · Cited by 13 · see citing works
Reversible posterior leukoencephalopathy syndrome following intravenous paclitaxel and intraperitoneal cisplatin chemotherapy for fallopian tube cancer
Onujiogu, N. A., Lengyel, E. R., & Yamada, S. D. (2008) · Gynecologic Oncology · doi:10.1016/j.ygyno.2008.04.032 · Cited by 13 · see citing works
Additional antihypertensive effect of magnesium supplementation with an angiotensin II receptor blocker in hypomagnesemic rats
Jin, K., Kim, T. H., Kim, Y. H., & Kim, Y. W. (2013) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2013.28.2.197 · Cited by 13 · see citing works
The Role of Platelet-Activating Factor and Magnesium in Obstetrics and Gynecology: Is There Crosstalk between Pre-Eclampsia, Clinical Hypertension, and HELLP Syndrome?
Chawla, N., Shah, H., Huynh, K., Braun, A., Wollocko, H., & Shah, N. C. (2023) · Biomedicines · doi:10.3390/biomedicines11051343 · Cited by 12 · see citing works
Magnesium taurate attenuates progression of hypertension and cardiotoxicity against cadmium chloride-induced hypertensive albino rats
Shrivastava, P., Choudhary, R., Nirmalkar, U., Singh, A., Shree, J., Vishwakarma, P. K., & Bodakhe, S. H. (2018) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2017.06.010 · Cited by 12 · see citing works
Movement Disorders and Other Neurologic Impairment Associated With Hypomagnesemia
Ray, S., & Park, K. W. (2023) · Neurology Clinical Practice · doi:10.1212/cpj.0000000000200202 · Cited by 12 · see citing works
PENGARUH PEMBERIAN JUS MENTIMUN (Cucumis sativus L.) TERHADAP TEKANAN DARAH SISTOLIK DAN DIASTOLIK PADA PENDERITA HIPERTENSI
Lebalado, L. P., & Mulyati, T. (2014) · Journal of Nutrition College · doi:10.14710/jnc.v3i3.6602 · Cited by 12 · see citing works

Authors: Sontia, B., & Touyz, R. M.
Affiliations: University of Ottawa (CA)
Corresponding author: Touyz, Rhian M.
ORCID: Touyz, Rhian M.
Venue: Archives of Biochemistry and Biophysics
Publisher: Elsevier BV
Published: 2007-02
Volume: 458
Issue: 1
Pages: 33-39
ISSN: 0003-9861 (ISSN-L)
DOI: 10.1016/j.abb.2006.05.005
OpenAlex: W1996458826
Cited by: 202
References: 120
Citations by year: 2026: 3 · 2025: 6 · 2024: 11 · 2023: 9 · 2022: 10 · 2021: 11 · 2020: 17 · 2019: 9 · 2018: 8 · 2017: 4 · 2016: 10 · 2015: 12 · 2014: 17 · 2013: 15 · 2012: 16
FWCI: 7.63
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Archives of Biochemistry and Biophysics (publishedVersion)
PubMed (publishedVersion)
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Magnesium in Health and Disease
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Physical Sciences › Materials Science › Biomaterials › Magnesium Alloys: Properties and Applications
Keywords: magnesium, hypertension, hypomagnesemia, blood pressure regulation, vascular tone, calcium channel blockade, prostacyclin, nitric oxide, metabolic syndrome, insulin homeostasis, glucose homeostasis, preeclampsia
MeSH terms: Animals, Humans, Hypertension, Magnesium

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Role of magnesium in hypertension

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks